Scar-removing gel with self-air-drying effect as well as preparation method and application of scar-removing gel

Abstract

The invention relates to scar removing gel with a self-air-drying effect and a preparation method and application thereof, and relates to the technical field of gel materials, the scar removing gel with the self-air-drying effect comprises the following components by weight: 10-12 wt% of silicone oil, 10-12 wt% of glycerin, 0.5-0.8 wt% of carbomer, 0.35-0.55 wt% of triethanolamine, 0.06-0.10 wt% of ethylparaben, and the balance of purified water. The scar-removing gel with the self-air-drying effect has the characteristics of scar removal, bacteriostasis, itching relieving, pigment fading, skin barrier repairing, good product stability and the like, and overcomes the defects in the prior art.

Description

Technical Field

[0001] The present invention relates to the technical field of gel materials, and in particular to a scar-removing gel with self-air-drying effect, and a preparation method and application thereof. Background Art

[0002] During the wound healing process, excessive healing reactions can lead to the formation of hypertrophic scars, which is an abnormal fibrous tissue proliferation phenomenon that is common in large-area skin injuries caused by surgery, burns, and accidental trauma. Hypertrophic scars are not only hard in texture, but are also often accompanied by uncomfortable symptoms such as itching, pain, and even cramps, which seriously affect the patient's quality of life and social function. In recent years, silicone gel, as a new scar treatment material, has received increasing clinical attention due to its inhibitory effect on scar hyperplasia, providing a new treatment strategy for scar management.

[0003] However, despite the potential of silicone gel in scar treatment, existing silicone-based scar dressing products on the market still face many challenges, such as: (1) poor scar removal effect; (2) poor film-forming and stability of the product, which cannot form an effective repair barrier; (3) the product is highly oily and viscous, easily staining clothing, absorbing dust and bacteria to irritate the wound surface, and affecting makeup; (4) it cannot effectively relieve scar itching; and (5) it cannot effectively lighten pigmentation. Summary of the invention

[0004] In order to solve the above problems, the present invention provides a scar removing gel with self-air drying effect and a preparation method and application thereof.

[0005] In a first aspect, the present invention provides a scar removal gel with self-air drying effect, wherein the scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0006] Silicone oil 10-12wt%, glycerol 10-12wt%, carbomer 0.5-0.8wt%, triethanolamine 0.35-0.55wt%, ethyl hydroxybenzoate 0.06-0.10wt%, and the balance is purified water.

[0007] Furthermore, the scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0008] Silicone oil 10wt%, glycerol 10wt%, carbomer 0.5wt%, triethanolamine 0.35wt%, ethylparaben 0.06wt%, and the balance is purified water.

[0009] Furthermore, the scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0010] Silicone oil 12wt%, glycerol 12wt%, carbomer 0.8wt%, triethanolamine 0.55wt%, ethylparaben 0.10wt%, and the balance is purified water.

[0011] Furthermore, the scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0012] Silicone oil 11wt%, glycerol 11wt%, carbomer 0.6wt%, triethanolamine 0.4wt%, ethylparaben 0.08wt%, and the balance is purified water.

[0013] Furthermore, the viscosity of the silicone oil is 200000-250000 mPa.s.

[0014] In a second aspect, the present invention provides a method for preparing the scar removing gel with self-air drying effect as described in any one of the first aspects, the preparation method comprising the following steps:

[0015] Obtaining silicone oil;

[0016] The silicone oil and the remaining components in the scar removing gel are stirred and mixed to obtain the scar removing gel with self-air-drying effect.

[0017] Furthermore, the working condition parameters of the stirring and mixing include: a stirring speed of 960 rpm to 1200 rpm, and a stirring time of 30 minutes to 45 minutes.

[0018] In a third aspect, the present invention provides the use of the scar-removing gel with self-air-drying effect as described in any one of the first aspect and the second aspect in the preparation of a product for treating flaky scars.

[0019] In a fourth aspect, the present invention provides the use of the scar-removing gel with self-air-drying effect as described in any one of the first aspect and the second aspect in the preparation of a product for treating linear hypertrophic scars after cesarean section.

