Medicine for treating multiple biotoxins

Through a traditional Chinese medicine powder containing ingredients such as Sophora cinnabaria, squama, dandelion, etc., combined with drying and ultrasonic vacuum freeze-drying technology, the problem of low efficiency in snake insect bite treatment in the existing technology is solved, and rapid and effective Treatment effect.

CN119185422AInactive Publication Date: 2024-12-27BEIJING QIXIANG BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202411334786.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-24
Publication Date
2024-12-27
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The prior art is difficult to quickly and effectively treat snake insect bites caused by a variety of biological toxins, especially snake bites. Traditional treatment methods are inefficient and have limited effects.

Method used

Using a drug formula, including Sophora glutinosa, dandelion, licorice, forsythia, wild chrysanthemum, purple-backed celestialis, snake bed, white fresh skin, Qianjinzi, Jiulong Pan and Half-branched Lotus, by drying, Ultra-fine crushing, extract drying and loading technology prepares Chinese medicine powder and mixes it with wine or water to quickly treat snake and insect bites.

Benefits of technology

This drug can quickly and effectively treat biological toxin bites such as poisonous bees, scorpions, green snakes, brown-edged green thorn moths, and has quick results and good results. It improves the clinical application ability of traditional Chinese medicinal materials, reduces the dosage and saves Medicinal materials.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine for treating various biotoxins. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 20 to 40 parts of radix sophorae flavescentis, 20 to 40 parts of fructus kochiae, 20 to 40 parts of herba taraxaci, 20 to 40 parts of liquorice root, 10 to 15 parts of fructus forsythiae, 10 to 15 parts of flos chrysanthemi indici, 10 to 15 parts of gynura bicolor, 10 to 15 parts of fructus cnidii and 10 to 15 parts of cortex dictamni. , 15-20 parts by mass of moleplant seeds, 22-26 parts by mass of bauhinia championii and 28-36 parts by mass of sculellaria barbata. The preparation method of the medicine comprises the following steps: step 1, drying the medicine; step 2, weighing the medicines in corresponding parts by mass; step 3, grinding the medicines; and step 4, finally mixing the medicines with wine or water. The traditional Chinese medicine can be used for quickly treating bite wounds of poisonous bees, scorpions, green snakes and green stauntonia moth, and is quick in treatment effect and good in effect.
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Description

Technical Field

[0001] The invention belongs to the field of medical technology, and in particular relates to a medicine for treating multiple biological toxins. Background Art

[0002] The so-called insect and snake bites refer to the damage done by insects and snakes to the human body. Different insects contain different venoms, and the severity and clinical manifestations of the damage to the human body vary greatly. The mildest ones are mild erythema, papules or wheals, accompanied by varying degrees of itching, burning and pain. The severest ones may have extensive skin damage or necrosis, joint pain, etc. Severe cases may even cause systemic poisoning symptoms, leading to anaphylactic shock and death. Insect bites should generally be treated locally. If there is a strange itching sensation at the site of the insect sting, you can apply ointment to relieve itching. For centipede bites, you can grind equal amounts of realgar and alum into powder, rinse with cold water and apply it to the affected area. Snake bites refer to the bite of a snake into the flesh, especially a wound caused by a snake that secretes venom through the snake's teeth or near the snake's teeth; therefore, we propose a drug for treating multiple biological toxins that can quickly treat multiple types of snake and insect bites. Summary of the invention

[0003] The purpose of the present invention is to provide a medicine for treating various biological toxins, which can quickly treat various types of snake and insect bites.

[0004] The technical solution adopted by the present invention is as follows:

[0005] A medicine for treating multiple biological toxins, comprising: 20-40 parts by weight of Sophora flavescens, 20-40 parts by weight of Kochia scoparia, 20-40 parts by weight of Taraxacum officinale, 20-40 parts by weight of Licorice, 10-15 parts by weight of Forsythia suspensa, 10-15 parts by weight of Chrysanthemum indica, 10-15 parts by weight of Gynura nigra, 10-15 parts by weight of Cnidium monnieri, 10-15 parts by weight of Dictamni cortex; 15-20 parts by weight of Leptochloa chinensis, 22-26 parts by weight of Nine Dragon Plate and 28-36 parts by weight of Scutellaria barbata.

