Iodine-125 patch and equipment for making the patch

Abstract

The present invention relates to the technical field of local radiotherapy of tumors, an iodine-125 patch and a device for making the patch. The iodine-125 patch includes a basement membrane layer, a radiation layer, a protective layer and an adhesive layer stacked in sequence, and the radiation layer includes uniformly distributed iodine-125 radioactive particles for accurately irradiating the tumor surface. The device for making the patch includes a cutting table, a first cutting assembly and two second cutting assemblies. The first cutting assembly includes a first drive assembly and three first blades, and the second cutting assembly includes a second drive assembly, an adsorption box and a second blade. The iodine-125 patch can achieve accurate irradiation while reducing the impact on surrounding normal tissues, and patients do not need to go to the hospital frequently. The present invention has the following advantages: strong targeting, can directly act on tumor tissue, and improve treatment efficiency. The trauma is small, and the recovery time is short compared to surgery. The device for making the patch can cut the iodine-125 patch into squares by the cooperation of the first cutting assembly and the two second cutting assemblies.

Description

Technical Field

[0001] The invention relates to the technical field of local tumor radiotherapy, and specifically relates to an iodine-125 patch and equipment for making the patch. Background Art

[0002] The incidence of skin and superficial tissue tumors, such as basal cell carcinoma, squamous cell carcinoma and malignant melanoma, has gradually increased in recent years. Tumors can be removed surgically in the early stages, but surgery may cause significant tissue damage, loss of function or psychological burden on patients. Radiotherapy is more gentle and effective, and plays an important role in cancer treatment for patients with tumors in deep tissues or who are not suitable for surgery.

[0003] At present, radiotherapy for superficial skin tumors mainly relies on external radiotherapy equipment or radiopharmaceutical injections. These methods have the following limitations: 1. Inconvenience: Patients need to go to the hospital frequently for treatment, which increases the economic burden and time cost of treatment. 2. Side effects: External radiotherapy may cause damage to surrounding healthy tissues, causing skin inflammation, ulcers and other adverse reactions. 3. The treatment effect is unstable. For small or scattered tumors, traditional methods may find it difficult to achieve sufficient irradiation effects. Summary of the invention

[0004] The object of the present invention is to provide an iodine-125 patch and a device for making the patch, wherein the iodine-125 patch can achieve precise irradiation while reducing the impact on surrounding normal tissues, and the patient does not need to go to the hospital frequently. The device for making the patch can cut the iodine-125 patch into squares through the cooperation of a first cutting component and two second cutting components.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: In the first technical solution, an iodine-125 patch includes a basement membrane layer, a radiation layer, a protective layer and an adhesive layer which are stacked in sequence and are detachable, and the radiation layer includes a plurality of iodine-125 radioactive particles which are evenly distributed and whose positions and quantities can be freely controlled, so as to realize precise irradiation of the tumor surface.

[0006] In the first technical solution, preferably, the base film layer is made of polyurethane or polyvinyl alcohol, and the thickness of the base film layer is 0.1 mm-0.3 mm.

[0007] In the first technical solution, preferably, the diameter of the iodine-125 radioactive particles is in the range of 0.5 mm to 1 mm.

[0008] In the first technical solution, preferably, the material of the protective layer is polyvinyl fluoride or polyphenylene sulfide, and the thickness of the protective layer is 0.05 mm-0.1 mm.

[0009] In the first technical solution, preferably, the adhesive layer is made of a medical-grade water-soluble adhesive.

[0010] In the first technical solution, preferably, the size of the iodine-125 patch is 5 cm x 5 cm.

[0011] In a second technical solution, a device for making a patch is used to make the iodine-125 patch as described in the first technical solution, comprising: a cutting table; a first cutting component, the first cutting component comprising a first driving component and three first blades, the three first blades are all arranged above the cutting table, and are arranged at equal intervals along the width extension direction of the cutting table, and the distance between two adjacent first blades is 5 cm, the first driving component is arranged above the first blade, the first driving component comprises three output ends, the three output ends of the first driving component are respectively connected to the three first blades, and are used to drive the first blades to move along the length extension direction of the cutting table and the height extension direction of the cutting table; two second cutting components are respectively arranged at the cutting table At both ends of the length extension direction, the two second cutting components are centrally symmetrical, the second cutting component is located between two adjacent first blades, the second cutting component includes a second driving component and an adsorption box, the first end of the adsorption box is rotatably connected to the top surface of the cutting table, the second end of the adsorption box is fixedly provided with a second blade, when the adsorption box is rotated to a horizontal state and the second end of the adsorption box is located above the cutting table, the second blade abuts against the top surface of the cutting table, the length extension direction of the second blade is the same as the width extension direction of the cutting table, the length of the second blade is greater than 5 cm, the second driving component is arranged on the top surface of the cutting table, and the output end of the second driving component is connected to the adsorption box for driving the adsorption box to rotate.

