Efficient composition for purification, prevention and control of porcine reproductive and respiratory syndrome

Abstract

The invention discloses an efficient composition for purification, prevention and control of porcine reproductive and respiratory syndrome. The efficient composition comprises the following raw materials in parts by weight: 5-10 parts of astragalus membranaceus, 2-3 parts of ginseng, 4-6 parts of platycodon grandiflorum, 4-6 parts of amomum cardamomum, 3-6 parts of poria cocos, 3-6 parts of tetrapanax papyriferus and 2-3 parts of antibiotic acetylisovaleryltylosin tartrate. The invention aims to provide the efficient composition for purifying, preventing and controlling the porcine reproductive and respiratory syndrome, and the obtained efficient composition for purifying, preventing and controlling the porcine reproductive and respiratory syndrome is simple in production process and suitable for large-scale production; the traditional Chinese medicines such as astragalus membranaceus, ginseng and the like used in the traditional Chinese medicine composition have the effects of tonifying qi and consolidating depletion, tonifying heart qi and supporting the healthy energy, the transfer factor is used for improving organism metabolism, improving in-vivo circulation and enhancing organism immunity so that the organism immune function can be improved, and the antibiotic acetylisovaleryltylosin tartrate is matched to control secondary infection. The above measures take multiple measures, and the porcine reproductive and respiratory syndrome is effectively prevented and controlled.

Description

Technical Field

[0001] The invention relates to the technical field of aquaculture, and in particular to a high-efficiency composition for purifying and preventing blue ear disease. Background Art

[0002] Blue ear disease is an acute and highly contagious disease caused by porcine reproductive and respiratory syndrome virus. Because the PRRSV virus is easy to mutate, its virulence may be enhanced and cause new epidemics and outbreaks. Therefore, it has the characteristics of rapid onset, widespread prevalence, high mortality rate, difficulty in prevention and control, and large economic losses, causing serious losses to the breeding industry.

[0003] Pigs of all breeds, ages and uses can be infected with blue ear disease, but pregnant sows and piglets under one month old are the most susceptible, because sick pigs and infected pigs are important sources of infection for this disease. The main transmission routes are contact infection, air transmission and semen transmission, and can also be vertically transmitted through the placenta. Susceptible pigs can be infected with the virus through multiple routes such as oral, nasal, muscle, abdominal, intravenous and intrauterine inoculation. Pigs can transmit the virus to other susceptible pigs through contact 2 to 14 weeks after being infected with the virus. The virus can be detected in the nasal cavity, feces and urine of sick pigs. Susceptible pigs can be infected by direct contact with infected pigs or contact with transportation vehicles and equipment contaminated with PRRSV. The movement of pigs is also an important way of transmission of this disease.

[0004] In view of these problems, it is necessary to develop a pharmaceutical composition for preventing and treating blue ear disease that can enhance immunity, establish an efficient immune system, and have good effects in preventing and treating blue ear disease. Summary of the invention

[0005] In order to overcome the above technical problems, the purpose of the present invention is to provide a high-efficiency composition for purification and prevention of blue ear disease. The obtained high-efficiency composition for purification and prevention of blue ear disease has a simple production process and is suitable for large-scale production. The Chinese medicine used in the invention, such as astragalus and ginseng, can replenish qi and strengthen the heart qi, play a role in strengthening the body, and use transfer factors to improve body metabolism, improve body circulation, and increase body immunity to enhance the body's immune function, and then cooperate with the antibiotic tartrate tyvalocin to control secondary infection. The above measures are multi-pronged and effectively prevent and control blue ear disease.

