Efficient acne-removing nanofiber mask and preparation method thereof

Abstract

The invention relates to an efficient acne-removing nanofiber mask and a preparation method thereof. The high-efficiency acne-removing nanofiber mask bag is prepared from an excipient, a humectant, an antibacterial agent and an oil-control anti-inflammatory agent, is soft in formula and has no irritation effect on skin. According to the efficient acne-removing nanofiber mask, the electrostatic spinning technology is adopted, the diameter of each produced fiber reaches 500 nm or below, is one thousandth of that of hair and is 100 times smaller than that of pores of the skin of a human body, acne-removing components can be conveyed to the deep layer of dermis in a targeted mode, functional components can be rapidly permeated and absorbed, and therefore the acne-removing effect is remarkably improved, and the effect is half of that of medicine. The efficient acne-removing nanofiber mask can accurately and rapidly diminish inflammation and remove acnes, does not leave acne marks, and has the effects of removing acnes and eliminating acne marks and acne scars. The preparation method of the product is simple, and mass production can be realized.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to a highly efficient acne-removing nanofiber mask and a preparation method thereof. Background Art

[0002] Acne, scientifically known as acne, is a chronic inflammatory disease of the sebaceous glands of the hair follicles caused by a combination of factors. The main causes of acne are excessive sebum secretion, blockage of the sebaceous gland ducts, and bacterial infection caused by genetic factors or strong stimulation of male hormones; greasy high-calorie diet, insomnia, staying up late, smoking, drinking, stress, etc. can all cause acne problems on the skin. Acne is divided into acne, papules, pustules, nodules, and cysts. Most acne, especially papules, pustules, nodules, and cysts, will produce acne marks. Acne marks are formed by infection, inflammation, or external force compression. It is often because the acne is not treated promptly and properly when it breaks out. The inflammatory response of skin cells causes damage to the skin tissue, resulting in the formation of acne marks. Sterilization, oil control, and anti-inflammatory, a three-pronged approach, kill acne marks in the bud.

[0003] There are many methods for removing acne, but because the epidermis of the skin is a dense stratum corneum, it has a natural barrier function that can block the invasion of foreign substances. Therefore, the acne-removing ingredients in many acne creams, acne lotions, and acne essences are difficult to penetrate the dense stratum corneum and cannot achieve the sterilization, anti-inflammatory and repair effects.

[0004] Facial masks are a kind of beauty and skin care products applied on the face. They can clean, beautify and protect the face, so they are widely loved. Anti-acne masks are becoming more and more common in the market, but most of them are in liquid state. During use, a carrier filled with mask liquid is usually applied to the face to moisturize the skin and provide other related effects. This conventional mask has two major defects when used: first, the mask liquid is easy to fall off the carrier during use, causing waste; second, because it cannot get rid of the water phase system, it is easy to breed microorganisms and cause the abuse of preservatives. At the same time, the use of preservatives causes allergies, irritation and inflammation symptoms to users, and the effect of anti-inflammatory and acne removal cannot be achieved.

[0005] On the other hand, electrospun nanofibers have the characteristics of large specific surface area, high porosity, excellent physical and mechanical properties, light weight and easy processing. Their morphology is similar to that of the extracellular matrix, and they themselves and the particles they carry are easily absorbed by the human body, and are absorbed faster than general materials. They have good application prospects in many fields such as biomedical materials, biosensors, cosmetics, skin beauty, etc.

[0006] At present, electrospinning mask related products have been developed in the cosmetics market. However, the existing electrospinning mask products only have a moisturizing effect and a poor acne removal effect.

[0007] In summary, in view of the above-mentioned problems existing in the common facial masks on the market, developing a facial mask product with efficient acne removal function will be more likely to be favored by consumers. Summary of the invention

[0008] In order to solve the transdermal absorption effect of acne-removing products, the purpose of the present invention is to provide an efficient acne-removing nanofiber mask and its preparation and use methods. The electrostatic spinning technology is adopted to spray the efficient acne-removing essence out of the nanofiber through a high-voltage electrostatic field and spin it onto a non-woven fabric, which is then dried into an efficient acne-removing nanofiber mask. The diameter of each nanofiber is less than 500nm, which is one thousandth of a hair and 100 times smaller than the pores of human skin. The acne-removing ingredients can be targeted to penetrate the epidermis and transported to the deep dermis, greatly improving transdermal absorption and achieving twice the effect with half the effort.