[0006] A method for preparing a drug for treating multiple biological toxins comprises the following steps:

[0007] Step 1: Dry the medicine;

[0008] The drying steps of the drug during the preparation process are specifically as follows:

[0009] Step 101: Process and clean the Chinese medicinal materials, slice or cut them, add deionized water with an amount of 0.3 to 2 times the dry weight of the Chinese medicinal materials, and soak them for 30 to 60 minutes after they are processed to the required standard, and grind them into ultrafine powder by a colloid mill to obtain a Chinese medicinal material slurry;

[0010] Step 102: filtering the Chinese medicinal material slurry to obtain a filtrate and a filter cake;

[0011] Step 103: placing the filter cake in a container, adding deionized water of 0.3-2 times the dry weight of the Chinese medicinal materials and mixing evenly, placing the container in a water bath and heating it to 80-100° C., and stirring and heating in a constant temperature water bath for 30-60 minutes to obtain a mixture of Chinese medicinal extract and medicinal residues;

[0012] Step 104: after sterilizing the filtrate obtained in the above step 102, add it to the mixture of the Chinese medicine extract and the medicinal residue obtained in the above step 103, fully mix them to form a suspension, dry them to a moisture content of less than 4.0% by ultrasonic vacuum freeze drying, and reload the active ingredients dissolved in the filtrate and the Chinese medicine extract on the medicinal residue to obtain a freeze-dried powder loaded with active ingredients; the ultrasonic vacuum freeze drying conditions are as follows: deep cooling the suspension of the mixture of the filtrate, the Chinese medicine extract and the medicinal residue under ultrasonic action to make it into uniform solid particles, the ultrasonic frequency is 10-20kHz, the ultrasonic power is 40-100W, the deep cooling temperature is -50--45°C, and the cooling time is 4-5h; stop refrigeration, start the vacuum device to a pressure of 0.02-0.06Mpa, program the temperature to 30°C under vacuum and ultrasonic action, the ultrasonic frequency is 10-20kHz, and the ultrasonic power is 40-100W to obtain freeze-dried powder.

[0013] Step 2: Weigh the corresponding mass fraction of the drug;

[0014] Step 3: After obtaining the freeze-dried powder, the freeze-dried powder loaded with active ingredients is crushed and ground again, passed through a 130-140 mesh sieve to obtain the Chinese medicine powder, and sealed in a bag.

[0015] Step 4: Finally, mix with wine or water, the mixing mass ratio of drug powder to wine or water is 1:4.

[0016] A use of a drug for treating multiple biological toxins in preparing a drug for treating biological toxins.

[0017] The technical effects achieved by the present invention are:

[0018] The invention discloses a medicine for treating multiple biological toxins, comprising: 30 parts by weight of sophora flavescens, 30 parts by weight of kochia scoparia, 30 parts by weight of dandelion, 30 parts by weight of liquorice, 15 parts by weight of forsythia, 15 parts by weight of wild chrysanthemum, 15 parts by weight of thyme, 15 parts by weight of thyme, 15 parts by weight of cnidium monnieri, 15 parts by weight of dittany; 18 parts by weight of kelp, 24 parts by weight of kojira and 32 parts by weight of scutellaria barbata. The medicine can quickly treat bites by venomous bees, scorpions, green snakes and brown-margined green moths, and the treatment is effective quickly and has a good effect.

[0019] The drug preparation method disclosed in the present invention has a wide range of applications and can be used to prepare and process Chinese medicinal materials whose effective ingredients are volatile ingredients, thermally unstable ingredients, easily hydrolyzed ingredients or contain a lot of starch and gum; the prepared Chinese medicinal powder has high effective ingredient dissolution, high bioavailability, fast drug absorption, good efficacy, reduced drug dosage, and saved medicinal materials; the powder is uniform and fine, with consistent color and good dispersibility; the clinical application ability of traditional Chinese medicinal materials is improved, the efficacy is retained, and the medication effect is better. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The present invention is a flow chart of a method for preparing a drug for treating various biological toxins. DETAILED DESCRIPTION

[0021] In order to make the purpose and advantages of the present invention more clearly understood, the present invention is specifically described below in conjunction with embodiments. It should be understood that the following text is only used to describe one or several specific embodiments of the present invention, and does not strictly limit the scope of protection of the specific claims of the present invention.

[0022] Embodiment 1:

[0023] A medicine for treating multiple biological toxins, comprising: 30 parts by mass of Sophora flavescens, 30 parts by mass of Kochia scoparia, 30 parts by mass of Taraxacum herba, 30 parts by mass of Licorice, 15 parts by mass of Forsythia suspensa, 15 parts by mass of Chrysanthemum indici, 15 parts by mass of Gynura nigra, 15 parts by mass of Cnidium monnieri, 15 parts by mass of Dictamni cortex; 18 parts by mass of Leptospermum officinale, 24 parts by mass of Nine Dragon Plate and 32 parts by mass of Scutellaria barbata.

