1,5-diaryl-1,2,4-triazole derivatives targeting myoferlin and synthesis and use thereof
By designing 1,5-diaryl-1,2,4-triazole compounds with nitrogen-containing five-membered heterocyclic structures, the problem of insufficient water solubility of Myoferlin targeted drugs was solved, and efficient inhibition of tumor cell proliferation and migration was achieved under various pH conditions, showing broad potential for anti-tumor applications.
Patent Information
- Application Number
- CN202311104918.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-08-30
- Publication Date
- 2025-12-05
- Estimated Expiration
- 2043-08-30
AI Technical Summary
Existing targeted drugs have insufficient water solubility for Myoferlin, which affects its drug-like properties under various pH conditions and makes it difficult to effectively inhibit the proliferation and migration of tumor cells.
A novel class of 1,5-diaryl-1,2,4-triazole compounds was designed and synthesized. By introducing a nitrogen-containing five-membered heterocyclic structure, the water solubility of the compounds under different pH conditions was significantly improved, and their binding ability to Myoferlin protein was enhanced.
It significantly improved the water solubility of the compound under pH conditions of 2.0, 7.4 and 9.0, enhanced the drug-likeness of the drug, and effectively inhibited the proliferation and migration of various cancer cells, showing broad prospects for anti-tumor applications.