[0020] The above technical solution provided by the embodiment of the present invention has at least the following advantages compared with the prior art:

[0021] The embodiment of the present invention provides a scar removal gel with self-air drying effect and its preparation method and application. The scar removal gel with self-air drying effect provided by the present invention has the characteristics of scar removal, antibacterial and antipruritic, pigment reduction, skin barrier repair and good product stability, which makes up for the shortcomings of the prior art. Specifically:

[0022] The present invention uses low-viscosity silicone oil to form a gel by cross-linking technology with ethylparaben and triethanolamine, which has the characteristics of rapid film formation and self-drying, reduces skin moisture evaporation, increases hydration of the stratum corneum, reduces epidermal water loss, reduces stimulation to keratinocytes, stops producing cytokines, and prevents dermal fiber cells from being activated, thereby reducing the formation of scars. The components interact with each other, making it have the effects of antibacterial and antipruritic, lightening pigments, and repairing skin barriers. Under the joint action of glycerol, the product has a better moisturizing effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0025] Figure 1 A schematic flow chart of a method for preparing a scar removing gel with self-air-drying effect provided in an embodiment of the present invention.

[0026] Figure 2 It is a reaction equation diagram involved in the preparation of silicone oil in the present invention.

[0027] Figure 3 The present invention is a flow chart of the production process involved in the preparation of silicone oil.

[0028] Figure 4 This is a picture of the skin appearance of the test subject before use in Application Example 1 of the present invention.

[0029] Figure 5 This is a picture of the skin appearance of the test subject after use in Application Example 1 of the present invention.

[0030] Figure 6 This is a picture of the skin appearance of the test subject before use in Application Example 2 of the present invention.

[0031] Figure 7 This is a picture of the skin appearance of the test subject after use in Application Example 2 of the present invention.

[0032] Figure 3In the middle: 1-sodium bicarbonate and water storage tank; 2-concentrated sulfuric acid storage tank; 3-M2 and M3 monomer tanks; 4-hydrolysis, neutralization, dehydration and polymerization comprehensive utilization kettle; 5-polymerization kettle; 6-de-lowering kettle; 7-first material delivery pump; 8-second material delivery pump; 9-vacuum pump; 10-first cooler; 11-second cooler; 12-buffer tank; 13-molecular sieve chromatography device; 14-low molecular tank; 15-finished product tank. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] Unless otherwise specified, various raw materials, reagents, instruments and equipment used in the present invention can be purchased from the market or prepared by existing methods.

[0035] In a first aspect, the present invention provides a scar removal gel with self-air drying effect, wherein the scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0036] Silicone oil 10-12wt%, glycerol 10-12wt%, carbomer 0.5-0.8wt%, triethanolamine 0.35-0.55wt%, ethyl hydroxybenzoate 0.06-0.10wt%, and the balance is purified water.

[0037] The scar removal gel with self-air drying effect provided by the present invention has the characteristics of scar removal, antibacterial and antipruritic, pigment reduction, skin barrier repair and good product stability, which makes up for the shortcomings of the prior art. Specifically:

[0038] The present invention uses low-viscosity silicone oil to form a gel by cross-linking technology with ethylparaben and triethanolamine, which has the characteristics of rapid film formation and self-drying, reduces skin moisture evaporation, increases hydration of the stratum corneum, reduces epidermal water loss, reduces stimulation to keratinocytes, stops producing cytokines, and prevents dermal fiber cells from being activated, thereby reducing the formation of scars. The components interact with each other, making it have the effects of antibacterial and antipruritic, lightening pigments, and repairing skin barriers. Under the joint action of glycerol, the product has a better moisturizing effect.

[0039] In some specific embodiments, the scar removal gel with self-air drying effect comprises the following components, measured by weight percentage:

[0040] Silicone oil 10wt%, glycerol 10wt%, carbomer 0.5wt%, triethanolamine 0.35wt%, ethylparaben 0.6wt%, and the balance is purified water.

[0041] In some specific embodiments, the scar removal gel with self-air drying effect comprises the following components, measured by weight percentage:

[0042] Silicone oil 12wt%, glycerol 12wt%, carbomer 0.8wt%, triethanolamine 0.55wt%, ethylparaben 0.10wt%, and the balance is purified water.

[0043] In some specific embodiments, the scar removal gel with self-air drying effect comprises the following components, measured by weight percentage:

[0044] Silicone oil 11wt%, glycerol 11wt%, carbomer 0.6wt%, triethanolamine 0.4wt%, ethylparaben 0.08wt%, and the balance is purified water.

