A chewable tablet suitable for people with diabetes and pulmonary nodules and its production process

Abstract

The present invention discloses a chewable tablet and a production process suitable for people with diabetes and lung nodules, and relates to the field of health care technology. The chewable tablet and the production process suitable for people with diabetes and lung nodules include five steps: washing and extracting, mixing and processing, freeze drying, crushing and sterilizing, and tableting. The chewable tablet suitable for people with diabetes and lung nodules has good effects of dispersing nodules and swelling, resolving phlegm, relieving cough, warming and resolving cold phlegm, and lowering blood sugar, so that the chewable tablet is more suitable for people with diabetes and lung nodules to eat, and it is also more convenient to eat. At the same time, the freezing method is used for drying during the processing process, which can maximize the retention of the effect of Chinese medicinal materials, reduce the loss of drug efficacy, and improve the reliability of the use of the chewable tablet. Secondly, it can help or improve the neurological dysfunction and complications caused by diabetes.

Description

Technical Field

[0001] The invention relates to the technical field of health care, and in particular to a chewable tablet suitable for people with diabetes and lung nodules and a production process. Background Art

[0002] Chinese patent document CN101444245A discloses a mulberry leaf chewable tablet with hypoglycemic effect, which is composed of the following raw materials in parts by weight: 1-10 parts of fine powder extract; 10-80 parts of pharmaceutical excipients; 1-30 parts of xylitol. The fine powder extract refers to: the dried clean mulberry leaves are decocted in water, concentrated, centrifuged at high speed, the centrifuge liquid is adsorbed by resin, then eluted with 85% ethanol, precipitated with alcohol, vacuum dried after precipitation and dehydration, crushed, sieved and spray dried to obtain a mulberry leaf fine powder extract with a total flavonoid content of not less than 20%. The mulberry leaf chewable tablet of the present invention can effectively control the increase of blood sugar without insulin metabolism, and provides a good clinical medicine for diabetic patients.

[0003] The above-mentioned mulberry leaf chewable tablet with hypoglycemic effect can only control the patient's blood sugar increase, and cannot help or improve the complications caused by diabetes. In addition, the efficacy of the chewable tablet is relatively single, resulting in a small scope of application. Therefore, a chewable tablet and production process suitable for people with diabetes and lung nodules are proposed. Summary of the invention

[0004] The purpose of the present invention is to provide a chewable tablet and a production process suitable for people with diabetes and lung nodules, so as to solve the problem that the complications caused by diabetes cannot be helped or improved and the effect of the chewable tablet is relatively single.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solution: a chewable tablet suitable for people with diabetes and lung nodules, comprising the following formula raw materials: 24-30 parts of traditional Chinese medicine, 80-90 parts of dextrin, 8-10 parts of polyvinyl pyrrolidone, 4-6 parts of magnesium stearate, 3-5 parts of aspartame, 3-5 parts of orange flavor, 4-6 parts of mannitol and 8-10 parts of vitamins.

[0006] Preferably, the Chinese medicine comprises the following formula ingredients: 4-6 parts of Prunella Vulgaris, 5-7 parts of Cat's Claw, 3-5 parts of Poria, 5-7 parts of Astragalus, 3-5 parts of Cassia Twig and 4-6 parts of Licorice.

[0007] Preferably, the vitamins include the following formula ingredients: 3-3.5 parts of B12 vitamin, 1-1.5 parts of vitamin C, 2-2.5 parts of vitamin D and 2-2.5 parts of vitamin E.