[0012] In the second technical solution, preferably, it also includes: two first material moving components, the two first material moving components are respectively arranged at the two ends of the width extension direction of the cutting table, and the structure is centrally symmetrical, the first material moving component includes a third driving component and a material moving rod, the material moving rod is a ring-shaped structure, an assembly cavity is provided inside the cutting table, the assembly cavity passes through the two end surfaces of the length extension direction of the cutting table, the top of the material moving rod is arranged on the top surface of the cutting table and can slide along the top surface of the cutting table, and the bottom of the material moving rod is arranged in the assembly cavity, And it can slide along the inner wall of the assembly cavity, the third driving component is arranged in the assembly cavity, and the output end of the third driving component is connected to the bottom of the material moving rod, for driving the material moving rod to move along the width extension direction of the cutting table; four material stopping rods are respectively fixed at the four corners of the top surface of the cutting table, and are all located between two of the material moving rods, in the width extension direction of the cutting table, two adjacent material stopping rods are collinear, and the spacing is greater than 10cm, and the bottom surface of the material moving rod is provided with an avoidance hole, and the avoidance hole matches the position of the material stopping rod.

[0013] In the second technical scheme, preferably, it also includes two second material moving assemblies, the top surface of the cutting table is provided with two assembly holes, the assembly holes pass through the bottom surface of the cutting table, the two assembly holes are centrally symmetrical, the positions of the two assembly holes correspond to the positions of the two second cutting assemblies, the two second material moving assemblies are respectively arranged in the two assembly holes, the second material moving assembly includes a fourth drive assembly, a transmission shaft and a material removing roller, the transmission shaft is arranged at the top of the assembly hole, both ends of the transmission shaft are rotatably connected to the side walls of the assembly hole, the material removing roller is fixedly arranged in the middle of the transmission shaft, the fourth drive assembly is arranged below the assembly hole, the output end of the fourth drive assembly is connected to the transmission shaft, for driving the transmission shaft to rotate, the cross-section of the material removing roller is elliptical, and the length and width of the assembly hole are both less than 5cm.

[0014] In the second technical scheme, preferably, a guide groove is provided on the top surface of the cutting table and located between the assembly hole and the adsorption box, and the guide groove is inclined downwardly near the bottom surface of the adsorption box on one side; the second cutting component also includes: an exhaust component, an air storage cavity is provided inside the adsorption box, and a discharge groove is provided on the end surface of the adsorption box provided with the second blade, in the height direction of the adsorption box, the discharge groove is inclined toward the side away from the second blade, and passes through the end surface of the second end of the adsorption box, and a plurality of ventilation holes are provided on the inner wall of the discharge groove away from the second blade, and the ventilation holes are connected with the air storage cavity, the exhaust component includes an exhaust pump, a ventilation hose and an electrically controlled exhaust valve, the exhaust pump is fixedly arranged on the top surface of the cutting table, the air inlet end of the exhaust pump is connected with the first end of the ventilation hose, and the second end of the ventilation hose is connected with the air storage cavity, A bending portion is provided at one end of the rod near the vacuum pump, and the position of the bending portion corresponds to the position of the vacuum pump, the electrically controlled exhaust valve is arranged on the end face of the adsorption box away from the second blade, and the electrically controlled exhaust valve is connected to the air storage chamber; a sealing ring is arranged on the side of the second blade close to the air hole and is fixedly connected to the adsorption box, the sealing ring is in a U-shaped structure, the discharge groove is located on the inner side of the sealing ring, and the sealing ring and the second blade together form a ring-shaped structure; a sealing plate is arranged on the end face of the second end portion of the adsorption box, the sealing plate is rotatably connected to the adsorption box at one end away from the second blade, the sealing plate can completely cover the opening of the discharge groove on the end face of the second end portion of the adsorption box, the cross-sectional shape of the sealing plate is a triangle, the end of the sealing plate close to the second blade is a wide head end, and a counterweight is fixedly provided on the wide head end of the sealing plate.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] (a) In the present invention, the radiation layer in the iodine-125 patch includes uniformly distributed iodine-125 radioactive particles, and iodine-125 can emit low-energy gamma rays and X-rays, has a short half-life, and is suitable for local radiotherapy of tumors. In the present invention, the patch achieves precise irradiation of the tumor surface, and the patient does not need to go to the hospital frequently. The present invention also has the following advantages: strong targeting, can directly act on tumor tissue, and improve treatment efficiency. Small trauma, compared with surgery, the application method causes less physical damage to the patient and a short recovery time.