[0006] The purpose of the present invention can be achieved through the following technical solutions:

[0007] A highly effective composition for purification and prevention of blue ear disease, comprising the following raw materials and their weight proportions: 5-10 parts of astragalus, 2-3 parts of ginseng, 4-6 parts of platycodon, 4-6 parts of white cardamom, 3-6 parts of tuckahoe, 3-6 parts of tongcao, and 2-3 parts of antibiotic tartrate tyvalocin;

[0008] The steps for preparing the highly effective composition for purifying and preventing blue ear disease are as follows:

[0009] S1: Pretreatment:

[0010] Take astragalus, ginseng, platycodon, white cardamom, poria, and tongcao, wash them with clean water respectively, dry them in a dry place, and then put them in an electric thermostatic box to dry;

[0011] S2: Crushing process:

[0012] Put the pre-treated astragalus, ginseng, platycodon, white cardamom, tuckahoe and tongcao into a crushing device for preliminary crushing until they are crushed into small pieces;

[0013] S3: Grinding treatment:

[0014] Mix the crushed small pieces of astragalus, ginseng, platycodon, cardamom seed, poria, and tongcao, add the antibiotic tartrate tyvalocin, continue to mix evenly, put into a grinding device for grinding, grind into fine powder, and pass through a 60-80 mesh sieve;

[0015] S4: Decoction

[0016] Add water to the mixture obtained after grinding, boil for 1-2 hours, filter after cooling to obtain a primary decoction, continue to add water and boil for 1-2 hours, filter after cooling to obtain a secondary decoction, mix the primary decoction and the secondary decoction, heat and concentrate to obtain a concentrated solution. The concentrated solution is packaged, sealed, and labeled, so as to obtain a high-efficiency composition for purification and prevention of blue ear disease. The Chinese medicine used in this invention, such as astragalus, ginseng, etc., replenishes qi and strengthens the heart, plays a role in strengthening the body, and uses transfer factors to improve the body's metabolism, improve the body's circulation, and increase the body's immunity to enhance the body's immune function, and then cooperates with the antibiotic tartrate tyvalcin to control secondary infection. The above measures are multi-pronged and effectively prevent and control blue ear disease.

[0017] Furthermore, in step S1, the drying temperature of the electric constant temperature drying oven is 80° C., and the constant temperature drying is performed until the moisture content is ≤1%.

[0018] The invention further lies in that the high-efficiency composition can be mixed with food for consumption.

[0019] The invention further comprises that when the high-efficiency composition is mixed with food, the usage amount is 2-3% of the weight of the food.

[0020] Furthermore, the high-efficiency composition is not limited to being made into a concentrated liquid form, but can also be made into a pill or a freeze-dried powder.

[0021] The method further comprises adding water to the mixture obtained after grinding, wherein the weight ratio of the water to the mixture is 10:1.

[0022] The invention further comprises: the relative density of the obtained concentrated solution is 1.2 to 1.3.

[0023] Beneficial effects of the present invention:

[0024] 1. The high-efficiency composition for purification and prevention of blue ear disease obtained by the invention has a simple production process and is suitable for large-scale production.

[0025] 2. The Chinese medicines used in the invention, such as astragalus and ginseng, can replenish qi and strengthen the heart, play a role in strengthening the body, and use transfer factors to improve the body's metabolism, improve the body's circulation, and increase the body's immunity to enhance the body's immune function, and then cooperate with the antibiotic tartrate tyvalocin to control secondary infection. The above measures are multi-pronged and effectively prevent and control blue ear disease. DETAILED DESCRIPTION

[0026] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Example 1

[0028] The steps for preparing the highly effective composition for purifying and preventing blue ear disease are as follows:

[0029] S1: Pretreatment:

[0030] Take 5 parts of Astragalus, 2 parts of Ginseng, 4 parts of Platycodon, 4 parts of White Cardamom, 3 parts of Poria, and 3 parts of Tongcao, wash them with clean water, dry them in a dry place, and then put them in an electric thermostatic box to dry;

[0031] S2: Crushing process:

[0032] Put 5 parts of astragalus, 2 parts of ginseng, 4 parts of platycodon, 4 parts of white cardamom, 3 parts of tuckahoe and 3 parts of tongcao into a crushing device for preliminary crushing until they are crushed into small pieces;

[0033] S3: Grinding treatment:

[0034] Mix 5 parts of crushed Astragalus, 2 parts of Ginseng, 4 parts of Platycodon, 4 parts of White Cardamom, 3 parts of Poria, and 3 parts of Smilax glabra, and add 2 parts of antibiotic Talbotrya japonica tartrate, continue to mix evenly, put into a grinding device for grinding, grind into fine powder, and pass through a 60-80 mesh sieve;

[0035] S4: Decoction

[0036] Add water to the mixture obtained after grinding, boil for 1 to 2 hours, filter after cooling to obtain a primary decoction, continue to add water and boil for 1 to 2 hours, filter after cooling to obtain a secondary decoction, mix the primary decoction and the secondary decoction, heat and concentrate to obtain a concentrated solution.