[0045] In some specific embodiments, the viscosity of the silicone oil is 200,000-250,000 mPa.s.

[0046] In some specific embodiments, the silicone oil can be directly commercially available or can be prepared by oneself according to the prior art. Specifically, the silicone oil in the present invention can be prepared by the following method:

[0047] Low-viscosity silicone oil is prepared by co-hydrolysis of dimethyldichlorosilane (M2) and trimethylmonochlorosilane (M3), followed by dehydration, polymerization and removal of low molecular weight reactions.

[0048] Basic principle: M2 and M3 are co-hydrolyzed, concentrated sulfuric acid is used to remove water, and then concentrated sulfuric acid is used for polymerization. After vacuum removal of low molecular weight substances, a series of low-viscosity silicone oils are obtained. The viscosity is adjusted by different ratios of M2 and M3. The reaction equation is shown in 2.

[0049] Test methods

[0050] Hydrolysis test

[0051] Add appropriate amount of water to a hydrolysis reactor equipped with a reflux condenser, a stirrer, a thermometer and a dropping bottle, and add appropriate amount of M2 and M3 monomers to the dropping bottle, then heat the hydrolysis reactor and start stirring. When the temperature is 34°C, start dropping M2 and M3 to mix the liquid. The hydrolysis temperature is preferably controlled at (34±1)°C. After dropping the mixed liquid, stir at a constant temperature for 0.5h, separate the oil and water to remove the hydrochloric acid, and then wash the hydrolyzate with sodium bicarbonate alkali and water until it is neutral.

[0052] Telomerization test

[0053] Add the hydrolyzate into the polymerization kettle at one time and start stirring, add appropriate amount of concentrated sulfuric acid, raise the temperature to (49±1)℃, keep the temperature constant for 0.5h to separate and remove water, add it into the polymerization kettle again, stir and add appropriate amount of concentrated sulfuric acid, raise the temperature to 80℃, keep the temperature constant for 1h, then raise the temperature to 100-120℃, keep the temperature constant for 2h, cool to room temperature, wash with sodium bicarbonate, water, alkali, and water until neutral.

[0054] Low-down test

[0055] Add all the telomerization products to the de-lowering kettle at once, raise the temperature to 40°C, start the vacuum pump, and reduce the pressure to remove low molecular weight substances. The vacuum degree is 0.05-0.09MPa. When the temperature rises to 170-200°C, keep the temperature constant until there is no outflow, then cool it down to room temperature to obtain a low viscosity silicone oil product. The removed low molecular weight substances are added to the telomerization kettle for recycling.

[0056] Production process flow chart Figure 3 As shown, Figure 3 In the middle: 1-sodium bicarbonate and water storage tank; 2-concentrated sulfuric acid storage tank; 3-M2 and M3 monomer tanks; 4-hydrolysis, neutralization, dehydration and polymerization comprehensive utilization kettle; 5-polymerization kettle; 6-de-lowering kettle; 7-first material delivery pump; 8-second material delivery pump; 9-vacuum pump; 10-first cooler; 11-second cooler; 12-buffer tank; 13-molecular sieve chromatography device; 14-low molecular tank; 15-finished product tank.

[0057] In a second aspect, the present invention provides a method for preparing the scar removing gel with self-air drying effect as described in any one of the first aspects, such as Figure 1 As shown, the preparation method comprises the following steps:

[0058] The obtained silicone oil has a molecular weight of 5800da, can form a film quickly and has the characteristics of self-air drying.

[0059] The silicone oil and the remaining components in the scar-removing gel are formed into a compound preparation by using cross-linking technology to obtain the scar-removing gel with self-air-drying effect.

[0060] In some specific embodiments, the working condition parameters of the stirring and mixing include: a stirring speed of 960 rpm to 1200 rpm, and a stirring time of 30 minutes to 45 minutes.

[0061] In a third aspect, the present invention provides the use of the scar-removing gel with self-air-drying effect as described in any one of the first aspect and the second aspect in the preparation of a product for treating flaky scars.

[0062] In a fourth aspect, the present invention provides the use of the scar-removing gel with self-air-drying effect as described in any one of the first aspect and the second aspect in the preparation of a product for treating linear hypertrophic scars after cesarean section.