[0017] (ii) In the present invention, the equipment for making the patch includes a cutting table, a first cutting assembly and two second cutting assemblies. When a larger iodine-125 patch is placed on the top surface of the cutting table, the iodine-125 patch can be cut into small square pieces through the cooperation of the first cutting assembly and the second cutting assembly, which is convenient for patients to apply. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 is a schematic diagram of the structure of the iodine-125 patch of the present invention;

[0019] Figure 2 It is an axonometric diagram of the device for making the patch in the present invention;

[0020] Figure 3 is an axonometric view of the cutting table of the present invention;

[0021] Figure 4 for Figure 3 The enlarged view of point A in the middle;

[0022] Figure 5 is a side view of the cutting table of the present invention;

[0023] Figure 6 is an axonometric view of the first cutting assembly in the present invention;

[0024] Figure 7 An isometric view of the second cutting assembly at one angle in the present invention;

[0025] Figure 8 It is an axonometric view of the second cutting assembly in the present invention from another angle;

[0026] Fig. 9 It is an axonometric exploded view of the adsorption box in the present invention;

[0027] Fig.10 It is an axonometric cross-sectional view of the adsorption box in the present invention;

[0028] Fig.11 It is an axonometric view of the first material moving assembly in the present invention;

[0029] Fig.12 It is an axonometric view of the second material moving assembly in the present invention;

[0030] Fig.13 An axonometric view of the device for making a patch according to the present invention after the first cutting assembly completes cutting;

[0031] Fig.14 An axonometric view of the device for making a patch according to the present invention after the second cutting assembly completes cutting;

[0032] Fig.15 An axonometric view of the apparatus for making patches of the present invention after the second cutting assembly removes the square iodine-125 patch;

[0033] Fig.16 for Fig.15 Enlarged view of point B in the middle.

[0034] Reference numerals include:

[0035] 1-base film layer, 2-radiation layer, 3-protective layer, 4-adhesive layer, 5-cutting table, 51-assembly cavity, 52-assembly hole, 53-guide groove, 6-first cutting component, 61-first drive component, 62-first blade, 7-second cutting component, 71-second drive component, 72-adsorption box, 721-air storage cavity, 722-discharge trough, 723-ventilation hole, 73-second blade, 74-vacuum component, 741-vacuum pump, 742-ventilation hose, 743-electrically controlled exhaust valve, 75-sealing ring, 76-blocking plate, 77-counterweight block, 8-first material moving component, 81-third drive component, 82-material moving rod, 821-avoidance hole, 822-bending portion, 9-material blocking rod, 10-second material moving component, 101-fourth drive component, 102-drive shaft, 103-feeding roller. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] Embodiment 1

[0038] See also Figure 1 The present invention provides a technical solution: an iodine-125 patch, comprising a basement membrane layer 1, a radiation layer 2, a protective layer 3 and an adhesive layer 4 which are stacked and detachable in sequence, the radiation layer 2 comprising uniformly distributed iodine-125 radioactive particles, and applying the radioactive particles directly to the tumor surface can achieve precise irradiation while reducing the impact on surrounding normal tissues. In the present invention, each layer is removable and replaceable, and in the radiation layer 2, the position and number of iodine-125 radioactive particles can be freely adjusted. Compared with traditional radiotherapy, patch therapy has the following advantages: strong targeting, can directly act on tumor tissue, and improve treatment efficiency. Less trauma, compared with surgery, the patch method causes less physical damage to the patient and has a short recovery time. Easy to operate, patients can change the patch at home to reduce the frequency of hospital visits. Adjustable, adjust the dose according to the condition.

