Red rice bran source small molecule peptide and application thereof
By extracting small-molecule peptide LCW from red rice bran and screening out peptides with tyrosinase inhibitory activity through alkaline protease hydrolysis, the problem of difficult to effectively inhibit melanin production in the prior art is solved, and a safe and effective whitening effect is achieved.
CN119684400AActive Publication Date: 2025-03-25KUNMING UNIV OF SCI & TECH
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Patent Information
- Application Number
- CN202411970855.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2044-12-30
AI Technical Summary
Technical Problem
The prior art is difficult to effectively inhibit the production of melanin, leading to pigmentation diseases, and chemical preparations have side effects, limiting their long-term use.
Method used
The small-molecule peptide Leu-Cys-Trp (LCW) was extracted from red rice bran, and peptides with tyrosinase inhibition activity were screened through alkaline protease hydrolysis and screening out to achieve inhibition of tyrosinase and thereby inhibit the synthesis of melanin.
Benefits of technology
LCW small molecule peptides have good tyrosinase inhibitory activity, can effectively inhibit the synthesis of melanin, provide a safe and effective whitening pathway, and are suitable for industrial production and marketing promotion.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a small-molecule peptide derived from red rice bran, the amino acid sequence of the small-molecule peptide is Leuu-Cys-Trp (LCW), and in-vitro tyrosinase activity and intracellular tyrosinase activity experiments of the small-molecule peptide LCW show that the small-molecule peptide can be used for detecting the content of tyrosinase. Results show that the activity of tyrosinase is inhibited by combining the LCW with amino acid residues of the tyrosinase through hydrogen bonds, electrostatic interaction force and hydrophobic force and combining the LCW with active centers Cu400 and Cu401 of the tyrosinase through Van der Waals force, and the LCW has copper ion chelation ability, and experiments prove that the LCW has good tyrosinase inhibition activity. And the small molecule peptide has the advantages of high safety, good water solubility and simple preparation, and is suitable for industrial production and market popularization and application.
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