Traditional Chinese medicine composition for preventing hair loss, growing hair and controlling oil

Abstract

The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 to 75 parts of radix angelicae, 5 to 75 parts of herba eupatorii, 1 to 12 parts of sandalwood, 2 to 17 parts of herba asari, 2 to 17 parts of cacumen biotae, 1 to 15 parts of flos magnoliae, 1 to 6 parts of rhizoma kaempferiae, 1 to 6 parts of flos caryophylli, 2 to 17 parts of folium mori, 1 to 17 parts of flos rosae rugosae, 1 to 12 parts of radix et rhizoma rhei, 1 to 12 parts of cortex moutan, 1 to 17 parts of liquorice root and 0.1 to 3 parts of borneol. Most of the medicines in the composition enter the lung meridian, are spicy and mild in nature and taste, and can be used for dredging the striae and interstices of the skin in a pungent manner, so that the lung essence can be used for moistening and nourishing hair, and a series of symptoms such as alopecia degree, sebum overflow, scalp desquamation, sparse hair and fine and soft hair of a subject can be improved. Clinical tests confirm that the composition disclosed by the invention has remarkable effects in the aspects of hair growth, hair loss prevention and oil control.

Description

Technical Field

[0001] The present invention specifically relates to a traditional Chinese medicine composition for preventing hair loss, promoting hair growth and controlling oiliness. Background Art

[0002] Hair loss is a complex and common health problem that plagues modern people. There are many reasons for hair loss, including genetics, hormone levels, malnutrition, mental stress, illness, and drug side effects. Among them, androgenic alopecia is the most common type of hair loss in men, accounting for about 90% of all hair loss cases. The causes of hair loss in women are more complicated, such as polycystic ovary syndrome, anemia, and abnormal thyroid function.

[0003] Traditional Chinese medicine calls hair loss "alopecia" and "oily wind". Clinically, the main manifestations are large-scale hair loss and thinning. Some patients also have loss of eyebrows and beards. The name of the disease is related to the occurrence and development of the disease and the clinical symptoms. Traditional Chinese medicine generally believes that the growth of hair depends entirely on essence and blood. The kidney stores essence, so "its beauty is in the hair" and "hair is the sign of the kidney". The growth and loss, moisture and dryness of hair not only depend on the nourishment of the essence and qi in the kidney, but also on the nourishment of blood, so it is called "hair is the surplus of blood". Therefore, hair loss is closely related to blood, liver and kidney. The current Chinese medicine prescriptions for the treatment of hair loss mainly start from qi, blood, liver, kidney, heart and spleen. Nourishing blood and generating hair are carried out throughout. According to different syndromes, either nourishing the yin of the liver and kidney to generate yin blood; or replenishing the acquired spleen and stomach to make the qi and blood biochemical active. In addition, for the concurrent symptoms, it is added or subtracted according to the syndrome.

[0004] However, hair loss is also closely related to the lungs. Dysfunction of the "lungs governing the skin and hair" may cause dry hair, which will fall out if it loses its moisture. Currently, there is no report on a Chinese medicine compound based on the TCM theory of "lungs governing the skin and hair" that can effectively prevent hair loss and promote hair growth. Summary of the invention

[0005] In order to solve the above problems, the present invention provides a Chinese medicine composition for preventing hair loss, promoting hair growth and controlling oiliness, which is prepared from raw materials containing the following weight ratios: 5-75 parts of Angelica dahurica, 5-75 parts of Cymbidium orientalis, 1-12 parts of Santalum album, 2-17 parts of Asarum, 2-17 parts of Platycladus orientalis leaves, 1-15 parts of Magnolia officinalis, 1-6 parts of Kaempferia galanga, 1-6 parts of Cloves, 2-17 parts of Morus alba leaves, 1-17 parts of Rose, 1-12 parts of Rhubarb, 1-12 parts of Paeonia suffruticosa, 1-17 parts of Licorice, and 0.1-3 parts of Borneolum.

