Method for preparing progesterone particulate matter, obtained progesterone particulate matter and injection of progesterone particulate matter

By pumping the progesterone solution into a precipitation solvent with high speed shearing or stirring, progesterone particles are prepared with good stability, which solves the problems of complex operation, poor stability and low bioavailability in the prior art, and achieves efficient preparation of particulate matter and improves bioavailability.

CN119679728APending Publication Date: 2025-03-25SICHUAN KELUN PHARMA RES INST CO LTD +1
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Patent Information

Application Number
CN202411788221.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2019-08-09
Filing Date
2019-12-23
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

In the prior art, the preparation of progesterone particles, especially crystals or powders, has problems such as complex operation, poor stability and low bioavailability.

Method used

Progesterone solution is pumped into a precipitation solvent with high speed shearing or vigorously stirred at a predetermined speed, and progesterone particles are obtained by separation and drying. This method can control the particle size and crystal form of the particulate matter, and improve the stability and bioavailability of the preparation.

Benefits of technology

The stability and bioavailability of progesterone particles are achieved, the operation is simple, suitable for industrial production, and the particle size range of the particulate matter can be controlled from 0.3 μm to 60 μm, preferably 10 to 30 μm.

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Abstract

The invention discloses a method for preparing progesterone particles, especially crystals or powder. The method comprises the following steps: step 1, dissolving progesterone in a solvent to provide a progesterone solution; step 2, pumping the progesterone solution into a high-speed sheared progesterone precipitation solvent at a preset speed so as to precipitate progesterone; and step 3, separating the precipitate and carrying out freeze drying to obtain the progesterone particulate matter, wherein the progesterone particles are progesterone crystals or progesterone powder. The micron-sized progesterone crystal or powder can be obtained through the method, and the stability is good. The progesterone injection prepared by adopting the progesterone sustained-release preparation not only realizes a sustained-release effect of at least 5 days, but also is good in stability. The method disclosed by the invention is simple to operate, low in cost and easy for industrial large-scale production.
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