[0024] The same method as in Example 2 is adopted to process and obtain corresponding medicines for treating bites by venomous bees, scorpions, green snakes and brown-margined green moths, and the recovery time is statistically analyzed.

[0025] Embodiment 2:

[0026] A method for preparing a drug for treating multiple biological toxins comprises the following steps:

[0027] Step 1: Dry the medicine;

[0028] The drying steps of the drug during the preparation process are specifically as follows:

[0029] Step 101: Process and clean the Chinese medicinal materials, slice or cut them, add deionized water with an amount of 0.3 to 2 times the dry weight of the Chinese medicinal materials, and soak them for 30 to 60 minutes after they are processed to the required standard, and grind them into ultrafine powder by a colloid mill to obtain a Chinese medicinal material slurry;

[0030] Step 102: Filter the Chinese medicinal material slurry to obtain a filtrate and a filter cake;

[0031] Step 103: placing the filter cake in a container, adding deionized water of 0.3-2 times the dry weight of the Chinese medicinal materials and mixing evenly, placing the container in a water bath and heating it to 80-100° C., and stirring and heating in a constant temperature water bath for 30-60 minutes to obtain a mixture of Chinese medicinal extract and medicinal residues;

[0032] Step 104: after sterilizing the filtrate obtained in the above step 102, add it to the mixture of the Chinese medicine extract and the medicinal residue obtained in the above step 103, fully mix them to form a suspension, dry them to a moisture content of less than 4.0% by ultrasonic vacuum freeze drying, and reload the active ingredients dissolved in the filtrate and the Chinese medicine extract on the medicinal residue to obtain a freeze-dried powder loaded with active ingredients; the ultrasonic vacuum freeze drying conditions are as follows: deep cooling the suspension of the mixture of the filtrate, the Chinese medicine extract and the medicinal residue under ultrasonic action to make it into uniform solid particles, the ultrasonic frequency is 10-20kHz, the ultrasonic power is 40-100W, the deep cooling temperature is -50--45°C, and the cooling time is 4-5h; stop refrigeration, start the vacuum device to a pressure of 0.02-0.06Mpa, program the temperature to 30°C under vacuum and ultrasonic action, the ultrasonic frequency is 10-20kHz, and the ultrasonic power is 40-100W to obtain freeze-dried powder.

[0033] Step 2: Weigh the corresponding mass fraction of the drug;

[0034] Step 3: After obtaining the freeze-dried powder, the freeze-dried powder loaded with active ingredients is crushed and ground again, passed through a 130-140 mesh sieve to obtain the Chinese medicine powder, and sealed and bagged.

[0035] Step 4: Finally, mix with wine or water, the mixing mass ratio of drug powder to wine or water is 1:4.

[0036] Apply the mixed medicine to the bite area of ​​the patient.

[0037] In this embodiment, the method has a wide range of applications and can be used to prepare and process Chinese medicinal materials whose effective ingredients are volatile ingredients, thermally unstable ingredients, easily hydrolyzed ingredients, or contain a lot of starch and gum; the prepared Chinese medicinal powder has high solubility of effective ingredients, high bioavailability, fast drug absorption, good efficacy, reduced medication dosage, and saved medicinal materials; the powder is uniform and fine, with consistent color and good dispersibility; the clinical application ability of traditional Chinese medicinal materials is improved, the efficacy is retained, and the medication effect is better.

[0038] Comparative Example 1:

[0039] A medicine for treating multiple biological toxins, comprising: 20 parts by weight of Sophora flavescens, 20 parts by weight of Kochia scoparia, 20 parts by weight of Taraxacum officinale, 20 parts by weight of Licorice, 10 parts by weight of Forsythia suspensa, 10 parts by weight of Chrysanthemum indica, 10 parts by weight of Gynura odoratum, 10 parts by weight of Cnidium monnieri, 10 parts by weight of Dictamni cortex; 15 parts by weight of Leptochloa chinensis, 22 parts by weight of Nine Dragon Plate, and 28 parts by weight of Scutellaria barbata;

[0040] The same method as in Example 2 is adopted to process and obtain the corresponding medicine for treating bites by venomous bees, scorpions, green snakes, and brown-margined green moths, and the recovery time is counted;