[0006] Furthermore, it is prepared from raw materials containing the following weight ratio: 10-60 parts of Angelica dahurica, 8-60 parts of Perilla frutescens, 2-10 parts of Santalum album, 1-15 parts of Asarum, 1-15 parts of Platycladus orientalis leaves, 1-15 parts of Magnolia officinalis, 1-6 parts of Kaempferia galanga, 1-6 parts of Cloves, 2-15 parts of Mulberry leaves, 1-15 parts of Rose, 2-10 parts of Rhubarb, 2-10 parts of Paeonia suffruticosa, 1-15 parts of Licorice, and 0.2-2 parts of Borneolum.

[0007] Furthermore, it is prepared from raw materials containing the following weight ratio: 25 parts of the Radix Angelicae Dahuricae, 8 parts of Perilla frutescens, 4 parts of Santalum album, 1 part of Asarum, 1 part of Platycladus orientalis, 1 part of Flos Magnoliae, 1 part of Kaempferia galanga, 1 part of Cloves, 2 parts of Folium Mori, 2 parts of Flos Rosae Rugosae, 2 parts of Radix Et Rhizoma Rhei, 2 parts of Cortex Moutan, 2 parts of Radix Glycyrrhizae, and 0.3 part of Borneolum.

[0008] Furthermore, it is a preparation prepared from the powder of the raw material medicine, or the water or organic solvent extract of the raw material medicine as the active ingredient, and the adjuvants acceptable to medicines or daily chemical products.

[0009] Furthermore, the preparation is an external preparation.

[0010] Furthermore, the external preparation is a solution, an ointment, a powder, a patch or an aerosol, preferably a powder.

[0011] The present invention also provides a method for preparing the aforementioned Chinese medicine composition, which comprises the following steps: (1) Weigh the raw materials according to the ratio; (2) The raw material drug is ground into powder, or the water or organic solvent extract of the raw material drug is added with excipients or auxiliary ingredients commonly used in medicines and daily chemical products.

[0012] The present invention also provides a use of the aforementioned traditional Chinese medicine composition in preparing a medicine for preventing hair loss, promoting hair growth and / or controlling oil.

[0013] The present invention also provides a use of the aforementioned traditional Chinese medicine composition in preparing daily chemical products for preventing hair loss, promoting hair growth and / or controlling oil.

[0014] The composition of the present invention is based on the relationship between hair loss and the lungs. The dysfunction of "lungs control skin and hair" may cause dry hair. Hair will fall off if it loses its warmth. The traditional Chinese medicine theory that lung qi is released and essence is delivered to the pores and hair is the basis for ensuring normal hair growth. It is based on the lungs controlling skin and hair and the function of the lungs to release essence. Angelica dahurica is used as the main drug; Perilla frutescens, sandalwood, and asarum are used as the assistant drugs; Platycladus orientalis, magnolia, galangal, clove, mulberry leaf, rose, rhubarb, peony bark, and liquorice are used as adjuvant drugs; and borneol is used as the messenger. The whole formula plays the role of releasing essence, warming and nourishing the pores and hair, regulating the opening and closing of the pores, and protecting the skin surface.

[0015] Most of the drugs in the composition of the present invention enter the lung meridian, and are pungent, fragrant and moist in nature and flavor, and can disperse and dredge the skin pores, so that the lung essence can moisturize and nourish the hair, thereby improving a series of symptoms such as the degree of hair loss, seborrhea, scalp desquamation, sparse hair, and fine and soft hair of the subject. Clinical trials have confirmed that the composition of the present invention has significant effects in hair growth, hair loss prevention and oil control.

[0016] Obviously, according to the above contents of the present invention, in accordance with common technical knowledge and customary means in the art, without departing from the above basic technical ideas of the present invention, other various forms of modification, replacement or change may be made.

