Gastrodia elata compound instant granules and preparation method thereof

Abstract

The invention discloses gastrodia elata compound instant granules and a preparation method thereof, and belongs to the technical field of medicine preparation, fresh gastrodia elata, rhizoma atractylodis lanceae and fresh ginger are washed, diced and then pulped by a juicer, and the traditional mode of drying or drying after cooking is abandoned for operation; the hydroxypropyl-beta-cyclodextrin is used as an auxiliary material of a taste masking agent to clathrate components in the composite gastrodia elata feed liquid, so that a certain taste masking effect is achieved, the auxiliary material is used for assisting in forming, the hygroscopicity of the composite gastrodia elata feed liquid is improved, forming is facilitated, the flowability of the granules is improved, sub-packaging and storage of the granules are facilitated, and the quality of the granules is improved. And a stability test is carried out on the prepared rhizoma gastrodiae compound instant granules, all detection indexes meet the quality standard provisions of the rhizoma gastrodiae compound instant granules, and the problems of enzymolysis loss of medicinal components and quality reduction are prevented, so that the compound rhizoma gastrodiae feed liquid is prepared into the instant granule preparation which is convenient to carry, store and take. The characteristics of original flavor, pharmacological activity and juiciness of the fresh gastrodia elata are reserved.

Description

Technical Field

[0001] The invention belongs to the technical field of drug preparation, and specifically relates to a compound Gastrodia elata instant granule and a preparation method thereof. Background Art

[0002] Gastrodia elata is the dried tuber of the orchid plant Gastrodia elata. Modern pharmacological research shows that the medicinal ingredients in Gastrodia elata have a wide range of biological activities such as sedation and hypnosis, anticonvulsant, anti-epileptic, anti-vertigo, anti-cardiovascular and cerebrovascular disease, anti-apoptosis, protection of nerve cells, improvement of memory and anti-aging.

[0003] As a Chinese medicinal material that can be used as both medicine and food, fresh Gastrodia elata contains a large amount of water and polysaccharides, so it is very easy to rot during storage. It is usually made into dried Gastrodia elata that is easier to preserve by steaming or drying it in the sun. However, too high drying temperature or long-term exposure to air can easily cause the loss of Gastrodia elata's nutrients and effective ingredients. With the gradual deepening of research on the medicinal value and health benefits of Gastrodia elata, commercial products that are directly preserved in fresh form have emerged, such as fresh Gastrodia elata, fresh Gastrodia elata juice drinks, etc. Although the current preservation technology can extend the shelf life of fresh Gastrodia elata to a certain extent, there will also be problems such as enzymatic loss of medicinal ingredients and quality degradation. Therefore, it is difficult to retain the original flavor, pharmacological activity and juicy characteristics of fresh Gastrodia elata when using Gastrodia elata to prepare medicines. Summary of the invention

[0004] In order to overcome the above-mentioned defects, the present invention provides a Gastrodia elata compound instant granule and a preparation method thereof, which solves the problem that Gastrodia elata is prepared by drying or sun-drying after steaming to make dried Gastrodia elata which is easier to preserve, but excessively high drying temperature or long-term exposure to air can easily cause loss of nutrients and effective ingredients in Gastrodia elata, resulting in enzymatic loss of medicinal ingredients and reduced quality.

[0005] To achieve the above object, the present invention provides the following technical solutions: a Gastrodia elata compound instant granule, the Gastrodia elata compound instant granule is made of a composite Gastrodia elata liquid and auxiliary materials;

[0006] The composite gastrodia elata liquid is made of gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0007] The auxiliary materials include hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose; the hydroxypropyl-β-cyclodextrin is used as a taste masking auxiliary material.

[0008] As a further solution of the present invention: the mass ratio of the Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice is 60-80:0-40:0-40, and the mass ratio of the composite Gastrodia elata liquid to the auxiliary material is 1-1.5:0.3-0.5.

[0009] As a further embodiment of the present invention: the mass ratio of hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose is 1:0.5:0.3:0.25:0.2.

