Ophthalmic imaging device and ophthalmic imaging method

Abstract

The present application discloses an ophthalmic imaging device and an ophthalmic imaging method, in which a light source detection module generates a scanning light beam incident on a light beam scanning module; the light beam scanning module modulates the incident angle of the scanning light beam, and the modulated scanning light beam enters the subject's eyeball, and the feedback light beam reflected by the retina passes through the light beam scanning module and is incident on the light source detection module; the light source detection module also generates a scanning image based on the feedback light beam; the imaging module generates fundus illumination light to illuminate the fundus, and collects a fundus image; thereby, the fundus image and the scanning image are compared to determine the position of the imaging area displayed by the scanning image on the retina, and the user can determine whether the current scanning image is the target area, and can also determine where the scanning image should move to reach the target area, that is, under the navigation of the fundus image, the target area can be found directly and quickly on the retina, and the operation steps are simple and the clinical efficiency is high.

Description

Technical Field

[0001] The present application relates to the field of ophthalmic imaging technology, and in particular to an ophthalmic imaging device and an ophthalmic imaging method. Background Art

[0002] The retina is an important part of the human eye. Currently, more than one billion people in the world suffer from retinal diseases. In order to more effectively diagnose and treat retinal diseases, the optimization of diagnostic devices is inevitable. In other words, high-resolution retinal imaging devices are of great significance for the diagnosis and efficacy evaluation of retinal diseases.

[0003] The single imaging range of the retinal imaging device in the prior art is small and can only cover a small area on the retina. It is difficult for the user to determine the specific position of the imaging area on the retina based on a single scanned image. If the user wants to observe a lesion or cell tissue, it is impossible to determine whether the scanned image is the area of ​​interest, nor is it possible to determine where the scanned image should move to reach the area of ​​interest. The user can only search by traversal, which takes a lot of time to find the area of ​​interest on the retina. In addition, the device operation steps are complicated and the clinical efficiency is low.

[0004] Early retinal imaging devices were mainly based on slit lamps or fundus cameras, but these technical means were affected by the aberrations of the imperfect human eye, resulting in low imaging resolution and the inability to observe the microscopic cellular structure of the retina. Summary of the invention

[0005] In order to solve the above technical problems, the embodiments of the present application provide an ophthalmic imaging device and an ophthalmic imaging method that can quickly locate a region of interest on the retina and are convenient and easy to use.

[0006] To achieve the above objectives, the present application provides the following technical solutions:

[0007] An ophthalmic imaging device comprises a light source detection module, a light beam scanning module and an imaging module;

[0008] The light source detection module is used to generate a scanning light beam incident on the light beam scanning module;

[0009] The beam scanning module is used to modulate the incident angle of the scanning beam, and the modulated scanning beam enters the eyeball of the subject, and the feedback beam reflected by the retina passes through the beam scanning module and is incident on the light source detection module;

[0010] The light source detection module is also used to obtain a reflection detection signal according to the feedback light beam, and the reflection detection signal is used to generate a scan image;

[0011] The image module is used to generate fundus illumination light to illuminate the fundus and to collect fundus images; the fundus images are used to compare with the scanned images to determine the position of the imaging area displayed by the scanned images on the retina.

[0012] Optionally, the ophthalmic imaging device also includes an acquisition control module, which is used to determine the relative position information of the scanned image and the target area based on the target area on the fundus image, and adjust the angle of the scanning light beam entering the subject's eyeball according to the relative position information.

[0013] Optionally, the image module includes a fixation unit, and the acquisition control module adjusts the angle at which the scanning light beam enters the subject's eyeball according to the relative position information, including:

[0014] The acquisition control module determines an adjustment signal of the fixation unit according to the relative position information, and the fixation unit guides the subject's eyeball to change its gaze direction according to the adjustment signal to adjust the angle at which the scanning light beam enters the subject's eyeball.

[0015] Optionally, the acquisition control module adjusts the angle at which the scanning light beam enters the subject's eyeball according to the relative position information, including:

[0016] The acquisition control module controls the optical path state of the light beam scanning module according to the relative position information to adjust the angle at which the scanning light beam enters the eyeball of the subject.