[0017] The above contents of the present invention are further described in detail below through specific implementation methods in the form of embodiments. However, this should not be understood as the scope of the above subject matter of the present invention being limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 Clinical use 0~6 months head hair effect change chart ① Figure 2 Clinical use 0~6 months head hair effect change chart ② Figure 3 Clinical use 0~6 months head hair effect change chart ③ Figure 4 Clinical use 0~6 months head hair effect change chart ④ Figure 5 Clinical use 0~6 months head hair effect change chart ⑤ Figure 6 Clinical use of 0~6 months of head hair effect change diagram ⑥ Figure 7 Clinical use 0~6 months head hair effect change chart ⑦ Figure 8 Clinical use of 0~6 months of head hair effect change diagram⑧ Fig. 9 Figure 9: Changes in the effect of head hair after 0 to 6 months of clinical use Fig.10 Figure ⑩ of the changes in the effects of head hair after 0 to 6 months of clinical use Fig.11 Clinical use 0~6 months head hair effect change diagram ⑪ Fig.12 Clinical use 0~6 months head hair effect change diagram ⑫ Fig.13 Figure ⑬: Changes in the effect of head hair after 0 to 6 months of clinical use Fig.14Figure ⑭: Changes in the effect of head hair after 0 to 6 months of clinical use DETAILED DESCRIPTION

[0019] The raw materials and equipment used in the specific embodiments of the present invention are all known products, which are obtained by purchasing commercially available products. Among them, the preparation process of the modern preparation made from the Chinese medicine composition of the present invention is mature and can be made by referring to the conventional methods of the prior art.

[0020] Example 1. Preparation of the composition of the present invention Ingredients: Angelica dahurica 10g, Perilla frutescens 8g, Sandalwood 2g, Asarum 1g, Platycladus orientalis 1g, Magnolia 1g, Kaempferia galanga 1g, Clove 1g, Mulberry leaf 2g, Rose 1g, Rhubarb 2g, Peony bark 2g, Licorice 1g, Borneol 0.2g Preparation method: Weigh the above raw materials according to the ratio, crush them into fine powder.

[0021] How to use: After washing your hair, squeeze out the moisture from your hair with a dry towel, apply an appropriate amount to the scalp before it dries, and massage locally to promote transdermal absorption of the powder. Use twice a week.

[0022] Example 2: Preparation of the composition of the present invention Recipe: Angelica dahurica 60g, Perilla frutescens 60g, Sandalwood 10g, Asarum 15g, Platycladus orientalis 15g, Magnolia 15g, Kaempferia galanga 6g, Clove 6g, Mulberry leaf 15g, Rose 15g, Rhubarb 10g, Peony bark 10g, Licorice 15g, Borneol 2g Preparation method: Weigh the above raw materials according to the ratio, add 10 times the amount of water and boil twice, each time for 1.5 hours, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to form a thick paste.

[0023] How to use: After washing your hair, squeeze out the moisture from your hair with a dry towel, apply an appropriate amount to the scalp before it dries, and massage locally to promote transdermal absorption of the powder. Use twice a week.

[0024] Example 3: Preparation of the composition of the present invention Formula: Angelica dahurica 25g, Perilla frutescens 8g, Sandalwood 4g, Asarum 1g, Platycladus orientalis 1g, Magnolia 1g, Kaempferia galanga 1g, Clove 1g, Mulberry leaf 2g, Rose 2g, Rhubarb 2g, Peony bark 2g, Licorice 2g, Borneol 0.3g Preparation method and use method: same as Example 1.

[0025] The beneficial effects of the present invention are described below through test examples.

[0026] Test Example 1 Study on the efficacy of the composition preparation of the present invention The Chinese medicine composition of the present invention is a Chinese medicine compound based on the TCM theory of "lungs govern the skin and hair". It was approved by the Chengdu Municipal Health Commission: Project 2021293, and the Chengdu University of Traditional Chinese Medicine Xinglin Scholars "Discipline Talent Scientific Research Promotion Plan Project" yyzx2021139. The two projects were combined for research. It took 3 years from project approval to results. A total of 64 cases were included, and 62 cases were subjected to clinical randomized double-blind studies. The study showed that it was effective in preventing hair loss, hair growth and oil control. The specific research methods and results are as follows: 1. Methods All cases were derived from patients who visited the outpatient clinic of Traditional Chinese Medicine Hospital of Pidu District, Chengdu City from 2022 to 2023, and female patients with hair loss who met the inclusion criteria were selected as research subjects.

[0027] Inclusion criteria: ① Female, aged 18 to 65 years old; ② Patients with conscious hair loss or thinning hair, which is related to poor diet, stress, and hormone secretion; ③ Subjects maintain consistent habits of hair washing, care, trimming, and dyeing.

