Preparation method and application of antibacterial hydrogel with enhanced antioxidant activity and NIR / pH dual responsiveness

By preparing an antibacterial hydrogel cross-linked with hollow copper sulfide nanoparticles and chitosan, and combining it with near-infrared photothermal and chemidynamic therapy, the problems of insufficient mechanical properties and high cytotoxicity of existing antibacterial hydrogels were solved, achieving efficient sterilization and rapid wound healing at low temperatures.

CN119548663BActive Publication Date: 2026-03-27CENT SOUTH UNIV
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Patent Information

Application Number
CN202411481251.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-10-23
Publication Date
2026-03-27
Estimated Expiration
2044-10-23

AI Technical Summary

Technical Problem

Existing antibacterial hydrogels have problems such as insufficient mechanical properties, poor self-healing ability, high cytotoxicity, and the possibility of secondary damage to damaged tissues when treating bacterial wound infections. In addition, traditional treatments rely on antibiotics, which leads to the risk of drug resistance.

Method used

A bi-responsive antibacterial hydrogel with NIR/pH dual-response properties was prepared by combining hollow copper sulfide nanoparticles with chitosan and epigallocatechin gallate (EGCG) and crosslinking agent 3-formylphenylboronic acid. The synergistic effect of near-infrared photothermal therapy and chemodynamic therapy enhanced its antioxidant activity and antibacterial ability.

Benefits of technology

The prepared hydrogel has good mechanical properties, self-healing properties and biocompatibility. It can quickly and effectively kill bacteria at low temperatures and reduce tissue damage, making it suitable for wound dressings in biomedical engineering.

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Abstract

The application relates to a preparation method of an antibacterial hydrogel with enhanced antioxidation activity and NIR / pH dual responsiveness, and the preparation method is as follows: hollow copper sulfide nanoparticles are first prepared, the hollow copper sulfide nanoparticles are dispersed into a chitosan solution to obtain a chitosan solution containing the hollow copper sulfide nanoparticles, then a crosslinking agent epigallocatechin gallate (EGCG) solution and a 3-formylphenylboronic acid solution (3-FPBA) are sequentially added for crosslinking, so as to obtain the antibacterial hydrogel with enhanced antioxidation activity and NIR / pH dual responsiveness. The hydrogel is used for wound dressings in biomedical engineering materials. The preparation method is simple, the preparation process is green and safe, higher solid-like performance is exhibited, meanwhile, excellent injectability is maintained, and the hydrogel can play a greater advantage in the healing process of bacterial wound infection.
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