Preparation and application of biocompatible nano hydrogel containing salvianolic acid C
By using the biocompatible nanohydrogel containing sanphenolic acid C, the problem that existing dry eye treatment drugs cannot fundamentally solve the dry eye disease problem, and the long-term retention of sanphenolic acid C in the eyes and effective antioxidant and anti-inflammatory effects of sanphenolic acid C in the eyes has been solved, which significantly improves the quality of life of patients with dry eye disease.
CN119700643APending Publication Date: 2025-03-28ZHUHAI HOSPITAL OF INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE (ZHUHAI SECOND PEOPLES HOSPITAL)
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Patent Information
- Application Number
- CN202411626480.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-14
- Publication Date
- 2025-03-28
AI Technical Summary
Technical Problem
Existing dry eye treatment drugs cannot fundamentally solve the problem of dry eye, and their low solubility and easy tear-rewashing properties limit their therapeutic effects and increase the risk of adverse reactions.
Method used
Using OHASacgel, a biocompatible nanohydrogel containing sanphenolic acid C, a biocompatible nanohydrogel supported by mixing hyaluronic acid with OHA and gelatin after oxidation reaction, was formed by loading sanphenolic acid C.
Benefits of technology
It significantly increases the retention time of sanphenolic acid C in the eyes, reduces the proportion of inflammatory macrophages, reduces oxidative damage, effectively alleviates damage caused by dry eye disease, and improves the patient's quality of life.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the technical field of traditional Chinese medicine anti-xerophthalmia treatment, and discloses preparation and application of a biocompatible nano hydrogel OHASacgel containing salvianolic acid C. According to the method, the traditional Chinese medicine salvianolic acid C is loaded into the biocompatible hydrogel, so that the retention time of the traditional Chinese medicine salvianolic acid C in xerophthalmia is further prolonged, and the curative effect of the traditional Chinese medicine salvianolic acid C on xerophthalmia is improved. Meanwhile, the proportion of inflammatory macrophages is reduced, oxidative damage is reduced, and damage caused by xerophthalmia is effectively relieved.
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