An engineered long-acting platelet delivery system for loading therapeutic drugs, its preparation method and application
By loading anti-tumor drugs into platelets and anchoring apoptosis inhibitor liposomes on their surface, an engineered long-acting platelet delivery system was prepared, which solved the problems of platelet instability and easy activation, and achieved the effects of tumor-targeted delivery and long-term storage, thus inhibiting tumor recurrence and metastasis.
CN119746100BActive Publication Date: 2026-05-26SHENYANG PHARMA UNIV
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHENYANG PHARMA UNIV
- Filing Date
- 2024-12-31
- Publication Date
- 2026-05-26
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Figure CN119746100B_ABST
Abstract
This invention relates to the field of pharmaceutical technology, specifically to an engineered long-acting platelet delivery system for loading therapeutic drugs, its preparation method, and its applications. The system comprises platelets loaded with therapeutic drugs and nanoparticles containing platelet apoptosis inhibitors. The engineered long-acting platelet delivery system of this invention enables stable in vitro storage and long-term in vivo circulation. Furthermore, by leveraging the efficient and natural wound tropism and tumor targeting properties of platelets, this system can precisely target residual and circulating tumor cells after surgery, thereby releasing cytotoxic chemotherapeutic drugs and effectively preventing postoperative tumor recurrence and metastasis.
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