Preparation method and application of exosome vector for treating Rater's syndrome

By preparing milk exosomes containing alkynyl groups on the surface and tricheneptide containing azide group, and connecting the two to form an exosome carrier, the problem of low blood-brain barrier transmission rate of trichenepide was solved, and a higher drug infiltration rate and better therapeutic effect was achieved.

CN119746098APending Publication Date: 2025-04-04YANTAI UNIV
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Patent Information

Application Number
CN202411957333.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-30
Publication Date
2025-04-04

AI Technical Summary

Technical Problem

In the prior art, trichenolide requires a large amount of oral administration due to the low blood-brain barrier transmission rate, resulting in adverse reactions such as diarrhea.

Method used

By preparing milk exosomes containing alkynyl groups on the surface and trafenopeptide containing azide groups, and using the reaction of alkynyl and azide groups, the two are connected to form an exosome carrier for treating Retel syndrome.

Benefits of technology

It improves the blood-brain barrier transmittance of trafenopeptide, reduces drug intake, and weakens adverse reactions while increasing the amount of drugs entering the brain, making the effect better.

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Abstract

The invention relates to a preparation method and application of an exosome carrier for treating the Rater's syndrome, and belongs to the technical field of pharmaceutical preparations. The invention provides a preparation method of an exosome carrier for treating the Rater's syndrome, which comprises the following steps: preparing a milk exosome containing alkynyl on the surface and trifinetide containing azido, and then connecting the milk exosome and the trifinetide by utilizing the reaction of the alkynyl and the azido to obtain the exosome carrier for treating the Rater's syndrome. The exosome carrier obtained according to the preparation method disclosed by the invention is good in stability and high in blood-brain barrier drug transmittance, and compared with independent administration, the exosome carrier can reduce the drug intake, reduce adverse reactions and increase the drug entry amount into the brain at the same time.
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