Cream formula for losing weight after eating and preparation method of cream formula

Abstract

The invention discloses a diet-loss weight-losing cream formula and a preparation method thereof. According to the composition, ginseng, the root of kudzu vine, lotus seeds, rhizoma polygonati, astragalus membranaceus, red dates, liquorice, resistant dextrin, konjac powder and isomaltooligosacharide are matched for use, synergistic interaction is achieved, metabolism of a human body is improved, fat consumption of the human body is promoted, and therefore the effect of reducing weight is achieved.

Description

Technical Field

[0001] The present application specifically relates to a fasting weight loss paste prescription and a preparation method thereof. Background Art

[0003] There are many ways to lose weight, and intermittent fasting is a popular way for young people to lose weight. The calorie intake can be controlled by alternating normal diet and low-calorie diet. However, during the low-calorie diet, the sudden decrease in food intake often leads to damage to the spleen and stomach or unsatisfied appetite, thereby increasing food intake. Therefore, it is necessary to provide a composition that can reduce appetite by regulating blood sugar, and can nourish the spleen and stomach under the low-calorie diet state, thereby reducing the damage to the spleen and stomach caused by intermittent fasting. Summary of the invention

[0004] The purpose of the present invention is to provide a fasting weight loss paste prescription and a preparation method thereof, which adopts compound plant ingredients, has high safety, good taste, and has the effect of significantly improving metabolism and promoting fat consumption.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] In a first aspect, the present invention provides a fasting weight loss paste, comprising the following raw materials in parts by weight: 2-4 parts of ginseng, 1-3 parts of kudzu root, 1-3 parts of lotus seeds, 1-2 parts of polygonatum, 5-13 parts of astragalus, 1-3 parts of red dates, 1-2 parts of licorice, 3-6 parts of resistant dextrin, 8-10 parts of konjac flour, and 5-10 parts of isomaltooligosaccharide.

[0007] Preferably, the fasting slimming cream comprises the following raw materials in parts by mass: 3 parts of ginseng, 2 parts of kudzu root, 2 parts of lotus seeds, 1 part of polygonatum, 10 parts of astragalus, 2 parts of red dates, 1 part of licorice, 5 parts of resistant dextrin, 9 parts of konjac powder, and 7 parts of isomaltooligosaccharide.

[0008] Preferably, the fasting slimming cream comprises the following raw materials in parts by mass: 4 parts of ginseng, 3 parts of kudzu root, 3 parts of lotus seeds, 1 part of polygonatum, 5 parts of astragalus, 3 parts of red dates, 2 parts of licorice, 6 parts of resistant dextrin, 10 parts of konjac flour, and 5 parts of isomaltooligosaccharide.

[0009] Preferably, the fasting slimming cream comprises the following raw materials in parts by mass: 2 parts of ginseng, 1 part of kudzu root, 1 part of lotus seeds, 2 parts of polygonatum, 13 parts of astragalus, 1 part of red dates, 1 part of licorice, 3 parts of resistant dextrin, 8 parts of konjac flour, and 10 parts of isomaltooligosaccharide.

[0010] In a second aspect, the present invention provides a method for preparing the fasting slimming cream according to the first aspect, the specific steps of which are as follows:

[0011] S1. Weigh ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice, resistant dextrin, konjac powder, and isomaltooligosaccharide according to the formula;

[0012] S2, the weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, liquorice are mixed and stirred to obtain a mixed powder, and ultrasonically extracted with a 65% v / v ethanol solution at 75-90°C and 100-120w for 2-4h, filtered, the filtrate is collected, and the ethanol is distilled under reduced pressure and recovered, and the filtrate is concentrated to a clear paste A for standby use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution is 1:4-6, and the water content of the clear paste A is 15-20wt%;

