Acne-removing composition and application thereof, acne-removing essence containing composition and preparation method of acne-removing essence

Abstract

The invention belongs to the field of cosmetics, and relates to an acne-removing composition and application thereof, acne-removing essence containing the composition and a preparation method of the acne-removing essence, and the acne-removing composition is prepared from the following components in parts by weight: 5-10 parts of centella asiatica extract, 1-10 parts of PCA zinc, 1-10 parts of water-soluble salicylic acid, 1-10 parts of peony root and bark extract, 1-10 parts of folium artemisiae argyi extract and the balance of pure water. The composition is simple in medicine use and proper in compatibility, the problem of removing or relieving the acne on the skin is solved by solving two factors (oil control and bacteriostasis) which influence the generation of the acne, and meanwhile, the safety problems of skin irritation, sensitivity and the like which are left by conventional products are not caused.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an anti-acne composition and application thereof, an anti-acne essence containing the composition and a preparation method thereof. Background Art

[0002] With the rapid development of modern information technology and a large number of industrialized production, people's pace of life has become faster, resulting in more and more skin problems. Acne is one of the typical skin problems. Acne, also known as "pimples", is the most common skin disease. 80% of people between the ages of 11 and 30 will suffer from this disease.

[0003] The pathogenesis of acne is complicated, and there are many factors that affect the occurrence of acne (commonly called pimples in daily life). The current research that has been reported on the occurrence of acne is mainly due to the massive reproduction of Propionibacterium acnes, which leads to the destruction of the skin's microecological environment, causing a large amount of skin sebum to decompose into free acid, resulting in inflammatory reactions such as redness, swelling, and pain in the skin. Macrophages play a mediating role in the inflammatory reaction process, and activated pro-inflammatory factors such as TNF-α and pro-inflammatory mediator NO will induce and enhance local inflammatory reactions, thereby aggravating the production of acne muscles. Internationally, clinical treatment of acne has always been dominated by oral antibiotics and hormone drugs. In recent years, the use of anti-acne drugs in China has shifted to non-retinoic acid products, but these products have large side effects, cannot be cured, and acne is prone to recurrence. Therefore, it is necessary to develop an acne-removing product that can effectively regulate acne muscles, inhibit acne regeneration, reduce inflammation and fight bacteria, and is mild, non-irritating, low-sensitivity and safe.

[0004] Chinese patent application with publication number CN117695190A discloses an acne-removing composition and its application and an acne-removing cream containing the acne-removing composition. The acne-removing composition includes avocado tree fat, phellodendron amurense extract, black willow bark extract, purslane extract, perilla extract, Centella asiatica extract and mung bean extract. It effectively regulates acne skin and inhibits acne regeneration, smoothes acne pits, removes acne marks, and can be directly applied or added to acne-removing skin care products; Chinese patent application with publication number CN 115381745 A discloses an acne-removing oil-control composition, including the following raw materials in parts by weight: 5-10 parts of Inula japonica extract, 3-6 parts of Centella asiatica extract, 2-5 parts of guava extract, 1-4 parts of peony root extract, 1-3 parts of lotus leaf extract, 2-5 parts of European Dryopteris extract, 1-3 parts of neem leaf extract, 1-3 parts of Agrimony foetida extract, 1-2 parts of fibronectin, and 2-6 parts of carboxymethyl deacetylated chitosan. It can be seen that the use of mild and effective acne-removing products containing Chinese herbal ingredients for the treatment of acne is increasingly valued and recognized. After searching, no combination of Centella asiatica extract, PCA zinc, water-soluble salicylic acid, peony root bark extract, and wormwood leaf extract and the use of the combination in acne-removing skin care products have been found so far. Summary of the invention

[0005] The purpose of the present invention is to provide an acne-removing active composition, which can remove or alleviate the problem of skin acne by solving the two major factors that affect the occurrence of acne (oil control and antibacterial), while not causing the safety problems such as skin irritation and sensitivity left by conventional products.

[0006] To achieve the above object, the present invention provides an acne-removing composition, which comprises the following components, calculated based on the total weight of the acne-removing composition as 100 parts by weight: 5-10 parts of Centella asiatica extract, 1-10 parts of PCA zinc, 1-10 parts of water-soluble salicylic acid, 1-10 parts of peony root bark extract, 1-10 parts of wormwood leaf extract, and the rest is pure water.