[0010] A method for preparing Gastrodia elata compound instant granules, the method comprising the following steps:

[0011] S1. Wash and cut fresh Gastrodia elata, Atractylodes lancea and ginger into pieces and soak them in water for 1-1.5 hours respectively, beat them with a juicer, and filter to obtain Gastrodia elata filtrate, Atractylodes lancea filtrate and ginger filtrate;

[0012] S2, then add water to the obtained gastrodia elata residue, atractylodes lancea residue and ginger residue for decoction, the decoction time is controlled at 30-50min, use a juicer to beat and filter to obtain gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate, then combine the obtained gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate with the gastrodia elata filtrate, atractylodes lancea filtrate and ginger filtrate obtained in S1, respectively, to obtain gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0013] S3, heating the obtained Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice in a water bath, and adding auxiliary materials to fully stir to obtain a composite Gastrodia elata liquid;

[0014] S4, add the composite Gastrodia elata liquid to the auxiliary materials and place it in a constant temperature water bath for heating, stir to dissolve it to obtain a prepared liquid, place the prepared liquid in a cool and dark place, and cool it to room temperature;

[0015] S5, spray drying or freeze drying the prepared formulation to obtain a dry powder;

[0016] S6, adding maltodextrin, calcium lactate, sucrose and L-arabinose as auxiliary materials to the obtained dry powder, mixing evenly to prepare composite Gastrodia elata juice powder, and mixing with soluble starch after crushing to obtain a granulation mixture;

[0017] S7. Spray ethanol wetting agent into the granulation mixture to make soft material granules, and dry the whole granules at 50-55° C. to obtain Gastrodia elata compound instant granules.

[0018] As a further solution of the present invention: in S3, the water bath heating temperature is controlled at 50-60°C, and the heating stirring time is 20-30min; in S4, the heating temperature in the water bath is controlled at 55-60°C, and the stirring time is 1-1.5min; and the added auxiliary material is hydroxypropyl-β-cyclodextrin.

[0019] As a further solution of the present invention: in S5, the conditions for spray drying are: setting the inlet air temperature to 180°C, setting the compressed air ratio to 100%, the injection volume to 15%, the atomizer pressure column height in the spray dryer to 40-50mm, and after the spray dryer is running, placing the peristaltic pump into the prepared liquid to feed the material for spray drying.

[0020] As a further scheme of the present invention: in S5, the freeze-drying conditions are: pre-freeze the prepared liquid, and the pre-freezing temperature is controlled at -80°C, the freezing time is 12 hours, and then vacuum freeze-drying is performed, the cold tank temperature of the vacuum freeze-drying is -50°C, and the drying time is 72 hours, and the prepared liquid after freeze-drying is ground into powder.

[0021] As a further solution of the present invention: in S6, the mass ratio of the composite gastrodia juice powder to the soluble starch is 1:0.8-1.2; in S7, the concentration of ethanol is 70-90%.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. In the present invention, fresh Gastrodia elata, Atractylodes macrocephala and ginger are washed, cut into pieces and then pulped with a juicer, the traditional method of steaming and then drying or sun-drying is abandoned, and hydroxypropyl-β-cyclodextrin is used as a taste-masking auxiliary material to encapsulate the components in the composite Gastrodia elata liquid, which plays a certain taste-masking role. The auxiliary materials are used to assist in molding, thereby improving the hygroscopicity of the composite Gastrodia elata liquid, which is conducive to molding, and the fluidity of the particles is increased, which is conducive to the packaging and storage of granules. In addition, the stability test of the prepared Gastrodia elata compound instant granules is carried out, and various detection indicators are in compliance with the quality standard of this product, thereby preventing the problems of enzymatic loss of effective ingredients and quality reduction. Therefore, the composite Gastrodia elata liquid is made into an instant granule preparation that is easy to carry, store and take, and retains the original flavor, pharmacological activity and juicy characteristics of fresh Gastrodia elata.

[0024] 2. In the present invention, the granular medicine made of Gastrodia elata, Atractylodes macrocephala and ginger can calm the liver and extinguish wind, stop dizziness, and can be used together with Atractylodes macrocephala to jointly treat the symptoms caused by wind-phlegm, and Atractylodes macrocephala can dry dampness and resolve phlegm, reduce adverse reactions and stop vomiting, and together with Gastrodia elata, it helps to eliminate phlegm and dampness in the body. Ginger is used as an auxiliary medicinal material in the granular medicine to reconcile the medicinal properties, enhance the effects of resolving phlegm and stopping vomiting, and also helps to alleviate the toxicity of Atractylodes macrocephala. The combined efficacy of Gastrodia elata, Atractylodes macrocephala and ginger has good specific pharmacodynamics and clinical applications. DETAILED DESCRIPTION

[0025] The technical solution of the present application is further described in detail below in conjunction with specific implementation methods.