[0013] S3, the clear paste A is mixed with sterile deionized water, sucrose, and soluble starch to obtain a mixed solution, and after instantaneous sterilization of the mixed solution, red yeast CGMCC: 2.5511, bifidobacterium catenella CGMCC: 1.3014, and bifidobacterium adolescentis CGMCC: 1.2190 are added to the mixed solution for anaerobic fermentation, and after the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high pressure sterilization is performed, and rotary evaporation is performed to concentrate to a clear paste B with a water content of 15-20wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose, and soluble starch is 1: 20-30: 4-6: 2-4, the mass ratio of red yeast, bifidobacterium catenella, and bifidobacterium adolescentis is 1: 0.5-0.7: 0.3-0.5, the total addition amount of red yeast, bifidobacterium catenella, and bifidobacterium adolescentis is 3-5wt% of the clear paste A, the fermentation starting temperature is 25-30°C, and the fermentation time is 12-16h;

[0014] S4, put the clear paste B in an electric frying pan, heat it with an induction cooker, stir while heating, and add resistant dextrin, konjac flour, and oligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming cream is obtained;

[0015] The ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates and liquorice are all dry powders.

[0016] Compared with the prior art, the invention has the following beneficial effects: the invention provides a fasting weight loss paste prescription and a preparation method thereof, wherein the fasting weight loss paste uses ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice, which are both medicinal and edible, in combination with resistant dextrin, konjac powder, and isomaltooligosaccharide, wherein ginseng has the effects of invigorating qi and strengthening the spleen, can enhance the spleen and stomach transportation and transformation function, and reduce fat accumulation, and the ginsenosides and other ingredients contained in it can regulate metabolism and promote fat burning; the puerarin and other ingredients contained in the kudzu root can improve blood circulation, promote metabolism, and contribute to the decomposition of fat; the lotus seed has the effects of invigorating the spleen and stopping diarrhea, nourishing the heart and calming the nerves, and can help regulate the body's water balance and reduce edema; the polygonatum has the effects of invigorating qi and nourishing yin, invigorating the spleen, moistening the lungs and benefiting the kidneys, can enhance the body's metabolic capacity, and promote the transformation and utilization of fat; the astragalus can invigorate qi and consolidate the exterior, promote diuresis and reduce swelling, and has a good weight loss effect on obesity caused by qi deficiency; the red dates can invigorate the middle and replenish qi, It nourishes blood and calms the mind, has a positive effect on regulating metabolic balance and promoting the rational distribution of fat. Licorice has the function of harmonizing various medicines, which can alleviate the strong nature of other medicinal materials. At the same time, it itself has the effect of strengthening the spleen and replenishing qi, which helps to improve the body's metabolism. The above 7 Chinese herbal medicines act synergistically on the human body's metabolic system through their respective characteristics and mechanisms of action. Among them, ginseng and astragalus can enhance the body's metabolic capacity, kudzu root and lotus seeds can help regulate the body's water balance and promote blood circulation, polygonatum and red dates can supplement nutrition and promote the rational distribution of fat, and licorice harmonizes various medicines, making the effects of the above medicinal materials more synergistic and mild. In addition, compared with the traditional decoction mode, the present invention first extracts ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates and licorice with alcohol, and then introduces specific strains for fermentation, so that the sugars, polyphenols and flavonoids in ginseng, kudzu root, lotus seeds, polygonatum, astragalus, red dates and licorice are fully released, which is more conducive to human absorption. DETAILED DESCRIPTION

[0017] In order to better understand the present invention, the present invention is further described below in conjunction with specific examples, wherein the terms used in the examples are for describing specific embodiments and do not constitute limitations on the scope of protection of the present invention.

[0018] The experimental methods in the following examples without specifying specific conditions are usually carried out under conventional conditions or under conditions recommended by the manufacturer. Unless otherwise specified, percentages and parts are calculated by weight.

[0019] Some raw materials and their sources are as follows:

[0020] Astragalus: Longxi Yifang Pharmaceutical Co., Ltd.;

[0021] Ginseng: Guangdong Huidakang Pharmaceutical Co., Ltd.;

[0022] Pueraria root: Zhejiang Yifang Pharmaceutical Co., Ltd.;

[0023] Lotus seeds: Guangxi Nanyao Pharmaceutical Co., Ltd.;

[0024] Red dates: Leling Maoyuan Red Dates Purchasing and Sales Co., Ltd.;

[0025] Polygonatum sibiricum: Longxi Yifang Pharmaceutical Co., Ltd.

