Method for high performance barcode magnetic beads
By increasing the molecular probe density on the surface of digital barcode magnetic beads and using surface modification reagents of controlled structures, the problems of insufficient sensitivity and limited dynamic range in clinical tests are solved, achieving higher test accuracy and lower false positive false negative rates.
CN119667142APending Publication Date: 2025-03-21APPLIED BIOCODE
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Patent Information
- Application Number
- CN202311462751.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-09-21
- Filing Date
- 2023-11-06
- Publication Date
- 2025-03-21
AI Technical Summary
Technical Problem
There are problems of insufficient sensitivity and limited dynamic range in clinical testing, resulting in false positive or false negative test results, and it is difficult for the prior art to effectively improve these indicators.
Method used
By increasing the molecular probe density on the surface of the digital barcode magnetic beads, surface modification reagents with controlled structures are used to increase surface function and reduce nonspecific binding of the molecular probe, thereby improving the sensitivity and dynamic range of the test.
Benefits of technology
The effect of improving the test sensitivity and dynamic range is achieved, reducing false negative and false positive test results, and improving the accuracy of bioassays.
✦ Generated by Eureka AI based on patent content.
Abstract
The present disclosure relates to a new method for constructing controlled structures on the surface of modified digital barcode magnetic beads (BMBs) that have higher capacity, higher fluorescence intensity, wider dynamic range and improved sensitivity in clinical applications.
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