[0007] According to the embodiments of the present application, based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition includes the following components in parts by weight: 5 parts of Centella asiatica extract, 2 parts of PCA zinc, 3 parts of water-soluble salicylic acid, 5 parts of peony root bark extract and 5 parts of wormwood leaf extract, and the rest is water.

[0008] According to the embodiments of the present application, based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition includes the following components in parts by weight: 5 parts of Centella asiatica extract, 1 part of PCA zinc, 5 parts of water-soluble salicylic acid, 5 parts of peony root bark extract, 5 parts of wormwood leaf extract, and the rest being water.

[0009] According to the embodiments of the present application, based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition includes the following components in parts by weight: 8 parts of Centella asiatica extract, 2 parts of PCA zinc, 2 parts of water-soluble salicylic acid, 5 parts of peony root bark extract, 8 parts of wormwood leaf extract, and the rest being water.

[0010] According to the embodiments of the present application, based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition includes the following components in parts by weight: 8 parts of Centella asiatica extract, 2 parts of PCA zinc, 2 parts of water-soluble salicylic acid, 8 parts of peony root bark extract, 5 parts of wormwood leaf extract, and the rest being water.

[0011] According to the embodiments of the present application, based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition includes the following components in parts by weight: 8 parts of Centella asiatica extract, 1 part of PCA zinc, 2 parts of water-soluble salicylic acid, 8 parts of peony root bark extract, 8 parts of wormwood leaf extract, and the rest being water.

[0012] Another aspect of the present application discloses the use of the above-mentioned acne-removing composition in the preparation of acne-removing skin care products.

[0013] Another aspect of the present application discloses an acne-removing essence, comprising the following raw materials, based on the total weight of the acne-removing essence as 100 weight percent: 2%-5% of the acne-removing composition described above, 3%-10% of glycerol, 0.2%-0.5% of carbomer, 3%-10% of butylene glycol, 0.5%-1% of a preservative, 0.05%-0.2% of sodium metabisulfite, 0.05%-0.2% of dipotassium glycyrrhizinate, and 73.1%-91.2% of water.

[0014] According to an embodiment of the present application, an acne-removing essence is composed of the following raw materials, with the total weight of the acne-removing essence being 100 weight percent: 5% of the above-mentioned acne-removing composition, 3% of glycerin, 0.3% of carbomer, 3% of butylene glycol, 0.5% of a preservative, 0.1% of sodium metabisulfite, 0.05% of dipotassium glycyrrhizate and 88% of water.

[0015] The present application also discloses a method for preparing the above-mentioned acne-removing essence, which is characterized by comprising the following steps:

[0016] S1: Add water, glycerin, carbomer and butylene glycol into the main pot, heat to 75-85°C while stirring, and stir until the materials are completely dissolved. Keep stirring for 15 minutes and then start to cool down;

[0017] S2: When the temperature drops to 45°C, add the anti-acne composition, preservatives, sodium metabisulfite and dipotassium glycyrrhizinate into the reaction pot, stir and mix evenly, and then cool to below 38°C before discharging to obtain the anti-acne essence.

[0018] The beneficial effects of the technical solution of the present invention compared with the prior art are:

[0019] 1. The anti-acne active composition provided by the present invention has simple medication and proper compatibility. It has been tested in clinical practice for many years and has the effect of removing acne. The pharmacological effects of the Centella asiatica extract and the Artemisia argyi extract in the formula include anti-inflammatory, damage repair, anti-oxidation, anti-aging, improvement of skin barrier hydration, anti-scarring, etc.; PCA zinc can reduce excessive sebum secretion, has high antibacterial activity, and only needs a low dose to inhibit the growth of bacteria on the skin surface; salicylic acid is a fat-soluble natural active ingredient with the effects of oil control, anti-inflammatory, and two-way keratin regulation; Paeonia suffruticosa root bark extract can significantly improve inflammatory damage to the skin without producing cytotoxicity, and also has excellent antioxidant properties, and has a good protective effect on acne skin caused by inflammation.

[0020] 2. The acne-removing composition of the present invention is composed of a variety of plant extracts, which are natural and non-irritating, effectively inhibit bacteria, relieve skin redness, inflammation and other discomforts, and can dissolve grease and dirt deep in the pores, unclog blocked hair follicles, expel toxins, and inhibit acne regeneration.