[0026] Licorice: Longxi Yifang Pharmaceutical Co., Ltd.

[0027] After purchasing, the above raw materials need to be cleaned, impurities removed, dried to constant weight, ground, sieved through a 60-mesh sieve, and then stored in a sealed container away from light.

[0028] Isomaltooligosaccharide: Shuowei Nutrition Technology (Guangzhou) Co., Ltd.

[0029] Resistant dextrin: Guangzhou Daoming Chemical Co., Ltd.;

[0030] Konjac flour: Henan Xinchun Food Co., Ltd.

[0031] Rat ghrelin ELISA kit: purchased from Wuhan Saipei Biotechnology Co., Ltd., catalog number: SP13329.

[0032] The mass proportions of the raw materials of the fasting slimming cream are as follows:

[0033] Composition 1: 3 parts of ginseng, 2 parts of kudzu root, 2 parts of lotus seeds, 1 part of polygonatum, 10 parts of astragalus, 2 parts of red dates, 1 part of licorice, 5 parts of resistant dextrin, 9 parts of konjac powder, 7 parts of isomaltooligosaccharide, and the preparation method thereof is as follows:

[0034] S1. Weigh ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice, resistant dextrin, konjac powder, and isomaltooligosaccharide according to the formula;

[0035] S2. Mix the weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates and licorice to obtain a mixed powder, extract it with a 65% v / v ethanol solution under ultrasonic conditions of 80°C and 110w for 3h, filter, collect the filtrate, distill it under reduced pressure and recover ethanol, and concentrate the filtrate to a clear paste A for standby use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution is 1:5, and the water content of the clear paste A is 17wt%;

[0036] S3, the clear paste A is mixed with sterile deionized water, sucrose and soluble starch to obtain a mixed solution, and after instantaneous sterilization of the mixed solution, red yeast CGMCC: 2.5511, bifidobacterium catenella CGMCC: 1.3014, and bifidobacterium adolescentis CGMCC: 1.2190 are added to the mixed solution for anaerobic fermentation, and after the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high pressure sterilization is performed, and rotary evaporation is performed to concentrate to a clear paste B with a water content of 18wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose and soluble starch is 1:25:5:3, the mass ratio of red yeast, bifidobacterium catenella and bifidobacterium adolescentis is 1:0.6:0.4, the total addition amount of red yeast, bifidobacterium catenella and bifidobacterium adolescentis 4wt% of the clear paste A, the fermentation starting temperature is 27°C, and the fermentation time is 14h;

[0037] S4. Place the paste B in an electric frying pan and heat it with an induction cooker. Stir while heating. At the same time, add resistant dextrin, konjac flour and isomaltooligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming paste is obtained.

[0038] Composition 2: 4 parts of ginseng, 3 parts of kudzu root, 3 parts of lotus seeds, 1 part of polygonatum, 5 parts of astragalus, 3 parts of red dates, 2 parts of licorice, 6 parts of resistant dextrin, 10 parts of konjac powder, 5 parts of isomaltooligosaccharide, and the preparation method thereof is as follows:

[0039] S1. Weigh ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice, resistant dextrin, konjac powder, and isomaltooligosaccharide according to the formula;

[0040] S2, the weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, liquorice are mixed and stirred to obtain a mixed powder, and ultrasonically extracted with a 65% v / v ethanol solution at 75°C and 100w for 4h, filtered, the filtrate is collected, and the ethanol is distilled under reduced pressure and recovered, and the filtrate is concentrated to a clear paste A for standby use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution is 1:4, and the water content in the clear paste A is 20wt%;