[0008] A chewable tablet production process suitable for people with diabetes and pulmonary nodules, comprising the following steps:

[0009] Step 1, washing and extraction: washing corresponding amounts of Prunella vulgaris, cat's claw, Poria cocos, Astragalus, cinnamon twig and licorice by water, and trying not to damage their surface pieces and rhizomes during the washing process, and then extracting the raw materials by carbon dioxide quenching process to obtain Chinese medicine extracts, and then filtering the Chinese medicine extracts by using a filter;

[0010] Step 2, mixing processing: adding the corresponding portions of dextrin, polyvinyl pyrrolidone and magnesium stearate in step 2 to a blender, then adding the Chinese medicine extract in step 1 to the blender, controlling the start of the blender, and the speed of the blender shaft is 500-600r / min, while raising the temperature inside the blender to 60-70 degrees Celsius, and the stirring time is controlled to 20-30min, then adding the corresponding portions of aspartame, mannitol and vitamins to the blender, then reducing the speed of the blender shaft to 200-300r / min, then reducing the temperature inside the blender to 50-60 degrees Celsius, and then stirring for 17-25min to obtain a pasty raw material;

[0011] Step 3, freeze drying: adding the paste material obtained in step 2 into a vacuum freeze dryer, which quickly freezes the paste material into a solid. Under a vacuum environment, the frozen water molecules directly sublimate into water vapor and escape. During the process, the water vapor is automatically condensed through a water vapor condenser in the vacuum system to obtain a dry solid substance.

[0012] Step 4, crushing and sterilizing: the solid material obtained in step 3 is put into a crushing device for crushing. After the crushing is completed, the powder can be obtained and collected, and then the powder is spread on a tray, and then the tray is placed in a powder sterilizer to sterilize the powder;

[0013] Step 5, tableting: The sterilized powder in step 4 is tableted using a tablet press to obtain a chewable tablet production process suitable for people with diabetes and lung nodules.

[0014] Preferably, in the step 1, the number of filter meshes inside the filter is controlled at 80-100.

[0015] Preferably, before the paste material in step 3 is added to the vacuum freeze dryer, it needs to be placed in a cool and ventilated place for natural cooling to prevent the paste material from being too high and causing an increase in freezing energy consumption.

[0016] Preferably, the powder sterilizer in step 4 is a dry heat sterilizer.

[0017] Preferably, the sterilization process of the medicinal powder in step 4 is divided into three stages, the temperature of the first stage is 160-170 degrees Celsius and maintained for 120-130 minutes, the temperature of the second stage is 170-180 degrees Celsius and maintained for 60 minutes, and the temperature of the third stage is 240-250 degrees Celsius and maintained for 45-50 minutes.

[0018] Preferably, after the sterilization of the medicine powder in the tray in step 4 is completed, the tray needs to be placed in a cool, windless and dry place for natural cooling, so that the subsequent processing of the medicine powder in the tray is convenient.

[0019] The chewable tablets of the present invention are suitable for use by people with diabetes and lung nodules: twice a day, 3 to 5 tablets each time, for three consecutive months, and a satisfactory effect is achieved during the course of treatment.

[0020] Beneficial Effects

[0021] Compared with the prior art, the present invention provides a chewable tablet and a production process suitable for people with diabetes and pulmonary nodules, which has the following beneficial effects:

[0022] 1. The chewable tablets suitable for people with diabetes and lung nodules have good effects of dispersing nodules and reducing swelling, resolving phlegm, relieving cough, warming and resolving cold phlegm and lowering blood sugar by reasonably matching various Chinese medicinal materials, making the chewable tablets more suitable for people with diabetes and lung nodules to eat, and more convenient to eat. At the same time, the freezing method is used for drying during the processing process, which can retain the effects of the Chinese medicinal materials to the maximum extent, reduce the loss of drug efficacy, and improve the reliability of the use of the chewable tablets.

[0023] 2. The chewable tablets suitable for people with diabetes and lung nodules contain added vitamin B12, vitamin C, vitamin D and vitamin E. Vitamin B12 can promote the health of the nervous system, help improve nerve function problems caused by diabetes, and help slow the progression of neuropathy. Both vitamin C and vitamin D have strong antioxidant properties and can resist damage from free radicals, thereby helping to prevent chronic complications related to diabetes. At the same time, vitamin D supplementation can promote calcium absorption and utilization, enhance bone density, and also help improve blood sugar control and reduce the risk of cardiovascular disease and microvascular complications, thereby improving the effectiveness of the chewable tablets. DETAILED DESCRIPTION

