A vas deferens contraceptive device and its preparation method

Abstract

The application discloses a vas deferens contraceptive device and a preparation method thereof, and relates to the technical field of medical devices. The device comprises a tubular outer wall, the inside of the tubular outer wall is filled with a sperm blocking layer and a mechanical support layer, the sperm blocking structure is a pore structure that can block sperm, and the mechanical support structure is a three-period minimal surface structure. The combination of the two structures can prevent sperm from passing through the vas deferens while ensuring the normal passage of tissue fluid. The device is mainly prepared through three steps of model slice design, ink configuration, 3D printing and device post-processing. Compared with vasectomy, the vas deferens contraceptive device and the preparation method thereof can avoid complications and fertility damage caused by epididymal stasis, and the implantation of the device has a smaller incision than vasectomy and is convenient for processing and manufacturing.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a vas deferens contraceptive device and its preparation method. Background Technology

[0002] Currently, the primary method of long-term male contraception in clinical practice is vasectomy. This procedure works by surgically creating a physical barrier at the vas deferens, preventing sperm from passing through and thus achieving contraception. This method is highly effective and can be reversed through vasectomy reversal. However, vasectomy also prevents the flow of tissue fluid, causing it to accumulate in the epididymis, leading to increased pressure and swelling. This condition can easily result in complications such as hematoma, sperm granuloma, short-term postoperative pain, and chronic pain syndrome, all of which can affect the patient's quality of life. Furthermore, epididymal swelling can lead to decreased sperm motility, impaired chief cell function, and a significantly lower in vitro fertilization rate, thus damaging the patient's fertility. Even after vasectomy reversal, the pregnancy rate remains lower than in the general population, reducing the reversibility of the procedure.

[0003] Developing a vasectomy contraceptive device and its preparation method to optimize existing vasectomy techniques, which only prevents sperm from passing through while allowing normal flow of tissue fluid, avoids complications caused by epididymal congestion, protects the fertility of the patient, improves the reversibility of contraception, and enriches the options for male contraception, has become a technical problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0004] The purpose of this invention is to provide a vas deferens contraceptive device and its preparation method, thereby solving the problems listed in the background art.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0006] The present invention provides a vas deferens contraceptive device and its preparation method, comprising a tubular outer wall, wherein the interior of the tubular outer wall is filled with a sperm blocking layer and a mechanical support layer;

[0007] The mechanical support layer is combined with the sperm blocking layer in a certain form to ensure the stability of the device and to continuously block sperm.

[0008] Preferably, the outer diameter of the tubular outer wall is 500–2000 μm, the axial length of the tubular outer wall is 500–10000 μm, and the wall thickness of the tubular outer wall is 10–100 μm.

[0009] Preferably, the sperm barrier layer has a porous structure, and the radial cross-sectional shape of one of the channels is one or more of the following: circular, elliptical, triangular, quadrilateral, pentagonal, hexagonal, polygonal, or other irregular shapes whose maximum size is sufficient to block sperm from passing through. The channels are arranged in a straight line, curved, spiral, or other irregular shape along the axial direction.

[0010] Furthermore, the multiple channels are combined with arbitrary spacing and arbitrary arrangement.

[0011] The sperm-blocking layer has an axial length of 20–5000 μm along the tubular outer wall, and the radial cross-section of the channel has a size range of no more than 2–6 μm.

[0012] Preferably, the mechanical support layer is a three-period minimal surface structure, and the mechanical support layer is one or more of Schwarz-P, Diamond, Gyroid, and Split-P;

[0013] The total axial length of the mechanical support layer along the tubular outer wall is 150–9980 μm, the wall thickness of the mechanical support layer is 35–65 μm, the porosity is 50%–85%, and the unit cell size is 150–450 μm.

[0014] Preferably, the tubular outer wall, the sperm barrier layer, and the mechanical support layer are integrally printed using a polymer-based material;

[0015] The Young's modulus of the polymer-based material is 1 MPa to 10 GPa.

[0016] The polymer-based material is one or more of polymethyl methacrylate, polyurethane, polystyrene, polyethylene oxide, polydimethylsiloxane, and commercial printing ink.