[0041] S3, the clear paste A is mixed with sterile deionized water, sucrose and soluble starch to obtain a mixed solution, and after instantaneous sterilization of the mixed solution, red yeast CGMCC: 2.5511, bifidobacterium catenella CGMCC: 1.3014, and bifidobacterium adolescentis CGMCC: 1.2190 are added to the mixed solution for anaerobic fermentation, and after the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high pressure sterilization is performed, and rotary evaporation is performed to concentrate to a clear paste B with a water content of 20wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose and soluble starch is 1:20:4:2, the mass ratio of red yeast, bifidobacterium catenella and bifidobacterium adolescentis is 1:0.5:0.3, the total addition amount of red yeast, bifidobacterium catenella and bifidobacterium adolescentis 3wt% of the clear paste A, the fermentation starting temperature is 25°C, and the fermentation time is 12h;

[0042] S4. Place the paste B in an electric frying pan and heat it with an induction cooker. Stir while heating. At the same time, add resistant dextrin, konjac flour and isomaltooligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming paste is obtained.

[0043] Composition 3: 2 parts of ginseng, 1 part of kudzu root, 1 part of lotus seed, 2 parts of polygonatum, 13 parts of astragalus, 1 part of red dates, 1 part of liquorice, 3 parts of resistant dextrin, 8 parts of konjac powder, and 10 parts of isomaltooligosaccharide; its preparation method is as follows:

[0044] S1. Weigh ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice, resistant dextrin, konjac powder, and isomaltooligosaccharide according to the formula;

[0045] S2. Mix the weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates and licorice to obtain a mixed powder, extract it with a 65% v / v ethanol solution under ultrasonic conditions of 90°C and 120w for 2h, filter, collect the filtrate, distill it under reduced pressure and recover ethanol, and concentrate the filtrate to a clear paste A for later use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution is 1:6, and the water content of the clear paste A is 15wt%;

[0046] S3, the clear paste A is mixed with sterile deionized water, sucrose and soluble starch to obtain a mixed solution, and after instantaneous sterilization of the mixed solution, red yeast CGMCC: 2.5511, bifidobacterium catenella CGMCC: 1.3014, and bifidobacterium adolescentis CGMCC: 1.2190 are added to the mixed solution for anaerobic fermentation, and after the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high pressure sterilization is performed, and rotary evaporation is performed to concentrate to a clear paste B with a water content of 15wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose and soluble starch is 1:30:6:4, the mass ratio of red yeast, bifidobacterium catenella and bifidobacterium adolescentis is 1:0.7:0.5, the total addition amount of red yeast, bifidobacterium catenella and bifidobacterium adolescentis 5wt% of the clear paste A, the fermentation starting temperature is 30°C, and the fermentation time is 16h;

[0047] S4. Place the paste B in an electric frying pan and heat it with an induction cooker. Stir while heating. At the same time, add resistant dextrin, konjac flour and isomaltooligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming paste is obtained.

[0048] Composition ①: The difference between composition 1 and composition 1 is that the raw material ginseng is missing, and its reduced mass is proportionally distributed to the mass of kudzu root, lotus seed, polygonatum, astragalus, red dates and licorice. The preparation method is the same as composition 1.

[0049] Composition ②: Different from composition 1, the raw material Pueraria root is missing, and its reduced mass is proportionally distributed to ginseng, lotus seeds, polygonatum, astragalus, red dates, and licorice. The preparation method is the same as composition 1.

[0050] Composition ③: Different from composition 1, the raw material lotus seeds are missing, and the reduced mass thereof is distributed proportionally to ginseng, kudzu root, polygonatum, astragalus, red dates, and licorice. The preparation method is the same as composition 1.

[0051] Composition ④: Different from composition 1, the raw material Polygonatum sibiricum is missing, and its reduced mass is proportionally distributed to ginseng, kudzu root, lotus seeds, astragalus, red dates, and licorice. The preparation method is the same as composition 1.

[0052] Composition ⑤: Different from composition 1, the raw material Astragalus is missing, and its reduced mass is proportionally distributed to ginseng, kudzu root, lotus seeds, polygonatum, red dates, and licorice. The preparation method is the same as composition 1.

[0053] Composition ⑥: Different from composition 1, the raw material red dates is missing, and its reduced mass is proportionally distributed to ginseng, kudzu root, lotus seeds, polygonatum, astragalus, and licorice. The preparation method is the same as composition 1.