[0009] The high-efficiency acne-removing nanofiber facial mask of the present invention is prepared by mixing excipients, moisturizers, antibacterial agents, and oil-controlling and anti-inflammatory agents, and can effectively solve the problem that the existing facial masks have poor acne-removing effects.

[0010] The present invention also provides a method for preparing the above-mentioned high-efficiency acne-removing nanofiber mask, which specifically comprises the following steps: Step (1), weighing 10-70 parts of excipients and 10-40 parts of moisturizing agents by weight; Step (2), adding 5 to 6 times the mass of distilled water to the composition weighed in step (1), stirring and heating to 80°C, keeping warm and stirring for 30 minutes until completely dissolved, starting to cool to below 40°C, adding 0.1 to 8 parts of antibacterial agent and 0.1 to 3 parts of oil control and anti-inflammatory agent, and stirring evenly to obtain a highly effective acne-removing essence; Step (3), spraying the high-efficiency acne-removing essence prepared in step (2) through a high-voltage electrostatic field to spin, collecting the fibers on a receiver, and then drying, winding, and slitting to obtain a high-efficiency acne-removing nanofiber mask.

[0011] Preferably, the excipient is at least one of polyvinyl alcohol, gelatin, extracellular polysaccharide, gum arabic, fermentation product of Aureobasidium pullulans, and locust bean gum.

[0012] Preferably, the moisturizing agent is at least one of sodium hyaluronate, hydrolyzed sodium hyaluronate, 1,3-propylene glycol, glycerin, betaine, and trehalose.

[0013] Preferably, the antibacterial agent is at least one of water-soluble totarol, mandelic acid, paeonol, honokiol, pyragon and salicylic acid.

[0014] Preferably, the oil-controlling and anti-inflammatory agent is at least one of Hypericum perforatum extract, Chrysanthemum indici extract, Centella asiatica extract, Scutellaria baicalensis extract, Chamomile flower, Honeysuckle extract, and dipotassium glycyrrhizinate.

[0015] Unless otherwise specified, the raw materials used in the present invention can be obtained from common commercial sources or prepared by conventional techniques in the art.

[0016] Compared with the prior art, the present invention has the following beneficial effects: (1) The high-efficiency acne-removing nanofiber mask of the present invention adopts electrostatic spinning technology. The diameter of each fiber produced is less than 500nm, which is one thousandth of a hair and 100 times smaller than the pores of human skin. It can target the acne-removing ingredients to the deep layer of the dermis, allowing the effective ingredients to penetrate and be absorbed quickly, thereby significantly improving the acne-removing effect and achieving twice the result with half the effort. It can effectively make the mask have the function of removing acne in addition to the function of moisturizing.

[0017] (2) The highly effective acne-removing nanofiber mask obtained by the electrospinning technology of the present invention is easy to store and carry, and is convenient to use. It can be applied to the face with water during use and can be stored for a long time without the use of preservatives, effectively solving the problem of waste of mask liquid and the use of preservatives caused by conventional masks.

[0018] (3) The present invention also creatively adds an antibacterial agent to increase the anti-inflammatory and antibacterial properties without affecting other properties of the mask, such as moisturizing properties. The mask can also be used on inflamed skin or sensitive skin. The high-efficiency acne-removing nanofiber mask of the present invention can accurately and quickly reduce inflammation and remove acne without leaving acne marks. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0020] Figure 1 Figure 2. The acne removal test results of the tester A using the nanofiber mask prepared in Example 1 for high efficiency acne removal on days D0 and D7 in the human efficacy test. Figure 2 Figure 2. The acne removal test results of the tester B using the nanofiber mask prepared in Example 1 for high efficiency acne removal on days D0 and D7 in the human efficacy test. Figure 3 Figure 2. The acne removal test results of the tester C using the nanofiber mask prepared in Example 1 for high efficiency acne removal on days D0 and D7 in the human efficacy test. DETAILED DESCRIPTION

[0021] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0022] A highly effective acne-removing nanofiber mask is prepared from the following components: polyvinyl alcohol, fermentation product of Aureobasidium pullulans, sodium hyaluronate, 1,3-propylene glycol, trehalose, water-soluble totarol, encapsulated salicylic acid (40%), Hypericum perforatum extract, Chrysanthemum indici extract, Centella asiatica extract, Scutellaria baicalensis extract, Honeysuckle extract, Chamomile flower extract, and dipotassium glycyrrhizate; all of the above components can be purchased through commercial channels.