[0017] A method for preparing a vas deferens contraceptive device includes the following steps:

[0018] S1. Design the radial slices of the vas deferens contraceptive device model;

[0019] S2. 3D printing is performed using polymer-based materials according to the slice design;

[0020] S3. The prepared device is deinked and then solidified to obtain the vas deferens contraceptive device.

[0021] Preferably, the slice design of the vas deferens contraceptive device model in step S1 has a thickness of 0.5-7 μm, a scan line width of 0.2-1.5 μm, and an inter-slice scan line angle difference of 0-90°.

[0022] Preferably, the core scanning rate of the 3D printing in step S2 is 10,000–500,000 μm / s, and the core laser power is 40–170 mW / cm². 2 ;

[0023] The mass fraction of the polymer-based material, excluding the printing ink, is 50% to 95%.

[0024] The initiator in step S2 is one or more of 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylacetone, lithium phenyl-2,4,6-trimethylbenzoylphosphonate, benzophenone and 2,4-dimethylthioxanthrone;

[0025] The initiator has a mass percentage of 0.01% to 1.5%.

[0026] Preferably, in step S3, the solvent used for deinking includes one or more of toluene, cyclohexanone, ethyl acetate, dichloromethane, propylene glycol methyl ether acetate, isopropanol, ethanol, and deionized water.

[0027] The post-curing treatment step in step S3 involves irradiating the device with ultraviolet light for 1 to 15 minutes.

[0028] Compared with the prior art, the beneficial technical effects of the present invention are as follows:

[0029] 1) The sperm-blocking structure can block sperm from passing through the vas deferens while allowing tissue fluid to pass through normally. This can avoid epididymal congestion caused by traditional vasectomy, as well as a series of complications and potential damage to fertility.

[0030] 2) The mechanical support structure in the vas deferens contraceptive device of the present invention can improve the fluid flow efficiency of the device, and at the same time give the device a certain resistance to pressure and shear, ensuring that the device can maintain structural integrity during surgery and the patient's activities.

[0031] 3) When implanting the vas deferens contraceptive device of the present invention, the surgical incision is smaller than that of vasectomy, and when contraception is reversed, only the contraceptive device needs to be removed surgically, and its success rate is higher than that of vasectomy reversal.

[0032] In summary, this invention only prevents sperm from passing through while allowing tissue fluid to flow normally, avoiding complications caused by epididymal congestion, protecting the patient's fertility, improving the reversibility of contraception, and enhancing the patient's quality of life. Attached Figure Description

[0033] The present invention will be further described below with reference to the accompanying drawings.

[0034] Figure 1 This is a schematic diagram of the vas deferens contraceptive device prepared according to Embodiment 1 of the present invention;

[0035] Figure 2 This is a schematic diagram of the vas deferens contraceptive device prepared according to Embodiment 2 of the present invention;

[0036] Figure 3 This is a schematic diagram of the vas deferens contraceptive device prepared according to Embodiment 3 of the present invention;

[0037] Figure 4 This is a schematic diagram of the vas deferens contraceptive device prepared according to Embodiment 4 of the present invention;

[0038] Figure 5 This is a schematic diagram of the vas deferens contraceptive device prepared according to Embodiment 5 of the present invention;

[0039] Figure 6 This is a schematic diagram of the vas deferens contraceptive device prepared according to Embodiment Six of the present invention;

[0040] Figure 7 This is a schematic diagram of the vas deferens contraceptive device prepared according to Comparative Example 1 of the present invention;

[0041] Figure 8 This is a schematic diagram of the vas deferens contraceptive device prepared in Comparative Example 2 of the present invention.

[0042] Explanation of reference numerals in the attached diagram: 1. Tubular outer wall; 2. Mechanical support layer; 3. Sperm barrier layer. Detailed Implementation

[0043] To make the technical problems to be solved, the technical solutions, and the beneficial effects of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0044] like Figure 1-8 As shown, a vas deferens contraceptive device includes a tubular outer wall, the interior of which is filled with a sperm-blocking layer and a mechanical support layer; the sperm-blocking layer is a channel with a maximum size of pores at a horizontal interface sufficient to prevent sperm from passing through.

[0045] The mechanical support layer is combined with the sperm blocking layer in a certain form to ensure the stability of the device and to continuously block sperm.

[0046] Specifically, the outer diameter of the tubular outer wall is 500–2000 μm, the axial length of the tubular outer wall is 500–10000 μm, and the wall thickness of the tubular outer wall is 10–100 μm.