[0063] It should be noted that, unless otherwise specified or described, the components and raw materials involved in the scar removal gel with self-air drying effect and the preparation method thereof provided by the embodiment of the present invention can be directly commercially available products. At the same time, unless otherwise specified or described, the steps involved in the preparation method can be carried out according to the steps and parameters disclosed in the prior art or using existing equipment, and the present invention document will not repeat them one by one.

[0064] The present invention will be further described below in conjunction with specific examples. It should be understood that these examples are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods in the following examples that do not specify specific conditions are usually measured according to national standards. If there is no corresponding national standard, then proceed according to general international standards, conventional conditions or according to the conditions recommended by the manufacturer.

[0065] Example 1

[0066] This example provides a scar removal gel with self-air drying effect. The scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0067] Silicone oil 10wt%, glycerol 10wt%, carbomer 0.5wt%, triethanolamine 0.35wt%, ethylparaben 0.06wt%, and the balance is purified water;

[0068] The viscosity of the silicone oil is 223830 mPa.s.

[0069] The preparation method of the scar removal gel with self-air drying effect comprises the following steps:

[0070] The components in the scar removing gel are stirred and mixed, the stirring speed is 960 revolutions per minute, and the mixing time is 30 minutes, so as to obtain the scar removing gel with self-air-drying effect.

[0071] Example 2

[0072] This example provides a scar removal gel with self-air drying effect. The scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0073] Silicone oil 12wt%, glycerol 12wt%, carbomer 0.8wt%, triethanolamine 0.55wt%, ethylparaben 0.10wt%, and the balance is purified water;

[0074] The viscosity of the silicone oil is 242986 mPa.s.

[0075] The preparation method of the scar removal gel with self-air drying effect comprises the following steps:

[0076] The components in the scar removing gel are stirred and mixed at a stirring speed of 1200 rpm for 45 minutes to obtain the scar removing gel with self-air drying effect.

[0077] Example 3

[0078] This example provides a scar removal gel with self-air drying effect. The scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0079] Silicone oil 10wt%, glycerol 10wt%, carbomer 0.8wt%, triethanolamine 0.55wt%, ethylparaben 0.10wt%, and the balance is purified water;

[0080] The viscosity of the silicone oil is 226795 mPa.s.

[0081] The preparation method of the scar removal gel with self-air drying effect comprises the following steps:

[0082] The components in the scar removing gel are stirred and mixed, the stirring speed during mixing is 960 rpm, and the mixing time is 45 minutes, to obtain the scar removing gel with self-air-drying effect.

[0083] Example 4

[0084] This example provides a scar removal gel with self-air drying effect. The scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0085] Silicone oil 12wt%, glycerol 12wt%, carbomer 0.5wt%, triethanolamine 0.35wt%, ethylparaben 0.06wt%, and the balance is purified water;

[0086] The viscosity of the silicone oil is 241323 mPa.s.

[0087] The preparation method of the scar removal gel with self-air drying effect comprises the following steps:

[0088] The components in the scar removing gel are stirred and mixed at a stirring speed of 1200 rpm for 30 minutes to obtain the scar removing gel with self-air drying effect.

[0089] Example 5

[0090] This example provides a scar removal gel with self-air drying effect, and the scar removal gel with self-air drying effect comprises the following components in terms of weight percentage:

[0091] Silicone oil 11wt%, glycerol 11wt%, carbomer 0.6wt%, triethanolamine 0.4wt%, ethylparaben 0.08wt%, and the balance is purified water;

[0092] The viscosity of the silicone oil is 234680 mPa.s.

[0093] The preparation method of the scar removal gel with self-air drying effect comprises the following steps:

[0094] The components in the scar removing gel are stirred and mixed at a stirring speed of 1200 rpm for 45 minutes to obtain the scar removing gel with self-air drying effect.

[0095] Test Case

[0096] 1. Antibacterial experiment:

[0097] 1.1 Test Materials ① Bacterial suspension: The test bacteria (Staphylococcus aureus, Escherichia coli, Candida albicans) were cultured on a slant for 24 h and washed with PBS to prepare a bacterial suspension (concentration: 10 μl was dropped on the control carrier and the number of recovered bacteria was 1×10 4 ~9×10 4 cfu / piece). ② Bacterial cloth: The carrier is a 10 mm × 10 mm cloth. After pressure steam sterilization, 10 μl of the above bacterial suspension is dropped on the carrier and placed in a 37°C constant temperature box to dry for 20 minutes.