[0054] Composition ⑦: Different from composition 1, the raw material licorice is missing, and its reduced mass is proportionally distributed to ginseng, kudzu root, lotus seeds, polygonatum, astragalus, and red dates. The preparation method is the same as composition 1.

[0055] Composition ⑧: Different from composition 1, it lacks the raw material resistant dextrin, and its reduced mass is proportionally distributed to konjac flour and isomaltooligosaccharide. The preparation method is the same as composition 1.

[0056] Composition ⑨: Different from composition 1, the raw material konjac flour is lacking, and the reduced mass thereof is distributed to resistant dextrin and isomaltooligosaccharide in proportion. The preparation method is the same as composition 1.

[0057] Composition ⑩: Different from composition 1, the raw material isomaltooligosaccharide is lacking, and its reduced mass is proportionally distributed to resistant dextrin and konjac flour. The preparation method is the same as composition 1.

[0058] Composition Compared with composition 1, step S4 is not performed, and the clear paste B prepared in step S3 is directly used as the final product.

[0059] Composition : Compared with composition 1, in step S4, the paste B is replaced with an equal mass of deionized water.

[0060] Composition The preparation method of is different from that of composition 1 in that only red yeast is used for fermentation, the total amount of added bacteria remains unchanged, and the remaining steps are the same as those of composition 1.

[0061] Composition The preparation method is different from that of composition 1 in that only catenella bifidobacterium is used for fermentation, the total amount of bacteria added remains unchanged, and the remaining steps are the same as those of composition 1.

[0062] Composition The preparation method is different from that of composition 1 in that only Bifidobacterium adolescentis is used for fermentation, the total amount of bacteria added remains unchanged, and the remaining steps are the same as those of composition 1.

[0063] Composition The preparation method is different from that of composition 1 in that red yeast rice, bifidobacterium catenella and bifidobacterium adolescentis are fermented in a mass ratio of 0.3:1:0.5, the total amount of added strains remains unchanged, and the remaining steps are the same as those of composition 1.

[0064] Composition The preparation method is different from that of composition 1 in that saccharomyces cerevisiae CGMCC: 2.3973 is used to replace red yeast CGMCC: 2.5511, the total amount of added strains remains unchanged, and the remaining steps are the same as those of composition 1.

[0065] Composition The preparation method is different from that of composition 1 in that Bifidobacterium bifidum CGMCC: 1.5091 of equal mass is used to replace Bifidobacterium catenulum CGMCC: 1.3014 and Bifidobacterium adolescentis CGMCC: 1.2190, the total amount of added strains remains unchanged, and the remaining steps are the same as those of composition 1.

[0066] Experiment 1: Animal experimental study

[0067] Experimental animals: SD rats, male, weighing 200±20 g, SPF grade, provided by Guangzhou Mingxun Biotechnology Co., Ltd., experimental animal use license: SCXK(Guangdong)2024-0070.

[0068] Housing conditions: Animals were housed in metabolic cages, maintaining a circadian rhythm, with room temperature of 22-25°C and relative humidity of 55-75%, and free access to food and water.

[0069] Drug samples: Compositions 1-3 and ① of the present invention The recommended oral dose for adults (60 kg) is 15 g / time, three times a day, equivalent to a rat dose of 4.69 g / kg. When feeding, distilled water is used to prepare the corresponding concentration.

[0070] Obese rat modeling: SD rats were selected and adaptively fed for 5 days. Ten rats were randomly selected as the normal control group and the rest as the model group. The model group used a high-fat diet and the normal control group used a conventional diet. They were fed for eight weeks, during which the rats had free access to water and food. The food intake, body weight, and body length were recorded weekly.

[0071] Animal administration: After successful modeling, the obese rats in the model group were randomly divided into 22 groups, namely, a model control group and a test group, with 5 rats in each group. The test group was intragastrically administered with corresponding doses of Compositions 1-3, ①- The model control group was gavaged with an equal amount of distilled water. All groups were given the drug once a day for 4 consecutive weeks. The normal control group consisted of normal rats, and its drug administration pattern was the same as that of the model control group.