[0039] The basement membrane layer 1 is made of a biocompatible material to ensure good adhesion between the patch and the skin, and has air permeability to reduce skin irritation. The basement membrane layer 1 uses a biocompatible polymer material, such as polyurethane or polyvinyl alcohol (PVA), which has good air permeability, flexibility and adhesion. The thickness of the basement membrane layer 1 is 0.1mm-0.3mm.

[0040] The radiation layer 2 evenly distributes iodine-125 radioactive particles on the basement membrane layer 1. The number and arrangement of particles are optimized to achieve the best treatment effect. The diameter of the iodine-125 radioactive particles ranges from 0.5mm to 1mm. Iodine-125 (I-125) is a commonly used radioactive isotope that emits low-energy gamma rays and X-rays, has a short half-life (about 59.4 days), and is suitable for local radiotherapy of tumors. Its low penetration ability enables it to effectively irradiate tumor cells without damaging surrounding normal tissues. The number, position, and activity of particles can be adjusted in real time according to different tumor types and sizes and preoperative particle planning.

[0041] The protective layer 3 covers the radiation layer 2 with a protective film to prevent particle leakage and protect the stability of the patch during use. The material of the protective layer 3 is polyvinyl fluoride or polyphenylene sulfide, which has good isolation effect and radiation resistance. The thickness of the protective layer 3 is 0.05mm-0.1mm.

[0042] The adhesive layer 4 uses a medical-grade water-soluble adhesive to enable the patch to be firmly attached to the skin surface, ensuring good adhesion to the skin while reducing irritation to the skin and ensuring that the particles will not shift during the treatment process.

[0043] The preparation steps of the patch in the present invention are as follows: 1. Preparation of radioactive particles. Iodine-125 particles are obtained through a professional radioactive source manufacturing organization to ensure that their activity and radioactivity meet medical standards. 2. Particle distribution. In a clean environment, the iodine-125 particles are evenly distributed on the basement membrane layer 1 to ensure that the particle density in each area is consistent to achieve uniform radiation. 3. Protective layer covering. The protective layer material is covered on the radiation layer 2 and fixed by heat sealing or pressure bonding to ensure the stability and safety of the particles. 4. Cutting and packaging. The prepared patch is cut into standard sizes and sterilely packaged to ensure that it remains sterile before use. The size of the patch in the present invention can be customized according to the size of the patient's tumor, usually 5cm x 5cm, which is suitable for most skin and superficial tissue tumors.

[0044] The method of using the patch of the present invention is as follows: 1. Preparation before use. The patient should ensure that the skin is clean and dry before use, and avoid using it on infected areas. 2. Apply the patch according to the steps. The patient carefully tears open the package and takes out the patch, taking care to avoid direct contact with the radiation layer 2. The patient then aligns the patch with the tumor area and presses it gently to make it fit tightly on the skin. 3. Remove the patch. When using, the patient can carefully remove the patch after the specified time. If there is any residual adhesive, it can be washed with warm water.

[0045] The precautions for the patch of the present invention are as follows: 1. Use monitoring. During the application period, the patient needs to regularly monitor the changes in the tumor area. If abnormal reactions occur, they should seek medical attention in time. 2. Avoid allergic reactions. Before the first use, a skin test is performed to rule out allergic reactions to the adhesive layer 4 or the basement membrane layer 1 material.

[0046] Embodiment 2

[0047] See also Figure 2-16 , a device for making a patch, comprising a cutting table 5, a first cutting assembly 6 and two second cutting assemblies 7. When a larger iodine-125 patch is placed on the top surface of the cutting table 5, the iodine-125 patch can be cut into small square pieces by the cooperation of the first cutting assembly 6 and the second cutting assembly 7, so that it is convenient for patients to apply. Before the iodine-125 patch is placed on the top surface of the cutting table 5, one side of the adhesive layer 4 has been covered with a protective sticker, so that the iodine-125 patch will not adhere to other objects.

[0048] See also Figure 2 and Figure 6 The first cutting assembly 6 includes a first driving assembly 61 and three first blades 62. In this embodiment, the first driving assembly 61 includes two first electric telescopic rods, two assembly rods, three first motors, three threaded rods, three sliders and three second electric telescopic rods. The three first blades 62 are respectively fixedly arranged at the output ends of the three second electric telescopic rods. After the first blades 62 are removed, the distance between two adjacent first blades 62 is adjustable. In this embodiment, the distance between two adjacent first blades 62 is 5 cm. The extension or shortening of the first electric telescopic rod and the second electric telescopic rod can drive the first blade 62 to move in the vertical direction. The first motor drives the threaded rod to rotate, which can drive the first blade 62 to move in the horizontal direction.