[0047] Specifically, the sperm barrier layer has a porous structure, and the radial cross-sectional shape of one of the channels is one or more of the following: circular, elliptical, triangular, quadrilateral, pentagonal, hexagonal, polygonal, or other irregular shapes whose maximum size is sufficient to block sperm from passing through. The channels are arranged in a straight line, curved, spiral, or other irregular shape along the axial direction, and are more preferably hexagonal.

[0048] Furthermore, the multiple channels are combined with arbitrary spacing and arbitrary arrangement.

[0049] The sperm-blocking layer has an axial length of 20–500 μm along the tubular outer wall, and is further selected from 100–400 μm; the radial cross-section of the channel has a size range of no more than 2–6 μm, and is further selected from 3–5 μm.

[0050] Specifically, the mechanical support layer is a three-period minimal surface structure, and the mechanical support layer is one or more of Schwarz-P, Diamond, Gyroid, and Split-P, with Schwarz-P and Diamond structures preferred.

[0051] The total axial length of the mechanical support layer along the tubular outer wall is 150–9980 μm, the wall thickness of the mechanical support layer is 35–65 μm, more preferably 40–60 μm, the porosity is 50%–85%, more preferably 60%–75%, and the unit cell size is 150–450 μm, more preferably 200–400 μm.

[0052] Specifically, the tubular outer wall, the sperm barrier layer, and the mechanical support layer are integrally printed using a polymer-based material;

[0053] The Young's modulus of the polymer-based material is 1 MPa to 10 GPa.

[0054] The polymer-based material is one or more of polymethyl methacrylate (PMMA), polyurethane (PU), polystyrene (PS), polyethylene oxide (PEO), polydimethylsiloxane (PDMS), and commercial printing inks.

[0055] A method for preparing a vas deferens contraceptive device includes the following steps:

[0056] S1. Design the radial slices of the vas deferens contraceptive device model;

[0057] S2. 3D printing is performed using polymer-based materials according to the slice design;

[0058] S3. The prepared device is deinked and then solidified to obtain the vas deferens contraceptive device.

[0059] Specifically, the slice thickness of the vas deferens contraceptive device model described in step S1 is designed to be 0.2–10 μm, the scan line width is 0.1–2 μm, and the inter-slice scan line angle difference is 0–90°.

[0060] Furthermore, the slices of the vas deferens contraceptive device model were designed with a thickness of 0.5–7 μm, a scan line width of 0.2–1.5 μm, and an inter-slice scan line angle difference of 0–45°.

[0061] Furthermore, the slices of the vas deferens contraceptive device model were designed with a thickness of 0.5–5 μm, a scan line width of 0.5–1.0 μm, and an inter-slice scan line angle difference of 0–30°.

[0062] Specifically, the core scanning rate of 3D printing in step S2 is 10,000 to 500,000 μm / s, and can be further selected as 50,000 to 40,000 μm / s, or even 100,000 to 350,000 μm / s.

[0063] The core laser power is 40–170 mW / cm². 2 Further selection of 50-150mW / cm 2 It can also be selected from 60 to 120 mW / cm 2 ;

[0064] The polymer-based material, excluding the printing ink, has a mass fraction of 50% to 95%; further, the polymer-based material, excluding the printing ink, has a mass fraction of 60% to 95%, and even more specifically, 75% to 95%.

[0065] The initiator in step S2 is one or more of 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylacetone, lithium phenyl-2,4,6-trimethylbenzoylphosphonate, benzophenone and 2,4-dimethylthioxanthrone;

[0066] The initiator has a mass percentage of 0.01% to 1.5%, and more preferably 0.05% to 1.2%, and even more preferably 0.1% to 1%.

[0067] The fluorescent dye in the printing ink is fluorescein isothiocyanate, and the concentration is prepared to be 0.1-1 mg / mL. The printing ink uses IP-S (commercial photosensitive resin, acrylic derivative, Nanoscribe).

[0068] Specifically, in step S3, the solvents used for deinking include one or more of toluene, cyclohexanone, ethyl acetate, dichloromethane, propylene glycol methyl ether acetate, isopropanol, ethanol, and deionized water.

[0069] The post-curing treatment step in step S3 involves irradiating the device with ultraviolet light for 1 to 15 minutes, preferably 1 to 10 minutes, and more preferably 2 to 7 minutes.