[0021] 3. The addition of the acne-removing active complex provided by the present invention to the essence has been shown to be more effective (1-2 weeks) and more effective in removing acne in patients with acne, with a total effective rate of 91.7% and a cure rate of 85%, which is significantly better than the common compound acne-removing products on the market.

[0022] 4. The acne-removing essence provided by the present invention has the effects of removing acne, removing acne marks, reducing inflammation and swelling, and has a fast onset and obvious effect. The acne-removing effect can be seen after 1-2 weeks of use, and there is no irritation. The preparation method is simple, and the acne-removing active composition can be directly added to the cosmetic matrix. The raw materials of the acne-removing essence of the present invention are easy to obtain, the preparation process is simple, the conditions are easy to control, and it can be promoted and applied. DETAILED DESCRIPTION

[0023] The present invention will be further described below in conjunction with specific examples. The following examples are used to illustrate the present invention but are not intended to limit the scope of the present invention.

[0024] On the one hand, the present invention illustrates an acne-removing composition, which includes the following components based on the total weight of the acne-removing composition of 100 parts by weight: 5-10 parts of Centella asiatica extract, 1-10 parts of PCA zinc, 1-10 parts of water-soluble salicylic acid, 1-10 parts of peony root bark extract, 1-10 parts of wormwood leaf extract, and the rest is pure water. Since the commonly used acne-removing effective ingredients on the market are mainly derived from chemically synthesized substances, such ingredients have the characteristics of strong efficacy and quick effect, but are highly irritating to the skin, easily destroying the original balance system of the skin and causing skin allergies. Therefore, the present application uses a variety of mild Chinese medicine components to provide an acne-removing active composition, which can remove or alleviate the problem of skin acne by solving the two major factors affecting the generation of acne (oil control and antibacterial).

[0025] Another aspect of the present application discloses the use of the above-mentioned acne-removing composition in the preparation of acne-removing skin care products.

[0026] In another aspect of the present application, an acne-removing essence is disclosed, comprising the following raw materials, based on the total weight of the acne-removing essence as 100 weight percent: 2%-5% of the acne-removing composition as described above, 3%-10% of glycerol, 0.2%-0.5% of carbomer, 3%-10% of butylene glycol, 0.5%-1% of a preservative, 0.05%-0.2% of sodium metabisulfite, 0.05%-0.2% of dipotassium glycyrrhizinate, and 73.1%-91.2% of water.

[0027] In this embodiment, an acne-removing essence is composed of the following raw materials, based on the total weight of the acne-removing essence being 100 weight percent: 5% of the above-mentioned acne-removing composition, 3% of glycerin, 0.3% of carbomer, 3% of butylene glycol, 0.5% of a preservative, 0.1% of sodium metabisulfite, 0.05% of dipotassium glycyrrhizate, and 88% of water.

[0028] The present application also discloses a method for preparing the above-mentioned acne-removing essence, comprising the following steps:

[0029] S1: Add water, glycerin, carbomer and butylene glycol into the main pot, heat to 75-85°C while stirring, and stir until the materials are completely dissolved. Keep stirring for 15 minutes and then start to cool down;

[0030] S2: When the temperature drops to 45°C, add the anti-acne composition, preservatives, sodium metabisulfite and dipotassium glycyrrhizinate into the reaction pot, stir and mix evenly, and then cool to below 38°C before discharging to obtain the anti-acne essence.

[0031] The main reagents and instruments involved in the embodiments of the present invention are as follows:

[0032] Glycerin, PTMusim Mas, Refined Glycerine; Carbomer, Tianci, TC-CARBOMER 380; Butylene glycol, OQ Chemicals; Preservative, Specco ParbFree® PE91; Sodium metabisulfite, Sinopharm Chemical Reagent Co., Ltd.; Dipotassium glycyrrhizinate, BGG; Water, laboratory-made RO pure water; Water-soluble salicylic acid, Jinan Xinzhiyuan Biotechnology Co., Ltd.; Centella asiatica extract was purchased from Fujian Lanhai; PCA zinc (trade name PCA-ZN) was purchased from Shanghai Huixin Biology; Paeonia suffruticosa root bark extract (trade name DA) was purchased from Shanghai Huixin Biology; Artemisia argyi extract (trade name Artemisia argyi hydrosol) was purchased from Fujian Lanhai.