[0017] Optionally, the acquisition control module is also used to calculate eye movement displacement values ​​based on the scanned image and / or the fundus image, and use the eye movement displacement values ​​to control the optical path state of the light beam scanning module to achieve eye movement tracking.

[0018] Optionally, the beam scanning module includes first to third galvanometer mirrors;

[0019] The first galvanometer is used to realize the lateral scanning of the scanning light beam;

[0020] The second galvanometer is used to realize the lateral tracking of the scanning light beam;

[0021] The third galvanometer is used to realize longitudinal scanning and longitudinal tracking of the scanning light beam.

[0022] Optionally, the beam scanning module includes a plurality of scanning elements; the ophthalmic imaging device further includes an acquisition control module, the acquisition control module includes a data acquisition unit, a calculation unit and a scanning element controller;

[0023] The data acquisition unit is used to receive the fundus image and the scanned image, or to receive the fundus image and the reflected detection signal, and the calculation unit generates the scanned image according to the reflected detection signal;

[0024] The calculation unit is used to determine the position of the imaging area displayed by the scanned image on the retina based on the fundus image;

[0025] The calculation unit is also used to send a scanning signal and / or a tracking signal to each scanning element in the light beam scanning module through the scanning element controller according to the scanning image, so as to control the deflection state of each scanning element in the light beam scanning module.

[0026] Optionally, the beam scanning module includes a beam phase modulation device for performing aberration compensation;

[0027] The light source detection module includes a wavefront detector, and the wavefront detector is used to generate a wavefront detection signal according to the feedback light beam;

[0028] The ophthalmic imaging device further comprises an acquisition control module, and the acquisition control module is used to control the beam phase modulation device in the beam scanning module to perform aberration compensation according to the wavefront detection signal.

[0029] Optionally, the ophthalmic imaging device further includes a pupil positioning module, which includes a pupil illumination light source and a pupil camera; the pupil illumination light source is used to generate pupil illumination light, and the pupil camera collects a pupil image for determining the displacement of the pupil.

[0030] An ophthalmic imaging method comprising:

[0031] Acquire a retina scanning image of an eyeball using a scanning device, acquire a fundus image using an imaging device, and select a target area in the fundus image;

[0032] According to the relative position information of the scanned image and the target area, adjusting the angle at which the scanning light beam of the scanning device enters the eyeball of the subject so that the scanning light beam is aligned with the target area of ​​the eyeball, thereby realizing navigation of the scanning light beam on the retina;

[0033] Acquire the retina scanning image of the eye in real time and perform aberration compensation on the scanning device;

[0034] Focusing the scanning device on the photoreceptor layer, obtaining a photoreceptor image, and performing real-time eye tracking;

[0035] The visual cell images are processed to obtain cell analysis results.

[0036] An ophthalmic imaging method comprising:

[0037] Acquire a retina scanning image of an eyeball using a scanning device, acquire a fundus image using an imaging device, and select a target area in the fundus image;

[0038] According to the relative position information of the scanned image and the target area, adjusting the angle at which the scanning light beam of the scanning device enters the eyeball of the subject so that the scanning light beam is aligned with the target area of ​​the eyeball, thereby realizing navigation of the scanning light beam on the retina;

[0039] Acquire the retina scanning image of the eye in real time and perform aberration compensation on the scanning device;

[0040] Focusing the scanning device on the photoreceptor layer, and obtaining the blood vessel image of the photoreceptor by line scanning;

[0041] The blood vessel images of the visual cells are processed to obtain blood flow analysis results.

[0042] Compared with the prior art, the above technical solution has the following advantages:

