Traditional Chinese medicine composition for treating cerebral apoplexy

Abstract

The invention relates to a traditional Chinese medicine composition for treating cerebral apoplexy. The traditional Chinese medicine composition is prepared from 10-30 parts by weight of poria cocos, 5-25 parts by weight of uncaria rhynchophylla, 5-25 parts by weight of salvia miltiorrhiza, 3-18 parts by weight of pericarpium citri reticulatae, 3-18 parts by weight of gastrodia elata, 3-18 parts by weight of ligusticum wallichii, 3-18 parts by weight of pinellia ternate, 1-15 parts by weight of arisaema cum bile and 1-15 parts by weight of carthamus tinctorius. The traditional Chinese medicine composition disclosed by the invention has the advantages of reducing phlegm, extinguishing wind, promoting blood circulation and dredging collaterals, is high in safety, and has a remarkable curative effect on cerebral apoplexy, particularly acute ischemic cerebral apoplexy.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating cerebral stroke. Background Art

[0002] Stroke is the second leading cause of death in the world and has become the leading cause of death in my country. Ischemic stroke (IS) is a type of disease that causes cerebral blood circulation disorder, ischemic necrosis or softening of localized brain tissue due to ischemia and hypoxia, resulting in corresponding neurological deficit symptoms. Ischemic stroke accounts for about 70% of all strokes, and the annual incidence of ischemic stroke in my country is currently increasing at a rate of 8.7%. Faced with a large patient population and increasing social medical expenses, the prevention and treatment of this disease is of great significance.

[0003] At present, Western medicine mainly uses vascular recanalization treatments such as intravenous thrombolysis, thrombectomy and endovascular therapy to treat ischemic stroke. In addition, neuroprotectants are also an effective treatment method, mainly including calcium ion antagonists, free radical scavengers and cell membrane stabilizers. However, there are multiple limitations to existing treatment methods. First, due to the limitation of the time window, these methods are only suitable for a small number of patients. Secondly, these methods may increase the risk of hemorrhagic transformation in patients, including intracranial hemorrhage, and in severe cases, can accelerate the death of patients. Therefore, there is an urgent need for a widely applicable treatment method for ischemic stroke in this field.

[0004] Cerebral stroke belongs to the category of "stroke disease" in traditional Chinese medicine. The earliest ancient document describing the symptoms of stroke disease is "Huangdi Neijing". The book mentions terms such as "bojue", "dajue", "pianfeng" and "pianku", which are all disease names describing the symptoms of "stroke". The first medical monograph that named "hemiplegia, numbness, and speech impairment" as "stroke disease" was Zhang Zhongjing's "Golden Chamber Synopsis". Modern Chinese medicine scholars have put forward their own views through multiple studies, and summarized the etiology and pathogenesis of stroke disease into seven categories: "wind, fire, phlegm, blood stasis, qi, deficiency, and poison".

[0005] Ischemic stroke has an acute onset, variable symptoms, and complex TCM syndromes with many concurrent syndromes. Studies have found that in the acute phase of ischemic stroke, the majority of syndromes are positive, mainly wind syndrome, phlegm-dampness syndrome, and blood stasis syndrome. There are often combined syndromes, with wind-phlegm, fire-phlegm, wind-fire, phlegm-stasis, wind-fire-phlegm, and wind-fire-stasis syndrome being the most common. In the recovery phase, the positive syndromes are mainly heat and phlegm-dampness, and the deficiency syndromes are mainly qi deficiency. In the sequelae phase, the syndromes are mainly blood stasis, internal wind, and deficiency syndromes, with qi deficiency and blood stasis syndrome being the main syndromes. Whether in the acute phase or the recovery phase, the method of promoting blood circulation and removing blood stasis is widely accepted by clinical physicians. Chinese herbal decoctions are mainly Xuefu Zhuyu Decoction and Tongqiao Huoxue Decoction. Chinese herbal injections extracted from blood-activating and stasis-removing drugs are also used in acute phase treatment because of their fast absorption and rapid action.

