Compositions and methods for diagnostic imaging

By using hydrophilic polymer-flavonoid conjugates and flavonoid oligomer encapsulated MINC-agents, the problem of insufficient contrast agent stability and signal intensity in existing imaging technologies is solved, and higher imaging signal intensity and safer imaging effects are achieved.

CN119698306APending Publication Date: 2025-03-25SUNTEC MEDICAL INC
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Patent Information

Application Number
CN202380059172.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-06-24
Filing Date
2023-06-21
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

In the existing CT, MRI, PET, SPECT, ultrasound and photoacoustic imaging technologies, the chemical stability, solubility, density and toxicity of contrast agents lead to difficulties in clinical application, and insufficient signal strength and distinction ability.

Method used

Micellars of the outer shell formed by hydrophilic polymer-flavonoid conjugates and inner shell formed by flavonoid oligomers are encapsulated to form MINC-agents to improve imaging signal strength and discrimination ability.

Benefits of technology

The residence time of imaging agents in tissues is extended, the accumulation and imaging signal intensity at target sites are improved, the accumulation and toxicity at non-target sites are reduced, and the signal intensity and safer imaging effects are provided.

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Abstract

The present invention provides a composition. The composition comprises a micelle having an outer shell comprising one or more polymer-flavonoid conjugates, optionally an inner shell comprising one or more flavonoid oligomers, and a diagnostic imaging agent encapsulated within the shell. The invention also provides a method of diagnostic imaging using the composition.
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