[0041] Comparative Example 2:

[0042] A medicine for treating multiple biological toxins, comprising: 40 parts by weight of Sophora flavescens, 40 parts by weight of Kochia scoparia, 40 parts by weight of Taraxacum officinale, 40 parts by weight of Licorice, 15 parts by weight of Forsythia suspensa, 15 parts by weight of Chrysanthemum indica, 15 parts by weight of Gynura odoratum, 15 parts by weight of Cnidium monnieri, 15 parts by weight of Dictamni cortex; 20 parts by weight of Leptochloa chinensis, 26 parts by weight of Nine Dragon Plate, and 36 parts by weight of Scutellaria barbata;

[0043] The same method as in Example 2 is adopted to process and obtain the corresponding medicine for treating bites by venomous bees, scorpions, green snakes, and brown-margined green moths, and the recovery time is counted;

[0044] In the present invention, Example 1, Comparative Example 1 and Comparative Example 2 are used in treating bites of venomous bees, scorpions, green snakes and brown-margined green moths as shown in the following table:

[0045] Poisonous Bee Scorpion Green Snake Chlorophyta rufipogon Embodiment 1 29min 31min 58min 35min Comparative Example 1 45min 43min 82min 56min Comparative Example 2 44min 43min 76min 67min

[0046] In summary: It can be seen from the table that a drug for treating multiple biological toxins disclosed in Example 1 includes: 30 parts by mass of Sophora flavescens, 30 parts by mass of Kochia scoparia, 30 parts by mass of Taraxacum, 30 parts by mass of Licorice, 15 parts by mass of Forsythia suspensa, 15 parts by mass of Chrysanthemum indica, 15 parts by mass of Gynura nigra, 15 parts by mass of Cnidium monnieri, 15 parts by mass of Dictamni; 18 parts by mass of Leptospermum officinale, 24 parts by mass of Nine Dragon Plate and 32 parts by mass of Scutellaria barbata, which can quickly treat bites from venomous bees, scorpions, green snakes and brown-edged green moths, and the treatment is quick and effective.

[0047] Embodiment three:

[0048] A use of a drug for treating multiple biological toxins in preparing a drug for treating biological toxins.

[0049] During clinical trials,

[0050] Case 1: A young man from Yanglou went to Chechang Village to collect persimmons in the autumn of 2004 and was stung 100 times by bees. The patient felt excruciating pain and his entire head was swollen. After taking the quick treatment, he recovered within 30 minutes.

[0051] Case 2: Scorpion wound: Zhang from Haycaoan Village, Chechang Village, was stung by a scorpion while sleeping in 2005 and fell into a coma due to the pain. He was cured after 30 minutes of rapid treatment technology. The patient felt that the pain gradually retreated from the heart to the palm of his hand (all stings by poisonous insects first transmit the toxicity to the heart like an electric shock).

[0052] Case 3: Centipede sting: Tian felt discomfort on his forearm while sleeping at night. The next day, purple blood blisters appeared on his forearm and buttocks. The blisters became straighter and straighter after another day. Other treatments were ineffective, so he found a quick treatment technique, which was to apply cotton wool with liquid medicine to the sting. He was completely back to normal after one day and one night.

[0053] Case 4: Look at the old lady above. She was stung by a bee from her left hand to the wrist. Three days later, blisters and swelling appeared all over her left hand to the wrist. After two days of using cotton wool soaked in quick-healing liquid and placing it on the affected area, the affected area returned to normal.

[0054] Case 5: Stings from the brown-margined green moth, commonly known as the foreign pepper, often occur in peanut fields in summer and autumn. The sting is extremely painful. The sender, Mr. Ye, felt unbearable pain two days after the sting. After soaking for a day and a night with the rapid treatment technology, he completely recovered to normal.

[0055] Case 6: Various mosquito bites and swellings were completely restored to normal after soaking with the quick treatment technology in a few hours.

[0056] Case 7: Bites and stings from various green snakes: This Chinese herbal medicine solution was used clinically to treat patients bitten by pit vipers within 60 minutes. The patient went to the treatment point for treatment within 1 hour after being bitten by the pit viper and was cured in 60 minutes. Another patient was bitten by a pit viper and was only 8 years old. When he arrived at the treatment point, his right upper limb to right chest was obviously red and swollen, protruding from the skin, higher than the left chest. After three days of soaking in the Chinese herbal medicine solution, there were no sequelae. Pit vipers contain two kinds of toxins at the same time, neurotoxin and blood toxin. This medicine solution can cure the bites and stings of venomous snakes. Treatment can be given immediately at the time and it is still effective a few days later.