[0006] So far, there are no reports on Chinese medicine formulas that can safely and effectively treat acute ischemic stroke. Summary of the invention

[0007] To solve the above technical problems, the present invention includes the following aspects:

[0008] A first aspect of the present invention provides a traditional Chinese medicine composition for treating stroke, wherein the traditional Chinese medicine composition is prepared from Poria cocos, Uncaria rhynchophylla, Salvia miltiorrhiza, Citrus reticulata, Gastrodia elata, Ligusticum chuanxiong, Pinellia ternata, Arisaema cinerea and Carthamus tinctorius.

[0009] Preferably, the traditional Chinese medicine composition is made of 10-30 weight parts of Poria cocos, 5-25 weight parts of Uncaria rhynchophylla, 5-25 weight parts of Salvia miltiorrhiza, 3-18 weight parts of Citrus reticulata, 3-18 weight parts of Gastrodia elata, 3-18 weight parts of Ligusticum chuanxiong, 3-18 weight parts of Pinellia ternata, 1-15 weight parts of Arisaema ciliata and 1-15 weight parts of Carthamus tinctorius.

[0010] More preferably, the traditional Chinese medicine composition is made of 15-25 weight parts of Poria cocos, 10-20 weight parts of Uncaria rhynchophylla, 10-20 weight parts of Salvia miltiorrhiza, 5-15 weight parts of Citrus reticulata, 5-15 weight parts of Gastrodia elata, 5-15 weight parts of Ligusticum chuanxiong, 5-15 weight parts of Pinellia ternata, 3-10 weight parts of Arisaema ciliata and 3-10 weight parts of Carthamus tinctorius.

[0011] Further preferably, the traditional Chinese medicine composition is made of 18-22 weight parts of Poria cocos, 12-18 weight parts of Uncaria rhynchophylla, 12-18 weight parts of Salvia miltiorrhiza, 8-12 weight parts of Citrus reticulata, 8-12 weight parts of Gastrodia elata, 8-12 weight parts of Ligusticum chuanxiong, 7-11 weight parts of Pinellia ternata, 4-8 weight parts of Arisaema ciliata and 4-8 weight parts of Carthamus tinctorius.

[0012] Most preferably, the Chinese medicine composition is made of 20 parts by weight of Poria cocos, 15 parts by weight of Uncaria rhynchophylla, 15 parts by weight of Salvia miltiorrhiza, 10 parts by weight of Citrus reticulata, 10 parts by weight of Gastrodia elata, 10 parts by weight of Ligusticum chuanxiong, 9 parts by weight of Pinellia ternata, 6 parts by weight of Arisaema ciliata and 6 parts by weight of Carthamus tinctorius.

[0013] Preferably, the traditional Chinese medicine composition further comprises pharmaceutically acceptable excipients.

[0014] Preferably, the Chinese medicine composition is an oral preparation.

[0015] Preferably, the dosage form of the Chinese medicine composition is tablets, capsules, granules, tinctures or decoctions.

[0016] More preferably, the dosage form of the Chinese medicine composition is a decoction.

[0017] Preferably, the preparation method of the Chinese medicine composition comprises the following steps: taking a prescribed amount of Poria cocos, Uncaria rhynchophylla, Salvia miltiorrhiza, Tangerine peel, Gastrodia elata, Ligusticum chuanxiong, Pinellia ternata, Arisaema cinerea and Carthamus tinctorius, adding 3-5 times the total weight of the Chinese medicinal materials in water, boiling over high heat and then decocting over low heat for 30 minutes, filtering and concentrating the Chinese medicine filtrate to a weight equal to the total weight of the Chinese medicinal materials initially added, and optionally adding pharmaceutically acceptable excipients to obtain the composition.

[0018] Preferably, water in an amount of 4 times the total weight of the Chinese medicinal materials is added in the above preparation method.