[0026] The present invention provides a technical solution: a Gastrodia elata compound instant granule, which is made of a composite Gastrodia elata liquid and auxiliary materials;

[0027] The compound gastrodia elata liquid is made of gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0028] The auxiliary materials include hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose, and L-arabinose; hydroxypropyl-β-cyclodextrin is used as a taste-masking auxiliary material.

[0029] The mass ratio of gastrodia elata juice, atractylodes lancea juice and ginger juice is 60-80:0-40:0-40, and the mass ratio of the composite gastrodia elata liquid to the auxiliary materials is 1-1.5:0.3-0.5.

[0030] The mass ratio of hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose is 1:0.5:0.3:0.25:0.2.

[0031] A method for preparing Gastrodia elata compound instant granules, the method comprising the following steps:

[0032] S1. Wash and cut fresh Gastrodia elata, Atractylodes lancea and ginger into pieces and soak them in water for 1-1.5 hours respectively, beat them with a juicer, and filter to obtain Gastrodia elata filtrate, Atractylodes lancea filtrate and ginger filtrate;

[0033] S2, then add water to the obtained gastrodia elata residue, atractylodes lancea residue and ginger residue for decoction, the decoction time is controlled at 30-50min, use a juicer to beat and filter to obtain gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate, then combine the obtained gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate with the gastrodia elata filtrate, atractylodes lancea filtrate and ginger filtrate obtained in S1, respectively, to obtain gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0034] S3, heating the obtained Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice in a water bath, and adding auxiliary materials to fully stir to obtain a composite Gastrodia elata liquid;

[0035] S4, add the composite Gastrodia elata liquid to the auxiliary materials and place it in a constant temperature water bath for heating, stir to dissolve it to obtain a prepared liquid, place the prepared liquid in a cool and dark place, and cool it to room temperature;

[0036] S5, spray drying or freeze drying the prepared formulation to obtain a dry powder;

[0037] S6, adding maltodextrin, calcium lactate, sucrose and L-arabinose as auxiliary materials to the obtained dry powder, mixing evenly to prepare composite Gastrodia elata juice powder, and mixing with soluble starch after crushing to obtain a granulation mixture;

[0038] S7. Spray ethanol wetting agent into the granulation mixture to make soft material granules, and dry the whole granules at 50-55° C. to obtain Gastrodia elata compound instant granules.

[0039] In S3, the water bath heating temperature is controlled at 50-60°C, and the heating stirring time is 20-30 minutes. In S4, the heating temperature in the water bath is controlled at 55-60°C, and the stirring time is 1-1.5 minutes. The added auxiliary material is hydroxypropyl-β-cyclodextrin.

[0040] In S5, the spray drying conditions are: the inlet air temperature is set to 180°C, the compressed air ratio is set to 100%, the injection volume is 15%, the atomizer pressure column height in the spray dryer is 40-50mm, and after the spray dryer is running, the peristaltic pump is placed in the prepared liquid to feed the material for spray drying.

[0041] In S5, the freeze-drying conditions are as follows: pre-freeze the prepared liquid, and the pre-freezing temperature is controlled at -80°C, the freezing time is 12 hours, and then vacuum freeze-drying is performed, the cold tank temperature of the vacuum freeze-drying is -50°C, and the drying time is 72 hours, and the prepared liquid after freeze-drying is ground into powder.

[0042] In S6, the mass ratio of the composite gastrodia elata juice powder to the soluble starch is 1:0.8-1.2, and in S7, the concentration of ethanol is 70-90%.

[0043] Embodiment 1:

[0044] A Gastrodia elata compound instant granule, which is made of a compound Gastrodia elata liquid and auxiliary materials;

[0045] The compound gastrodia elata liquid is made of gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0046] The auxiliary materials include hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose, and L-arabinose; hydroxypropyl-β-cyclodextrin is used as a taste-masking auxiliary material.

[0047] The mass ratio of gastrodia elata juice, atractylodes lancea juice and ginger juice is 60-80:0-40:0-40, and the mass ratio of the composite gastrodia elata liquid to the auxiliary materials is 1-1.5:0.3-0.5.

[0048] The mass ratio of hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose is 1:0.5:0.3:0.25:0.2.