[0072] Record: Food intake and body weight were recorded weekly. After 4 weeks of administration, the rats were anesthetized with ether (no food or water for 12 h before anesthesia). When the rats were completely unconscious, blood was drawn from their abdominal arteries for Experiment 2. The rats were then killed and dissected. The perinephric and pergenital fat pads and omental fat were separated and weighed. The fat body ratio (%) was calculated according to the formula: (perinephric fat + pergenital fat + omental fat) / body weight × 100%.

[0073] Statistical analysis: Origin8 was used for statistical analysis. The experimental data were expressed as mean ± standard deviation. One-way analysis of variance was used for comparison among groups. P < 0.05 (*) indicates that the difference is statistically significant.

[0074] Test results:

[0075] Table 1 Compositions 1-3, Composition ①- Weight gain and body fat ratio of rats (mean ± standard deviation, n = 5)

[0076]

[0077]

[0078] Note: “*” means p < 0.05 compared with the normal control group; “#” means p < 0.05 compared with the model control group.

[0079] The results in Table 1 show that the compositions 1-3 have a significant weight loss effect compared with the model control group and the normal control group.

[0080] Comparison of composition 1 with compositions ①-⑦ showed that there was a certain synergistic effect between the ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates and liquorice described in the present invention.

[0081] Comparison of composition 1 with compositions ⑧-⑩ showed that there was a certain synergistic effect among the resistant dextrin, konjac flour and isomaltooligosaccharide of the present invention.

[0082] Comparative composition 1 and composition - The results show that there is a certain synergistic effect between the ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice and resistant dextrin, konjac flour and isomaltooligosaccharide.

[0083] Comparative composition 1 and composition - The results showed that fermentation with specific strains in a certain dosage ratio had a certain synergistic effect.

[0084] Experiment 2: Determination of the effect of the composition on satiety in rats

[0085] Ghrelin is a hormone that can increase appetite, allowing the body to take in more food, absorb more calories and store more fat. Its concentration is positively correlated with hunger.

[0086] In Experiment 1, composition 1 and composition , Composition The blood samples obtained by drawing blood from the abdominal aorta of rats in the model control group were centrifuged in batches in a whole blood centrifuge, and the supernatant was collected, packaged, and placed in a -80°C refrigerator for testing.

[0087] The above serum was tested using a rat ghrelin ELISA kit, catalog number: SP13329, and the test method was referred to the kit instructions. The test results are shown in Table 2 below.

[0088] Ghrelin content relative to model control group / % = (1-(model control group-combination group) / model control group) × 100%

[0089] Table 2 Effect of the composition on ghrelin

[0090]

[0091] Note: “#” represents p<0.05 compared with the model control group.

[0092] According to Table 2, composition 1 can significantly reduce the concentration of ghrelin in rats, and by comparing composition 1 with composition , Composition The data show that there is a synergistic effect between ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice and resistant dextrin, konjac flour and isomaltooligosaccharide in the composition of the present application.

[0093] Test 3: Acute toxicity test

[0094] Experimental animals: SD rats. The selection conditions refer to Experiment 1.

[0095] Experimental drug: Composition 1, the recommended oral dose for adults (60 kg) is 15 g / time, three times a day, equivalent to a rat dose of 4.69 g / kg. During feeding, distilled water was used to prepare the corresponding concentration for feeding.

[0096] Experimental method: Two SD rats were selected, fasted for 12 hours before administration, and then gavaged with 4.69 g / kg to observe the rats' reactions. The results showed that no animals died due to the administration. Due to the limitations of drug concentration and administration volume, LD50 could not be determined, so a maximum tolerance test was conducted.

[0097] Maximum tolerance test method: 10 SD rats were selected, fasted for 12 hours before administration, and gavaged with 2-10 times the unit dose, with a unit dose of 4.69 g / kg. The control group was gavaged with an equal amount of distilled water. The rats were observed for 7 days after administration, and the rats' body weight, mental state, activity, fur gloss, appetite and excretion, death and other symptoms were recorded.