[0019] The second aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine composition, which comprises the following steps: taking a prescribed amount of Poria cocos, Uncaria rhynchophylla, Salvia miltiorrhiza, Tangerine peel, Gastrodia elata, Ligusticum chuanxiong, Pinellia ternata, Arisaema cinerea and Carthamus tinctorius, adding 3-5 times the total weight of the Chinese medicinal materials in water, boiling over high heat and then decocting over low heat for 30 minutes, filtering and concentrating the Chinese medicine filtrate to a weight equal to the total weight of the Chinese medicinal materials initially added, and optionally adding pharmaceutically acceptable excipients to obtain the composition.

[0020] Preferably, water in an amount of 4 times the total weight of the Chinese medicinal materials is added in the above preparation method.

[0021] The third aspect of the present invention provides use of the above-mentioned Chinese medicine composition in the preparation of a medicament for treating cerebral stroke.

[0022] Preferably, the cerebral stroke is ischemic cerebral stroke. More preferably, the ischemic cerebral stroke is acute ischemic cerebral stroke.

[0023] The fourth aspect of the present invention provides the use of the above-mentioned Chinese medicine composition in the preparation of a drug for reducing the content of inflammatory factors in the brain.

[0024] Preferably, the inflammatory factor is TNF-α and / or IL-β.

[0025] The common pharmacological effects of the Chinese medicinal raw materials selected in the present invention in this field are as follows:

[0026] Poria: sweet, light, neutral in nature, enters the heart, spleen, and kidney meridians. Poria promotes diuresis and eliminates dampness, strengthens the spleen and stomach, calms the mind and soothes the nerves, and is used to treat urinary dysfunction, edema, phlegm and cough, poor appetite, abdominal distension, loose stools, dizziness, palpitations, insomnia, nocturnal emission, turbid urine, residual urine, leucorrhea and other dampness symptoms.

[0027] Uncaria rhynchophylla: sweet in taste, cool in nature, and enters the liver and pericardium meridians. Uncaria rhynchophylla can clear blood and calm the liver, calm the wind and calm the convulsions, and is used to treat epilepsy and convulsions, high fever convulsions, colds and convulsions, crying in children, eclampsia during pregnancy, headaches and dizziness, etc.

[0028] Danshen: bitter, slightly cold, enters the heart meridian and liver meridian. Danshen removes blood stasis and relieves pain, promotes blood circulation and menstruation, clears the heart and relieves restlessness, and is used to treat irregular menstruation, amenorrhea, dysmenorrhea, scar accumulation, chest and abdominal stabbing pain, heat arthralgia pain, sores and swelling, restlessness and insomnia, hepatosplenomegaly, angina pectoris and other symptoms.

[0029] Tangerine peel: bitter, pungent, warm, enters the lung and spleen meridians. Tangerine peel regulates qi and strengthens the spleen, dries dampness and resolves phlegm, and is used to treat chest and abdominal distension, loss of appetite, vomiting and diarrhea, cough and excessive phlegm.

[0030] Gastrodia elata: sweet, pungent, neutral, enters the liver meridian. Gastrodia elata can calm wind and stop spasms, calm liver yang, dispel wind and dredge collaterals, and is used to treat acute and chronic convulsions, convulsions, tetanus, vertigo, headache, hemiplegia, limb numbness, rheumatic pain and other symptoms.

[0031] Chuanxiong: warm in nature, pungent in taste, enters the liver meridian, gallbladder meridian, and pericardium meridian. Chuanxiong promotes blood circulation and qi, dispels wind and relieves pain, and is used to treat chest pain, chest and flank pain, swelling and pain due to falls, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to urinary tract infections, headache, rheumatic pain, etc.

[0032] Pinellia: spicy, warm in nature, enters the spleen, stomach, and lung meridians. Pinellia ternata dries dampness and resolves phlegm, relieves adverse reactions and stops vomiting, eliminates lumps and resolves knots, and is used to treat damp phlegm and cold phlegm, cough, asthma, excessive phlegm, phlegm and fluid, dizziness and palpitations, dizziness due to wind phlegm, phlegm and headache, vomiting and nausea, chest and abdominal distension, and plum pit qi.