[0037] Example 2

[0038] The steps for preparing the highly effective composition for purifying and preventing blue ear disease are as follows:

[0039] S1: Pretreatment:

[0040] Take 10 parts of Astragalus, 3 parts of Ginseng, 6 parts of Platycodon, 6 parts of White Cardamom, 6 parts of Poria, and 6 parts of Tongcao, wash them with clean water, dry them in a dry place, and then put them in an electric thermostatic box to dry;

[0041] S2: Crushing process:

[0042] Put the pre-treated 10 parts of Astragalus, 3 parts of Ginseng, 6 parts of Platycodon, 6 parts of White Cardamom, 6 parts of Poria, and 6 parts of Tongcao into a crushing device for preliminary crushing until they are crushed into small pieces;

[0043] S3: Grinding treatment:

[0044] Mix 10 parts of crushed Astragalus, 3 parts of Ginseng, 6 parts of Platycodon, 6 parts of White Cardamom, 6 parts of Poria, and 6 parts of Tongcao small pieces and add 3 parts of antibiotic Talvalocin tartrate, continue to mix evenly, put into a grinding device for grinding, grind into fine powder, and pass through a 60-80 mesh sieve;

[0045] S4: Decoction

[0046] Add water to the mixture obtained after grinding, boil for 1 to 2 hours, filter after cooling to obtain a primary decoction, continue to add water and boil for 1 to 2 hours, filter after cooling to obtain a secondary decoction, mix the primary decoction and the secondary decoction, heat and concentrate to obtain a concentrated solution.

[0047] Example 3

[0048] The steps for preparing the highly effective composition for purifying and preventing blue ear disease are as follows:

[0049] S1: Pretreatment:

[0050] Take 8 parts of Astragalus, 3 parts of Ginseng, 5 parts of Platycodon, 5 parts of White Cardamom, 5 parts of Poria, and 5 parts of Tongcao, wash them with clean water, dry them in a dry place, and then put them in an electric thermostatic box to dry;

[0051] S2: Crushing process:

[0052] Put 8 parts of astragalus, 3 parts of ginseng, 5 parts of platycodon, 5 parts of white cardamom, 5 parts of tuckahoe and 5 parts of tongcao into a crushing device for preliminary crushing until they are crushed into small pieces;

[0053] S3: Grinding treatment:

[0054] Mix 8 parts of crushed Astragalus, 3 parts of Ginseng, 5 parts of Platycodon, 5 parts of White Cardamom, 5 parts of Poria, and 5 parts of Tongcao small pieces and add 3 parts of antibiotic Talvalocin tartrate, continue to mix evenly, put into a grinding device for grinding, grind into fine powder, and pass through a 60-80 mesh sieve;

[0055] S4: Decoction

[0056] Add water to the mixture obtained after grinding, boil for 1 to 2 hours, filter after cooling to obtain a primary decoction, continue to add water and boil for 1 to 2 hours, filter after cooling to obtain a secondary decoction, mix the primary decoction and the secondary decoction, heat and concentrate to obtain a concentrated solution.

[0057] Example 4

[0058] Buy traditional antibiotics for treating blue ear disease in pigs on the market.

[0059] Comparative Example

[0060] 100 pigs in a pig farm of a farmer in Anhui Province were diagnosed with highly pathogenic porcine blue ear disease. The 100 pigs were divided into four groups, each with 25 pigs. The drugs obtained in Examples 1 to 4 were used for treatment. The treatment conditions were 10g of the drug was mixed with 1kg of water, and the drug was mixed with the same food and fed to the pigs three times a day for 10 days. After 10 days, the cure, improvement and deterioration of the pigs were observed and recorded. The results are shown in Table 1.