[0028] Exclusion criteria: ① Patients aged 65 years or above or 16 years or below, or those who are allergic to the ingredients of this formula; ② Patients who are allergic to daily shampoos or conditioners; ③ Patients who have experienced severe stress events (such as death of relatives, etc.) in the past six months; ④ Patients who have used hormonal contraceptives or other hormone replacement therapies in the past six months; ⑤ Patients who have used other hair growth treatments in the past three months; ⑥ Patients who have used drugs such as cyproterone, spironolactone, finasteride, etc. in the past six months; ⑦ Patients with diabetes, hypertension, hepatitis, immunodeficiency, HIV, hyperthyroidism or other autoimmune diseases; ⑧ Patients with other skin diseases that may interfere with the study, including alopecia areata, cicatricial alopecia, and static alopecia; ⑨ Patients who are breastfeeding, pregnant, or planning to become pregnant during the study.

[0029] 64 cases were screened, and 62 subjects actually met the inclusion criteria. They were randomly divided into a control group and a treatment group with 31 cases in each group. The age of the patients in the control group ranged from 16 to 65 years old, with an average age of (33.90±8.62 years old); the age of the patients in the treatment group ranged from 16 to 65 years old, with an average age of (33.63±8.84). There was no statistically significant difference in gender and age between the control group and the treatment group ( p >0.05). All subjects underwent blood routine, urine routine, stool routine, sex hormones (E2, T), thyroid function (TSH), liver function (ALT, AST), and renal function (UA, CREA, UREA) tests before inclusion, and the above test indicators were rechecked 6 months after treatment.

[0030] Experimental group: Use Xiangxiangxiu Hair Diffuser (prepared according to Example 3); after washing hair, squeeze the hair dry with a dry towel, apply a proper amount to the scalp before the scalp dries, massage locally to promote transdermal absorption of the powder, and use twice a week.

[0031] Control group: used placebo drug, which was made by low-temperature baking and drying of rice straw, grinding it into powder, adding a small amount of corn starch and spices, and the method of use was the same as that of the experimental group.

[0032] The efficacy of each group of patients was observed and statistically analyzed before use (at the first diagnosis and treatment), after the third month of use, and after the sixth month of use.

[0033] The efficacy evaluation criteria are: Observation indicators: ①Main indicator: the number of regenerated hair of the patient, according to the star point on the top of the patient's head before and after treatment. ②Secondary indicator: common symptoms of androgenic alopecia, according to the changes in subjective symptom scores before and after treatment to judge the patient's satisfaction with the aromatherapy.

[0034] Observation items and scoring criteria: After comparing the severity of the corresponding observation items with the initial diagnosis, the score is determined. For example, "3" means that the signs of the observation items have not improved; "2" means that the signs of the observation items have improved slightly; "1" means that the signs of the observation items have been mostly relieved; "0" means that the signs of the observation items have been completely relieved. Specifically, the symptoms of the patients at the first diagnosis and treatment, 3 months of use, and 6 months of use are scored according to Table 1. If the corresponding signs are present at the initial diagnosis, it is indicated by "3", otherwise it is indicated by "0".

[0035] Table 1 Symptom scores of patients Basic cure: This study did not include cure as an observation indicator because hair growth and shedding is a dynamic process that is affected by many objective factors, such as metabolism, hormone levels, mood changes, external environment, work pressure, seasonal changes, and other factors.

[0036] Markedly effective: The number of terminal hair and vellus hair increased significantly compared with the initial diagnosis; the physical signs of the observed items were completely relieved compared with the initial diagnosis.

[0037] Effective: The number of terminal hair and vellus hair increased to a certain extent compared with the initial diagnosis; the physical signs of the observation items were mostly alleviated compared with the initial diagnosis.

[0038] Ineffective: Ineffective means no improvement compared with before treatment.

[0039] 2. Results Results Figures 1 to 14 , and Tables 2~4.

[0040] Table 2 Physical sign scores of patients in the experimental group at the first diagnosis and treatment, 3 months of use, and 6 months of observation Note: There were no significant changes in two hormone items E2, two hormone items T, thyroid stimulating hormone, liver function and kidney function during the treatment.

