Traditional Chinese medicine composition for treating children cough due to yin deficiency and lung heat

Abstract

The invention relates to a traditional Chinese medicine composition for treating children cough due to yin deficiency and lung heat. The traditional Chinese medicine composition is prepared from 200 to 250 g of poria cocos, 50 to 100 g of semen plantaginis, 50 to 80 g of rhizoma arisaematis, 50 to 100 g of radix et rhizoma rhei, 50 to 80 g of herba ephedrae, 20 to 40 g of amber, 50 to 80 g of bulbus fritillariae cirrhosae, 150 to 200 g of flos lonicerae, 50 to 100 g of radix stemonae preparata, 20 to 40 g of rhizoma pinelliae, 50 to 100 g of radix platycodonis, 100 to 150 g of radix ophiopogonis, 50 to 80 g of radix trichosanthis, 50 to 100 g of folium eriobotryae, 20 to 40 g of shredded antelope, 10 to 30 g of rhizoma gastrodiae, 5 to 15 g of flos carthami, 20 to 40 g of radix scutellariae, 50 to 100 g of gypsum, 10 to 30 According to the traditional Chinese medicine composition, through respective unique effects and mutual synergistic effects, the treatment effect is jointly achieved, the effects of clearing away heat and purging fire, moistening the lung to arrest cough and reducing phlegm and eliminating phlegm are achieved, the effect on children cough caused by yin deficiency and lung heat is remarkable, the cough symptom of sick children can be obviously improved, the disease course is shortened, and the clinical treatment effect is improved.

Description

Technical Field

[0001] The invention relates to the field of medicine, and more particularly to a traditional Chinese medicine composition for treating cough due to yin deficiency and lung heat in children. Background Art

[0002] Cough in children is one of the common symptoms of respiratory diseases. Infection, asthma, foreign bodies, allergies, etc. can all cause cough in children. When treating children, it is necessary to clarify the cause, make an accurate judgment based on the symptoms of the disease, and formulate a corresponding treatment plan. Children's cough is divided into exogenous cough and internal injury cough; among them, exogenous cough includes wind-cold cough, wind-heat cough, and wind-dryness cough; internal injury cough includes phlegm-heat cough, phlegm-damp cough, yin deficiency and lung heat cough, and spleen and lung qi deficiency cough; coughs caused by different causes have different treatment methods. Yin deficiency and lung heat cough are more common in children's coughs, which are related to viral infections, improper diet, and getting angry, and affect lung function. For yin deficiency and lung heat cough, Chinese patent medicines with the effect of nourishing yin and tonifying the lungs are usually used, such as Lily Gujin Oral Liquid, Ma Xing Shi Gan Tang, Children's Lung Heat Kechuan Granules, Yangyin Qingfei Pills, etc., but the above-mentioned drugs are generally effective and slow to take effect. Summary of the invention

[0003] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating cough due to yin deficiency and lung heat in children. The traditional Chinese medicine composition, through the unique efficacy of each medicine and the synergistic effect between each other, jointly exerts the therapeutic effect, achieves the efficacy of clearing away heat and purging fire, moistening the lungs and relieving cough, and resolving phlegm and removing phlegm, has a significant effect on cough due to yin deficiency and lung heat in children, can significantly improve the cough symptoms of children, shorten the course of the disease, and improve the clinical efficacy.

[0004] To achieve the above object, the present invention adopts the following technical solution:

[0005] A traditional Chinese medicine composition for treating cough due to yin deficiency and lung heat in children, the traditional Chinese medicine composition comprising 200-250g of Poria cocos, 50-100g of Plantago seed, 50-80g of Arisaema, 50-100g of Rhubarb, 50-80g of Ephedra, 20-40g of Amber, 50-80g of Fritillaria cirrhosa, 150-200g of Honeysuckle, 50-100g of Stemona japonica, 20-40g of Pinellia ternata, and 50-100g of Platycodon grandiflorum. , Ophiopogon japonicus 100-150g, Radix Trichosanthis 50-80g, loquat leaf 50-100g, antelope silk 20-40g, Gastrodia elata 10-30g, safflower 5-15g, Scutellaria baicalensis 20-40g, Gypsum 50-100g, Gardenia jasminoides 10-30g, Citrus aurantium 10-30g, Apricot 50-100g, Uncaria rhynchophylla 50-100g, Hawksbill turtle 10-30g, and Citrus aurantium 10-30g.