[0043] The ophthalmic imaging device provided in the embodiment of the present application includes a light source detection module, a light beam scanning module and an image module, wherein the light source detection module is used to generate a scanning light beam incident on the light beam scanning module; the light beam scanning module is used to modulate the incident angle of the scanning light beam, the modulated scanning light beam enters the subject's eyeball, and the feedback light beam reflected by the retina is incident on the light source detection module through the light beam scanning module; the light source detection module is also used to obtain a reflection detection signal based on the feedback light beam, and the reflection detection signal is used to generate a scanning image; the image module is used to generate fundus illumination light to illuminate the fundus, and collect fundus images; because the imaging area displayed by the fundus image is significantly larger than and includes the imaging area displayed by the scanning image, the fundus image and the scanning image can be compared to determine the position of the imaging area displayed by the scanning image on the retina, so that the user can determine whether the current scanning image is the target area, and can also determine where the scanning image should move to reach the target area, that is, under the navigation of the fundus image, the user can directly and quickly find the target area on the retina, and the operation steps are simple and the clinical efficiency is high, that is, the ophthalmic imaging device provided in the embodiment of the present application can quickly locate the area of ​​interest on the retina and is convenient and easy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0045] Figure 1 A schematic diagram of optical path transmission of an ophthalmic imaging device provided in an embodiment of the present application;

[0046] Figure 2 A schematic diagram of acquisition control logic of an acquisition control module in an ophthalmic imaging device provided in an embodiment of the present application;

[0047] Figure 3 A schematic diagram of a light beam scanning module in an ophthalmic imaging device provided in an embodiment of the present application to implement fundus scanning and eye tracking;

[0048] Figure 4 A schematic diagram of the workflow of an ophthalmic imaging device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0049] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0050] As described in the background technology section, how to provide an ophthalmic imaging device that can quickly locate a region of interest on the retina and is convenient and easy to use is a technical problem that needs to be solved urgently by those skilled in the art.

[0051] In view of this, an embodiment of the present application provides an ophthalmic imaging device, Figure 1 FIG. 4 shows a schematic diagram of the optical path transmission of an ophthalmic imaging device provided in an embodiment of the present application. Figure 1 As shown, the ophthalmic imaging device includes a light source detection module 10, a light beam scanning module 20 and an imaging module 30;

[0052] The light source detection module 10 is used to generate a scanning light beam incident on the light beam scanning module 20;

[0053] The light beam scanning module 20 is used to modulate the incident angle of the scanning light beam. The modulated scanning light beam enters the subject's eyeball E, and the feedback light beam reflected by the retina passes through the light beam scanning module 20 and enters the light source detection module 10.

[0054] The light source detection module 10 is also used to obtain a reflection detection signal according to the feedback light beam, and the reflection detection signal is used to generate a scan image;

[0055] The image module 30 is used to generate fundus illumination light to illuminate the fundus and to collect fundus images; the fundus images are used to compare with the scanned images to determine the position of the imaging area displayed by the scanned images on the retina.

[0056] Optional, such as Figure 1 As shown, the light source detection module 10 includes an infrared collimated light source 11 and a reflection detector 12; wherein, the infrared collimated light source 11 is used to generate an infrared collimated light beam, which is incident on the light beam scanning module 20 as a scanning light beam; the reflection detector 12 is used to generate a reflection detection signal based on the feedback light beam, and the reflection detection signal is used to generate a scanning image. Specifically, the reflection detector 12 can be used only to generate a reflection detection signal, and can also generate a scanning image based on the reflection detection signal.

[0057] Optionally, the infrared collimated light source 11 can be an infrared laser, an infrared band superluminescent diode or a supercontinuum laser, etc. A light source that directly emits collimated light can be used, or a collimating optical device can be set outside the laser to collimate the light beam before emitting it. Of course, it is also possible not to use an infrared light source, but to replace it with a light source of other bands actually needed.

[0058] It can be understood that the light beam scanning module 20 can realize the lateral and / or longitudinal scanning of the subject's eyeball by modulating the incident angle of the scanning light beam entering the subject's eyeball, and transmit the feedback light beam reflected by the retina to the light source detection module 10, so that the light source detection module 10 (specifically the reflection detector 12 in the light source detection module 10) obtains the reflection detection signal based on the feedback light beam for generating a scanned image.

[0059] Optional, such as Figure 1 As shown, the image module 30 includes a fundus illumination light source 31 and a fundus camera 32. The fundus illumination light source 31 is used to generate fundus illumination light to illuminate the fundus, which is reflected by the fundus and then collected by the fundus camera 32 to generate a fundus image. The fundus camera 32 can collect the fundus image of the subject in real time.

[0060] Optionally, the fundus illumination light source 31 may be a fundus illumination LED.