[0049] The preparation method of Gastrodia elata compound quick-dissolving granules comprises the following steps:

[0050] S1. Wash and cut fresh Gastrodia elata, Atractylodes lancea and ginger into pieces and soak them in water for 1-1.5 hours respectively, beat them with a juicer, and filter to obtain Gastrodia elata filtrate, Atractylodes lancea filtrate and ginger filtrate;

[0051] S2, then add water to the obtained gastrodia elata residue, atractylodes lancea residue and ginger residue for decoction, the decoction time is controlled at 30-50min, use a juicer to beat and filter to obtain gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate, then combine the obtained gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate with the gastrodia elata filtrate, atractylodes lancea filtrate and ginger filtrate obtained in S1, respectively, to obtain gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0052] S3, heating the obtained Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice in a water bath, and stirring them fully to obtain a composite Gastrodia elata liquid;

[0053] S4, add the composite Gastrodia elata liquid to the auxiliary materials and place it in a constant temperature water bath for heating, stir to dissolve it to obtain a prepared liquid, place the prepared liquid in a cool and dark place, and cool it to room temperature;

[0054] S5, spray drying the prepared formulation to obtain a dry powder;

[0055] S6, adding maltodextrin, calcium lactate, sucrose and L-arabinose as auxiliary materials to the obtained dry powder, mixing evenly to prepare composite Gastrodia elata juice powder, and mixing with soluble starch after crushing to obtain a granulation mixture;

[0056] S7. Spray ethanol wetting agent into the granulation mixture to make soft material granules, and dry the whole granules at 50-55° C. to obtain Gastrodia elata compound instant granules.

[0057] In S3, the water bath heating temperature is controlled at 50-60°C, and the heating stirring time is 20-30 minutes. In S4, the heating temperature in the water bath is controlled at 55-60°C, and the stirring time is 1-1.5 minutes. The added auxiliary material is hydroxypropyl-β-cyclodextrin.

[0058] In S5, the spray drying conditions are: the inlet air temperature is set to 180°C, the compressed air ratio is set to 100%, the injection volume is 15%, the atomizer pressure column height in the spray dryer is 40-50mm, and after the spray dryer is running, the peristaltic pump is placed in the prepared liquid to feed the material for spray drying.

[0059] In S6, the mass ratio of the composite gastrodia elata juice powder to the soluble starch is 1:0.8-1.2, and in S7, the concentration of ethanol is 80%.

[0060] Embodiment 2:

[0061] A Gastrodia elata compound instant granule, which is made of a compound Gastrodia elata liquid and auxiliary materials;

[0062] The compound gastrodia elata liquid is made of gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0063] The auxiliary materials include hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose, and L-arabinose; hydroxypropyl-β-cyclodextrin is used as a taste-masking auxiliary material.

[0064] The mass ratio of gastrodia elata juice, atractylodes lancea juice and ginger juice is 60-80:0-40:0-40, and the mass ratio of the composite gastrodia elata liquid to the auxiliary materials is 1-1.5:0.3-0.5.

[0065] The mass ratio of hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose is 1:0.5:0.3:0.25:0.2.

[0066] The preparation method of Gastrodia elata compound quick-dissolving granules comprises the following steps:

[0067] S1. Wash and cut fresh Gastrodia elata, Atractylodes lancea and ginger into pieces and soak them in water for 1-1.5 hours respectively, beat them with a juicer, and filter to obtain Gastrodia elata filtrate, Atractylodes lancea filtrate and ginger filtrate;

[0068] S2, then add water to the obtained gastrodia elata residue, atractylodes lancea residue and ginger residue for decoction, the decoction time is controlled at 30-50min, use a juicer to beat and filter to obtain gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate, then combine the obtained gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate with the gastrodia elata filtrate, atractylodes lancea filtrate and ginger filtrate obtained in S1, respectively, to obtain gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0069] S3, heating the obtained Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice in a water bath, and stirring them fully to obtain a composite Gastrodia elata liquid;

[0070] S4, add the composite Gastrodia elata liquid to the auxiliary materials and place it in a constant temperature water bath for heating, stir to dissolve it to obtain a prepared liquid, place the prepared liquid in a cool and dark place, and cool it to room temperature;

[0071] S5, freeze-drying the prepared formulation to obtain a dry powder;

[0072] S6, adding maltodextrin, calcium lactate, sucrose and L-arabinose as auxiliary materials to the obtained dry powder, mixing evenly to prepare composite Gastrodia elata juice powder, and mixing with soluble starch after crushing to obtain a granulation mixture;

[0073] S7. Spray ethanol wetting agent into the granulation mixture to make soft material granules, and dry the whole granules at 50-55° C. to obtain Gastrodia elata compound instant granules.