[0049] See also Figure 2 and Fig.13 When the iodine-125 patch needs to be cut, the first driving component 61 first drives the first blade 62 to move downward to contact the top surface of the cutting table 5, and then drives the first blade 62 to move in the horizontal direction. The three first blades 62 will cut the larger iodine-125 patch into two long strips with a width of 5 cm.

[0050] See also Figure 2 and Figure 7-8 The second cutting assembly 7 includes a second driving assembly 71, a suction box 72 and a second blade 73. In this embodiment, the second driving assembly 71 includes a second motor, two gears and a driving shaft. The second motor can drive one of the gears to rotate, the two gears are meshed with each other, and the other gear can drive the suction box 72 to rotate through the driving shaft.

[0051] See also Figure 2 and Figure 13-14 After the larger iodine-125 patch is cut by the first cutting assembly 6, the two separated long strips of 5 cm in width only need to be placed close to the second cutting assemblies 7 on both sides, and the second driving assembly 71 can drive the adsorption box 72 to rotate toward the side close to the cutting table 5. When the adsorption box 72 rotates to a horizontal state, the second blade 73 abuts against the top surface of the cutting table 5, and the second blade 73 cuts the long strip of iodine-125 patch into squares of 5 cm x 5 cm, which is convenient for patients to apply.

[0052] See also Figure 2-3 , Figure 5 and Fig.11 The equipment for making the patch also includes two first material moving components 8 and four material blocking rods 9. The structures of the two first material moving components 8 are centrally symmetrical. The first material moving component 8 includes a third driving component 81 and a material moving rod 82. The material moving rod 82 is a ring-shaped structure. An assembly cavity 51 is provided inside the cutting table 5. The top of the material moving rod 82 is provided on the top surface of the cutting table 5. The bottom of the material moving rod 82 is provided in the assembly cavity 51. The third driving component 81 is provided in the assembly cavity 51. The four material blocking rods 9 are respectively fixed at the four corners of the top surface of the cutting table 5 to play a limiting role. Please refer to Figure 2 and Fig.13 , the iodine-125 patch of larger size will be placed between two material shifting rods 82 and four material blocking rods 9 before cutting, to prevent the iodine-125 patch from moving at will. In the present embodiment, the third drive assembly 81 comprises the third electric telescopic rod and a positioning plate, and the third electric telescopic rod is fixed on the inner wall of the assembly chamber 51 by the positioning plate, and the elongation and shortening of the third electric telescopic rod can drive the material shifting rod 82 to move in the horizontal direction. The bottom surface of the material shifting rod 82 is provided with an avoidance hole 821, so when the material shifting rod 82 on both sides moves, the third electric telescopic rod can pass through the avoidance hole 821, and the third electric telescopic rod will not interfere with the movement of the material shifting rod 82.

[0053] See also Figure 14-15 , after two strip patches of 5cm in width are all cut into the square of 5cm x 5cm, the 3rd driving assembly 81 on both sides drives two material shifting rods 82 to approach each other until they are fitted together. Subsequently, the first driving assembly 61 drives the two first blades 62 of the outermost side to move, and re-cuts and separates two strip patches of 5cm in width. On the width extension direction of the cutting table 5, two adjacent material blocking rods 9 are collinear, and the spacing is greater than 10cm, so the first blade 62 and the material blocking rod 9 will not interfere. Then two second cutting assemblies 7 continue to work, and continue to cut out the square patch of 5cm x 5cm. Only need to constantly repeat the above operation, the iodine-125 patch of the larger size of the top surface of the cutting table 5 will all be cut into the square of 5cmx 5cm, is convenient for the patient to apply.