[0041] Table 3 Physical sign scores of patients in the control group at the first diagnosis and treatment, 3 months of use and 6 months of observation Note: There were no significant changes in two hormone items E2, two hormone items T, thyroid stimulating hormone, liver function and kidney function during the treatment.

[0042] Table 4 Statistical results of the efficacy of each group after the sixth month of treatment Number of subjects Number of people cured Number of people with significant effect Effective number of people Invalid number of people Total Effectiveness Experimental Group 31 0 12 13 5 80.65% Control group 31 0 0 6 22 19.35% Note: One case in the experimental group did not receive the final efficacy evaluation; three cases in the control group did not receive the final efficacy evaluation, so they were not included in the efficacy evaluation results; total effective rate = (number of markedly effective patients + number of effective patients) / number of subjects * 100%.

[0043] The results show that the powder prepared from the composition of the present invention based on the lung's governing function of hair and the lung's function of dispersing and promoting hair can achieve significant effects of hair growth, hair loss prevention and oil control in patients with non-alopecia areata by external application to the scalp.

[0044] In summary, the present invention has remarkable effects in preventing hair loss, promoting hair growth and controlling oil, and is safe and effective, and has practical promotion and application value.

Claims

1. A Chinese medicine composition for preventing hair loss, promoting hair growth and controlling oiliness, characterized in that: It is prepared from raw materials containing the following weight ratios: 5-75 parts of Angelica dahurica, 5-75 parts of Cymbidium orientalis, 1-12 parts of Santalum album, 2-17 parts of Asarum, 2-17 parts of Platycladus orientalis leaves, 1-15 parts of Magnolia officinalis, 1-6 parts of Kaempferia galanga, 1-6 parts of Cloves, 2-17 parts of Morus alba leaves, 1-17 parts of Rose, 1-12 parts of Rhubarb, 1-12 parts of Paeonia suffruticosa, 1-17 parts of Licorice, and 0.1-3 parts of Borneolum.

2. The Chinese medicine composition according to claim 1, characterized in that: It is prepared from raw materials containing the following weight ratios: 10-60 parts of Angelica dahurica, 8-60 parts of Perilla frutescens, 2-10 parts of Santalum album, 1-15 parts of Asarum, 1-15 parts of Platycladus orientalis leaves, 1-15 parts of Magnolia officinalis, 1-6 parts of Kaempferia galanga, 1-6 parts of Cloves, 2-15 parts of Mulberry leaves, 1-15 parts of Rose, 2-10 parts of Rhubarb, 2-10 parts of Paeonia suffruticosa, 1-15 parts of Licorice, and 0.2-2 parts of Borneolum.

3. The Chinese medicine composition according to claim 1, characterized in that: It is prepared from raw materials containing the following weight ratios: 25 parts of the Radix Angelicae Dahuricae, 8 parts of Perilla frutescens, 4 parts of Santalum album, 1 part of Asarum, 1 part of Platycladus orientalis, 1 part of Flos Magnoliae, 1 part of Kaempferia galanga, 1 part of Cloves, 2 parts of Folium Mori, 2 parts of Flos Rosae Rugosae, 2 parts of Radix Et Rhizoma Rhei, 2 parts of Cortex Moutan, 2 parts of Radix Glycyrrhizae, and 0.3 part of Borneolum.

4. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that: It is a preparation made from the powder of the raw material medicine, or the water or organic solvent extract of the raw material medicine as the active ingredient, and the adjuvants acceptable to medicines or daily chemical products.

5. The Chinese medicine composition according to claim 4, characterized in that: The preparation is an external preparation.

6. The composition according to claim 5, characterized in that: The external preparation is a solution, ointment, powder, patch or aerosol, preferably a powder.

7. A method for preparing the Chinese medicine composition according to any one of claims 1 to 6, characterized in that: It includes the following steps: (1) Weigh the raw materials according to the ratio; (2) The raw material drug is ground into powder, or the water or organic solvent extract of the raw material drug is added with excipients or auxiliary ingredients commonly used in medicines and daily chemical products.

8. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicament for preventing hair loss, promoting hair growth and / or controlling oiliness.

9. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of daily chemical products for preventing hair loss, promoting hair growth and / or controlling oil.

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