[0033] Example 1

[0034] The present embodiment provides an acne-removing active composition, which is composed of the following components based on 100 parts by weight of the total weight of the acne-removing active composition: 5 parts of Centella asiatica extract, 2 parts of PCA zinc, 3 parts of water-soluble salicylic acid, 5 parts of Paeonia suffruticosa root bark extract, 5 parts of Artemisia argyi extract, and the rest is water.

[0035] Use the above composition to prepare anti-acne active composition essence:

[0036] S1: Based on the total weight of the anti-acne active composition essence being 100 weight percent, add 88% water, 3% glycerin, 0.3% carbomer and 3% butylene glycol into a main pot, heat to 75-85°C while stirring, and stir until the materials are completely dissolved, keep warm and stir for 15 minutes, then start to cool down;

[0037] S2: When the temperature drops to 45°C, 5% of the above acne-removing composition, 0.5% of preservative, 0.1% of sodium pyrosulfite, and 0.05% of dipotassium glycyrrhizinate are added into the reaction pot, stirred and mixed evenly, and the temperature is dropped to below 38°C before discharging to obtain No. 1 acne-removing essence.

[0038] Example 2

[0039] The present embodiment provides an acne-removing active composition, which is composed of the following components based on 100 parts by weight of the total weight of the acne-removing active composition: 5 parts of Centella asiatica extract, 2 parts of PCA zinc, 3 parts of water-soluble salicylic acid, 5 parts of Paeonia suffruticosa root bark extract, 5 parts of Artemisia argyi extract, and the rest is water.

[0040] Use the above composition to prepare anti-acne active composition essence:

[0041] S1: Based on the total weight of the anti-acne active composition essence being 100 weight percent, add 88% water, 3% glycerin, 0.3% carbomer and 3% butylene glycol into a main pot, heat to 75-85°C while stirring, and stir until the materials are completely dissolved, keep warm and stir for 15 minutes, then start to cool down;

[0042] S2: When the temperature drops to 45°C, 5% of the above acne-removing composition, 0.5% of preservative, 0.1% of sodium pyrosulfite, and 0.05% of dipotassium glycyrrhizinate are added into the reaction pot, stirred and mixed evenly, and the temperature is dropped to below 38°C before discharging to obtain No. 2 acne-removing essence.

[0043] Example 3

[0044] The present embodiment provides an anti-acne active composition, which is composed of the following components based on 100 parts by weight of the total weight of the anti-acne active composition: 8 parts of Centella asiatica extract, 2 parts of PCA zinc, 2 parts of water-soluble salicylic acid, 5 parts of Paeonia suffruticosa root bark extract, 8 parts of Artemisia argyi extract, and the rest is water.

[0045] Use the above composition to prepare anti-acne active composition essence:

[0046] S1: Based on the total weight of the anti-acne active composition essence being 100 weight percent, add 88% water, 3% glycerin, 0.3% carbomer and 3% butylene glycol into a main pot, heat to 75-85°C while stirring, and stir until the materials are completely dissolved, keep warm and stir for 15 minutes, then start to cool down;

[0047] S2: When the temperature drops to 45°C, add 5% of the above acne-removing composition, 0.5% of preservative, 0.1% of sodium pyrosulfite, and 0.05% of dipotassium glycyrrhizinate into the reaction pot, stir and mix evenly, and cool to below 38°C before discharging to obtain No. 3 acne-removing essence.

[0048] Example 4

[0049] The present embodiment provides an acne-removing active composition, which is composed of the following components based on 100 parts by weight of the total weight of the acne-removing active composition: 8 parts of Centella asiatica extract, 2 parts of PCA zinc, 2 parts of water-soluble salicylic acid, 8 parts of Paeonia suffruticosa root bark extract, 5 parts of Artemisia argyi extract, and the rest is water.

[0050] Use the above composition to prepare anti-acne active composition essence:

[0051] S1: Based on the total weight of the anti-acne active composition essence being 100 weight percent, add 88% water, 3% glycerin, 0.3% carbomer and 3% butylene glycol into a main pot, heat to 75-85°C while stirring, and stir until the materials are completely dissolved, keep warm and stir for 15 minutes, then start to cool down;

[0052] S2: When the temperature drops to 45°C, 5% of the above acne-removing composition, 0.5% of preservative, 0.1% of sodium pyrosulfite, and 0.05% of dipotassium glycyrrhizinate are added into the reaction pot, stirred and mixed evenly, and the temperature is dropped to below 38°C before discharging to obtain No. 4 acne-removing essence.