[0074] In S3, the water bath heating temperature is controlled at 50-60°C, and the heating stirring time is 20-30 minutes. In S4, the heating temperature in the water bath is controlled at 55-60°C, and the stirring time is 1-1.5 minutes. The added auxiliary material is hydroxypropyl-β-cyclodextrin.

[0075] In S5, the freeze-drying conditions are as follows: pre-freeze the prepared liquid, and the pre-freezing temperature is controlled at -80°C, the freezing time is 12 hours, and then vacuum freeze-drying is performed, the cold tank temperature of the vacuum freeze-drying is -50°C, and the drying time is 72 hours, and the prepared liquid after freeze-drying is ground into powder.

[0076] In S6, the mass ratio of the composite gastrodia elata juice powder to the soluble starch is 1:0.8-1.2, and in S7, the concentration of ethanol is 80%.

[0077] The difference between Example 1 and Example 2 is that in Example 1, the prepared formulation is spray-dried to obtain a dry powder; and in Example 2, the prepared formulation is freeze-dried to obtain a dry powder.

[0078] The physical and chemical index test results of the dry powders obtained by different drying methods were obtained according to Examples 1-2:

[0079]

[0080]

[0081] It can be seen from the above table that the powder obtained by spray drying is more fine and uniform, but the yield of spray drying is lower than that of freeze drying. After trying a variety of excipients, the wall sticking problem of spray drying always exists, resulting in too much loss. This scheme preferably adopts the freeze drying method.

[0082] Embodiment 3:

[0083] A Gastrodia elata compound instant granule, which is made of a compound Gastrodia elata liquid and auxiliary materials;

[0084] The compound gastrodia elata liquid is made of gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0085] The auxiliary materials include hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose, and L-arabinose; hydroxypropyl-β-cyclodextrin is used as a taste-masking auxiliary material.

[0086] The mass ratio of gastrodia elata juice, atractylodes lancea juice and ginger juice is 60-80:0-40:0-40, and the mass ratio of the composite gastrodia elata liquid to the auxiliary materials is 1-1.5:0.3-0.5.

[0087] The mass ratio of hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose is 1:0.5:0.3:0.25:0.2.

[0088] The preparation method of Gastrodia elata compound quick-dissolving granules comprises the following steps:

[0089] S1. Wash and cut fresh Gastrodia elata, Atractylodes lancea and ginger into pieces and soak them in water for 1-1.5 hours respectively, beat them with a juicer, and filter to obtain Gastrodia elata filtrate, Atractylodes lancea filtrate and ginger filtrate;

[0090] S2, then add water to the obtained gastrodia elata residue, atractylodes lancea residue and ginger residue for decoction, the decoction time is controlled at 30-50min, use a juicer to beat and filter to obtain gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate, then combine the obtained gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate with the gastrodia elata filtrate, atractylodes lancea filtrate and ginger filtrate obtained in S1, respectively, to obtain gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0091] S3, heating the obtained Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice in a water bath, and stirring them fully to obtain a composite Gastrodia elata liquid;

[0092] S4, add the composite Gastrodia elata liquid to the auxiliary materials and place it in a constant temperature water bath for heating, stir to dissolve it to obtain a prepared liquid, place the prepared liquid in a cool and dark place, and cool it to room temperature;

[0093] S5, freeze-drying the prepared formulation to obtain a dry powder;

[0094] S6, adding maltodextrin, calcium lactate, sucrose and L-arabinose as auxiliary materials to the obtained dry powder, mixing evenly to prepare composite Gastrodia elata juice powder, and mixing with soluble starch after crushing to obtain a granulation mixture;

[0095] S7. Spray ethanol wetting agent into the granulation mixture to make soft material granules, and dry the whole granules at 50-55° C. to obtain Gastrodia elata compound instant granules.

[0096] In S3, the water bath heating temperature is controlled at 50-60°C, and the heating stirring time is 20-30 minutes. In S4, the heating temperature in the water bath is controlled at 55-60°C, and the stirring time is 1-1.5 minutes. The added auxiliary material is hydroxypropyl-β-cyclodextrin.

[0097] In S5, the freeze-drying conditions are as follows: pre-freeze the prepared liquid, and the pre-freezing temperature is controlled at -80°C, the freezing time is 12 hours, and then vacuum freeze-drying is performed, the cold tank temperature of the vacuum freeze-drying is -50°C, and the drying time is 72 hours, and the prepared liquid after freeze-drying is ground into powder.