[0061] Table 1 Test results of cure, improvement and deterioration of pigs after medication cycle in Examples 1 to 4

[0062]

[0063] Result analysis: From Table 1, it can be seen that the high-efficiency composition for purification and prevention of blue ear disease disclosed in the present invention has better curative effect than the traditional antibiotic drugs for treating blue ear disease in pigs purchased on the market; the different proportions of the high-efficiency composition for purification and prevention of blue ear disease in the present invention have a slight effect on the curative effect within a certain range, but the overall result is significantly better than the traditional antibiotic drugs for treating blue ear disease in pigs purchased on the market. The Chinese medicines such as astragalus and ginseng used in the present invention can replenish qi and strengthen the body, replenish the heart qi, play a role in strengthening the body, and use transfer factors to improve the body's metabolism, improve the body's circulation, and increase the body's immunity to enhance the body's immune function, and then cooperate with the antibiotic tartrate tyvalcin to control secondary infection. The above measures are multi-pronged and effectively prevent and control blue ear disease.

[0064] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0065] The above contents are merely examples and explanations of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the invention or exceed the scope defined by the claims, they shall all fall within the protection scope of the present invention.

Claims

1. A highly effective composition for purification and prevention of blue ear disease, comprising the following raw materials and their weight proportions: 5-10 parts of astragalus, 2-3 parts of ginseng, 4-6 parts of platycodon, 4-6 parts of white cardamom, 3-6 parts of tuckahoe, 3-6 parts of tongcao, and 2-3 parts of antibiotic tartrate tyvalocin; The steps for preparing the high-efficiency composition for purifying and preventing blue ear disease are as follows: S1: Pretreatment: Take astragalus, ginseng, platycodon, white cardamom, poria, and tongcao, wash them with clean water respectively, dry them in a dry place, and then put them in an electric thermostatic box to dry; S2: Crushing treatment: Put the pre-treated astragalus, ginseng, platycodon, white cardamom, tuckahoe and tongcao into a crushing device for preliminary crushing until they are crushed into small pieces; S3: Grinding treatment: Mix the crushed small pieces of astragalus, ginseng, platycodon, cardamom seed, poria, and tongcao, add the antibiotic tartrate tyvalocin, continue to mix evenly, put into a grinding device for grinding, grind into fine powder, and pass through a 60-80 mesh sieve; S4: Decoction The mixture obtained after grinding is added with water, boiled for 1-2 hours, filtered after cooling to obtain a primary decoction, and water is added to continue boiling for 1-2 hours, filtered after cooling to obtain a secondary decoction, and the primary decoction and the secondary decoction are mixed and heated to obtain a concentrated solution. The concentrated solution is packaged, sealed, and labeled, thereby obtaining a highly effective composition for purification and prevention of blue ear disease.

2. The highly effective composition for purifying and preventing blue ear disease according to claim 1, characterized in that: In step S1, the drying temperature of the electric constant temperature drying oven is 80° C., and the constant temperature drying is performed until the moisture content is ≤1%.

3. The highly effective composition for purifying and preventing blue ear disease according to claim 1, characterized in that: The high-efficiency composition can be mixed with food when used.

4. The highly effective composition for purifying and preventing blue ear disease according to claim 3, characterized in that: When the high-efficiency composition is mixed with food, the usage amount is 2-3% of the weight of the food.

5. The highly effective composition for purifying and preventing blue ear disease according to claim 1, characterized in that: The high-efficiency composition is not limited to being prepared into concentrated liquid form, but can also be prepared into pills or freeze-dried powder.

6. The highly effective composition for purifying and preventing blue ear disease according to claim 1, characterized in that: Water was added to the mixture obtained after grinding, and the weight ratio of water to the mixture was 10:

1.

7. The highly effective composition for purifying and preventing blue ear disease according to claim 1, characterized in that: The relative density of the obtained concentrated solution is 1.2 to 1.3.

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