[0024] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Embodiment 1:

[0026] A chewable tablet suitable for people with diabetes and lung nodules, comprising the following formula raw materials: 24 parts of traditional Chinese medicine, 80 parts of dextrin, 8 parts of polyvinyl pyrrolidone, 4 parts of magnesium stearate, 3 parts of aspartame, 3 parts of orange flavor, 4 parts of mannitol and 8 parts of vitamins. The traditional Chinese medicine comprises the following formula raw materials: 4 parts of selfheal, 5 parts of cat's claw, 3 parts of polia crus, 5 parts of astragalus, 3 parts of cassia twig and 4 parts of licorice. The vitamins comprise the following formula raw materials: 3 parts of B12 vitamin, 1 part of vitamin C, 2 parts of vitamin D and 2 parts of vitamin E.

[0027] A chewable tablet production process suitable for people with diabetes and pulmonary nodules, comprising the following steps:

[0028] Step 1, washing and extraction: washing corresponding amounts of Prunella vulgaris, cat's claw, Poria, Astragalus, Cinnamon twig and Licorice by water, and trying not to damage their surface sheets and rhizomes during the washing process, and then extracting the raw materials by carbon dioxide quenching process to obtain Chinese medicine extracts, and then filtering the Chinese medicine extracts by using a filter, and the number of filter meshes inside the filter in step 1 is controlled at 80;

[0029] Step 2, mixing processing: adding corresponding portions of dextrin, polyvinyl pyrrolidone and magnesium stearate in step 2 to a blender, then adding the Chinese herbal extract in step 1 to the blender, controlling the start of the blender, and the speed of the blender shaft is 500r / min, while raising the temperature inside the blender to 60 degrees Celsius, and the stirring time is controlled to 20min, then adding corresponding portions of aspartame, mannitol and vitamins to the blender, then reducing the speed of the blender shaft to 200r / min, then reducing the temperature inside the blender to 50 degrees Celsius, and then stirring for 17min to obtain a pasty raw material;

[0030] Step 3, freeze drying: the paste material obtained in step 2 is added into a vacuum freeze dryer, and the vacuum freeze dryer quickly freezes the paste material into a solid. Under the vacuum environment, the frozen water molecules are directly sublimated into water vapor and escape. During the process, the water vapor is automatically condensed through the water vapor condenser in the vacuum system to obtain a dry solid substance. Before the paste material in step 3 is added into the vacuum freeze dryer, it needs to be placed in a cool and ventilated place for natural cooling;

[0031] Step 4, crushing and sterilizing: the solid material obtained in step 3 is put into the crushing equipment for crushing treatment. After the crushing is completed, the powder can be obtained and collected, and then the powder is spread on the tray, and the tray is immediately placed in the powder sterilizer to sterilize the powder. The powder sterilizer in step 4 adopts a dry heat sterilizer. The sterilization process of the powder in step 4 is divided into three stages. The temperature of the first stage is 160 degrees Celsius and maintained for 120 minutes, the temperature of the second stage is 170 degrees Celsius and maintained for 60 minutes, and the temperature of the third stage is 240 degrees Celsius and maintained for 45 minutes. After the sterilization of the powder in the tray in step 4 is completed, the tray needs to be placed in a cool, windless and dry place for natural cooling;

[0032] Step 5, tableting: The sterilized powder in step 4 is tableted using a tablet press to obtain a chewable tablet production process suitable for people with diabetes and lung nodules.

[0033] Embodiment 2:

[0034] A chewable tablet suitable for people with diabetes and lung nodules, comprising the following formula raw materials: 27 parts of traditional Chinese medicine, 85 parts of dextrin, 9 parts of polyvinyl pyrrolidone, 5 parts of magnesium stearate, 4 parts of aspartame, 4 parts of orange flavor, 5 parts of mannitol and 9 parts of vitamins. The traditional Chinese medicine comprises the following formula raw materials: 5 parts of selfheal, 6 parts of cat's claw, 4 parts of polia crus, 6 parts of astragalus, 4 parts of cassia twig and 5 parts of liquorice. The vitamins comprise the following formula raw materials: 3.25 parts of B12 vitamin, 1.25 parts of vitamin C, 2.25 parts of vitamin D and 2.25 parts of vitamin E.