[0070] Example 1

[0071] Modeling software is used to create the device model, such as... Figure 1 As shown, the mechanical support layer 2 adopts a Schwarz-P structure, and the sperm blocking layer 3 adopts a regular hexagonal channel;

[0072] The device dimensions are a = 3000; b = 1400; c = 200; d = 1400; e = 50; f = 6.54; g = 8.66; h = 15; i = 300; j = 45~55; k = 1000, in μm.

[0073] After building the model, save it in STL format;

[0074] The model was sliced ​​using 3D printing matching slicing software. The slicing mode was fixed, the slice thickness was 2μm, the scan line width was 1μm, the interlayer angle difference was 0°, and the slice file was saved.

[0075] Using commercial printing ink (IP-S) as raw material, a two-photon micro-nano printer was used, with a scanning rate of 290,000 μm / s and a core laser power of 100 mW / cm². 2 Print the imported slice file;

[0076] The printed device was soaked in propylene glycol methyl ether acetate, isopropanol and deionized water in sequence to remove excess ink, and then the device was irradiated under ultraviolet light for 5 minutes for a re-curing step. After drying the device, the vas deferens contraceptive device was obtained.

[0077] Example 2

[0078] Modeling software is used to create the device model, such as... Figure 2 As shown, the mechanical support layer 2 adopts a diamond structure, and the sperm blocking layer 3 adopts a circular channel;

[0079] The device dimensions are a = 500; b = 30; c = 20; d = 450; e = 10; f = 2; g = 3; h = 5; i = 35~45; j = 150; k = 500, in μm.

[0080] After building the model, save it in STL format;

[0081] The model was sliced ​​using 3D printing matching slicing software in adaptive mode, with a slice thickness of 0.5–3 μm, a scan line width of 0.2 μm, and an interlayer angle difference of 15°. The sliced ​​file was then saved.

[0082] Ink was prepared using PMMA as the raw material, comprising 50% PMMA (mass fraction, same below), 0.01% 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylacetone, and 49.99% dichloromethane. 0.1 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro / nano printer was used, with a scanning rate of 10000 μm / s and a core laser power of 40 mW / cm². 2 Print the imported slice file.

[0083] The printed device was soaked in dichloromethane to remove excess ink, and then irradiated under a UV lamp for 1 minute for a re-curing step. After drying, the vas deferens contraceptive device was obtained.

[0084] Example 3

[0085] Modeling software is used to create the device model, such as... Figure 3 As shown, the mechanical support layer 2 adopts a Gyroid structure, and the sperm blocking layer 3 adopts an equilateral triangular channel.

[0086] The device dimensions are a = 2000; b = 350; c = 1500; d = 150; e = 25; f = 3; g = 5; h = 9; i = 200; j = 45~55; k = 700, in μm.

[0087] After building the model, save it in STL format;

[0088] The model was sliced ​​using 3D printing matching slicing software. The slicing mode was adaptive, the slice thickness was 1-5 μm, the scan line width was 0.6 μm, the interlayer angle difference was 30°, and the slice file was saved.

[0089] Ink was prepared using PU as the raw material, comprising 60% PU (mass fraction, same below), 0.4% lithium phenyl 2,4,6-trimethylbenzoylphosphonate, and 39.6% ethyl acetate. 0.3 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro / nano printer was used, with a scanning rate of 100,000 μm / s and a core laser power of 80 mW / cm². 2 Print the imported slice file.

[0090] The printed device was soaked in ethyl acetate to remove excess ink, and then irradiated under a UV lamp for 3 minutes for a re-curing step. After drying, the vas deferens contraceptive device was obtained.

[0091] Example 4

[0092] Modeling software is used to create the device model, such as... Figure 4 As shown, the mechanical support layer 2 adopts a Split-P structure, and the sperm blocking layer 3 adopts a square channel;

[0093] The device dimensions are a = 5000; b = 550; c = 375; d = 700; e = 2625; f = 950; g = 65; h = 4; i = 6; j = 10; k = 45~55; l = 250; m = 750, with units in μm.

[0094] After building the model, save it in STL format;

[0095] The model was sliced ​​using 3D printing matching slicing software in adaptive mode, with a slice thickness of 3-5 μm, a scan line width of 1.2 μm, and an interlayer angle difference of 45°. The sliced ​​file was then saved.