[0098] 1.2 Methods

[0099] 1.2.1 Antibacterial test method

[0100] 1.2.1.1 Test group: The carriers stained with bacteria were mixed with the prepared gel at a ratio of 5g of antibacterial agent per carrier, so that they were in full contact with the carriers stained with bacteria and fully acted. After the predetermined time of action, the carriers stained with bacteria were taken out with sterile tweezers and put into a test tube containing 5.0ml of PBS. The electric mixer was mixed for 20s to fully elute the residual bacteria on the carriers into PBS. Then, 10-fold serial dilutions were made with PBS. The appropriate dilution was selected, and 0.5ml was aspirated to inoculate the plate for live bacterial culture count.

[0101] 1.2.1.2 Control group: Mix the infected carrier with PBS at a ratio of 5.0 ml PBS per carrier. After 10 minutes,

[0102] The carrier was removed with sterile tweezers and placed in a test tube containing 5.0 ml of PBS. An electric mixer was used to mix for 20 seconds to allow the bacteria on the carrier to be fully eluted into PBS. Then, a 10-fold serial dilution was made with PBS. After selecting an appropriate dilution, 0.5 ml was aspirated and inoculated into a plate for live bacterial culture count as a positive control group.

[0103] The test was repeated 3 times, and the inhibition rate was calculated as follows:

[0104] Nc-NsNc×100%

[0105] Wherein: X is the inhibition rate, %; Nc is the average colony count of the positive control group, cfu / piece; Ns is the average colony count of the carrier in the test group, cfu / piece.

[0106] Evaluation criteria: If the inhibition rate is ≥50%, it has an antibacterial effect; if the inhibition rate is ≥90%, it has a strong antibacterial effect.

[0107] The experimental results are shown in Table 1, Table 2, Table 3, Table 4 and Table 5.

[0108] Table 1

[0109]

[0110] Table 2

[0111]

[0112] Table 3

[0113]

[0114] Table 4

[0115]

[0116] Table 5

[0117]

[0118] 2. Gel Stability Determination

[0119] Centrifugation method: Take 5 g of sample, place it in a centrifuge tube, centrifuge it at 2500 r·min-1 for 30 min, and observe whether water is separated and stratification occurs.

[0120] Sample retention and observation method: Take 10g of sample and store it at room temperature away from light for 6 months, and observe whether there are obvious changes in uniformity, consistency, pH value and appearance.

[0121] Heat and cold resistance test: Place the sample in an 85°C water bath for 6 hours, take it out, and place it at room temperature to observe whether the appearance changes and whether the gel has stratification; then place the sample in a -18°C refrigerator for 24 hours, take it out and thaw it, and observe whether the appearance changes and whether the gel has stratification. The test results are shown in Table 6 below.

[0122] Table 6

[0123]

[0124] 3. Moisture retention test:

[0125] 3.1 Instrument moisture permeable cup (cylinder + clamp + cover): a cylinder made of corrosion-resistant material, with a flange at each end of the cylinder, the inner diameter of the flange is (35.7 ± 0.1) mm (cross-sectional area is 10 cm 2) , with an outer diameter of 55mm and a height of 36mm for the moisture permeable cup. One end of the cylinder is sealed with a sealing rubber ring and a circular cover plate, and the diameter of the circular cover plate is the same as the outer diameter of the cylinder. The other end of the cylinder is an annular clamping plate with an opening area of ​​10cm2. The outer diameter of the clamping plate is equal to the outer diameter of the cylinder, and the inner diameter is equal to the inner diameter of the cylinder. The thickness of the annular clamping plate is required to be 0.3mm.

[0126] Hydrophobic filter membrane: polyvinylidene fluoride (PVDF) hydrophobic circular filter membrane, diameter 50 mm, filter diameter 0.45 μm. The same batch of experiments used the same brand of hydrophobic circular membrane.

[0127] Constant temperature and humidity test chamber: There is circulating air and the temperature can be maintained at (37±1)℃, the air can be evenly distributed, and the relative humidity (RH) is maintained at no more than 20% during the entire experiment.

[0128] Other equipment: balance with an accuracy of 0.01g; thermometer and hygrometer; glass slide for scraping.