[0035] A chewable tablet production process suitable for people with diabetes and pulmonary nodules, comprising the following steps:

[0036] Step 1, washing and extraction: washing corresponding amounts of Prunella vulgaris, cat's claw, Poria, Astragalus, cinnamon twig and licorice by water, and trying not to damage the surface and rhizome during the washing process, and then extracting the raw materials by carbon dioxide quenching process to obtain the Chinese medicine extract, and then filtering the Chinese medicine extract by using a filter, and the number of filter meshes inside the filter in step 1 is controlled at 90;

[0037] Step 2, mixing processing: adding corresponding portions of dextrin, polyvinyl pyrrolidone and magnesium stearate in step 2 to a blender, then adding the Chinese herbal extract in step 1 to the blender, controlling the start of the blender, and the speed of the blender shaft is 550 r / min, while raising the temperature inside the blender to 65 degrees Celsius, and the stirring time is controlled to 25 minutes, then adding corresponding portions of aspartame, mannitol and vitamins to the blender, then reducing the speed of the blender shaft to 250 r / min, then reducing the temperature inside the blender to 55 degrees Celsius, and then stirring for 21 minutes to obtain a pasty raw material;

[0038] Step 3, freeze drying: the paste material obtained in step 2 is added into a vacuum freeze dryer, and the vacuum freeze dryer quickly freezes the paste material into a solid. Under the vacuum environment, the frozen water molecules are directly sublimated into water vapor and escape. During the process, the water vapor is automatically condensed through the water vapor condenser in the vacuum system to obtain a dry solid substance. Before the paste material in step 3 is added into the vacuum freeze dryer, it needs to be placed in a cool and ventilated place for natural cooling;

[0039] Step 4, crushing and sterilizing: the solid material obtained in step 3 is put into the crushing equipment for crushing treatment. After the crushing is completed, the powder can be obtained and collected, and then the powder is spread on the tray, and the tray is immediately placed in the powder sterilizer to sterilize the powder. The powder sterilizer in step 4 adopts a dry heat sterilizer. The sterilization process of the powder in step 4 is divided into three stages. The temperature of the first stage is 165 degrees Celsius and maintained for 125 minutes, the temperature of the second stage is 175 degrees Celsius and maintained for 60 minutes, and the temperature of the third stage is 245 degrees Celsius and maintained for 47 minutes. After the sterilization of the powder in the tray in step 4 is completed, the tray needs to be placed in a cool, windless and dry place for natural cooling;

[0040] Step 5, tableting: The sterilized powder in step 4 is tableted using a tablet press to obtain a chewable tablet production process suitable for people with diabetes and lung nodules.

[0041] Embodiment three:

[0042] A chewable tablet suitable for people with diabetes and lung nodules, comprising the following formula raw materials: 30 parts of traditional Chinese medicine, 90 parts of dextrin, 10 parts of polyvinyl pyrrolidone, 6 parts of magnesium stearate, 5 parts of aspartame, 5 parts of orange flavor, 6 parts of mannitol and 10 parts of vitamins. The traditional Chinese medicine comprises the following formula raw materials: 6 parts of selfheal, 7 parts of cat's claw, 5 parts of polia corydalis, 7 parts of astragalus, 5 parts of cassia twig and 6 parts of licorice. The vitamins comprise the following formula raw materials: 3.5 parts of B12 vitamin, 1.5 parts of vitamin C, 2.5 parts of vitamin D and 2.5 parts of vitamin E.