[0053] Example 5

[0054] The present embodiment provides an anti-acne active composition, which is composed of the following components based on 100 parts by weight of the total weight of the anti-acne active composition: 8 parts of Centella asiatica extract, 1 part of PCA zinc, 2 parts of water-soluble salicylic acid, 8 parts of Paeonia suffruticosa root bark extract, 8 parts of Artemisia argyi extract, and the rest is water.

[0055] Use the above composition to prepare anti-acne active composition essence:

[0056] S1: Based on the total weight of the anti-acne active composition essence being 100 weight percent, add 88% water, 3% glycerin, 0.3% carbomer and 3% butylene glycol into a main pot, heat to 75-85°C while stirring, and stir until the materials are completely dissolved, keep warm and stir for 15 minutes, then start to cool down;

[0057] S2: When the temperature drops to 45°C, 5% of the above acne-removing composition, 0.5% of preservative, 0.1% of sodium pyrosulfite, and 0.05% of dipotassium glycyrrhizinate are added into the reaction pot, stirred and mixed evenly, and the temperature is dropped to below 38°C before discharging to obtain No. 5 acne-removing essence.

[0058] Example 6 Skin patch test

[0059] The anti-acne essence prepared in Examples 1-5 and two commercially available anti-acne essence samples were used.

[0060] The skin reaction grading standards for skin closure patch test are as follows:

[0061] Table 1

[0062]

[0063] Patients: Thirty-five patients with facial acne who met the subject criteria.

[0064] The acne-removing active composition in the embodiment is placed in the small chamber of the spot tester, with an amount of about 0.020mL-0.025mL. The control well is a blank control (no substance is placed). The spot tester with the test substance added is applied to the back or curved side of the forearm of the subject with a hypoallergenic tape, and the palm is gently pressed to evenly apply it to the skin for 24 hours. The skin reaction is observed according to the standards in the table below 30 minutes (after the indentation disappears), 24 hours and 48 hours after the removal of the test substance spot tester, and the observation results are recorded, as shown in Table 2:

[0065] Table 2

[0066]

[0067] The human skin patch test results show that the anti-acne active composition essence has no irritation to the skin and is superior to two commercially available samples.

[0068] Example 7 Toxicology Test

[0069] The anti-acne essence prepared in Examples 1-5 and two commercially available anti-acne essence samples used in Example 6 were used.

[0070] The dorsal hair on both sides of the spine of the experimental animals (4 animals) was shaved to a range of 3*3cm and the application area was 2.5*2.5cm.

[0071] Take 0.5 ml of Examples 1-5 and two commercially available samples and apply them on the left side of the skin, and the other side of the skin as a control, apply once a day for 14 consecutive days. Starting from the second day, shave before each application, use warm water to remove the residual test substance, observe the results after one hour, and score according to P491 of the Cosmetic Safety Technical Specifications. The control area and the test area are treated in the same way. Calculate the average score of each animal per day according to the formula, and determine the skin irritation intensity according to P492 of the specification.

[0072] Table 3 is the score record of the skin irritation reaction of the above experimental animals:

[0073] Table 3

[0074]

[0075] Table 4 is the record of multiple skin irritation experiments on rabbits:

[0076] Table 4

[0077]

[0078] The results of multiple skin irritation experiments show that the acne-removing active composition is non-irritating and is superior to commercially available samples.

[0079] Example 8 Efficacy Test

[0080] Experiment on inhibiting Propionibacterium acnes

[0081] The drug sensitivity test stipulated in the "Hygiene Standards for Disposable Hygiene Products" and the pharmacopoeias of many countries was used to evaluate the drug sensitivity effect of the test substance by the number of colonies inhibited by the test substance against Propionibacterium acnes. Propionibacterium acnes was inoculated on a slant of Clostridium enrichment medium with agar powder and cultured anaerobically at (37±1)℃ for 48~72 h. After the colony was fully grown, the colony was eluted with 5 mL of Clostridium enrichment medium. The eluate was collected and its concentration was adjusted to 106CFU / mL, and the live bacteria were counted by plate method. 1g of each of the acne active composition, the acne essence containing the acne active composition, and the commercially available acne reference product were weighed and added to the above 0.1mL bacterial suspension, and 9mL PBS was added to mix, and 1mL was placed in 3 parallel plates, and then the Clostridium enrichment medium was added and cultured anaerobically at (37±1)℃ for 48-72h, and the colony count was repeated 3 times, and the average was taken. At the same time, physiological saline was set as a blank control.