[0129] 3.2 Methods

[0130] 3.2.1 Experimental Group Place the PVDF membrane flat between the cover plate and the annular splint and fix it. Squeeze the sample to be tested onto the PVDF membrane, spread the sample evenly with a glass slide, and wipe off the excess sample on the annular splint. Seal one end of the permeable cup with a sealing rubber ring and a cover plate, then add purified water for the experiment so that the distance between the liquid surface and the blank filter membrane after placement is (15±1) mm, and the general amount of water added is 20g. Then transfer the filter membrane and the annular splint with the sample spread to the cylinder of the permeable cup, fix it, weigh it as a whole, and record the mass. According to the above operation, a total of 3 samples were prepared, namely sample 1, sample 2, and sample 3, and the masses were marked as W sample 1, W sample 2, and W sample 3, respectively, with an accuracy of 0.01g.

[0131] 3.2.2 Control group Take a set of permeable cups, place the PVDF membrane flat between the cover plate and the annular clamp, and fix it; squeeze the sample to be tested on the PVDF membrane, use a glass slide to evenly scrape the sample, and wipe off the excess sample on the annular clamp, then transfer the scraped sample filter membrane and annular clamp to the cylinder of the permeable cup, fix it, weigh the whole, and record the mass. According to the above operation, prepare 3 samples, namely control 1, control 2, and control 3, and mark the mass as W control 1, W control 2, and W control 3, respectively, with an accuracy of 0.01g.

[0132] 3.2.3 Blank Group Take a set of permeable cups, seal one end of the permeable cup with a sealing rubber ring and a cover plate, then add purified water for the experiment, so that the distance between the liquid surface and the blank filter membrane after placement is (15±1) mm. The general amount of water added is 20g. Place the filter membrane on the other end of the permeable cup, then cover it with a clamp, fix it, and weigh the whole mass. According to the above operation, prepare a total of 3 samples, namely Blank 1, Blank 2, and Blank 3, and mark the masses as W Blank 1, W Blank 2, and W Blank 3, respectively, with an accuracy of 0.01g.

[0133] 3.2.4 Test process Place the prepared samples in a constant temperature and humidity test chamber in sequence, with the samples facing upwards. The test temperature is (37±1)℃ and the relative humidity is not more than 20%. After standing for (24h±10min), take out the test samples from the constant temperature and humidity test chamber, balance at room temperature for 15min, and weigh the samples. The masses of sample 1, sample 2, and sample 3 are marked as W sample 1', W sample 2', and W sample 3', respectively. The masses of control 1, control 2, and control 3 are marked as W 对照1 , W 对照2 , W 对照3 , the masses of blank 1, blank 2, and blank 3 are marked as W 空白1 ',W 空白2 ',W 空白3 ', accurate to 0.01g. (Note: The experimental materials and tools used must correspond one to one to ensure the accuracy of the weighing data).

[0134] 3.3 Result calculation standard

[0135] Use the following formula to calculate the moisturizing property of the product

[0136] Moisture retention = C-(AB) / C x100%

[0137] Among them, the average value of 24h weight loss in the experimental group is:

[0138] A=(Wsample1-Wsample1+Wsample2-Wsample2+Wsample3-Wsample3') / 3

[0139] The average weight loss of the control group in 24 hours:

[0140] B=(W control 1-W control 1++W control 2-W control 2′+W control 3-W control 3′) / 3

[0141] Average value of mass loss in the blank group over 24 hours:

[0142] C=(Wblank1-Wblankr+Wblank2-Wblank2'+Wblank3-Wblank3') / 3

[0143] Where: mass unit is g

[0144] The moisturizing data of the product is affected by the thickness of the sample film. Considering the actual amount of application, the sample film thickness is selected to be 0.3 mm. The test results are shown in Table 7 below.

[0145] Table 7

[0146]

[0147]

[0148] 4. Film-forming properties

[0149] Apply an appropriate amount of this product on a dry flat glass or other suitable film-forming plate and spread it evenly. Under the condition of 36℃~37℃, it should form a semi-transparent film that is not easy to fall off after natural drying, indicating that it has good film-forming properties. The conclusion is shown in Table 8 below.

[0150] Table 8

[0151] Product Name in conclusion Example 1 Good film-forming property Example 2 Good film-forming property Example 3 Good film-forming property Example 4 Good film-forming property Example 5 Good film-forming property

[0152] Application Example 1

[0153] In this example, the scar removal gel with self-air drying effect obtained in Example 1 was applied to subjects with flaky scars to examine its effect of lightening pigments and repairing the skin barrier.

