Protein complex structure similar template searching method

By constructing a protein complex template database and a fusion template database, and using search methods for global templates and local templates, the problems of low search accuracy and insufficient automation of protein complex templates in the existing technology are solved, and higher search accuracy and automation are achieved.

CN119694412AActive Publication Date: 2025-03-25ZHEJIANG UNIV OF TECH
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Patent Information

Application Number
CN202411174508.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-08-26
Publication Date
2025-03-25
Estimated Expiration
2044-08-26

AI Technical Summary

Technical Problem

The existing method of searching for protein complex templates has flaws in terms of accuracy and automation, especially the template database is incomplete and redundant, resulting in low search accuracy of protein complex templates and requires manual intervention.

Method used

By constructing a protein complex template database and a fusion template database, global template and local template search methods are adopted, and the sequence and structure comparison are compared with tools such as CD-HIT, TM-align and USalign, and the search process is automated to improve the accuracy of template search.

Benefits of technology

It improves the accuracy and automation of protein complex template search, enhances the integrity of the database, reduces manual intervention, and improves the user experience of users in the field of non-structural biology.

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Abstract

A protein complex structure similar template searching method comprises the following steps: firstly, constructing a protein complex template database and a fusion template database; inputting a single-chain structure of the target protein, searching a global template and a local template in the compound template database according to the structure, and searching the global template and the local template again in the fusion template database if the quality of the searched templates is poor; and finally, selecting an optimal template obtained by searching in the two databases as a structural similar template of the target protein. The invention provides the protein complex structure similar template searching method with relatively high precision.
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