Moisturizing and repairing medical light guide gel and preparation method thereof

Abstract

The invention relates to the technical field of medical cosmetology, and discloses a moisturizing and repairing medical light guide gel and a preparation method thereof, the moisturizing and repairing medical light guide gel comprises the following raw materials by mass: 90-95 parts of a solvent; 2-5 parts of a lubricant, 0-10 parts of a repairing agent, 1-10 parts of a polymer matrix, 2-5 parts of a humectant, 0-5 parts of a preservative and 1-3 parts of a neutralizer. The light guide gel can well solve the problems that pain is caused in the photoelectric medical beauty treatment process and a long repair period is caused by small skin defects after treatment, and natural physiological reactions generated when a patient feels pain in the treatment process are reduced through the added lidocaine hydrochloride and the humectant during actual operation; and a repairing agent is added, so that the repairing period of a patient is shortened. The gel is used in cooperation with light treatment equipment, the heat insulation and light guide effects are achieved, the skin scald problem caused by the too high temperature in the laser medical beauty treatment process is avoided, and the effects of effectively guiding light and relieving the pain of a patient are achieved.

Description

Technical Field

[0001] The invention relates to the technical field of medical cosmetology, and in particular to a moisturizing and repairing medical light-guiding gel and a preparation method thereof. Background Art

[0002] Light-guiding gel often plays a key role in photoelectric medical beauty treatments. It is a polymer gel product, usually composed of carbomer, glycerin and water. It is used in conjunction with phototherapy equipment and applied to the surface of the skin that needs phototherapy. It can evenly distribute the light source in the treatment area, and play a role in heat insulation and light guidance, avoiding skin burns caused by excessive temperature during laser medical beauty treatments, and can effectively improve the treatment effect and ensure safety during the treatment process.

[0003] The light-guiding gel currently on the market usually consists of carbomer, glycerin, water and other components, and some of them are added with preservatives, viscosity adjustment, and odor improvement ingredients, such as ethylparaben, triethanolamine, and flavors. As the existing light-guiding gel products are easy to dry out, which can easily cause local overheating during laser treatment and cause skin damage, and some models may even cause allergies and other problems, the light-guiding gel in the present invention can solve the existing pain caused by overheating during treatment, and add skin repair preparations to bring better treatment experience to patients during treatment.

[0004] In order to reduce the pain caused to patients during photoelectric medical beauty treatment and the long recovery period caused by minor skin defects after treatment, lidocaine hydrochloride and moisturizers are added during actual operations to reduce the natural physiological reactions of patients due to pain during treatment, thereby improving the efficiency of the treatment operation. The addition of repair agents reduces the patient's recovery period and facilitates the patient's work and life. Summary of the invention

[0005] 1. Technical issues to be resolved

[0006] In view of the deficiencies in the prior art, the present invention provides a moisturizing and repairing medical light-guiding gel and a preparation method thereof, which has the advantages of analgesia and moisturizing, and solves the problems of excessive local temperature, physiological reactions of the skin caused by painful stimulation affecting the efficiency of treatment, and tiny skin defects caused by photoelectric treatment and a long repair cycle.

[0007] (II) Technical solution

[0008] To achieve the above object, the present invention provides the following technical solution: a moisturizing and repairing medical light-guiding gel, which is composed of the following raw materials in percentage by mass:

[0009] Water: 90.85%~95.35%; Polyethylene glycol PEG400: 2.5%~5%, extracellular vesicles: 0%~0.01%, Carbomer 940: 0.8%, Glycerin: 0.5%~2.5%, Ethyl parahydroxybenzoate: 0.05%, Triethanolamine: 0.8%, Lidocaine hydrochloride 0.08%~0.8%; Carbomer is used as the gel matrix material, in which the carboxyl ions repel each other to form a gel, and the lubricant polyethylene glycol is added to make the gel smoother and the system more stable, and glycerin is added as a moisturizer with low cost and good moisturizing performance, and Ethyl parahydroxybenzoate is used as a preservative with low addition amount and high safety, and the alkaline triethanolamine adjusts the pH value of Carbomer to form a stable polymer gel structure with strong stability.