[0054] See also Figure 2-4 and Fig.12 , the equipment for making patch also includes two second material moving assemblies 10, and the top surface of cutting table 5 is provided with two assembly holes 52, and two second material moving assemblies 10 are respectively arranged in two assembly holes 52. The second material moving assembly 10 includes the fourth drive assembly 101, transmission shaft 102 and material-pickling roller 103, and the fourth drive assembly 101 can drive transmission shaft 102 to rotate, and then drive the iodine-125 patch of elongated shape to be close to the second cutting assembly 7. In the present embodiment, the fourth drive assembly 101 includes the third motor, transmission belt, the first transmission wheel and the second transmission wheel. The third motor work can drive the first transmission wheel to rotate, and the first transmission wheel can drive the second transmission wheel to rotate by transmission belt, and the second transmission wheel can drive the material-pickling roller 103 to rotate by transmission shaft 102.

[0055] See also Figure 13-14 , after the iodine-125 patch of larger size is placed on the top surface of cutting platform 5, iodine-125 patch can cover assembly hole 52.After the iodine-125 patch of larger size cuts and separates two strip-shaped patches with a width of 5cm, the strip-shaped patch of 5cm can still cover assembly hole 52.The fourth drive assembly 101 works subsequently, and the rotation of material-pick roller 103 can drive the strip-shaped patch with a width of 5cm to approach the second cutting assembly 7.When the strip-shaped patch with a width of 5cm exceeds material-stopping rod 9, when the distance exceeded is just 5cm, the fourth drive assembly 101 stops working.The second cutting assembly 7 works subsequently, and the strip-shaped iodine-125 patch is cut into the square of 5cm x 5cm.

[0056] See also Fig.12 , the cross section of feeding roller 103 is oval, and the length and width of assembly hole 52 are all less than 5cm.When the iodine-125 patch of larger size covers assembly hole 52, the major axis of feeding roller 103 is in horizontal state, and now the top of feeding roller 103 is no more than the end surface of cutting platform 5, so the iodine-125 patch of larger size can not produce wrinkles, ensures the accuracy of cutting.When the fourth driving assembly 101 works, drives feeding roller 103 to rotate, the major axis of feeding roller 103 can rotate to vertical state, and the top of feeding roller 103 can exceed the end surface of cutting platform 5, so feeding roller 103 can drive iodine-125 patch near the second cutting assembly 7.

[0057] See also Figure 2-4 and Figure 13-14, the top surface of the cutting table 5 and between the assembly hole 52 and the adsorption box 72 are provided with a guide groove 53, and the bottom surface of the guide groove 53 near the adsorption box 72 side is tilted downward. When the second material moving assembly 10 drives the elongated patch with a width of 5cm to exceed the material blocking rod 9, the end of the elongated patch will enter the guide groove 53 and tilt downward. Once the elongated iodine-125 patch is cut into a square of 5cm x 5cm, the square patch cut off will slide downward along the inner wall of the guide groove 53, automatically completing the separation with the remaining elongated patch, and will not affect the subsequent cutting process.

[0058] See also Figure 2 , Figure 7-8 and Figure 13-16 The second cutting assembly 7 also includes an air extraction assembly 74, a sealing ring 75 and a blocking plate 76. The air extraction assembly 74 can make the adsorption box 72 absorb the cut 5cm x 5cm square patch. After the second driving assembly 71 drives the adsorption box 72 to rotate in the opposite direction, the square patch can be removed to facilitate the collection of the cut square patch. The sealing ring 75 and the blocking plate 76 can increase the air tightness around the adsorption box 72 to ensure that the adsorption box 72 can definitely absorb the square patch.

[0059] See also Figure 7-10 The interior of the adsorption box 72 is provided with an air storage cavity 721, a discharge groove 722 and a plurality of ventilation holes 723. The air extraction assembly 74 includes an air extraction pump 741, a ventilation hose 742 and an electrically controlled exhaust valve 743. When the square patch slides to the bottom of the guide groove 53, the air extraction pump 741 works to extract the air in the air storage cavity 721 through the ventilation hose 742, and the air in the guide groove 53 is also extracted through the ventilation holes 723. At this time, the square patch in the guide groove 53 will be sucked up and fit against the inner wall of the discharge groove 722. Please refer to Figure 14-16 , then the second drive assembly 71 drives the adsorption box 72 to rotate in the opposite direction. In the process, due to the atmospheric pressure, the square patch will not fall. When the position of the square patch is changed to upward, the air pump 741 stops working, the electric control exhaust valve 743 opens, and external air enters the air storage cavity 721, and the square patch is no longer adsorbed, and the square patch slides downward along the discharge chute 722 to leave the adsorption box 72, and the square iodine-125 patch of 5cm x 5cm can fall into the recovery box and be collected.