[0057] In summary, this drug has a quick effect and good effect when it is prepared to treat biological toxins such as snakes, insects, wasps, and scorpions.

[0058] The above is only a preferred embodiment of the present invention. It should be noted that, for those skilled in the art, several improvements and modifications can be made without departing from the principles of the present invention, and these improvements and modifications should also be considered as the protection scope of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention shall be implemented according to the conventional means in the art unless otherwise specified and limited.

Claims

1. A drug for treating multiple biological toxins, characterized in that: include: 20-40 parts by weight of Sophora flavescens, 20-40 parts by weight of Kochia scoparia, 20-40 parts by weight of Taraxacum herba, 20-40 parts by weight of Licorice, 10-15 parts by weight of Forsythia suspensa, 10-15 parts by weight of Chrysanthemum indici, 10-15 parts by weight of Gynura nigra, 10-15 parts by weight of Cnidium monnieri, 10-15 parts by weight of Dictamni cortex; 15-20 parts by weight of Leptospermum officinale, 22-26 parts by weight of Nine Dragon Plate and 28-36 parts by weight of Scutellaria barbata.

2. A method for preparing a drug for treating multiple biological toxins, for preparing the drug for treating multiple biological toxins as claimed in claim 1, characterized in that: The following steps are involved: Step 1: Dry the medicine; Step 2: Weigh the corresponding mass fraction of the drug; Step 3: Grind the medicine. Step 4: Finally mix with wine or water.

3. The method for preparing a drug for treating multiple biological toxins according to claim 2, characterized in that: The drying steps of the drug during the preparation process are specifically as follows: Step 101: Process and clean the Chinese medicinal materials, slice or cut them, soak them in deionized water after they are processed to the required standard, and grind them into ultrafine powder by a colloid mill to obtain a Chinese medicinal material slurry; Step 102: Filter the Chinese medicinal material slurry to obtain a filtrate and a filter cake; Step 103: placing the filter cake in a container, adding deionized water and mixing evenly, and heating in a constant temperature water bath to obtain a mixture of a Chinese medicine extract and medicinal residues; Step 104: After sterilization, the filtrate obtained in the above step 102 is added to the mixture of the Chinese medicine extract and the medicinal residue obtained in the above step 103, and the mixture is fully mixed to form a suspension. The mixture is dried by ultrasonic vacuum freeze drying until the moisture content is less than 4.0%. The active ingredients dissolved in the filtrate and the Chinese medicine extract are re-loaded on the medicinal residue to obtain a freeze-dried powder loaded with active ingredients.

4. The method for preparing a drug for treating multiple biological toxins according to claim 3, characterized in that: The ultrasonic vacuum freeze-drying conditions are as follows: deep cooling a suspension of a mixture of a filtrate, a Chinese medicine extract and medicinal residues under ultrasonic action to form uniform solid particles, the ultrasonic frequency is 10-20kHz, the ultrasonic power is 40-100W, the deep cooling temperature is -50--45°C, and the cooling time is 4-5h; stopping refrigeration, starting a vacuum device to a pressure of 0.02-0.06Mpa, and program-raising the temperature to 30°C under vacuum and ultrasonic action, the ultrasonic frequency is 10-20kHz, and the ultrasonic power is 40-100W to obtain freeze-dried powder.

5. The method for preparing a drug for treating multiple biological toxins according to claim 4, characterized in that: In the step 3, after obtaining the freeze-dried powder, the freeze-dried powder loaded with the active ingredient is crushed and ground again, passed through a 130-140 mesh sieve to obtain the traditional Chinese medicine powder, and sealed and bagged.

6. The method for preparing a drug for treating multiple biological toxins according to claim 5, characterized in that: In step 101, after qualified processing, deionized water with an amount of 0.3-2 times the dry weight of the Chinese medicinal materials is added and soaked for 30-60 minutes.

7. The method for preparing a drug for treating multiple biological toxins according to claim 6, characterized in that: In step 103, 0.3-2 times the dry weight of the Chinese medicinal materials is added with deionized water and mixed evenly, and then the container is placed in a water bath and heated to 80-100° C., and then heated in a constant temperature water bath with stirring for 30-60 minutes.

8. Use of the drug for treating multiple biological toxins as claimed in claim 1 in the preparation of drugs for treating biological toxins.