[0010] Preferably, the solvent is one or more of water, water for injection, and physiological saline.

[0011] Preferably, the lubricant is one or more of polyethylene glycol PEG400, polyethylene glycol PEG600, polyethylene glycol PEG800, and polyvinyl alcohol PVA.

[0012] Preferably, the repair agent exists in the form of vesicles; the repair agent is cell exosomes. Added to the gel in the form of liquid vesicles, tiny vesicles with a particle size range of 30-150nm dispersed in the gel can improve light scattering and make light propagation more effective. The exosomes' own anti-inflammatory, anti-fibrosis (inhibit scar formation), antioxidant effects (reduction of oxygen free radicals), promotion of angiogenesis and fibroblast function and enhancement of matrix integrity are also beneficial to promoting skin renewal.

[0013] Preferably, the polymer matrix is ​​one or more of carbomer 940, carbomer 980, carboxymethyl cellulose CMC, sodium alginate, etc.

[0014] Preferably, the moisturizing agent is one or more of glycerin, cocoa butter, vaseline, cholesterol and animal fat.

[0015] Preferably, the preservative is one or more of ethyl parahydroxybenzoate and propyl parahydroxybenzoate.

[0016] Preferably, the neutralizer is one or more of triethanolamine, sodium hydroxide, and sodium bicarbonate, and the anesthetic is lidocaine hydrochloride.

[0017] Preferably,

[0018] Another technical problem to be solved by the present invention is to provide a method for preparing a moisturizing and repairing medical light-guiding gel, which comprises the following steps:

[0019] Step 1: weigh the above-mentioned raw materials according to proportion;

[0020] Step 2: Put glycerin and carbomer in a mortar, grind them together, and then soak them in water. Use a stirring device and set the speed to 600 rpm to obtain dissolved material A for later use.

[0021] Step 3: Add PEG400, exosomes, and ethyl paraben to the dissolved material A in step 2 in sequence, use a stirring device, set the speed to 600 rpm, stir for 8-12 hours until the mixture is evenly dispersed, and obtain dissolved material B;

[0022] Step 4: Take a certain amount of triethanolamine and dilute it 10 times with water until it is uniform;

[0023] Step 5: Use a stirring device, set the speed to 350 rpm, add triethanolamine to the dissolved material A obtained in step 3, and stir for 20-30 minutes to form a gel.

[0024] (III) Beneficial effects

[0025] Compared with the prior art, the present invention provides a moisturizing and repairing medical light-guiding gel and a preparation method thereof, which has the following beneficial effects:

[0026] The beneficial effects of the present invention are: the pain caused during the photoelectric medical beauty treatment and the tiny skin defects caused after the treatment lead to a longer repair period, reducing the patient's natural physiological reaction due to the pain during the treatment, thereby improving the efficiency of the treatment operation, adding a repair agent to shorten the patient's recovery period, and facilitating the patient's work and life. DETAILED DESCRIPTION

[0027] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] Example 1

[0029] The present embodiment provides a moisturizing and repairing medical light-guiding gel, which is composed of the following raw materials in percentage by mass: including the following raw materials in weight proportions: solvent 90.85% to 95.35%; lubricant 2.5% to 5%, repair agent 0% to 0.01%, polymer matrix 0.8%, moisturizer 0.5% to 2.5%, preservative 0.05%, neutralizer: 0.8%, and anesthetic 0.08% to 0.8%.

[0030] Among them, the solvent is one or more of water, water for injection, and normal saline; the lubricant is one or more of polyethylene glycol PEG400, polyethylene glycol PEG600, polyethylene glycol PEG800, and polyvinyl alcohol PVA; the repair agent is extracellular exosomes; the polymer matrix is ​​one or more of carbomer 940, carbomer 980, carboxymethyl cellulose CMC, sodium alginate, etc.; the moisturizer is one or more of glycerin, cocoa butter, vaseline, cholesterol, and animal fat; the preservative is one or more of ethyl parahydroxybenzoate and propyl parahydroxybenzoate; the neutralizer is one or more of triethanolamine, sodium hydroxide, and sodium bicarbonate; and the anesthetic is lidocaine hydrochloride.