[0043] A chewable tablet production process suitable for people with diabetes and pulmonary nodules, comprising the following steps:

[0044] Step 1, washing and extraction: washing corresponding amounts of Prunella vulgaris, cat's claw, Poria, Astragalus, Cinnamon twig and Licorice by water, and trying not to damage their surface sheets and rhizomes during the washing process, and then extracting the raw materials by carbon dioxide quenching process to obtain Chinese medicine extracts, and then filtering the Chinese medicine extracts by using a filter, and the number of filter meshes inside the filter in step 1 is controlled to be 100;

[0045] Step 2, mixing processing: adding corresponding portions of dextrin, polyvinyl pyrrolidone and magnesium stearate in step 2 to a blender, then adding the Chinese herbal extract in step 1 to the blender, controlling the start of the blender, and the speed of the blender shaft is 600r / min, while raising the temperature inside the blender to 70 degrees Celsius, and the stirring time is controlled to 30min, then adding corresponding portions of aspartame, mannitol and vitamins to the blender, then reducing the speed of the blender shaft to 300r / min, then reducing the temperature inside the blender to 60 degrees Celsius, and then stirring for 25min to obtain a pasty raw material;

[0046] Step 3, freeze drying: the paste material obtained in step 2 is added into a vacuum freeze dryer, and the vacuum freeze dryer quickly freezes the paste material into a solid. Under the vacuum environment, the frozen water molecules are directly sublimated into water vapor and escape. During the process, the water vapor is automatically condensed through the water vapor condenser in the vacuum system to obtain a dry solid substance. Before the paste material in step 3 is added into the vacuum freeze dryer, it needs to be placed in a cool and ventilated place for natural cooling;

[0047] Step 4, crushing and sterilizing: the solid material obtained in step 3 is put into the crushing equipment for crushing treatment. After the crushing is completed, the powder can be obtained and collected, and then the powder is spread on the tray, and the tray is immediately placed in the powder sterilizer to sterilize the powder. The powder sterilizer in step 4 adopts a dry heat sterilizer. The sterilization process of the powder in step 4 is divided into three stages. The temperature of the first stage is 170 degrees Celsius and maintained for 130 minutes, the temperature of the second stage is 180 degrees Celsius and maintained for 60 minutes, and the temperature of the third stage is 250 degrees Celsius and maintained for 50 minutes. After the sterilization of the powder in the tray in step 4 is completed, the tray needs to be placed in a cool, windless and dry place for natural cooling;

[0048] Step 5, tableting: The sterilized powder in step 4 is tableted using a tablet press to obtain a chewable tablet production process suitable for people with diabetes and lung nodules.

[0049] It can be seen from this that some chewable tablets with hypoglycemic effects can only control the patient's blood sugar increase, and cannot help or improve the complications caused by diabetes. The chewable tablets suitable for people with diabetes and lung nodules have added B12 vitamin, vitamin C, vitamin D and vitamin E. Among them, B12 vitamin can promote the health of the nervous system, help improve the nerve function problems caused by diabetes, and help slow the progression of neuropathy. Both vitamin C and vitamin D have strong antioxidant properties and can resist damage from free radicals, thereby helping to prevent chronic complications related to diabetes. At the same time, vitamin D supplementation can promote calcium absorption and utilization, and enhance bone density. At the same time, it also helps to improve blood sugar control, reduce the risks of cardiovascular diseases and microvascular complications, and improve the effectiveness of the chewable tablets; secondly, the efficacy of the chewable tablets is relatively single, resulting in a relatively narrow scope of application. The chewable tablets suitable for people with diabetes and lung nodules have good effects of dispersing nodules and swelling, resolving phlegm, relieving cough, warming and resolving cold phlegm and lowering blood sugar through reasonable combination of various Chinese medicinal materials, making the chewable tablets more suitable for people with diabetes and lung nodules to eat, and it is also more convenient to eat. At the same time, the use of freezing for drying during the processing process can maximize the retention of the effects of the Chinese medicinal materials, reduce the loss of efficacy, and improve the reliability of the use of the chewable tablets.

Claims

1. A chewable tablet suitable for people with diabetes and pulmonary nodules, characterized in that: The formula comprises the following raw materials: 24-30 parts of traditional Chinese medicine, 80-90 parts of dextrin, 8-10 parts of polyvinyl pyrrolidone, 4-6 parts of magnesium stearate, 3-5 parts of aspartame, 3-5 parts of orange essence, 4-6 parts of mannitol and 8-10 parts of vitamins.