[0098] In S6, the mass ratio of the composite gastrodia elata juice powder to the soluble starch is 1:0.8-1.2, and in S7, the concentration of ethanol is 70%.

[0099] Example 4

[0100] A Gastrodia elata compound instant granule, which is made of a compound Gastrodia elata liquid and auxiliary materials;

[0101] The compound gastrodia elata liquid is made of gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0102] The auxiliary materials include hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose, and L-arabinose; hydroxypropyl-β-cyclodextrin is used as a taste-masking auxiliary material.

[0103] The mass ratio of gastrodia elata juice, atractylodes lancea juice and ginger juice is 60-80:0-40:0-40, and the mass ratio of the composite gastrodia elata liquid to the auxiliary materials is 1-1.5:0.3-0.5.

[0104] The mass ratio of hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose is 1:0.5:0.3:0.25:0.2.

[0105] The preparation method of Gastrodia elata compound quick-dissolving granules comprises the following steps:

[0106] S1. Wash and cut fresh Gastrodia elata, Atractylodes lancea and ginger into pieces and soak them in water for 1-1.5 hours respectively, beat them with a juicer, and filter to obtain Gastrodia elata filtrate, Atractylodes lancea filtrate and ginger filtrate;

[0107] S2, then add water to the obtained gastrodia elata residue, atractylodes lancea residue and ginger residue for decoction, the decoction time is controlled at 30-50min, use a juicer to beat and filter to obtain gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate, then combine the obtained gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate with the gastrodia elata filtrate, atractylodes lancea filtrate and ginger filtrate obtained in S1, respectively, to obtain gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0108] S3, heating the obtained Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice in a water bath, and stirring them fully to obtain a composite Gastrodia elata liquid;

[0109] S4, add the composite Gastrodia elata liquid to the auxiliary materials and place it in a constant temperature water bath for heating, stir to dissolve it to obtain a prepared liquid, place the prepared liquid in a cool and dark place, and cool it to room temperature;

[0110] S5, freeze-drying the prepared formulation to obtain a dry powder;

[0111] S6, adding maltodextrin, calcium lactate, sucrose and L-arabinose as auxiliary materials to the obtained dry powder, mixing evenly to prepare composite Gastrodia elata juice powder, and mixing with soluble starch after crushing to obtain a granulation mixture;

[0112] S7. Spray ethanol wetting agent into the granulation mixture to make soft material granules, and dry the whole granules at 50-55° C. to obtain Gastrodia elata compound instant granules.

[0113] In S3, the water bath heating temperature is controlled at 50-60°C, and the heating stirring time is 20-30 minutes. In S4, the heating temperature in the water bath is controlled at 55-60°C, and the stirring time is 1-1.5 minutes. The added auxiliary material is hydroxypropyl-β-cyclodextrin.

[0114] In S5, the freeze-drying conditions are as follows: pre-freeze the prepared liquid, and the pre-freezing temperature is controlled at -80°C, the freezing time is 12 hours, and then vacuum freeze-drying is performed, the cold tank temperature of the vacuum freeze-drying is -50°C, and the drying time is 72 hours, and the prepared liquid after freeze-drying is ground into powder.

[0115] In S6, the mass ratio of the composite gastrodia elata juice powder to the soluble starch is 1:0.8-1.2, and in S7, the concentration of ethanol is 80%.

[0116] Embodiment 5:

[0117] A Gastrodia elata compound instant granule, which is made of a compound Gastrodia elata liquid and auxiliary materials;

[0118] The compound gastrodia elata liquid is made of gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0119] The auxiliary materials include hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose, and L-arabinose; hydroxypropyl-β-cyclodextrin is used as a taste-masking auxiliary material.

[0120] The mass ratio of gastrodia elata juice, atractylodes lancea juice and ginger juice is 60-80:0-40:0-40, and the mass ratio of the composite gastrodia elata liquid to the auxiliary materials is 1-1.5:0.3-0.5.

[0121] The mass ratio of hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose is 1:0.5:0.3:0.25:0.2.