[0031] Among them, the repair agent is cell exosomes. Added into the gel in the form of liquid vesicles, tiny vesicles with a particle size range of 30-150nm dispersed in the gel can improve light scattering and make light propagation more effective. The exosomes' own anti-inflammatory, anti-fibrosis (inhibit scar formation), antioxidant effects (reduction of oxygen free radicals), promotion of angiogenesis and fibroblast function and enhancement of matrix integrity are also beneficial to promoting skin renewal.

[0032] Among them, the anesthetic effect of lidocaine can relieve pain during laser treatment, thereby reducing pain for patients undergoing photoelectric treatment and improving the efficiency of laser treatment.

[0033] Example 2

[0034] The present embodiment provides a moisturizing and repairing medical light-guiding gel. The present embodiment differs from the embodiment 1 in that the following ratios are different. The specific ratios of the present embodiment are: water: 92.85%; polyethylene glycol PEG400 5%, extracellular vesicles: 0%, carbomer 940: 0.8%, glycerol: 0.5%, ethyl paraben: 0.05%, triethanolamine: 0.8%, and lidocaine hydrochloride 0.08%.

[0035] Example 3

[0036] The present embodiment provides a moisturizing and repairing medical light-guiding gel. The present embodiment differs from the embodiment 1 in that the following ratios are different. The specific ratios of the present embodiment are: water: 92.84%; polyethylene glycol PEG4005%, extracellular vesicles: 0.01%, carbomer 940: 0.8%, glycerol: 0.5%, ethyl parahydroxybenzoate: 0.05%, triethanolamine: 0.8%, and lidocaine hydrochloride 0.1%.

[0037] Example 4

[0038] The present embodiment provides a moisturizing and repairing medical light-guiding gel. The present embodiment differs from the embodiment 1 in that the following ratios are different. The specific ratios of the present embodiment are: water: 93.35%; polyethylene glycol PEG400 2.5%, extracellular vesicles: 0%, carbomer 940: 0.8%, glycerol: 2.5%, ethyl parahydroxybenzoate: 0.05%, triethanolamine: 0.8%, and lidocaine hydrochloride 0.3%.

[0039] Example 5

[0040] The present embodiment provides a moisturizing and repairing medical light-guiding gel. The present embodiment differs from the embodiment 1 in that the following ratios are different. The specific ratios of the present embodiment are: water: 93.34%; polyethylene glycol PEG400 2.5%, extracellular vesicles: 0.01%, carbomer 940: 0.8%, glycerol: 2.5%, ethyl parahydroxybenzoate: 0.05%, triethanolamine: 0.8%, and lidocaine hydrochloride 0.8%.

[0041] In order to better understand the technical solution of the present invention, further description is given below in combination with experimental data.

[0042] Comparative Example 1 is composed of the following raw materials in percentage by mass:

[0043] Water: 93.35%; Polyethylene glycol PEG400 2.5%, Cell exosomes: 0%, Carbomer 940: 0.8%, Glycerin: 2.5%, Ethyl paraben: 0.05%, Triethanolamine: 0.8%.

[0044] Performance testing:

[0045] The hydrogels in the examples and comparative examples were selected for the following tests:

[0046] Pain relief test: Using the numerical rating system (NRS rating), volunteers applied two gels on their faces, compared the pain and rated it.

[0047] Skin repair test: The examples were applied on the wound surface, and the skin repair status was compared with that of the untreated control group under the same conditions.

