A degradable bone filling material and its preparation method and application

The bone filling material formed by the mixture of silk fibroin, chitosan and biphasic calcium phosphate prepared by freeze-drying solves the problems of insufficient mechanical properties and biodegradability of existing bone filling materials, and achieves high strength, safety and modular drug-loaded bone defect treatment effects.

CN119424744BActive Publication Date: 2025-09-19川北医学院附属医院
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Patent Information

Application Number
CN202411577093.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-11-06
Publication Date
2025-09-19
Estimated Expiration
2044-11-06

AI Technical Summary

Technical Problem

Existing bone filling materials have deficiencies in mechanical properties, safety and biodegradability, especially the use of chemical cross-linking agents may lead to problems of biological toxicity and poor degradability.

Method used

A mixture of silk fibroin, chitosan and biphasic calcium phosphate is freeze-dried to form a core skeleton structure, and a porous structure and hydrogel are covered on its surface, avoiding the use of cross-linking agents. Physical cross-linking and protein covalent binding are used to form a skeleton with high mechanical support properties, combined with methacryloyl-RGD peptide to promote cell attachment and bone formation.

Benefits of technology

It has achieved high mechanical strength, good biodegradability and safety, can be modularly loaded with drugs, promotes bone formation, is suitable for the treatment of bone defects and the preparation of drugs for skeletal system diseases, and has a simple preparation process and low cost.

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Abstract

The present invention discloses a degradable bone filling material, a preparation method and an application thereof, and belongs to the field of biomedical technology. The preparation method comprises: mixing a silk fibroin solution, a chitosan solution and a base gel, adding biphasic calcium phosphate, freezing and freeze-drying after mixing under heating conditions, taking out and soaking in water and placing it in a mold for freeze-drying to obtain a core skeleton structure; taking another silk fibroin solution, a chitosan solution containing methacryloylated RGD peptide and a base gel, mixing them, adding biphasic calcium phosphate, freezing and freeze-drying after mixing under heating conditions, covering the surface of the core skeleton structure, freezing and freeze-drying, taking out and soaking in water and freezing and freeze-drying again to obtain a porous skeleton structure; covering the surface of the porous skeleton structure with hydrogel, and obtaining. The present invention also discloses a degradable bone filling material and an application thereof. The degradable bone filling material prepared by the present invention has high mechanical strength, no biological toxicity and has the effect of promoting osteogenesis, and can be used to prepare bone tissue organoids and drugs or preparations for treating bone defects and skeletal system diseases.
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