[0098] The experimental results showed that after 7 days of administration, no adverse reactions were observed, the rats were healthy and lively, and their spirits, activities, fur, appetite, and excretion all showed abnormal reactions. The weight of rats in each group increased, and there was no death. After autopsy, there were no obvious abnormal changes in the rats in each group.

[0099] The embodiments described above are part of the embodiments of the present application, rather than all of the embodiments. The detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents the selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present application.

Claims

1. A fasting slimming cream, characterized in that: The invention comprises the following raw materials in parts by weight: 2-4 parts of ginseng, 1-3 parts of kudzu root, 1-3 parts of lotus seeds, 1-2 parts of polygonatum, 5-13 parts of astragalus, 1-3 parts of red dates, 1-2 parts of liquorice, 3-6 parts of resistant dextrin, 8-10 parts of konjac powder, and 5-10 parts of isomaltooligosaccharide; The preparation method of the slimming cream comprises the following steps: S1. Weigh ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, licorice, resistant dextrin, konjac powder, and isomaltooligosaccharide according to the formula; S2, the weighed ginseng, kudzu root, lotus seed, polygonatum, astragalus, red dates, liquorice are mixed and stirred to obtain a mixed powder, and ultrasonically extracted with a 65% v / v ethanol solution at 75-90°C and 100-120w for 2-4h, filtered, the filtrate is collected, and the ethanol is distilled under reduced pressure and recovered, and the filtrate is concentrated to a clear paste A for standby use; wherein the mass ratio of the mixed powder to the 65% v / v ethanol solution is 1:4-6, and the water content of the clear paste A is 15-20wt%; S3, the clear paste A is mixed with sterile deionized water, sucrose, and soluble starch to obtain a mixed solution, and after instantaneous sterilization of the mixed solution, red yeast CGMCC: 2.5511, bifidobacterium catenella CGMCC: 1.3014, and bifidobacterium adolescentis CGMCC: 1.2190 are added to the mixed solution for anaerobic fermentation, and after the fermentation is completed, ultrasonic homogenization is performed, insoluble matter is filtered out, high pressure sterilization is performed, and rotary evaporation is performed to concentrate to a clear paste B with a water content of 15-20wt%; wherein the mass ratio of clear paste A, sterile deionized water, sucrose, and soluble starch is 1: 20-30: 4-6: 2-4, the mass ratio of red yeast, bifidobacterium catenella, and bifidobacterium adolescentis is 1: 0.5-0.7: 0.3-0.5, the total addition amount of red yeast, bifidobacterium catenella, and bifidobacterium adolescentis is 3-5wt% of the clear paste A, the fermentation starting temperature is 25-30°C, and the fermentation time is 12-16h; S4. Place the paste B in an electric frying pan and heat it with an induction cooker. Stir while heating. At the same time, add resistant dextrin, konjac flour and isomaltooligosaccharide. When the "hanging flag" phenomenon appears, the fasting slimming paste is obtained.

2. The fasting slimming cream according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 3 parts of ginseng, 2 parts of kudzu root, 2 parts of lotus seeds, 1 part of polygonatum, 10 parts of astragalus, 2 parts of red dates, 1 part of liquorice, 5 parts of resistant dextrin, 9 parts of konjac powder, and 7 parts of isomaltooligosaccharide.

3. The fasting slimming cream according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 4 parts of ginseng, 3 parts of kudzu root, 3 parts of lotus seeds, 1 part of polygonatum, 5 parts of astragalus, 3 parts of red dates, 2 parts of liquorice, 6 parts of resistant dextrin, 10 parts of konjac powder, and 5 parts of isomaltooligosaccharide.

4. The fasting slimming cream according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 2 parts of ginseng, 1 part of kudzu root, 1 part of lotus seed, 2 parts of polygonatum, 13 parts of astragalus, 1 part of red dates, 1 part of liquorice, 3 parts of resistant dextrin, 8 parts of konjac powder, and 10 parts of isomaltooligosaccharide.

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