[0023] In Examples 1-3, the components included and their corresponding mass fractions are shown in Table 1.

[0024] Table 1 Mass fractions of each component of the highly effective anti-acne nanofiber mask of Examples 1-3

[0025] The preparation methods of the highly effective acne-removing nanofiber facial masks in the above-mentioned embodiments 1-3 all adopt the following processing steps for product production: Step (1), weighing 10-70 parts of excipients and 10-40 parts of moisturizing agents by weight; Step (2), adding 5 to 6 times the mass of distilled water to the composition weighed in step (1), stirring and heating to 80°C, keeping warm and stirring for 30 minutes until completely dissolved, starting to cool to below 40°C, adding 0.1 to 8 parts of antibacterial agent and 0.1 to 3 parts of oil control and anti-inflammatory agent, and stirring evenly to obtain a highly effective acne-removing essence; Step (3), spraying the high-efficiency acne-removing essence prepared in step (2) through a high-voltage electrostatic field to spin, collecting the fibers on a receiver, and then drying, winding, and slitting to obtain a high-efficiency acne-removing nanofiber mask.

[0026] Comparative Example 1: All the components of the above Example 1 were weighed according to their mass fractions, and 4 times of deionized water was added, and stirred for 30 minutes until they were completely dissolved, to prepare the acne-removing essence of Comparative Example 1.

[0027] 1. Stability test The products of Examples 1-3 prepared above were subjected to stability tests, and the change indicators of appearance such as texture, color, and odor were evaluated. The test results are shown in Table 2.

[0028]

[0029] From the stability test results in the above table, it can be seen that the texture, color and smell of Examples 1-3 are relatively stable without obvious changes, and there are only slight changes from the 6th week. It can be seen that the present invention can effectively improve the stability of the product through the reasonable combination of the components.

[0030] 2. Acne removal effect test Test products: The acne removal effect of the highly efficient acne removal nanofiber mask prepared in Example 1 and the acne removal essence prepared in Comparative Example 1 were tested. The test results are shown in Table 3.

[0031] Testers: Testers with similar number of acne and degree of skin lesions on the left and right sides of the face were selected, including only acne (mild): 50 people, papules and pustules (moderate): 40 people, nodules and cysts (severe): 30 people.

[0032] Usage: After cleansing the face in the morning and evening every day, the tester takes an appropriate amount of this product and evenly applies it to the affected area, and gently massages until it is completely absorbed; on the left side, apply or spray water on the acne area, and then stick the highly efficient acne-removing nanofiber mask prepared in Example 1 on the acne, and on the right side, use the acne-removing essence prepared in Comparative Example 1. One course of treatment is 7 days, and 4 courses of treatment are observed.

[0033] Acne treatment effect evaluation criteria: Recovery: Skin lesions subsided, inflammation basically disappeared, and acne marks faded.

[0034] Markedly effective: Most of the skin lesions disappeared and the inflammation was significantly alleviated.

[0035] Effective: Skin lesions partially subsided and inflammation improved.

[0036] Ineffective: The skin lesions do not subside significantly, or even increase.

[0037] The test results are shown in Table 3 below.

[0038]

[0039] According to the above table, more people have recovered from acne, papules, pus cells and nodular cysts after using Example 1. The comparison between the example and the comparative example shows that in terms of acne removal performance, Example 1 is better than Comparative Example 1.

[0040] 3. Human efficacy test Several testers A, B, and C with severe acne were selected. After cleansing their faces every morning and evening, they applied or sprayed water on the acne areas, and applied the nanofiber mask for high-efficiency acne removal prepared in Example 1 on the acne areas, and then gently massaged until all the acne was absorbed. Testers A, B, and C were photographed before using the product in Example 1 (D0) and 7 days after using the product in Example 1 (D7). The test results are shown in the figure below. Figure 1-3shown.

