Molecular POCT full-automatic integrated detection device and method

By designing a fully automatic integrated nucleic acid detection device based on isothermal amplification technology, the problems of low automation and difficult to control the liquid usage in the prior art are solved, and nucleic acid detection with high accuracy and automation are achieved.

CN119709958APending Publication Date: 2025-03-28SHANGHAI GENEXT MEDICAL TECH +1
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Patent Information

Application Number
CN202411567276.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-04
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The existing household molecular POCT nucleic acid detection technology has low degree of automation, requires artificial operation, and the liquid usage is difficult to accurately control, affecting the detection accuracy.

Method used

A fully automatic integrated nucleic acid detection device for molecular POCT based on isothermal amplification technology is designed, integrating nucleic acid extraction and amplification, and quantitative addition of the termination liquid is achieved by using a peristaltic pump, and the liquid is automatically flowed into the detection chamber through the liquid level difference channel to improve the degree of automation.

Benefits of technology

A fully automated nucleic acid detection process has been realized, which reduces artificial operations, improves the accuracy and automation of detection, and reduces detection errors.

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Abstract

The invention provides a molecular POCT full-automatic integrated nucleic acid detection device and method, the molecular POCT full-automatic integrated nucleic acid detection device comprises a base, a detection unit and a control module, the base comprises a heating module, a peristaltic pump motor and a pushing motor, and the detection unit comprises a sample bin, an amplification bin, a liquid chamber, a detection bin and a peristaltic pump. Communication of the sample bin and the amplification bin is achieved by pushing the motor to move, quantitative adding of stop buffer is achieved through the peristaltic pump, liquid in the amplification bin is controlled to automatically flow into the detection bin in a delayed mode through the liquid level difference, and detection liquid is further evenly mixed by arranging the baffle in the detection bin. Meanwhile, the height of the liquid level in the detection bin is controlled so that the detection test strip can be just contacted. According to the device, sample extraction, nucleic acid amplification and detection are integrated, pollution possibly caused by step-by-step operation is reduced, and meanwhile, integration and automation of the device are improved.
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