[0154] Department: Burns and Plastic Surgery Department; Clinical manifestations: Flaky scars with multiple hyperplasia and pigmentation; Formation time: 1 week; Treatment: Use scar removal gel for treatment, apply three times a day.

[0155] Results: After 3 months of use, the scars were smoothed, there was no pigmentation, and the skin was smooth. Figure 4 This is a picture of the skin appearance of the subject before use in Application Example 1 of the present invention. Figure 5 This is a picture of the skin appearance of the test subject after use in Application Example 1 of the present invention.

[0156] Application Example 2

[0157] In this example, the scar removal gel with self-air drying effect obtained in Example 1 was applied to subjects with linear hypertrophic scars after cesarean section.

[0158] Department: Obstetrics and Gynecology; Clinical manifestation: Linear hypertrophic scar after cesarean section; Formation time: 2 years; Treatment: Use scar removal gel for treatment, apply three times a day.

[0159] Results: After 6 months of use, the scars were smoothed and there was no pigmentation. Figure 6 This is a picture of the skin appearance of the subject before use in Application Example 2 of the present invention. Figure 7 This is a picture of the skin appearance of the test subject after use in Application Example 2 of the present invention.

[0160] Various embodiments of the present invention may be presented in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity, and should not be understood as a rigid limitation on the scope of the present invention; therefore, the range description should be considered to have specifically disclosed all possible sub-ranges and single numerical values ​​within the range. For example, the range description from 1 to 6 should be considered to have specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5 and 6, which apply regardless of the range. In addition, whenever a numerical range is indicated herein, it is meant to include any cited number (fractional or integer) within the indicated range.

[0161] The foregoing is merely a specific embodiment of the present invention, which enables those skilled in the art to understand or implement the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A scar removal gel with self-air drying effect, characterized in that: The scar removal gel having self-air drying effect comprises the following components in percentage by weight: Silicone oil 10-12wt%, glycerol 10-12wt%, carbomer 0.5-0.8wt%, triethanolamine 0.35-0.55wt%, ethyl hydroxybenzoate 0.06-0.10wt%, and the balance is purified water.

2. The scar removing gel with self-air drying effect according to claim 1, characterized in that: The scar removal gel having self-air drying effect comprises the following components in percentage by weight: Silicone oil 10wt%, glycerol 10wt%, carbomer 0.5wt%, triethanolamine 0.35wt%, ethylparaben 0.06wt%, and the balance is purified water.

3. The scar removing gel with self-air drying effect according to claim 1, characterized in that: The scar removal gel having self-air drying effect comprises the following components in percentage by weight: Silicone oil 12wt%, glycerol 12wt%, carbomer 0.8wt%, triethanolamine 0.55wt%, ethylparaben 0.10wt%, and the balance is purified water.

4. The scar removing gel with self-air drying effect according to claim 1, characterized in that: The scar removal gel having self-air drying effect comprises the following components in percentage by weight: Silicone oil 11wt%, glycerol 11wt%, carbomer 0.6wt%, triethanolamine 0.4wt%, ethylparaben 0.08wt%, and the balance is purified water.

5. The scar removing gel with self-air drying effect according to any one of claims 1 to 4, characterized in that: The viscosity of the silicone oil is 200000-250000 mPa.s.

6. A method for preparing the scar removing gel with self-air drying effect as claimed in any one of claims 1 to 5, characterized in that: The preparation method comprises the following steps: Obtaining silicone oil; The silicone oil and the remaining components in the scar removing gel are stirred and mixed to obtain the scar removing gel with self-air-drying effect.

7. The method for preparing the scar removing gel with self-air drying effect according to claim 6, characterized in that: The working condition parameters of the stirring and mixing include: a stirring speed of 960 rpm to 1200 rpm, and a stirring time of 30 minutes to 45 minutes.

8. Use of the scar-removing gel with self-air-drying effect as claimed in any one of claims 1 to 7 in the preparation of products for treating flaky scars.

9. Use of the scar-removing gel with self-air drying effect as claimed in any one of claims 1 to 7 in the preparation of a product for treating linear hypertrophic scars after cesarean section.

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