[0033] Arisaema: bitter, slightly pungent, cool, enters the lung, liver, and spleen meridians. Arisaema can clear away heat and resolve phlegm, calm wind and calm convulsions, and is used to treat phlegm-heat cough, yellow and thick sputum, stroke, phlegm, epilepsy, and other symptoms.

[0034] Safflower: warm in nature, pungent in taste, and enters the heart and liver meridians. Safflower promotes blood circulation, relieves blood stasis and relieves pain. It is used to treat amenorrhea, dysmenorrhea, lochia retention, lumps and masses, injuries from falls, sores, swelling and pain, etc.

[0035] The technical effects produced by the present invention are:

[0036] The Chinese medicine composition of the present invention has a reasonable formula and compatibility, and the inventor has obtained the preferred components and content ratios of the Chinese medicine composition of the present invention through a large number of experiments. The Chinese medicine composition of the present invention can resolve phlegm and extinguish wind, promote blood circulation and dredge collaterals, has high safety, and has a significant effect on treating stroke, especially acute ischemic stroke. DETAILED DESCRIPTION

[0037] The present invention is further described below in conjunction with examples, but the embodiments of the present invention are not limited thereto. The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0038] Example 1

[0039] Take 20g of Poria, 15g of Uncaria, 15g of Salvia miltiorrhiza, 10g of Citrus reticulata, 10g of Gastrodia elata, 10g of Ligusticum chuanxiong, 9g of Pinellia ternata, 6g of Arisaema cinerea and 6g of Carthamus tinctorius, add 400mL of purified water, boil over high heat and then simmer over low heat for 30 minutes, filter and concentrate the Chinese medicine filtrate to 100mL to obtain the Chinese medicine decoction 1 of the present invention.

[0040] Example 2

[0041] Take 10g of Poria, 20g of Uncaria, 20g of Salvia miltiorrhiza, 10g of Citrus reticulata, 10g of Gastrodia elata, 10g of Ligusticum chuanxiong, 9g of Pinellia ternata, 6g of Arisaema cinerea and 6g of Carthamus tinctorius, add 400mL of purified water, boil over high heat and then simmer over low heat for 30 minutes, filter and concentrate the Chinese medicine filtrate to 100mL to obtain the Chinese medicine decoction 2 of the present invention.

[0042] Example 3

[0043] Take 20g of Poria, 10g of Uncaria, 10g of Salvia miltiorrhiza, 15g of Citrus reticulata, 15g of Gastrodia elata, 10g of Ligusticum chuanxiong, 9g of Pinellia, 6g of Arisaema cinerea and 6g of Carthamus tinctorius, add 400mL of purified water, boil over high heat and then simmer over low heat for 30 minutes, filter and concentrate the Chinese medicine filtrate to 100mL to obtain the Chinese medicine decoction 3 of the present invention.

[0044] Example 4

[0045] Take 20g of Poria, 10g of Uncaria, 10g of Salvia miltiorrhiza, 10g of Citrus reticulata, 10g of Gastrodia elata, 15g of Ligusticum chuanxiong, 14g of Pinellia ternata, 6g of Arisaema cinerea and 6g of Carthamus tinctorius, add 400mL of purified water, boil over high heat and then simmer over low heat for 30 minutes, filter and concentrate the Chinese medicine filtrate to 100mL to obtain the Chinese medicine decoction 4 of the present invention.

[0046] Comparative Example 1 (Poria cocos replaced by Alisma orientalis)

[0047] Take 20g of Alisma, 15g of Uncaria, 15g of Salvia miltiorrhiza, 10g of Citrus reticulata, 10g of Gastrodia elata, 10g of Ligusticum chuanxiong, 9g of Pinellia, 6g of Arisaema cinerea and 6g of Carthamus tinctorius, add 400mL of purified water, boil over high heat, then simmer over low heat for 30 minutes, filter and concentrate the Chinese medicine filtrate to 100mL to obtain Chinese medicine decoction comparative example 1.

