Method for improving bioavailability of phytosterol
The phytosterol nanolipid carrier technology was encapsulated and spray-dried and prepared into effervescent tablets, which solved the problems of high oil content, poor sensory characteristics and insufficient absorption in the existing phytosterol products, and achieved higher bioavailability and stability.
CN119700698AActive Publication Date: 2025-03-28JIANGNAN UNIV
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Patent Information
- Application Number
- CN202411921467.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-25
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2044-12-25
AI Technical Summary
Technical Problem
Existing plant sterol products have problems such as high oil content, poor sensory characteristics and insufficient intestinal absorption, which affects their cholesterol-lowering activity.
Method used
Using phytosterol nanolipid carrier technology, phytosterols are encapsulated in nanostructured lipid carriers and made into solid dispersions by spray drying, and finally prepared into oral effervescent tablets.
Benefits of technology
The bioavailability and bioaccessibility of phytosterols have been improved, and the problems of poor solubility and poor taste have been overcome, achieving higher stability and rapid disintegration effects.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of development, utilization and utilization of phytosterol, in particular to a preparation method of phytosterol effervescent tablets. The preparation method comprises the following steps: preparing a phytosterol nano lipid carrier suspension, mixing the phytosterol nano lipid carrier suspension with an excipient, and carrying out spray drying to obtain the solid dispersion of the phytosterol nano carrier. Further preparing the phytosterol effervescent tablet from the solid dispersion of the phytosterol nano-carrier, a disintegrating agent and auxiliary materials; the prepared nanostructured lipid carrier has a nanoscale size and good polydispersity, and the encapsulation efficiency can reach 96.9%. The prepared phytosterol effervescent tablet has better flavor and uniformity, is convenient to take, has better taste, has higher stability and can be quickly disintegrated; the biological accessibility can reach 43.3%, and the content of phytosterol in the effervescent tablet can reach 25.76 mg / g. The bioaccessibility of the phytosterol is greatly improved under the condition of overcoming the problems of poor solubility and bad taste of the phytosterol; and the method has a relatively high application value.
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