[0060] See also Figure 2 , Fig.11 and Figure 13-15The end of the material moving rod 82 close to the air pump 741 is provided with a bending portion 822. When the third driving assembly 81 drives the two material moving rods 82 to approach each other, the material moving rod 82 can avoid the air pump 741 through the bending portion 822. When the second driving assembly 71 drives the adsorption box 72 to rotate in the opposite direction, the ventilation hose 742 can move freely inside the bending portion 822, and the material moving rod 82 will not interfere with the ventilation hose 742.

[0061] See also Figure 7-10 , the sealing ring 75 is in a U-shaped structure, the discharge groove 722 is located at the inner side of the sealing ring 75, and the sealing ring 75 and the second blade 73 are enclosed together to form a ring-shaped structure. The blocking plate 76 adsorption box 72 is rotatably connected, and can completely cover the opening of the discharge groove 722 located on the end face of the adsorption box 72. When the adsorption box 72 rotates to a horizontal state, after the second blade 73 cuts the long strip of iodine-125 patch, the sealing ring 75 can close the space between the adsorption box 72 and the guide groove 53, and the blocking plate 76 can block the opening of the discharge groove 722 located on the end face of the adsorption box 72. Therefore, when the air pump 741 works, only the air in the air storage cavity 721 and the guide groove 53 will be sucked away, ensuring that the square patch will definitely be sucked up and fit with the inner wall of the discharge groove 722.

[0062] See also Figure 7-10 and Figure 14-16 The cross-sectional shape of the blocking plate 76 is triangular, and the end of the blocking plate 76 close to the second blade 73 is a wide head end, and a counterweight block 77 is fixedly provided at the wide head end of the blocking plate 76. When the second driving assembly 71 drives the adsorption box 72 to rotate in the opposite direction, the blocking plate 76 and the counterweight block 77 will shift their overall center of gravity, and under the action of inertia, the blocking plate 76 and the counterweight block 77 can automatically rotate away from the opening of the discharge trough 722 on the end surface of the adsorption box 72, ensuring that the 5 cm x 5 cm square iodine-125 patch inside the discharge trough 722 can slide smoothly and leave the adsorption box 72.

[0063] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0064] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. An iodine-125 patch, characterized in that: It includes a basement membrane layer, a radiation layer, a protective layer and an adhesive layer which are stacked in sequence and can be removed. The radiation layer includes a number of evenly distributed iodine-125 radioactive particles whose positions and quantities can be freely controlled, so as to achieve precise irradiation of the tumor surface.

2. The iodine-125 patch according to claim 1, characterized in that The base film layer is made of polyurethane or polyvinyl alcohol, and the thickness of the base film layer is 0.1 mm-0.3 mm.

3. The iodine-125 patch according to claim 1, characterized in that The diameter of the iodine-125 radioactive particles ranges from 0.5 mm to 1 mm.

4. The iodine-125 patch according to claim 1, characterized in that The material of the protective layer is polyvinyl fluoride or polyphenylene sulfide, and the thickness of the protective layer is 0.05mm-0.1mm.

5. The iodine-125 patch according to claim 1, characterized in that The material of the adhesive layer is a medical-grade water-soluble adhesive.

6. The iodine-125 patch according to claim 1, characterized in that The size of the iodine-125 patch is 5 cm x 5 cm.

7. A device for making a patch, for making the iodine-125 patch as claimed in claim 6, characterized in that: include: Cutting table; A first cutting assembly, the first cutting assembly comprises a first driving assembly and three first blades, the three first blades are all arranged above the cutting table and are arranged at equal intervals along the width extension direction of the cutting table, and the distance between two adjacent first blades is 5 cm, the first driving assembly is arranged above the first blade, the first driving assembly comprises three output ends, the three output ends of the first driving assembly are respectively connected to the three first blades, and are used to drive the first blades to move along the length extension direction of the cutting table and the height extension direction of the cutting table; Two second cutting assemblies are respectively arranged at the two ends of the length extension direction of the cutting table, the two second cutting assemblies are centrally symmetrical, the second cutting assembly is located between two adjacent first blades, the second cutting assembly includes a second driving assembly and an adsorption box, the first end of the adsorption box is rotatably connected to the top surface of the cutting table, the second end of the adsorption box is fixedly provided with a second blade, when the adsorption box is rotated to a horizontal state and the second end of the adsorption box is located above the cutting table, the second blade abuts against the top surface of the cutting table, the length extension direction of the second blade is the same as the width extension direction of the cutting table, the length of the second blade is greater than 5 cm, the second driving assembly is arranged on the top surface of the cutting table, and the output end of the second driving assembly is connected to the adsorption box for driving the adsorption box to rotate.