[0082] Antibacterial rate X = (AB) / A × 100%

[0083] Where A is the average number of colonies recovered from the control sample; B is the average number of colonies recovered from the test sample.

[0084] Table 5 is a record of the effect of inhibiting Propionibacterium acnes in vitro:

[0085] Table 5

[0086]

[0087] The experimental results of inhibiting Propionibacterium acnes showed that both the acne-removing active composition and the essence added with the acne-removing active composition had good antibacterial effects and were superior to commercially available products.

[0088] Example 9 Anti-inflammatory Experimental Test

[0089] In vitro NO and TNF-a content inhibition test The MTT method was used to detect and analyze the inhibitory effect of the anti-acne active composition on RAW264.7 cells. This study detected the inhibitory effect of the anti-acne active composition on LPS-induced RAW264.7 cells to produce NO and TNF-a. The effect of the test substance on the production of NO and TNF-a by LPS-stimulated RAW264.7 cells.

[0090] Table 6

[0091]

[0092] As shown in Table 6 above, when the amount of the acne-removing active composition added is 0.1%, the content of NO and TNF-a can be significantly reduced. Comparing the acne-removing essence without the acne-removing active composition (negative control) and the commercially available acne-removing standard product, the acne-removing essence with 0.1% of the acne-removing active composition added can significantly reduce the content of NO and pro-inflammatory factor TNF-a produced by LPS-stimulated RAW264.7 cells.

[0093] Example 10 Efficacy Evaluation

[0094] 48 subjects were selected and used for two weeks. During the use period, other acne-removing products were not allowed to be used, but basic skin care was maintained and photos were taken to record the changes in acne every day. Table 7 is the timetable for human acne removal, and Table 8 is the evaluation table for human acne removal effects.

[0095] Timeline for effective acne treatment in humans

[0096] Table 7

[0097] Human acne removal effect evaluation table

[0098] Table 8

[0099] Results: 91.7% of the volunteers who used the acne essence containing the acne active composition had effective acne removal, while 75.0% of the commercially available acne control products had effective acne removal, and the time to take effect was faster than that of the control products. The human acne removal effect evaluation table (Table 8) showed that the acne removal effect of the acne essence containing the acne active composition was significant in terms of acne redness, swelling, pain, etc. More than 85% of the volunteers had significant acne removal effects using the acne essence containing the acne active composition, and it had a good effect of reducing redness, swelling, and pain.

[0100] Since the anti-acne active composition described in this embodiment has a good effect in treating acne, it can be used in the preparation of anti-acne skin care products.

[0101] In summary, the technical solution of the present application has the following beneficial effects:

[0102] 1. The anti-acne active composition provided by the present invention has simple medication and proper compatibility. It has been tested in clinical practice for many years and has the effect of removing acne. The pharmacological effects of the Centella asiatica extract and the Artemisia argyi extract in the formula include anti-inflammatory, damage repair, anti-oxidation, anti-aging, improvement of skin barrier hydration, anti-scarring, etc.; PCA zinc can reduce excessive sebum secretion, has high antibacterial activity, and only needs a low dose to inhibit the growth of bacteria on the skin surface; salicylic acid is a fat-soluble natural active ingredient with the effects of oil control, anti-inflammatory, and two-way keratin regulation; Paeonia suffruticosa root bark extract can significantly improve inflammatory damage to the skin without producing cytotoxicity, and also has excellent antioxidant properties, and has a good protective effect on acne skin caused by inflammation.

[0103] 2. The acne-removing composition of the present invention is composed of a variety of plant extracts, which are natural and non-irritating, effectively inhibit bacteria, relieve skin redness, inflammation and other discomforts, and can dissolve grease and dirt deep in the pores, unclog blocked hair follicles, expel toxins, and inhibit acne regeneration.

[0104] 3. The addition of the acne-removing active complex provided by the present invention to the essence has been shown to be more effective (1-2 weeks) and more effective in removing acne in patients with acne, with a total effective rate of 91.7% and a cure rate of 85%, which is significantly better than the common compound acne-removing products on the market.