[0048] Comparative Example 2 (Chuanxiong replaced with Panax notoginseng)

[0049] Take 20g of Poria cocos, 15g of Uncaria rhynchophylla, 15g of Salvia miltiorrhiza, 10g of Citrus reticulata, 10g of Gastrodia elata, 10g of Panax notoginseng, 9g of Pinellia ternata, 6g of Arisaema cinerea and 6g of Carthamus tinctorius, add 400mL of purified water, boil over high heat, then simmer over low heat for 30 minutes, filter and concentrate the Chinese medicine filtrate to 100mL to obtain Chinese medicine decoction comparative example 2.

[0050] Test Example 1: Brain protection effect of the Chinese medicine composition of the present invention on acute ischemic stroke model in rats

[0051] 1. Test methods

[0052] 1.1. Construction of tMCAO rat model

[0053] Rats were anesthetized with a gas anesthesia machine and fixed on the operating table in the supine position. The skin was cut longitudinally along the midline of the neck, and the right common carotid artery (CCA), external carotid artery (ECA), and internal carotid artery (ICA) were carefully separated. The ECA was ligated and cut, and straightened to form a straight line with the ICA. A small cut was made on the ECA, and a round-headed siliconized nylon thread with a length of 4.0 cm and a diameter of 0.26 mm was inserted from this opening into the ICA about 2 cm to the beginning of the rat's anterior cerebral artery to block the blood supply of the middle cerebral artery and monitor cerebral blood flow. After 2 hours of ischemia, the nylon thread was carefully withdrawn, the ECA opening was ligated, and the surgical incision was sutured.

[0054] 1.2 Trial Grouping and Dosing Regimen

[0055] Rats after tMCAO surgery were randomly divided into 7 groups, namely, a model group, groups 1-4 of embodiments of the present invention, and groups 1-2 of comparative examples, with 10 rats in each group. Except for the model group, rats in the remaining test groups were orally administered the decoction prepared by embodiments 1-4 of the present invention and comparative examples 1-2 at a dose of 1 mL / kg within 5 minutes after tMCAO ischemic surgery, and reperfusion was performed 120 minutes after ischemic surgery. Behavioral evaluation and TTC staining were performed 24 hours after reperfusion, and the volume of cerebral infarction and biochemical determination of inflammatory factors in brain tissue were analyzed and counted.

[0056] 1.3 Neurobehavioral scores of tMCAO rats

[0057] The behavior of the rats was observed 24 hours after ischemia-reperfusion. A four-level scoring method (0-4 points) was used: ① completely normal behavior was 0 points; ② the tail of the rat was lifted off the ground, and the forelimbs on the contralateral side of the surgery were internally rotated and adducted, which was 1 point; ③ the rat was placed on the ground, and the two sides were squeezed by hand to check its resistance. If the resistance on the contralateral side of the surgery decreased, it was 2 points; ④ the rat was placed on the ground and observed to walk. If it circled around the contralateral side of the surgery, it was 3 points; ⑤ the injury was extremely severe and it could no longer move independently, it was 4 points. The higher the score, the more severe the neurobehavioral damage.

[0058] 1.4. Determination of cerebral infarction volume in tMCAO rats

[0059] After 24 h of ischemia-reperfusion, the rats were decapitated and the brains were removed. The olfactory tract, cerebellum and lower brainstem were removed and the brains were cut coronally into 6 slices (the 1st to 5th slices were 2 mm thick each, and the 6th slice was 4 mm thick). The brains were quickly placed in 5 mL of 4% TTC (1.5 mL) and 1 mol·L -1Stain in a solution of K2HPO4 (0.1 mL) (37°C, protected from light) for 20-30 minutes, turning over every 5 minutes. After TTC staining, normal tissue is stained dark red and infarcted tissue is white. Arrange each group of brain slices neatly and take pictures for preservation. Use image analysis system software Photoshop to process and count, calculate the infarct area of ​​each slice, and finally superimpose and convert it into infarct volume. The infarct volume is expressed as a percentage of the cerebral hemisphere occupied to eliminate the influence of cerebral edema. Cerebral infarction volume ratio (%) = (volume of the contralateral hemisphere of surgery - volume of the non-infarcted part of the hemisphere of surgery) / volume of the contralateral hemisphere of surgery × 100%.

