Cell manipulation method based on thin film resonator and microchip

By setting the liquid of the cells to be patterned on the film resonator and applying an excitation signal, the film vibrates to form an eddy current field, and the rapid, non-destructive and parallel manipulation of the cells is achieved, and the problems of large impact on cells and low patterning efficiency in the prior art are solved.

CN119639731APending Publication Date: 2025-03-18SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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Patent Information

Application Number
CN202411927754.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-25
Publication Date
2025-03-18

AI Technical Summary

Technical Problem

The existing cell manipulation technology has a great impact on cells and is low in patterning efficiency, making it difficult to achieve fast, lossless, and parallel manipulation effects of multiple cells.

Method used

Using a cell manipulation method based on a film resonator, a liquid containing the cells to be patterned is provided on the film of the film resonator, so that the films are all located in the liquid, and a preset excitation signal is applied to drive the film to vibrate according to the preset resonance mode to form an eddy current field to pattern the cells.

Benefits of technology

It is achieved to improve the cell manipulation speed while ensuring manipulation accuracy, avoid direct contact with cells, reduce the impact on cells, reduce the liquid heating effect, and support parallel manipulation of a large number of cells.

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Abstract

The invention provides a cell manipulation method based on a thin film resonator and a microchip, and the cell manipulation method comprises the steps: arranging a liquid containing cells on a thin film of the thin film resonator, and driving the thin film to vibrate according to a preset resonance mode; and a vortex field is formed in the liquid through film resonance, and the cells are dragged to move towards a stress balance point of the vortex field above an antinode, so that the patterning control of the cells is realized. According to the invention, the resonance mode of the thin film resonator is controlled through the driving frequency of the electric signal to manipulate cells, so that the cell manipulation speed and the cell manipulation precision are improved; meanwhile, an eddy current field is generated through resonance to realize cell manipulation, direct contact with cells is avoided, the original state of the cells can be kept, and unnecessary cell stimulation and damage are avoided; and finally, array manufacturing of the microchip is realized by adopting a micromachining process, parallel manipulation of a large number of cells can be realized, and the cell patterning complexity and manipulation efficiency are improved.
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