[0096] Ink was prepared using PEO as the raw material, comprising 70% PEO (mass fraction, same below), 0.8% benzophenone, and 29.2% deionized water. 0.5 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro / nano printer was used, with a scanning rate of 200,000 μm / s and a core laser power of 120 mW / cm². 2 Print the imported slice file.

[0097] The printed device was soaked in ethanol and deionized water sequentially to remove excess ink, and then irradiated under ultraviolet light for 7 minutes for a re-curing step. After drying, the vas deferens contraceptive device was obtained.

[0098] Example 5

[0099] Modeling software is used to create the device model, such as... Figure 5 As shown, the mechanical support layer 2 adopts a Schwarz-P structure, and the sperm blocking layer 3 adopts an elliptical channel.

[0100] Device dimensions: a = 10000; b = 330; c = 500; d = 660; e = 1000; f = 990; g = 1500; h = 1320; i = 2000; j = 1700; k = 100; l = 3; m = 5; n = 11; o = 6; p = 450; q = 55~65; r = 2000, in μm.

[0101] After building the model, save it in STL format;

[0102] The model was sliced ​​using 3D printing matching slicing software. The slicing mode was adaptive, the slice thickness was 5-6 μm, the scan line width was 1.5 μm, the interlayer angle difference was 60°, and the slice file was saved.

[0103] Ink was prepared using PS as the raw material, comprising 80% PS (mass fraction, same below), 1.2% benzophenone, and 18.8% toluene. 0.7 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro / nano printer was used, with a scanning rate of 400,000 μm / s and a core laser power of 150 mW / cm². 2 Print the imported slice file.

[0104] The printed device was sequentially soaked in toluene and cyclohexanone to remove excess ink, and then irradiated under ultraviolet light for 10 minutes for a re-curing step. After drying, the vas deferens contraceptive device was obtained.

[0105] Example 6

[0106] Modeling software is used to create the device model, such as... Figure 6 As shown, the mechanical support layer 2 adopts a Schwarz-P structure, and the sperm blocking layer 3 adopts a regular pentagonal channel;

[0107] The device dimensions are a = 7500; b = 350; c = 660; d = 700; e = 1320; f = 1050; g = 2020; h = 1400; i = 65; j = 5; k = 7; l = 11; m = 55~65; n = 400; o = 1250, in μm.

[0108] After building the model, save it in STL format;

[0109] The model was sliced ​​using 3D printing matching slicing software. The slicing mode was adaptive, the slice thickness was 7μm, the scan line width was 1.5μm, the interlayer angle difference was 90°, and the slice file was saved.

[0110] Ink was prepared using PDMS as the raw material, comprising 95% PDMS (mass fraction, same below), 1.5% 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylacetone, and 3.5% dichloromethane. 1 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro / nano printer was used, with a scanning rate of 500,000 μm / s and a core laser power of 170 mW / cm². 2 Print the imported slice file.

[0111] The printed device was sequentially soaked in dichloromethane to remove excess ink, and then irradiated under ultraviolet light for 15 minutes for a re-curing step. After drying, the vas deferens contraceptive device was obtained.

[0112] Comparative Example 1

[0113] The difference from Embodiment 1 is that the entire device is a sperm-blocking structure, and the device model is as follows: Figure 7 As shown.

[0114] The difference between Comparative Example 2 and Example 1 is that the entire device is a mechanical barrier structure, and the device model is as follows: Figure 8 As shown.

[0115] The devices prepared in Examples 1-6 and Comparative Examples 1-2 were tested and evaluated in the vas deferens of mice, and the results are shown below:

[0116] Examples 1-6 effectively blocked sperm from passing through the vas deferens in vivo while allowing tissue fluid to pass through. Three months after implantation in mice, no swelling of the epididymis was observed, and the mice's reproductive capacity was not significantly impaired. Furthermore, Examples 1-6 maintained structural integrity even under pressure from surgery and normal mouse activity.

[0117] Comparative Example 1, due to having only a sperm-blocking structure, exhibits very low liquid permeability during fluid simulations. Furthermore, mechanical simulations indicate that this structure may lose its structural integrity when subjected to compression caused by surgery or normal mouse activity.