[0060] 1.5. Biochemical tissue determination of brain tissue inflammatory factors

[0061] The rats in each test group were decapitated and the injured hemibrain was taken out. After being blotted dry with filter paper, it was weighed, and physiological saline was added at a weight-to-volume ratio of 1:9. A 10% tissue homogenate was prepared using a homogenizer, and then centrifuged for 10 minutes and the supernatant was taken. The content of inflammatory factors in brain tissue was determined according to the instructions of the TNF-α and IL-β kits.

[0062] 2. Test results

[0063] 2.1. Results of neurobehavioral scores and cerebral infarction volume percentage in rats

[0064] The effects of the Chinese herbal decoctions in each experimental group on the behavioral scores and cerebral infarction volume percentage of tMCAO model rats are shown in Table 1.

[0065] Table 1 Behavioral scores and percentage of cerebral infarction volume of rats after administration of decoction in each test group

[0066] Experimental Group Behavioral scoring Percentage of cerebral infarction volume (%) Model Group 2.9±0.7 48.3±6.8 Example 1 Group 1.6±0.5 21.6±3.5 Example 2 Group 1.9±0.6 28.5±4.2 Example 3 Group 2.0±0.7 31.2±4.9 Example 4 Group 2.1±0.6 32.5±5.1 Comparative Example 1 2.3±0.9 38.4±5.5 Comparative Example 2 2.4±0.7 37.1±5.8

[0067] As can be seen from Table 1 above, the cerebral infarction volume percentage and behavioral score of the model group rats are 48.3 ± 6.8% and 2.9 ± 0.7 respectively, suggesting that the model animals have obvious cerebral ischemic damage. Compared with the model group and the comparative example 1-2 group, after the decoction of the embodiment of the present invention 1-4 is given to the model rats, the cerebral infarction volume percentage and behavioral score of the rats are significantly decreased (with statistical difference), indicating that the Chinese medicine decoction of the present invention has a significant effect for treating ischemic stroke model rats, suggesting that the decoction of the present invention can be used for treating stroke clinically, particularly acute ischemic stroke. Surprisingly, after the model rats orally take the decoction of the embodiment of the present invention 1, the cerebral infarction volume percentage and behavioral score of the rats decrease most significantly, producing an excellent therapeutic effect that is difficult to expect.

[0068] 2.2. Results of determination of inflammatory factors TNF-α and IL-β in rat brain

[0069] The effects of Chinese herbal decoctions in each experimental group on inflammatory factors in the brain of tMCAO model rats are shown in Table 2.

[0070] Table 2 TNF-α and IL-β levels in the brain of rats after administration of decoction in each test group

[0071] Experimental Group TNF-α(pg / μgprot) IL-β (pg / μgprot) Model Group 29.36±2.75 643.8±38.6 Example 1 Group 8.26±1.21 396.4±23.7 Example 2 Group 14.57±1.46 451.2±26.3 Example 3 Group 16.24±1.72 469.4±27.9 Example 4 Group 17.93±1.68 482.5±25.4 Comparative Example 1 20.59±1.94 538.2±29.1 Comparative Example 2 22.74±2.05 557.1±32.5

[0072] As shown in Table 2 above, compared with the model group and the comparative example 1-2 group, the Example 1-4 group of the present invention can significantly reduce the TNF-α and IL-1β content levels of the injured side brain tissue (with statistical differences). The above test results suggest that the therapeutic improvement effect of the Chinese herbal decoction of the present invention (especially the Chinese herbal decoction of Example 1) on ischemia-reperfusion injury in rat models may be related to its inhibition of the expression of inflammatory factors.

