Preparation method of gamma-deuterated amino-acid ester
By reacting deuterated with deuterated reagents under the action of the catalytic system, the existing deuterated amino acid synthesis methods have solved the problems of poor universality and poor uniformity of deuterated amino acid synthesis methods, and achieved high selectivity deuterated at the γ-position of amino acids, which are highly efficient, environmentally friendly and low-cost.
Patent Information
- Application Number
- CN202411597401.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-11
- Publication Date
- 2025-03-28
AI Technical Summary
The existing deuterated amino acid synthesis methods are poor in popularity, resulting in a specific synthetic route for each amino acid, which significantly increases the time and cost, and the uniformity of deuteratedness is poor, limiting its application in labeling and tracer experiments.
A method of preparing γ-deuterated amino acid ester is adopted. Deuterated reaction with deuterated reagent under normal pressure under the action of the catalytic system. Palladium acetate, 2-hydroxynicotinamide and silver trifluoroacetate are used as the catalytic system, and heavy water is used as the deuterium source and solvent to achieve high regioselective deuterated at the γ position of amino acid ester compounds.
It achieves high selective deuterated at the γ amino acid position, simple reaction operation, high deuteration and yield, simple separation, low cost, environmentally friendly reagents, and is suitable for the preparation of a variety of amino acid esters.