[0006] As the preferred embodiment of the present invention, the Chinese medicine composition is composed of 200g of Poria, 80g of Plantago, 60g of Arisaema, 100g of Rhubarb, 60g of Ephedra, 40g of Amber, 75g of Fritillaria, 200g of Honeysuckle, 80g of Stemona, 40g of Pinellia, 100g of Platycodon, 120g of Ophiopogon, 60g of Radix Trichosanthis, 100g of Eriobotrya japonica, 20g of Antelope Silk, 10g of Gastrodia, 5g of Carthamus, 25g of Scutellaria, 80g of Gypsum, 20g of Gardenia, 25g of Citrus aurantium, 100g of Apricot, 100g of Uncaria rhynchophylla, 20g of Hawksbill Turtle, and 15g of Citrus aurantium.

[0007] The present invention also provides a Baoyuan powder for treating cough due to yin deficiency and lung heat in children. The preparation method of the Baoyuan powder is as follows: pulverize the antelope silk and hawksbill turtle in the above-mentioned traditional Chinese medicine composition into fine powder, mix the remaining 23 medicinal materials, pulverize them into fine powder, mix the above-mentioned two medicinal powders, pass through a 100-mesh sieve, and package them to obtain the Baoyuan powder.

[0008] Advantages and beneficial effects of the present invention:

[0009] (1) The Chinese medicine composition provided by the present invention has the effects of nourishing yin and promoting fluid production, moistening the lungs and clearing the heart, and can help improve the symptoms of dry mouth, dry tongue and cough caused by dry lungs; Radix Stemonae has the effects of relieving cough and resolving phlegm, warming the lungs, and dispersing heat and relieving exterior symptoms; Radix Trichosanthis has the effects of slightly cold in nature, sweet and slightly bitter in taste, can clear away heat and promote fluid production, and assist Radix Ophiopogonis and Radix Stemonae to improve the symptoms of cough caused by lung heat; Flos Lonicerae has the effects of cold in nature, sweet in taste, and can assist in clearing away heat and moistening the lungs; Arisaema is warm in nature, bitter and pungent in taste, and can dry out dampness and resolve phlegm; Apricot kernel has the effects of bitter in taste, can descend and also has the properties of clearing, promoting circulation and opening; Ephedra is warm in nature, pungent and slightly bitter in taste, and has the effects of sweating and resolving exterior symptoms, promoting lung function and relieving asthma, and promoting diuresis and reducing swelling; Poria and Pinellia are sweet, light and neutral in taste, and can invigorate the spleen and eliminate dampness, descend adverse reactions and resolve phlegm, and relieve the symptoms of cough caused by phlegm. Cough symptoms caused by dampness; the above five herbs are mainly combined with other herbs to restore the lung's function of dispersing and descending; Scutellaria baicalensis and Gypsum are bitter and cold in nature, can effectively remove heat and toxins, reduce inflammatory reactions, and have a good effect on cough caused by getting angry; Gypsum can also relieve restlessness and thirst, help relieve symptoms such as irritability and thirst caused by cough; Platycodon grandiflorum is bitter and pungent in taste, neutral in nature, and belongs to the lung meridian, can eliminate phlegm and relieve cough, promote lung function and relieve throat pain; Plantago seed is cold in nature and sweet in taste, Plantago seed is diuretic and relieves stranguria, Platycodon grandiflorum is lung-promoting and expectorant, and the combination of the two can promote diuresis and eliminate dampness, promote lung function and relieve cough; Safflower and Citrus aurantium are pungent in taste and warm in nature; Citrus aurantium is bitter, pungent, and slightly cold. The three herbs can regulate qi and relieve fullness, regulate qi mechanism, and relieve symptoms such as cough and chest tightness caused by sluggish qi mechanism, and at the same time, combined with Scutellaria baicalensis , Platycodon grandiflorum clears the lungs and relieves cough; Fritillaria cirrhosa, slightly cold in nature, bitter and sweet in taste, is a good medicine for resolving phlegm and relieving cough. It has the effects of clearing heat and dispersing stagnation, moistening the lungs and relieving cough. It can treat symptoms such as lung heat and dry cough, dry cough with little phlegm, etc., and is especially suitable for chronic cough due to internal injuries, dry phlegm and hot phlegm. Loquat leaf, slightly cold in nature and bitter in taste, belongs to the lung and stomach meridians, and can clear the lungs and relieve cough, and reduce adverse reactions and stop vomiting. The two medicines can be used together to enhance the effects of moistening the lungs and relieving cough, resolving phlegm and removing phlegm. Rhubarb and antelope silk are cold in nature and bitter in taste; Hawksbill turtle is cold in nature and sweet in taste, and has the effect of clearing heat and detoxifying. Gardenia jasminoides is bitter and cold in nature; it has the functions of purging fire and relieving restlessness, clearing heat and promoting dampness, cooling blood and detoxifying. Rhubarb is used frequently, and in order to purge accumulation, cool blood and detoxify, it is combined with loquat leaf, Fritillaria cirrhosa, Scutellaria baicalensis, Platycodon grandiflorum, antelope silk, Gardenia jasminoides and other drugs to improve the heat evil blocking the lungs. Ephedra can restore the lung's function of descending and dispersing; Uncaria rhynchophylla, which is cool in nature and sweet in taste, has the effects of clearing away heat and calming the liver, relieving spasms and calming wind; Gastrodia elata, which is sweet and neutral in nature, can calm wind and stop spasms, dispel wind and dredge meridians. The combination of the two herbs can relieve symptoms such as itchy throat, dry throat, and sore throat caused by cough by clearing the throat; at the same time, Uncaria rhynchophylla can also relieve spasms of bronchial smooth muscles and help relieve asthma; Amber, which is neutral in nature and sweet in taste, has the effects of clearing away heat and detoxifying, can assist in reducing lung heat, and cooperate with Uncaria rhynchophylla to relieve cough; at the same time, the tranquilizing effect of amber also helps to improve the sleep of children; when treating cough, the above 25 herbs work together to exert a therapeutic effect through their unique effects and synergistic effects with each other, so as to achieve the effects of clearing heat and purging fire, moistening the lungs and relieving cough, and resolving phlegm and removing phlegm.