[0073] Although specific embodiments of the present invention have been described, it will be appreciated by those skilled in the art that various changes and modifications may be made to the present invention without departing from the scope or spirit of the present invention. Therefore, the present invention is intended to cover all such changes and modifications that fall within the scope of the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating stroke, characterized in that: The traditional Chinese medicine composition is prepared from Poria cocos, Uncaria rhynchophylla, Salvia miltiorrhiza, dried orange peel, Gastrodia elata, Chuanxiong, Pinellia tuber, Arisaema cinerea and safflower.

2. The Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition is prepared from 10-30 parts by weight of Poria cocos, 5-25 parts by weight of Uncaria rhynchophylla, 5-25 parts by weight of Salvia miltiorrhiza, 3-18 parts by weight of Citrus reticulata, 3-18 parts by weight of Gastrodia elata, 3-18 parts by weight of Ligusticum chuanxiong, 3-18 parts by weight of Pinellia ternata, 1-15 parts by weight of Arisaema ciliata and 1-15 parts by weight of Carthamus tinctorius.

3. The Chinese medicine composition according to claim 2, characterized in that: The traditional Chinese medicine composition is prepared from 15-25 parts by weight of Poria cocos, 10-20 parts by weight of Uncaria rhynchophylla, 10-20 parts by weight of Salvia miltiorrhiza, 5-15 parts by weight of Citrus reticulata, 5-15 parts by weight of Gastrodia elata, 5-15 parts by weight of Ligusticum chuanxiong, 5-15 parts by weight of Pinellia ternata, 3-10 parts by weight of Arisaema ciliata and 3-10 parts by weight of Carthamus tinctorius.

4. The Chinese medicine composition according to claim 3, characterized in that: The traditional Chinese medicine composition is prepared from 18-22 parts by weight of Poria cocos, 12-18 parts by weight of Uncaria rhynchophylla, 12-18 parts by weight of Salvia miltiorrhiza, 8-12 parts by weight of Citrus reticulata, 8-12 parts by weight of Gastrodia elata, 8-12 parts by weight of Ligusticum chuanxiong, 7-11 parts by weight of Pinellia ternata, 4-8 parts by weight of Arisaema ciliata and 4-8 parts by weight of Carthamus tinctorius.

5. The Chinese medicine composition according to claim 4, characterized in that: The traditional Chinese medicine composition is prepared from 20 parts by weight of Poria cocos, 15 parts by weight of Uncaria rhynchophylla, 15 parts by weight of Salvia miltiorrhiza, 10 parts by weight of Citrus reticulata, 10 parts by weight of Gastrodia elata, 10 parts by weight of Ligusticum chuanxiong, 9 parts by weight of Pinellia ternata, 6 parts by weight of Arisaema ciliata and 6 parts by weight of Carthamus tinctorius.

6. The Chinese medicine composition according to any one of claims 1 to 5, characterized in that: The traditional Chinese medicine composition further includes pharmaceutically acceptable excipients.

7. The Chinese medicine composition according to claim 6, characterized in that: The Chinese medicine composition is an oral preparation.

8. The Chinese medicine composition according to claim 7, characterized in that: The dosage form of the Chinese medicine composition is tablet, capsule, granule, tincture or decoction.

9. The method for preparing the Chinese medicine composition according to any one of claims 1 to 8, characterized in that: The preparation method comprises the following steps: taking a prescribed amount of Poria cocos, Uncaria rhynchophylla, Salvia miltiorrhiza, dried orange peel, Gastrodia elata, Chuanxiong, Pinellia ternata, Arisaema cinerea and safflower, adding water 3-5 times the total weight of the Chinese medicinal materials, boiling over high heat and then decocting over low heat for 30 minutes, filtering and concentrating the Chinese medicinal filtrate to a weight equal to the total weight of the Chinese medicinal materials initially added, and optionally adding pharmaceutically acceptable excipients to obtain the product.

10. Use of the Chinese medicine composition according to any one of claims 1 to 8 in the preparation of a medicament for treating cerebral stroke.