[0041] like Figure 1 The pictures of tester A before using the product of Example 1 (D0) and 7 days after using the product of Example 1 (D7) are as follows. Figure 1 The results showed that the acne area was red, swollen and inflamed before using the product, but it has been significantly improved and basically healed after using the product for 7 days. At the same time, the acne marks on other parts of the face have also faded to a certain extent, and the entire facial area has an overall brightening effect. During this period, tester A did not experience severe acne recurrence.

[0042] like Figure 2 The pictures of tester B before using the product of Example 1 (D0) and 7 days after using the product of Example 1 (D7) are as follows. Figure 2 The results showed that the acne area was red, swollen and inflamed before using the product, but it has been significantly improved and basically healed after using the product for 7 days. At the same time, the acne marks on other parts of his face have also faded to a certain extent, and the entire facial area has an overall brightening effect. During this period, tester B did not experience severe acne recurrence.

[0043] like Figure 3 The pictures of tester C before using the product of Example 1 (D0) and 7 days after using the product of Example 1 (D7) are as follows. Figure 2 The results showed that the acne area was red, swollen and inflamed before using the product, and it was significantly improved after using the product for 7 days and was basically cured. At the same time, the improvement effect of facial acne was obvious, and the feedback from the user was that the product of Example 1 was mild and non-irritating, and he was willing to continue using it.

[0044] Based on the above experimental results, it is shown that the nanofiber mask for high-efficiency acne removal of the present invention has excellent acne removal effect, can also promote rapid repair of damaged skin, and fade acne marks.

[0045] The above embodiments are several specific implementation methods of the present invention, which are intended to help understand the principles of the embodiments of the present invention, but the implementation methods of the present invention are not limited to the above embodiments; at the same time, any modifications, equivalent substitutions or improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An efficient acne-removing nanofiber mask, characterized in that: The composition is composed of the following components in parts by mass: 10-70 parts of excipients, 10-40 parts of moisturizers, 0.1-8 parts of antibacterial agents, and 0.1-3 parts of oil-controlling and anti-inflammatory agents; the preparation method of the highly effective anti-acne nanofiber mask comprises the following steps: Step (1), weighing 10-70 parts of excipients and 10-40 parts of moisturizing agents by weight; Step (2), adding 5 to 6 times the mass of distilled water to the composition weighed in step (1), stirring and heating to 80°C, keeping warm and stirring for 30 minutes until completely dissolved, starting to cool to below 40°C, adding 0.1 to 8 parts of antibacterial agent and 0.1 to 3 parts of oil control and anti-inflammatory agent, and stirring evenly to obtain a highly effective acne-removing essence; Step (3), spraying the high-efficiency acne-removing essence prepared in step (2) through a high-voltage electrostatic field to spin, collecting the fibers on a receiver, and then drying, winding, and slitting to obtain a high-efficiency acne-removing nanofiber mask.

2. The high-efficiency acne-removing nanofiber mask according to claim 1, characterized in that: The excipient is at least one of polyvinyl alcohol, gelatin, extracellular polysaccharide, gum arabic, fermentation product of Aureobasidium pullulans and locust bean gum.

3. The high-efficiency acne-removing nanofiber mask according to claim 1, characterized in that: The moisturizing agent is at least one of sodium hyaluronate, hydrolyzed sodium hyaluronate, 1,3-propylene glycol, glycerol, betaine and trehalose.

4. The high-efficiency acne-removing nanofiber mask according to claim 1, characterized in that: The antibacterial agent is at least one of water-soluble totarol, mandelic acid, paeonol, honokiol, pyragonine and salicylic acid.

5. The high-efficiency acne-removing nanofiber mask according to claim 1, characterized in that: The oil-controlling and anti-inflammatory agent is at least one of Hypericum perforatum extract, wild chrysanthemum extract, Centella asiatica extract, Scutellaria baicalensis extract, chamomile flower, honeysuckle extract and dipotassium glycyrrhizinate.

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