[0010] (2) The Chinese medicine composition provided by the present invention has the functions of clearing away heat and detoxifying. The Poria cocos and Pinellia ternata in the prescription can strengthen the spleen and eliminate dampness, reduce adverse reactions and resolve phlegm when used in combination with other drugs. It has a therapeutic effect on lung heat cough caused by viral infection, improper diet, internal heat, etc. It can solve the lung heat cough in children from the root, significantly improve the cough symptoms of children, shorten the course of the disease, and improve the clinical efficacy. As many as 74.2% of children were cured within one week after taking the medicine, and the total effective rate reached 100%.

[0011] (3) Compared with the existing Chinese patent medicines for treating cough due to yin deficiency and lung heat, the Chinese medicine composition provided by the present invention has better therapeutic effect and higher total effective rate. Most importantly, it can significantly shorten the coughing time of children and alleviate cough symptoms. DETAILED DESCRIPTION

[0012] The present invention discloses a Chinese medicine composition for treating cough due to deficiency of Yin and heat of lung in children. Those skilled in the art can refer to the contents of this article and appropriately improve the component parameters or process parameters to achieve the above. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are deemed to be included in the scope of protection of the present invention.

[0013] Example 1

[0014] The present embodiment provides a traditional Chinese medicine composition for treating cough due to yin deficiency and lung heat in children, wherein the traditional Chinese medicine composition is composed of 200g of Poria cocos, 80g of Plantago seed, 60g of Arisaema, 100g of Rhubarb, 60g of Ephedra, 40g of Amber, 75g of Fritillaria cirrhosa, 200g of Honeysuckle, 80g of Stemona japonica, 40g of Pinellia ternata, 100g of Platycodon grandiflorum, 120g of Ophiopogon japonicus, 60g of Radix Trichosanthis, 100g of Loquat Leaf, 20g of Antelope Silk, 10g of Gastrodia elata, 5g of Carthamus tinctorius, 25g of Scutellaria baicalensis, 80g of Gypsum, 20g of Gardenia jasminoides, 25g of Fructus Aurantii Immaturus, 100g of Apricot, 100g of Uncaria rhynchophylla, 20g of Hawksbill turtle, and 15g of Citrus aurantium.

[0015] The Chinese medicine composition provided in this embodiment can be made into an oral preparation when actually used; the oral preparation includes powders, granules, tablets, capsules, decoctions or pills, etc. Among the above dosage forms, powders have the advantage of being simple to prepare, so powders are preferred.

[0016] Example 2

[0017] The present embodiment provides a Baoyuan powder for treating cough due to yin deficiency and lung heat in children. The preparation method of the Baoyuan powder is as follows: pulverize the antelope silk and hawksbill turtle in the above-mentioned traditional Chinese medicine composition into fine powder, mix the remaining 23 medicinal materials, pulverize them into fine powder, mix the above-mentioned two medicinal powders, pass through a 100-mesh sieve, and package them to obtain the powder.