[0061] Since the imaging area displayed by the fundus image is significantly larger than the imaging area displayed by the scanned image, and the imaging area displayed by the fundus image includes the imaging area displayed by the scanned image, the fundus image and the scanned image can be used for comparison to determine the position of the imaging area displayed by the scanned image on the retina. In actual use, only the fundus image and the scanned image can be output, and the doctor can directly observe and compare the scanned image and the fundus image to manually determine the position of the imaging area displayed by the scanned image on the retina; the device can also automatically perform image registration to determine the area corresponding to the scanned image in the fundus image, superimpose the scanned image on the fundus image for display, or mark the imaging area of ​​the scanned image on the fundus image for easy observation by the doctor. Thus, the user can determine whether the current scanned image is the target area, and can also determine where the scanned image should move to reach the target area, that is, under the navigation of the fundus image, the user can directly and quickly find the target area on the retina, and the operation steps are simple and the clinical efficiency is high. It can be seen that the ophthalmic imaging device provided in the embodiment of the present application can quickly locate the area of ​​interest on the retina and is convenient and easy to use.

[0062] Optionally, in some embodiments of the present application, the ophthalmic imaging device further includes an acquisition control module 40, Figure 2 A schematic diagram of the acquisition control logic of an acquisition control module 40 in an ophthalmic imaging device provided in an embodiment of the present application is shown. The acquisition control module 40 is used to determine the relative position information of the scanned image and the target area based on the target area on the fundus image, and adjust the angle of the scanning light beam entering the subject's eyeball based on the relative position information of the scanned image and the target area.

[0063] Specific, combined Figure 1 and Figure 2 As shown, the acquisition control module 40 receives the reflection detection signal generated by the reflection detector 12 in the light source detection module 10, and generates a scanning image according to the reflection detection signal, or the acquisition control module 40 directly receives the scanning image generated by the reflection detector 12 in the light source detection module 10; the acquisition control module 40 also receives the fundus image generated by the fundus camera 32 in the image module 30; the user can select a target area (i.e., an area of ​​interest) on the fundus image by observing the fundus image, and the acquisition control module 40 can locate the target area on the fundus image, determine the relative position information between the scanning image and the target area, and adjust the angle of the scanning light beam output by the light beam scanning module 20 entering the subject's eyeball E according to the relative position information between the scanning image and the target area.

[0064] Optionally, in some embodiments of the present application, such as Figure 1As shown, the image module 30 also includes a fixation unit 33, and the acquisition control module 40 adjusts the angle of the scanning light beam entering the subject's eyeball according to the relative position information of the scanned image and the target area, including:

[0065] The acquisition control module 40 determines the adjustment signal of the fixation unit 33 according to the relative position information of the scanned image and the target area. The fixation unit 33 guides the subject's eyeball to change the gaze direction according to the adjustment signal to adjust the angle of the scanning light beam entering the subject's eyeball.

[0066] Specifically, Figure 2 As shown, the acquisition control module 40 includes a data acquisition unit 41, a calculation unit 42 and a fixation unit controller 43;

[0067] The data acquisition unit 41 is used to receive the scanning image generated by the reflection detector 12 in the light source detection module 10 and the fundus image generated by the fundus camera 32 in the image module 30;

[0068] Alternatively, the data acquisition unit 41 is used to receive the reflection detection signal generated by the reflection detector 12 in the light source detection module 10 and the fundus image generated by the fundus camera 32 in the image module 30; the calculation unit 42 is used to generate a scan image according to the reflection detection signal;

[0069] The calculation unit 42 is used to determine the position of the imaging area displayed by the scanned image on the retina based on the fundus image and the scanned image;

[0070] The calculation unit 42 is also used to determine the relative position information of the scanned image and the target area based on the target area on the fundus image, and determine the adjustment signal of the fixation unit 33 based on the relative position information of the scanned image and the target area, and send the adjustment signal to the fixation unit 33 through the fixation unit controller 43, so that the fixation unit 33 guides the subject's eye E to change the gaze direction according to the adjustment signal to adjust the angle of the scanning light beam entering the subject's eye, so as to align the scanning light beam with the target area of ​​the subject's eye, thereby realizing the navigation of the scanning light beam on the retina.

