Fucoidin calcium ion injectable hydrogel as well as preparation method and application thereof
By using hydrogels formed by fucoidan and calcium ions in vivo, the existing anti-blocking materials have been solved, and good anti-blocking effect and cell compatibility have been achieved.
CN119680020APending Publication Date: 2025-03-25SUZHOU JINYISHENG BIOTECHNOLOGY CO LTD +1
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Patent Information
- Application Number
- CN202411883819.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-19
- Publication Date
- 2025-03-25
AI Technical Summary
Technical Problem
The existing anti-adhesion materials have poor fixity, strong fluidity, and difficulty in staying for a long time, resulting in poor anti-adhesion effects. Some materials may cause inflammatory reactions or allergies, which are costly and insufficient mechanical properties.
Method used
The hydrogel is formed by electrostatic interaction between fucoidan and calcium ions in aqueous solution. The injectable hydrogel is prepared through simple stirring and extrusion processes to improve the fluidity and immobilization of the material.
Benefits of technology
It achieves good mechanical properties and self-healing properties, can effectively prevent wound adhesions, has good cell compatibility and safety, and is suitable for preventing abdominal and liver adhesions.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses fucoidin calcium ion injectable hydrogel as well as a preparation method and application thereof, and belongs to the field of medical biological materials. According to the preparation method of the fucoidin calcium ion injectable hydrogel, fucoidin and calcium chloride are taken as raw materials and form the hydrogel through electrostatic interaction in an aqueous solution, namely, hydroxyl, sulfonic acid groups and calcium ions are subjected to electrostatic interaction, the operation is simple and convenient, the reaction condition is mild, the cost is low, and the method is suitable for industrial production. And the safety problems of cytotoxicity and the like caused by introduction of an organic solvent and a cross-linking agent are effectively avoided. The fucoidin calcium ion hydrogel provided by the invention has good mechanical properties, good self-healing performance and good cell compatibility, can be used as an anti-adhesion blocking agent for preventing adhesion of liver, cecum and other parts, and can prevent adhesion after liver resection operation and abdominal cavity operation and secondary adhesion caused by adhesion release operation.
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