[0018] The Baoyuan powder provided by the present invention has the effects of clearing away heat and purging fire, moistening the lungs and relieving cough, and resolving phlegm and expectoration. It also has the merit of clearing away heat and detoxifying. The Poria cocos and Pinellia tuber in the prescription can invigorate the spleen and eliminate dampness, reduce adverse reactions and resolve phlegm after being used in combination with other drugs. It has therapeutic effects on lung heat cough caused by viral infection, improper diet, getting angry, etc. It can solve the lung heat cough in children from the root, significantly improve the cough symptoms of children, and shorten the course of the disease. This prescription has been used in Jilin Children's Hospital for many years. The therapeutic effect of Baoyuan powder described in Example 2 of the present invention is illustrated by clinical data below, and the specific situation is as follows:

[0019] Clinical Data

[0020] 1. General Information

[0021] Methods A total of 124 children with yin deficiency and lung heat cough who came to Jilin Children's Hospital for treatment from January 2019 to June 2020 were collected (Western medicine diagnostic criteria: in addition to cough, accompanied by other upper respiratory tract-related symptoms, such as sneezing, runny nose, nasal congestion, throat irritation or discomfort, etc., which may be accompanied by fever, and fewer systemic symptoms; the diagnostic criteria of traditional Chinese medicine for yin deficiency and lung heat cough refer to "Chinese Pediatrics": dry cough without sputum, or less and sticky sputum, not easy to cough up, thirst and dry throat, itchy throat and hoarseness, hot hands and feet, or cough with blood, hot flashes in the afternoon, red tongue with little coating, and thin pulse). They were divided into a study group and a control group by random number table method, with 62 cases in each group, including 34 males and 28 females in the study group and 32 males and 30 females in the control group. There was no statistically significant difference in the clinical data of the two groups of children, and they were comparable.

[0022] 2. Treatment Methods

[0023] The control group was given Yangyin Qingfei Pills (Hulunbuir Songlu Pharmaceutical Co., Ltd., each pill weighs 9g), and the specific usage and dosage are: 1 to 3 years old, 1.5g once, twice a day; 3 to 5 years old, 2g once, twice a day; 5 to 8 years old, 3g once, twice a day; 8 to 12 years old, 6g once, twice a day; the research group was given the Baoyuan powder of Example 2 (0.35-0.5g once per year old, 2-3 times a day, less than 1 year old is calculated as one year old, 1 year old is calculated as 2 years old, 2 years old is calculated as 3 years old, and so on, the specific usage and dosage are: within 1 year old: 0.5g once, twice a day; 2 to 3 years old: 1g once, twice a day; 4 to 6 years old, 2g once, twice a day; 7 to 10 years old, 3.5g once, twice a day; over 10 years old, 5g once, twice a day). Both groups took the medicine continuously for 1 week. During the medication period, the children in both groups were forbidden to eat raw, cold, spicy, fried and other foods.

[0024] 3. Observation indicators and methods:

[0025] (1) Compare the treatment effects between the study group and the control group.

[0026] (2) Cough symptom score: refer to the Guidelines for the Diagnosis and Treatment of Cough (2015), see Table 1.

[0027] Table 1 Daytime and nighttime cough symptom scores

[0028] Points Daytime and nighttime cough symptom score Nocturnal cough symptom score 0 No cough No cough 1 Occasional short cough Coughing briefly while falling asleep or occasionally at night 2 Frequent coughing that slightly affects daily activities Coughing slightly affects sleep at night 3 Frequent coughing that seriously affects daily activities Coughing seriously affects sleep at night

[0029] (3) Severity of cough: The cough visual analogue scale was used for assessment. Parents of the child recorded the severity of the cough by drawing a scale on a straight line ranging from 0 to 10 cm every day. 0 indicated no symptoms and 10 indicated the most severe cough.

[0030] (4) Compare the time it takes for cough to disappear between the study group and the control group.

[0031] 4. Efficacy evaluation criteria:

[0032] According to the Standards for Diagnosis and Efficacy of Pediatric Diseases in Traditional Chinese Medicine, cured: cough disappears, dry and wet rales disappear on auscultation, and if there is fever, the body temperature drops to normal; improved: cough is relieved, breath sounds are clear, and sputum is reduced; ineffective: cough symptoms and signs are not improved or worsen.

[0033] Total effective rate = (cured + improved) / total number of cases × 100%.

[0034] 5. Statistical methods:

[0035] SPSS 26.0 was used for statistical analysis. X ±s), and the t test was used for comparison between groups; count data were expressed as frequency / percentage (%), and the chi-square test was used for comparison between groups. 2 P<0.05 was statistically significant.