[0071] Optionally, the fixation unit 33 can be a display screen or an LED array. When the computing unit 42 controls the fixation unit 33 through the fixation unit controller 43 to guide the subject's eye E to change its gaze direction, a fixation pattern (such as a bright cross) will be displayed on the fixation unit 33 (such as a display screen), and the subject's eyes will be required to stare at the fixation pattern. The fixation unit controller 43 changes the position of the fixation pattern according to the adjustment signal, thereby guiding the subject's eye to rotate and change its gaze direction, thereby aligning the scanning light beam with the target area of ​​the subject's eye.

[0072] Optional, such as Figure 1As shown, the image module 30 also includes a lens 34, a beam splitter 35 and a lens 36. The light emitted by the fundus illumination light source 31 can pass through the beam splitter 35 and the lens 36 to enter the subject's eye. The light reflected by the fundus can pass through the lens 36, the beam splitter 35 and the lens 34 in turn and then be collected by the fundus camera 32 to generate a fundus image.

[0073] Optionally, in some other embodiments of the present application, the acquisition control module 40 adjusts the angle of the scanning light beam entering the subject's eyeball according to the relative position information of the scanned image and the target area, including:

[0074] The acquisition control module 40 controls the optical path state of the light beam scanning module 20 according to the relative position information of the scanned image and the target area, so as to adjust the angle at which the scanned light beam enters the eyeball of the subject.

[0075] It can be understood that the acquisition control module 40 controls the change of the optical path state of the light beam scanning module 20 according to the relative position information of the scanned image and the target area, so that the incident angle of the scanning light beam output by the light beam scanning module 20 and entering the subject's eyeball will change, thereby making the scanning light beam aligned with the target area of ​​the subject's eyeball, thereby realizing the navigation of the scanning light beam on the retina.

[0076] Optionally, in some other embodiments of the present application, the acquisition control module 40 adjusts the angle of the scanning light beam entering the subject's eyeball according to the relative position information of the scanned image and the target area, including:

[0077] The acquisition control module 40 determines the adjustment signal of the fixation unit 33 according to the relative position information of the scanned image and the target area. The fixation unit 33 guides the subject's eyeball to change the gaze direction according to the adjustment signal. The acquisition control module 40 controls the optical path state of the light beam scanning module 20 according to the relative position information of the scanned image and the target area to adjust the angle of the scanning light beam entering the subject's eyeball.

[0078] That is, in the present embodiment, the acquisition control module 40 controls the fixation unit 33 to guide the subject's eyeball to change its gaze direction, and controls the change of the optical path state of the light beam scanning module 20 according to the relative position information of the scanned image and the target area, so as to adjust the angle at which the scanning light beam enters the subject's eyeball, thereby aligning the scanning light beam with the target area of ​​the subject's eyeball, thereby realizing the navigation of the scanning light beam on the retina.

[0079] Considering that existing retinal imaging devices are usually unable to track eye movements, common eye jerking can cause tearing and blurring of the scanned image, resulting in low availability of the scanned image. Based on this, optionally, in some embodiments of the present application, the acquisition control module 40 is also used to calculate the eye movement displacement value based on the scanned image and / or fundus image, and use the eye movement displacement value to control the optical path state of the light beam scanning module 20 to achieve eye movement tracking and solve the problem of image tearing and blurring and low image availability caused by large eye jerking.

[0080] It is understandable that the fundus image has a larger field of view, and the acquisition control module 40 can calculate the displacement value of the large-amplitude jump of the human eye based on the fundus image, while the scanning image has a smaller field of view, and the acquisition control module 40 can calculate the displacement value of the small-amplitude tremor of the human eye based on the scanning image. Then, the acquisition control module 40 calculates two tracking signals based on the two displacement values ​​and superimposes them on the control signal of the optical path state of the control beam scanning module 20 to achieve multi-scale real-time eye tracking. Of course, any one of the displacement values ​​can also be selected for tracking.