[0105] 4. The acne-removing essence provided by the present invention has the effects of removing acne, removing acne marks, reducing inflammation and swelling, and has a fast onset and obvious effect. The acne-removing effect can be seen after 1-2 weeks of use, and there is no irritation. The preparation method is simple, and the acne-removing active composition can be directly added to the cosmetic matrix. The raw materials of the acne-removing essence of the present invention are easy to obtain, the preparation process is simple, the conditions are easy to control, and it can be promoted and applied.

[0106] The above are only preferred embodiments of the present invention, and are not intended to limit the implementation methods and protection scope of the present invention. Those skilled in the art should be aware that all solutions obtained by equivalent substitutions and obvious changes made using the specification of the present invention should be included in the protection scope of the present invention.

Claims

1. An anti-acne composition, characterized in that: Taking the total weight of the anti-acne composition as 100 parts by weight, the composition comprises the following components in parts by weight: 5-10 parts of Centella asiatica extract, 1-10 parts of PCA zinc, 1-10 parts of water-soluble salicylic acid, 1-10 parts of peony root bark extract, 1-10 parts of wormwood leaf extract, and the rest is pure water.

2. An anti-acne composition according to claim 1, characterized in that: Based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition comprises the following components in parts by weight: 5 parts of Centella asiatica extract, 2 parts of PCA zinc, 3 parts of water-soluble salicylic acid, 5 parts of Paeonia suffruticosa root bark extract and 5 parts of Artemisia argyi extract, and the rest being water.

3. An anti-acne composition according to claim 1, characterized in that: Based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition comprises the following components in parts by weight: 5 parts of Centella asiatica extract, 1 part of PCA zinc, 5 parts of water-soluble salicylic acid, 5 parts of peony root bark extract, 5 parts of wormwood leaf extract, and the rest being water.

4. The anti-acne composition according to claim 1, characterized in that: Based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition comprises the following components in parts by weight: 8 parts of Centella asiatica extract, 2 parts of PCA zinc, 2 parts of water-soluble salicylic acid, 5 parts of Paeonia suffruticosa root bark extract, 8 parts of Artemisia argyi extract, and the remainder being water.

5. The anti-acne composition according to claim 1, characterized in that: Based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition comprises the following components in parts by weight: 8 parts of Centella asiatica extract, 2 parts of PCA zinc, 2 parts of water-soluble salicylic acid, 8 parts of Paeonia suffruticosa root bark extract, 5 parts of Artemisia argyi extract, and the remainder being water.

6. The anti-acne composition according to claim 1, characterized in that: Based on the total weight of the anti-acne composition being 100 parts by weight, the anti-acne composition comprises the following components in parts by weight: 8 parts of Centella asiatica extract, 1 part of PCA zinc, 2 parts of water-soluble salicylic acid, 8 parts of peony root bark extract, 8 parts of wormwood leaf extract, and the rest being water.

7. Use of the anti-acne composition according to any one of claims 1 to 6 in the preparation of anti-acne skin care products.

8. An anti-acne essence, characterized in that: The invention comprises the following raw materials, based on the total weight of the anti-acne essence being 100 weight percent: 2%-5% of the anti-acne composition according to any one of claims 1 to 6, 3%-10% of glycerol, 0.2%-0.5% of carbomer, 3%-10% of butylene glycol, 0.5%-1% of a preservative, 0.05%-0.2% of sodium metabisulfite, 0.05%-0.2% of dipotassium glycyrrhizinate and 73.1%-91.2% of water.

9. The anti-acne essence according to claim 8, characterized in that: The invention is composed of the following raw materials, based on the total weight of the anti-acne essence being 100 weight percent: 5% of the anti-acne composition according to any one of claims 1 to 6, 3% of glycerol, 0.3% of carbomer, 3% of butylene glycol, 0.5% of a preservative, 0.1% of sodium pyrosulfite, 0.05% of dipotassium glycyrrhizate and 88% of water.

10. A method for preparing the anti-acne essence according to claim 8, characterized in that: The following steps are involved: S1: Add water, glycerin, carbomer and butylene glycol into the main pot, heat to 75-85°C while stirring, and stir until the materials are completely dissolved. Keep stirring for 15 minutes and then start to cool down; S2: When the temperature drops to 45°C, add the anti-acne composition, preservatives, sodium metabisulfite and dipotassium glycyrrhizinate into the reaction pot, stir and mix evenly, and then cool to below 38°C before discharging to obtain the anti-acne essence.

Images