[0122] The preparation method of Gastrodia elata compound quick-dissolving granules comprises the following steps:

[0123] S1. Wash and cut fresh Gastrodia elata, Atractylodes lancea and ginger into pieces and soak them in water for 1-1.5 hours respectively, beat them with a juicer, and filter to obtain Gastrodia elata filtrate, Atractylodes lancea filtrate and ginger filtrate;

[0124] S2, then add water to the obtained gastrodia elata residue, atractylodes lancea residue and ginger residue for decoction, the decoction time is controlled at 30-50min, use a juicer to beat and filter to obtain gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate, then combine the obtained gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate with the gastrodia elata filtrate, atractylodes lancea filtrate and ginger filtrate obtained in S1, respectively, to obtain gastrodia elata juice, atractylodes lancea juice and ginger juice;

[0125] S3, heating the obtained Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice in a water bath, and stirring them fully to obtain a composite Gastrodia elata liquid;

[0126] S4, add the composite Gastrodia elata liquid to the auxiliary materials and place it in a constant temperature water bath for heating, stir to dissolve it to obtain a prepared liquid, place the prepared liquid in a cool and dark place, and cool it to room temperature;

[0127] S5, freeze-drying the prepared formulation to obtain a dry powder;

[0128] S6, adding maltodextrin, calcium lactate, sucrose and L-arabinose as auxiliary materials to the obtained dry powder, mixing evenly to prepare composite Gastrodia elata juice powder, and mixing with soluble starch after crushing to obtain a granulation mixture;

[0129] S7. Spray ethanol wetting agent into the granulation mixture to make soft material granules, and dry the whole granules at 50-55° C. to obtain Gastrodia elata compound instant granules.

[0130] In S3, the water bath heating temperature is controlled at 50-60°C, and the heating stirring time is 20-30 minutes. In S4, the heating temperature in the water bath is controlled at 55-60°C, and the stirring time is 1-1.5 minutes. The added auxiliary material is hydroxypropyl-β-cyclodextrin.

[0131] In S5, the freeze-drying conditions are as follows: pre-freeze the prepared liquid, and the pre-freezing temperature is controlled at -80°C, the freezing time is 12 hours, and then vacuum freeze-drying is performed, the cold tank temperature of the vacuum freeze-drying is -50°C, and the drying time is 72 hours, and the prepared liquid after freeze-drying is ground into powder.

[0132] In S6, the mass ratio of the composite gastrodia elata juice powder to the soluble starch is 1:0.8-1.2, and in S7, the concentration of ethanol is 90%.

[0133] Use different concentrations of ethanol as wetting agent to prepare soft materials:

[0134] The difference between Example 3, Example 4 and Example 5 is that: in Example 3, 70% ethanol is used as the wetting agent, in Example 4, 80% ethanol is used as the wetting agent, and in Example 5, 90% ethanol is used as the wetting agent;

[0135] The experimental results of the effect of wetting agent concentration on product properties were obtained according to Examples 3-5:

[0136]

[0137] From the above table, we can know that according to the comparison of water content, forming rate, angle of repose and moisture absorption rate, the granulation effect of soft material made by spraying ethanol wetting agent with a concentration of 80% is the best.

[0138] According to the optimal molding process, Gastrodia compound instant granules were prepared and stability tests were carried out:

[0139] The Gastrodia Compound Instant Granules were sealed in composite film bags and stored naturally at room temperature for 6 months. After sampling inspection at 0, 3, and 6 months, there was no significant change in the properties of the samples at each month compared with those at 0 month. The inspections at each month were all qualified, as follows:

[0140] Storage time is 0 months: This product is light yellow granules with a slightly sweet taste. Parahydroxybenzyl alcohol spots should be detected, and the particle size is ≤15%, the moisture content is ≤8.0%, and the solubility is ≤5min;

[0141] After 3 months of storage, the product is light yellow in color and slightly sweet in taste. It should be tested positive, with a particle size of 0.71% and a moisture content of 5.29%, which is in compliance with regulations.

[0142] The storage time is 6 months: it is light yellow granules with a slightly sweet taste, should be detected positive, and the particle size is 0.98%, and the moisture content is 6.27%, which meets the regulations.

[0143] Conclusion: The Gastrodia elata compound instant granules were sealed in composite film bags and stored naturally at room temperature for 6 months. All test indicators were in line with the quality standards of this product, which preliminarily showed that the quality of this product was stable.

[0144] In the description of the present invention, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0145] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or a communication; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0146] In the present invention, unless otherwise clearly specified and limited, the first feature "on" or "under" the second feature may be that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. In the description of this specification, the description with reference to the terms "one scheme", "some schemes", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the scheme or example are included in at least one scheme or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same scheme or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more schemes or examples in a suitable manner.

