Maggot bionic hydrogel as well as preparation method and application thereof

By developing a bionic hydrogel of grain insects, using chitosan and drug components to form a gradient void structure, the excessive damage and side effects of existing wound treatment methods are solved, and effective debridement and healing of wounds are achieved.

CN119679993APending Publication Date: 2025-03-25SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Application Number
CN202411623951.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-14
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The existing methods for treating wounds have problems such as excessive damage, high side effects, and difficult management. Although the external treatment method of grain worm has the effect of treating wounds, it has limited sources, poor efficacy, and high prices.

Method used

A bionic hydrogel of grain insects was developed. Through the appearance of bionic grain insects and drug release rules, chitosan hydrogel dressings were used to combine debridement enzymes, insect antimicrobial peptides and angiopoietin-like proteins to form a gradient void structure to achieve effective drug release and wound healing.

Benefits of technology

The hydrogel provides a wet healing environment, and through gradient void structure and drug release rules, it achieves effective debridement, antibacterial and promotes healing of wounds, avoiding excessive damage and side effects of traditional methods.

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Abstract

The invention relates to maggot bionic hydrogel and a preparation method and application thereof, and belongs to the technical field of biology, the hydrogel comprises a base part and a needle part arranged on the base part; the needle part is composed of needles arranged in an array mode, the porosity between needle tips of the needles is smaller than the porosity of the base part, and the good medicine release effect with the fast lower part and the slow upper part is achieved. Compared with the prior art, the porosity of the needle part of the hydrogel is smaller than that of the base part, the porosity increasing effect from bottom to top is formed, and the hydrogel has the drug carrying capacity with the bionic effect, such as debridement, antibiosis and healing promotion drugs; the hydrogel provides a wet healing environment for a wound surface, and forms a temperature-sensitive shrinkage effect under the influence of body temperature so as to quickly release and load drugs, realize various conforming functions of debridement, antibiosis, healing promotion and the like, and can be used for treating various wound surfaces.
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