[0081] Specifically, Figure 1 As shown, the beam scanning module 20 includes a plurality of scanning elements, such as a first galvanometer 21A, a second galvanometer 21B and a third galvanometer 21C; Figure 2 As shown, the acquisition control module 40 includes a data acquisition unit 41, a calculation unit 42 and a scanning element controller 44;

[0082] The data acquisition unit 41 is used to receive the scanning image generated by the reflection detector 12 in the light source detection module 10 and the fundus image generated by the fundus camera 32 in the image module 30;

[0083] Alternatively, the data acquisition unit 41 is used to receive the reflection detection signal generated by the reflection detector 12 in the light source detection module 10 and the fundus image generated by the fundus camera 32 in the image module 30; the calculation unit 42 is used to generate a scan image according to the reflection detection signal;

[0084] The calculation unit 42 is used to determine the position of the imaging area displayed by the scanned image on the retina based on the fundus image and the scanned image;

[0085] The calculation unit 42 is also used to send a scanning signal and / or a tracking signal to each scanning element in the light beam scanning module 20 through the scanning element controller 44 according to the scanned image, so as to control the polarization state of each scanning element in the light beam scanning module 20 .

[0086] More specifically, Figure 1 As shown, the beam scanning module 20 includes a first galvanometer 21A, a second galvanometer 21B and a third galvanometer 21C;

[0087] The first galvanometer mirror 21A is also called a horizontal fast scanning mirror, and is used to achieve lateral scanning of the scanning beam;

[0088] The second galvanometer mirror 21B is also called a vertical slow-scan mirror, and is used to achieve longitudinal scanning and longitudinal tracking of the scanning beam;

[0089] The third galvanometer mirror 21C is also called a horizontal tracking mirror, and is used to achieve lateral tracking of the scanning light beam.

[0090] The first to third galvanometers serve as reflectors with variable angles, including but not limited to resonant mirrors, scanning galvanometers, acousto-optic modulators, MEMS galvanometers, etc.; "horizontal" and "vertical" are only used to indicate the two directions of two-dimensional rotation of the galvanometer, and do not limit its association with the actual horizontal and vertical planes, and the same applies to "transverse" and "longitudinal"; "fast scanning" and "slow scanning" are examples of galvanometer specifications set according to actual needs in this embodiment. Those skilled in the art can adopt galvanometers of different specifications according to needs, and can combine the transverse scanning and transverse tracking functions on the same galvanometer, or split the longitudinal scanning and longitudinal tracking functions into two galvanometers, or combine the transverse and longitudinal scanning on the same two-dimensional galvanometer; if the entire device only needs to realize the scanning function and does not need tracking, then only one two-dimensional galvanometer or two one-dimensional galvanometers need to be retained, which are used to realize the transverse and longitudinal scanning of the scanning beam respectively.

[0091] Accordingly, if Figure 2 As shown, in the acquisition control module 40, the calculation unit 42 sends a scanning signal and / or a tracking signal to the first galvanometer 21A, the second galvanometer 21B and the third galvanometer 21C in the light beam scanning module 20 through the scanning element controller 44 according to the scanned image, so as to control the deflection state of the first galvanometer 21A, the second galvanometer 21B and the third galvanometer 21C in the light beam scanning module 20.

[0092] Optional, such as Figure 1 As shown, the beam scanning module 20 also includes a beam phase modulation device 22 for aberration compensation. The beam phase modulation device 22 can be a deformable mirror, a spatial light modulator, a transmissive compensation mirror or other devices that can achieve phase modulation. Figure 1 As shown, the light beam scanning module 20 also includes a plurality of spherical reflectors to form a plurality of eyeball pupil conjugate surfaces, and the first galvanometer 21A, the second galvanometer 21B, the third galvanometer 21C and the light beam phase modulator 22 are each placed on an eyeball pupil conjugate surface. If it is necessary to delete some functions and reduce the number of eyeball pupil conjugate surfaces, the reflectors and galvanometers / light beam phase modulators on the light path can be reduced accordingly. In addition, those skilled in the art can also use transmissive optical elements to replace spherical reflectors to form the required eyeball pupil conjugate surfaces as needed.

[0093] For example, Figure 1 As shown, the light beam scanning module 20 includes ten spherical reflectors, namely spherical reflectors 1 to spherical reflectors 10, and five conjugate links are used to form six eye-pupil conjugate planes, wherein the light source detection module 10, the first galvanometer 21A, the second galvanometer 21B, the third galvanometer 21C, the light beam phase modulation device 22 and the pupil of the subject's eye E are respectively located on these six eye-pupil conjugate planes.