[0048] Volunteer Number Pain score comparison Example Pain Score 1 Moderate pain Mild pain 2 Moderate pain Mild pain 3 Moderate pain Mild pain 4 Moderate pain Mild pain 5 Moderate pain Mild pain 6 Moderate pain Mild pain 7 Moderate pain Mild pain 8 Moderate pain Moderate pain 9 Moderate pain Mild pain 10 Moderate pain Mild pain

[0049] Table 1 Pain result recording form

[0050] Example 6

[0051] This embodiment provides a method for preparing a moisturizing and repairing medical light-guiding gel, comprising the following steps:

[0052] Step S1: weigh the above component raw materials according to proportion;

[0053] Step S2: putting glycerol and carbomer in a mortar, grinding them together, and then soaking them in water; using a stirring device, setting the speed to 600 rpm, to obtain dissolved material A for later use;

[0054] Step S3: PEG400, exosomes, and ethyl paraben are sequentially added to the dissolved material A in step 2, and a stirring device is used, the speed is set to 600 rpm, and the mixture is stirred for 8-12 hours until the mixture is evenly dispersed, to obtain dissolved material B;

[0055] Step S4: Take a certain amount of triethanolamine and dilute it 10 times with water until it is uniform;

[0056] Step S5: using a stirring device, setting the rotation speed to 350 rpm, adding triethanolamine to the dissolved material A obtained in step 3 and stirring for 20-30 minutes to form a gel.

[0057] The beneficial effects of the present invention are: it can effectively solve the pain in the process of photoelectric medical beauty and enhance the repair effect. During the actual operation, the added lidocaine hydrochloride and moisturizer are used to relieve the pain and moisturizing effects of the patient's photoelectric treatment during the operation, reduce the patient's natural physiological reaction due to the pain during treatment, thereby improving the efficiency of the treatment operation, and adding extracellular vesicles.

[0058] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A moisturizing and repairing medical light-guiding gel, characterized in that: The invention comprises the following raw materials in proportion by weight: 90.85% to 95.35% of solvent; 2.5% to 5% of lubricant; 0% to 0.01% of repair agent; 0.8% of polymer matrix; 0.5% to 2.5% of moisturizing agent; 0.05% of preservative; 0.8% of neutralizing agent; and 0.08% to 0.8% of anesthetic.

2. The moisturizing and repairing medical light-guiding gel according to claim 1, characterized in that: The solvent is one or more of water, water for injection and physiological saline.

3. The moisturizing and repairing medical light-guiding gel according to claim 1, characterized in that: The lubricant is one or more of polyethylene glycol PEG400, polyethylene glycol PEG600, polyethylene glycol PEG800, and polyvinyl alcohol PVA.

4. The moisturizing and repairing medical light-guiding gel according to claim 1, characterized in that: The repair agent is in the form of microspheres; the repair agent is cell exosomes.

5. The moisturizing and repairing medical light-guiding gel according to claim 1, characterized in that: The polymer matrix is ​​one or more of carbomer 940, carbomer 980, carboxymethyl cellulose CMC, sodium alginate and the like.

6. The moisturizing and repairing medical light-guiding gel according to claim 1, characterized in that: The moisturizing agent is one or more of glycerin, cocoa butter, vaseline, cholesterol and animal fat.

7. The moisturizing and repairing medical light-guiding gel according to claim 1, characterized in that: The preservative is one or more of ethyl p-hydroxybenzoate and propyl p-hydroxybenzoate.

8. The moisturizing and repairing medical light-guiding gel according to claim 1, characterized in that: The neutralizer is one or more of triethanolamine, sodium hydroxide, and sodium bicarbonate, and the anesthetic is lidocaine hydrochloride, and the anesthetic is in a paste form.

9. A moisturizing and repairing medical light-guiding gel and a preparation method thereof, used for preparing the gel according to any one of claims 1 to 5, characterized in that: The following steps are involved: Step 1: weigh the above-mentioned raw materials according to proportion; Step 2: Put the moisturizer and the polymer matrix in a mortar, grind them together, and then soak them in water. Use a stirring device and set the speed to 600 rpm to obtain dissolved material A for later use; Step 3: Add lubricant, repair agent and preservative to the dissolved material A in step 2 in sequence, use a stirring device, set the speed to 600 rpm, stir for 8-12 hours until the mixture is evenly dispersed, and obtain dissolved material B; Step 4: Take a certain amount of neutralizer and dilute it with water until it is uniform; Step 5: Use a stirring device, set the speed to 350 rpm, add the dissolved material A obtained in step 3 to the neutralizer and stir for 20-30 minutes to form a gel.