2. A chewable tablet suitable for people with diabetes and lung nodules according to claim 1, characterized in that: The traditional Chinese medicine comprises the following formula raw materials: 4-6 parts of selfheal, 5-7 parts of cat's claw, 3-5 parts of polia, 5-7 parts of astragalus, 3-5 parts of cassia twig and 4-6 parts of liquorice.

3. A chewable tablet suitable for people with diabetes and lung nodules according to claim 2, characterized in that: The vitamins include the following formula ingredients: 3-3.5 parts of B12 vitamin, 1-1.5 parts of vitamin C, 2-2.5 parts of vitamin D and 2-2.5 parts of vitamin E.

4. A chewable tablet production process suitable for people with diabetes and pulmonary nodules, characterized by: The steps include: Step 1, washing and extraction: washing corresponding amounts of Prunella vulgaris, cat's claw, Poria cocos, Astragalus, cinnamon twig and licorice by water, and trying not to damage their surface pieces and rhizomes during the washing process, and then extracting the raw materials by carbon dioxide quenching process to obtain Chinese medicine extracts, and then filtering the Chinese medicine extracts by using a filter; Step 2, mixing processing: adding the corresponding portions of dextrin, polyvinyl pyrrolidone and magnesium stearate in step 2 to a blender, then adding the Chinese medicine extract in step 1 to the blender, controlling the start of the blender, and the speed of the blender shaft is 500-600r / min, while raising the temperature inside the blender to 60-70 degrees Celsius, and the stirring time is controlled to 20-30min, then adding the corresponding portions of aspartame, mannitol and vitamins to the blender, then reducing the speed of the blender shaft to 200-300r / min, then reducing the temperature inside the blender to 50-60 degrees Celsius, and then stirring for 17-25min to obtain a pasty raw material; Step 3, freeze drying: adding the paste material obtained in step 2 into a vacuum freeze dryer, which quickly freezes the paste material into a solid. Under a vacuum environment, the frozen water molecules directly sublimate into water vapor and escape. During the process, the water vapor is automatically condensed through a water vapor condenser in the vacuum system to obtain a dry solid substance. Step 4, crushing and sterilizing: the solid material obtained in step 3 is put into a crushing device for crushing. After the crushing is completed, the powder can be obtained and collected, and then the powder is spread on a tray, and then the tray is placed in a powder sterilizer to sterilize the powder; Step 5, tableting: The sterilized powder in step 4 is tableted using a tablet press to obtain a chewable tablet production process suitable for people with diabetes and lung nodules.

5. The process for producing chewable tablets suitable for people with diabetes and lung nodules according to claim 4, characterized in that: In the step 1, the number of filter meshes inside the filter is controlled at 80-100.

6. The process for producing chewable tablets suitable for people with diabetes and lung nodules according to claim 5, characterized in that: Before adding the paste raw material into the vacuum freeze dryer in step 3, it needs to be placed in a cool and ventilated place for natural cooling.

7. The process for producing chewable tablets suitable for people with diabetes and lung nodules according to claim 6, characterized in that: The powder sterilizer in step 4 is a dry heat sterilizer.

8. The process for producing chewable tablets suitable for people with diabetes and lung nodules according to claim 7, characterized in that: The sterilization process of the medicinal powder in step 4 is divided into three stages. The temperature of the first stage is 160-170 degrees Celsius and maintained for 120-130 minutes, the temperature of the second stage is 170-180 degrees Celsius and maintained for 60 minutes, and the temperature of the third stage is 240-250 degrees Celsius and maintained for 45-50 minutes.

9. The process for producing chewable tablets suitable for people with diabetes and lung nodules according to claim 8, characterized in that: After the sterilization of the medicine powder in the tray in step 4 is completed, the tray needs to be placed in a cool, windless and dry place for natural cooling.