[0094] In this embodiment, if Figure 1 As shown, the light source detection module 10 may further include a wavefront detector 13, and the wavefront detector 13 is used to generate a wavefront detection signal according to the feedback light beam. Optionally, the wavefront detector 13 may be a Hartmann-Shack wavefront sensor.

[0095] Accordingly, if Figure 2 As shown, the acquisition control module 40 is also used to control the beam phase modulation device 22 in the beam scanning module 20 to perform aberration compensation according to the wavefront detection signal generated by the wavefront detector 13.

[0096] Specifically, Figure 2 As shown, in the acquisition control module 40, the data acquisition unit 41 is also used to acquire the wavefront detection signal generated by the wavefront detector 13 according to the feedback light beam; the calculation unit 42 generates a wavefront dot matrix based on the wavefront detection signal; or, the data acquisition unit 41 can also acquire the wavefront detection signal generated by the wavefront detector 13 according to the feedback light beam, and the wavefront dot matrix generated according to the wavefront detection signal; further, the calculation unit 42 generates a correction signal according to the wavefront dot matrix; the acquisition control module 40 also includes a compensation controller 45, and the compensation controller 45 controls the wavefront compensation amount of the beam phase modulation device 22 in the beam scanning module 20 according to the correction signal, so as to realize aberration compensation, improve the lateral and longitudinal resolution of the ophthalmic imaging device, and achieve ultra-high-definition cell-level retinal imaging resolution.

[0097] Optionally, in other embodiments of the present application, the beam phase modulation device 22 may not be set. In this case, there is no need to set the spherical reflectors 1 to 10, that is, the scanning light beam emitted from the light source detection module 10 is transmitted to the first galvanometer 21A, the second galvanometer 21B and the third galvanometer 21C (the order is not limited) in sequence, and then incident on the subject's eyeball E to achieve two-dimensional scanning and / or tracking.

[0098] like Figure 1 As shown, the light source detection module 10 may further include a spectroscope 14 , a spectroscope 15 and a lens 16 .

[0099] During specific operation, the infrared collimated light source 11 generates an infrared collimated light beam, which passes through the beam splitter 14 and the beam splitter 15 and is incident on the beam scanning module 20 as a scanning light beam; the beam scanning module 20 modulates the incident angle of the scanning light beam, and allows the modulated scanning light beam to enter the subject's eyeball E; the feedback light beam reflected by the retina is then incident on the light source detection module 10 through the beam scanning module 20, and part of the light in the feedback light beam is reflected by the beam splitter 15 to the wavefront detector 13 and is received by the wavefront detector 13, and the wavefront detector 13 generates a wavefront detection signal based on the received feedback light beam; part of the light in the feedback light beam is transmitted through the beam splitter 15, the beam splitter 14 and the lens 16 and is received by the reflection detector 12, and the reflection detector 12 generates a reflection detection signal or a scanning image based on the received feedback light beam.

[0100] like Figure 2 As shown, in the acquisition control module 40, the data acquisition unit 41 acquires the reflection detection signal generated by the reflection detector 12 according to the feedback light beam, transmits it to the calculation unit 42, and is processed by the calculation unit 42 to generate a real-time video-level frame rate scanning image; the calculation unit 42 calculates the direction and speed of the eye movement in real time based on the real-time scanning image, and various existing calculation methods can be used, such as the Normalized Cross Correlation (NCC) matching algorithm. According to the calculation results, the scanning signal and the tracking signal are sent to the first galvanometer 21A, the second galvanometer 21B and the third galvanometer 21C in the beam scanning module 20 through the scanning element controller 44, and the first galvanometer 21A, the second galvanometer 21B and the third galvanometer 21C are controlled to realize fundus scanning, and the scanning beam is made to move in the same direction and speed as the eye in real time to obtain a stable image, so as to achieve the purpose of eye movement tracking and real-time image stabilization.