[0036] 6. Results:

[0037] 6.1 Treatment effect:

[0038] The total effective rate of the study group was 100%, which was significantly higher than that of the control group. See Table 2 for details.

[0039] Table 2 Comparison of treatment effects between the study group and the control group

[0040] Group Number of cases cure Improvement invalid Total effective rate (%) Research Group 62 46 16 0 <![CDATA[100% * ]]> Control group 62 29 21 12 80.6％

[0041] Note: Compared with the total effective rate of the control group, *P<0.05.

[0042] 6.2: Comparison of cough symptom scores

[0043] Before treatment, there was no significant difference in cough symptom scores between the two groups (P>0.05). After one week of treatment, the daytime cough and nighttime cough symptom scores of the two groups were lower than those before treatment, and the scores of the study group were lower than those of the control group, with significant differences (P<0.05), as shown in Table 3.

[0044] Table 3 Comparison of cough symptom scores between the study group and the control group before and after treatment ( point)

[0045]

[0046] 6.3: Comparison of cough symptom scores

[0047] Before treatment, there was no significant difference in cough severity scores between the two groups (P>0.05). After one week of treatment, the cough severity scores of the two groups were lower than those before treatment, and the score of the study group was lower than that of the control group, with significant differences (P<0.05), as shown in Table 4.

[0048] Table 4 Comparison of cough severity scores between the study group and the control group before and after treatment ( point)

[0049] Group Before treatment After treatment Research Group 6.72±0.57 0.41±0.13 Control group 6.67±0.49 1.78±0.42

[0050] 6.4: Comparison of cough disappearance time

[0051] The cough disappearance time in the study group was (2.87±0.72) d, which was significantly shorter than that in the control group (5.69±1.42) d.

[0052] It can be seen from the above clinical data that the Baoyuan powder provided by the present invention has better therapeutic effect, can significantly shorten the coughing time of children, alleviate coughing symptoms, and significantly shorten the course of the disease. The number of children cured within one week is as high as 74.2%.

[0053] The above description is a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating cough due to yin deficiency and lung heat in children, characterized in that: The Chinese medicine composition comprises 200-250g of Poria cocos, 50-100g of Plantago seed, 50-80g of Arisaema, 50-100g of Rhubarb, 50-80g of Ephedra, 20-40g of Amber, 50-80g of Fritillaria cirrhosa, 150-200g of Honeysuckle, 50-100g of Stemona japonica, 20-40g of Pinellia ternata, 50-100g of Platycodon grandiflorum, 100-150g of Radix Ophiopogonis and 100-150g of Radix Ophiopogonis. g, Radix Trichosanthis 50-80g, loquat leaf 50-100g, antelope silk 20-40g, Gastrodia elata 10-30g, safflower 5-15g, scutellaria 20-40g, gypsum 50-100g, Gardenia 10-30g, Citrus aurantium 10-30g, Apricot 50-100g, Uncaria rhynchophylla 50-100g, Hawksbill turtle 10-30g, Citrus aurantium 10-30g.

2. A Chinese medicine composition for treating cough due to yin deficiency and lung heat in children according to claim 1, characterized in that: The traditional Chinese medicine composition consists of 200g of Poria cocos, 80g of Plantago seed, 60g of Arisaema, 100g of Rhubarb, 60g of Ephedra, 40g of Amber, 75g of Fritillaria cirrhosa, 200g of Honeysuckle, 80g of Stemona japonica, 40g of Pinellia ternata, 100g of Platycodon grandiflorum, 120g of Ophiopogon japonicus, 60g of Radix Trichosanthis, 100g of Eriobotrya japonica, 20g of Antelope silk, 10g of Gastrodia elata, 5g of Carthamus tinctorius, 25g of Scutellaria baicalensis, 80g of Gypsum, 20g of Gardenia jasminoides, 25g of Citrus aurantium, 100g of Apricot, 100g of Uncaria rhynchophylla, 20g of Hawksbill turtle, and 15g of Citrus aurantium dulcis.

3. A Baoyuan powder for treating cough due to yin deficiency and lung heat in children, characterized in that: The preparation method of the Baoyuan powder is as follows: pulverize the antelope silk and hawksbill turtle in the traditional Chinese medicine composition of claim 1 or 2 into fine powder, mix the remaining 23 medicinal materials, pulverize into fine powder, mix the above two medicinal powders, pass through a 100-mesh sieve, and package to obtain the powder.

Images