8. The device for making a patch according to claim 7, characterized in that: Also includes: Two first material moving assemblies, the two first material moving assemblies are respectively arranged at the two ends of the width extension direction of the cutting table, and the structure is centrally symmetrical, the first material moving assembly includes a third driving assembly and a material moving rod, the material moving rod is a ring-shaped structure, an assembly cavity is provided inside the cutting table, the assembly cavity runs through the two end surfaces of the length extension direction of the cutting table, the top of the material moving rod is arranged on the top surface of the cutting table and can slide along the top surface of the cutting table, the bottom of the material moving rod is arranged in the assembly cavity and can slide along the inner wall of the assembly cavity, the third driving assembly is arranged in the assembly cavity, and the output end of the third driving assembly is connected to the bottom of the material moving rod, which is used to drive the material moving rod to move along the width extension direction of the cutting table; Four material blocking rods are fixedly arranged at the four corners of the top surface of the cutting table, and are all located between the two material moving rods. In the width extension direction of the cutting table, two adjacent material blocking rods are collinear, and the spacing between them is greater than 10 cm. The bottom surface of the material moving rod is provided with an avoidance hole, and the avoidance hole matches the position of the material blocking rod.

9. The device for making a patch according to claim 8, characterized in that: It also includes two second material moving assemblies, the top surface of the cutting table is provided with two assembly holes, the assembly holes pass through the bottom surface of the cutting table, the two assembly holes are centrally symmetrical, the positions of the two assembly holes correspond to the positions of the two second cutting assemblies, the two second material moving assemblies are respectively arranged in the two assembly holes, the second material moving assembly includes a fourth driving assembly, a transmission shaft and a material removing roller, the transmission shaft is arranged at the top of the assembly hole, both ends of the transmission shaft are rotatably connected to the side walls of the assembly hole, the material removing roller is fixedly arranged in the middle of the transmission shaft, the fourth driving assembly is arranged below the assembly hole, the output end of the fourth driving assembly is connected to the transmission shaft, for driving the transmission shaft to rotate, the cross-section of the material removing roller is elliptical, and the length and width of the assembly hole are both less than 5cm.

10. The device for making a patch according to claim 9, characterized in that: A guide groove is provided on the top surface of the cutting table and between the assembly hole and the adsorption box, and the bottom surface of the guide groove close to the adsorption box is inclined downward; The second cutting assembly also includes: The suction component comprises an air storage cavity inside the adsorption box, and a discharge groove is provided on the end face of the adsorption box provided with the second blade. In the height direction of the adsorption box, the discharge groove is inclined toward the side away from the second blade and passes through the end face of the second end of the adsorption box. A plurality of ventilation holes are provided on the inner wall of the discharge groove on the side away from the second blade, and the ventilation holes are connected with the air storage cavity. The suction component comprises an air pump, a ventilation hose and an electrically controlled exhaust valve. The air pump is fixedly arranged on the top face of the cutting table, the air inlet end of the air pump is connected with the first end of the ventilation hose, and the second end of the ventilation hose is connected with the air storage cavity. The material moving rod is provided with a bending portion at one end close to the air pump, and the position of the bending portion corresponds to the position of the air pump. The electrically controlled exhaust valve is arranged on the end face of the adsorption box on the side away from the second blade, and the electrically controlled exhaust valve is connected with the air storage cavity. A sealing ring is arranged on a side of the second blade close to the vent hole and is fixedly connected to the adsorption box, the sealing ring is in a U-shaped structure, the discharge groove is located on the inner side of the sealing ring, and the sealing ring and the second blade are together surrounded to form a ring-shaped structure; A sealing plate is arranged on the end face of the second end of the adsorption box, and the sealing plate is rotatably connected to the adsorption box at one end away from the second blade. The sealing plate can completely cover the opening of the discharge trough on the end face of the second end of the adsorption box. The cross-sectional shape of the sealing plate is triangular, and the end of the sealing plate close to the second blade is a wide head end, and a counterweight block is fixedly provided on the wide head end of the sealing plate.

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