Claims

1. A Gastrodia elata compound instant granule, characterized in that: The Gastrodia elata compound instant granules are made from a compound Gastrodia elata liquid and auxiliary materials; The composite gastrodia elata liquid is prepared by mixing fresh gastrodia elata juice, fresh atractylodes lancea juice and ginger juice in a certain proportion; The auxiliary materials include hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose; the hydroxypropyl-β-cyclodextrin is used as a taste masking auxiliary material.

2. The Gastrodia elata compound instant granules according to claim 1, characterized in that: The mass ratio of the fresh Gastrodia elata juice, fresh Atractylodes macrocephala juice and ginger juice is 60-80:0-40:0-40, and the mass ratio of the composite Gastrodia elata liquid to the auxiliary materials is 1-1.5:0.3-0.

5.

3. The Gastrodia elata compound instant granules according to claim 1, characterized in that: The mass ratio of the hydroxypropyl-β-cyclodextrin, maltodextrin, calcium lactate, sucrose and L-arabinose is 1:0.5:0.3:0.25:0.

2.

4. A method for preparing Gastrodia elata compound fast-dissolving granules, according to the Gastrodia elata compound fast-dissolving granules according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: S1. Wash and cut fresh Gastrodia elata, Atractylodes lancea and ginger into pieces and soak them in water for 1-1.5 hours respectively, beat them with a juicer, and filter to obtain Gastrodia elata filtrate, Atractylodes lancea filtrate and ginger filtrate; S2, then add water to the obtained gastrodia elata residue, atractylodes lancea residue and ginger residue for decoction, the decoction time is controlled at 30-50min, use a juicer to beat and filter to obtain gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate, then combine the obtained gastrodia elata secondary filtrate, atractylodes lancea secondary filtrate and ginger secondary filtrate with the gastrodia elata filtrate, atractylodes lancea filtrate and ginger filtrate obtained in S1, respectively, to obtain gastrodia elata juice, atractylodes lancea juice and ginger juice; S3, heating the obtained Gastrodia elata juice, Atractylodes macrocephala juice and ginger juice in a water bath, and adding auxiliary materials to fully stir to obtain a composite Gastrodia elata liquid; S4, add the composite Gastrodia elata liquid to the auxiliary materials and place it in a constant temperature water bath for heating, stir to dissolve it to obtain a prepared liquid, place the prepared liquid in a cool and dark place, and cool it to room temperature; S5, spray drying or freeze drying the prepared formulation to obtain a dry powder; S6, adding maltodextrin, calcium lactate, sucrose and L-arabinose as auxiliary materials to the obtained dry powder, mixing evenly to prepare composite Gastrodia elata juice powder, and mixing with soluble starch after crushing to obtain a granulation mixture; S7. Spray ethanol wetting agent into the granulation mixture to make soft material granules, and dry the whole granules at 50-55° C. to obtain Gastrodia elata compound instant granules.

5. The method for preparing a Gastrodia elata compound instant granule according to claim 4, characterized in that: In S3, the water bath heating temperature is controlled at 50-60°C, and the heating stirring time is 20-30 minutes. In S4, the heating temperature in the water bath is controlled at 55-60°C, and the stirring time is 1-1.5 minutes. The added auxiliary material is hydroxypropyl-β-cyclodextrin.

6. The method for preparing the Gastrodia elata compound fast-dissolving granules according to claim 4, characterized in that: In S5, the spray drying conditions are: setting the inlet air temperature to 180°C, setting the compressed air ratio to 100%, the injection volume to 15%, the atomizer pressure column height in the spray dryer to 40-50mm, and after the spray dryer is running, placing the peristaltic pump into the prepared liquid to feed the material for spray drying.

7. The method for preparing the Gastrodia elata compound fast-dissolving granules according to claim 4, characterized in that: In S5, the freeze-drying conditions are as follows: pre-freeze the prepared liquid, and the pre-freezing temperature is controlled at -80°C, the freezing time is 12 hours, and then vacuum freeze-drying is performed, the cold tank temperature of the vacuum freeze-drying is -50°C, and the drying time is 72 hours, and the prepared liquid after freeze-drying is ground into powder.

8. The method for preparing the Gastrodia elata compound fast-dissolving granules according to claim 4, characterized in that: In the S6, the mass ratio of the composite gastrodia elata juice powder to the soluble starch is 1:0.8-1.2, and in the S7, the concentration of ethanol is 70-90%.

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