Preparation method of DL-p-chlorophenylglycine

Through continuous production and three-stage tubular reactor series connection, trimethyl cyanosilane and supported catalysts were used to solve the problems of low automation, long reaction period and highly toxic sodium cyanide in the existing DL-p-chlorophenyl glycine preparation method, and the preparation effect of high purity and high yield was achieved.

CN119684142APending Publication Date: 2025-03-25LANZHOU ZHAOFENG CHEMICAL TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202411817485.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-11
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The existing preparation method of DL-p-chlorophenylglycine has problems with low degree of automation, long reaction period, and the need to use highly toxic sodium cyanide, and the uneven mixing of ammonia and reactants in the tubular reactor leads to a decrease in yield.

Method used

Using a continuous production method, a three-stage tubular reactor is connected in series, trimethyl cyanosilane is used to replace sodium cyanide, and a supported catalyst with ammonia adsorption is added to the reactor to improve the reaction efficiency and purity.

Benefits of technology

The purity and yield of DL-p-chlorophenylglycine is improved, the reaction time is shortened, the use of highly toxic sodium cyanide is avoided, and high purity and yield are maintained in long-term production.

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Abstract

The invention discloses a preparation method of DL-p-chlorophenylglycine, and belongs to the technical field of DL-p-chlorophenylglycine. The preparation method comprises the steps of equipment preparation, Bucherer-Bergs reaction and alkaline hydrolysis reaction. The method comprises the following steps: preparing equipment, filling a first tubular reactor with a ceramic Pall ring filler, filling a second tubular reactor with a first catalyst, filling a third tubular reactor with a second catalyst, and then connecting a bottom outlet of the first-stage tubular reactor with a top inlet of the second-stage tubular reactor, and a bottom outlet of the second-stage tubular reactor is connected with a top inlet of the third-stage tubular reactor. The continuous production method is adopted, the automation degree is high, the use of virulent sodium cyanide as a cyaniding reagent can be avoided, the purity and yield of the prepared DL-p-chlorophenylglycine are high, and the purity and yield of the DL-p-chlorophenylglycine are not obviously reduced in long-term production.
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