[0118] Comparative Example 2, having only a mechanical support structure, does not have the function of blocking sperm.

[0119] As can be seen from the above embodiments, the vas deferens contraceptive device and its preparation method provided by the present invention, wherein the sperm blocking structure can block sperm passage while allowing tissue fluid to pass through the vas deferens, thereby avoiding complications and fertility damage caused by epididymal congestion; the mechanical support structure can improve the fluid flow efficiency of the device while giving the device a certain degree of pressure resistance, ensuring that the device can maintain its structural integrity without damage during surgery and patient activity. Compared with existing vasectomy, the vas deferens contraceptive device can avoid related complications and protect the patient's fertility, improve the reversibility of ligation, and, due to its small size, the surgical incision caused by the device is smaller than that of vasectomy.

[0120] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0121] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A vas deferens contraceptive device comprising a tubular outer wall, characterised in that: The inside of the tubular outer wall is filled with a sperm barrier layer and a mechanical support layer; The mechanical support layer is combined with the sperm barrier layer in a certain form to ensure that the device is stable and continuously blocks sperm; The outer diameter of the tubular outer wall is 500-2000 μm, the axial length of the tubular outer wall is 500-10000 μm, and the wall thickness of the tubular outer wall is 10-100 μm; The sperm barrier layer is a porous channel structure, the radial cross-sectional shape of one of the channels is one or more of a circle, an ellipse, a triangle, a quadrilateral, a pentagon, a hexagon, a polygon, or other irregular shape with a maximum size sufficient to block sperm from passing through, and the channels are arranged in a straight line, a curve, a spiral, or other irregular shape along the axial direction; And a plurality of the channels are combined in any spacing and any arrangement; The axial length of the sperm barrier layer along the tubular outer wall is 20-5000 μm, and the size of the radial cross-section of the channel is in the range of not more than 2-6 μm; The mechanical support layer is a three-period minimal surface structure, and the mechanical support layer is one or more of Schwarz-P, Diamond, Gyroid, and Split-P; The total axial length of the mechanical support layer along the tubular outer wall is 150-9980 μm, the wall thickness of the mechanical support layer is 35-65 μm, the porosity is 50%-85%, and the unit cell size is 150-450 μm.

2. A vas deferens contraceptive device according to claim 1, wherein: The tubular outer wall, the sperm barrier layer, and the mechanical support layer are integrally printed using a high polymer-based material; The Young's modulus of the high polymer-based material is 1 MPa-10 GPa; The high polymer-based material uses one or more of polymethyl methacrylate, polyurethane, polystyrene, polyethylene oxide, polydimethylsiloxane, and commercial printing ink.

3. A method of manufacturing a vasectomy device for manufacturing a vasectomy device according to any one of claims 1-2, characterized in that: Comprising the following steps: S1, slicing design of the vas deferens contraceptive device model along the radial direction; S2, 3D printing using a high polymer-based material according to the slicing design; S3, deinking and resolidification of the device prepared, to obtain the vas deferens contraceptive device.

4. A method of making a vas deferens contraceptive device according to claim 3, wherein: The thickness of the slicing design of the vas deferens contraceptive device model in step S1 is 0.5-7 μm, the scanning line width is 0.2-1.5 μm, and the interlayer scanning line angle difference is 0-90°.

5. The method of claim 3, wherein the method further comprises the step of:

5. coating the device with a biocompatible material. The core scanning rate of the 3D printing in step S2 is 10000-500000 μm / s, and the core laser power is 40-170 mW / cm2; The mass fraction of the high polymer-based material other than the printing ink is 50%-95%; The initiator in step S2 is one or more of 2-hydroxy-4-(2-hydroxyethoxy)-2-methylbenzophenone, lithium phenyl-2,4,6-trimethylbenzoylphosphinate, benzophenone, and 2,4-dimethylthioxanthone; The mass percentage of the initiator is 0.01%-1.5%.

6. A method of making a vas deferens contraceptive device according to claim 3, wherein: In step S3, the solvent used for deinking includes one or more of toluene, cyclohexanone, ethyl acetate, dichloromethane, propylene glycol methyl ether acetate, isopropyl alcohol, ethanol, and deionized water; The post-curing finishing step in step S3 is irradiation of the device with ultraviolet light for 1 to 15 minutes.

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