[0101] Figure 3 FIG. 2 shows a schematic diagram of a scanning method for realizing fundus scanning and eye tracking by a light beam scanning module 20 in an ophthalmic imaging device provided in an embodiment of the present application, and FIG. Figure 2 and Figure 3As shown, the scanning element controller 44 in the acquisition control module 40 applies a transverse scanning signal K1 to the first galvanometer (horizontal fast scanning mirror 21A) in the beam scanning module 20, applies a transverse tracking signal K3 to the third galvanometer (horizontal tracking mirror 21C) in the beam scanning module 20, and applies a longitudinal scanning signal and a superposition signal K2 of the longitudinal tracking signal to the second galvanometer (vertical slow scanning mirror 21B) in the beam scanning module 20. The first galvanometer (horizontal fast scanning mirror 21A) realizes transverse scanning of the scanning beam under the action of the transverse scanning signal K1, and the second galvanometer (vertical slow scanning mirror 21B) realizes longitudinal scanning of the scanning beam under the action of the superposition signal K2, thereby forming a two-dimensional scan on the retina, and the reflection signal of each scanned point will be spliced ​​into a scanned image; at the same time, the third galvanometer (horizontal tracking mirror 21C) realizes transverse tracking of the scanning beam under the action of the transverse tracking signal K3, and the vertical slow scanning mirror 21B also realizes longitudinal tracking of the scanning beam under the action of the superposition signal K2, thereby realizing two-dimensional fundus scanning and eye tracking at the same time.

[0102] Optionally, the beam scanning module 20 also supports a line scanning mode, that is, the second galvanometer (vertical slow scanning mirror 21B) and the third galvanometer (horizontal tracking mirror 21C) are stopped, and the movement of the first galvanometer (horizontal fast scanning mirror 21A) is retained. The first galvanometer (horizontal fast scanning mirror 21A) realizes the horizontal scanning of the scanning beam under the action of the horizontal scanning signal K1. In this way, the acquisition control module 40 can obtain the line scanning image information of the high-speed horizontal scanning according to the reflected detection signal, which can be used to obtain dynamic fundus information, such as blood flow velocity measurement. In order to measure a specific blood vessel, it is necessary to determine the target blood vessel area in the fundus image, first navigate the scanning beam to the target blood vessel area on the retina, and then stop the second galvanometer and the third galvanometer for line scanning measurement. Alternatively, stop the first galvanometer (horizontal fast scanning mirror 21A) and the third galvanometer (horizontal tracking mirror 21C), and keep the second galvanometer (vertical slow scanning mirror 21B). The second galvanometer (vertical slow scanning mirror 21B) realizes the longitudinal scanning of the scanning light beam under the action of the longitudinal scanning signal K2. In this embodiment, the second galvanometer uses a slow scanning mirror. If high-speed scanning image information is required, a matching galvanometer can be selected according to needs.

[0103] It can be understood that the computing unit 42 in the acquisition control module 40 also controls the working status of the first galvanometer 21A, the second galvanometer 21B and the third galvanometer 21C in the light beam scanning module 20 through the scanning element controller 44 to control whether the light beam scanning module 20 is in a line scanning mode or a two-dimensional fundus scanning and eye tracking mode.

[0104] It should be noted that the present application does not limit the placement order of the first galvanometer (horizontal fast-scanning mirror 21A), the second galvanometer (vertical slow-scanning mirror 21B), the third galvanometer (horizontal tracking mirror 21C) and the beam phase modulation device 22, and they can be adjusted and swapped in the optical path according to actual conditions.

[0105] It should also be noted that Figure 1 The optical path topology structure shown is only a preferred optical path structure, which has the advantages of simple optical path structure and better performance. In other embodiments, other forms of optical path topology structures may be used, depending on the specific situation.

[0106] Optionally, in some embodiments of the present application, such as Figure 1 As shown, the ophthalmic imaging device further includes a pupil positioning module 50, which includes a pupil illumination light source 51, a pupil camera 52 and a moving part (not shown in the figure); the pupil illumination light source 51 is used to generate pupil illumination light, and the pupil camera 52 collects a pupil image to determine the displacement of the pupil;

[0107] The moving component is used to adjust the relative position of the optical axis of the ophthalmic imaging device and the pupil according to the displacement of the pupil, so that the optical axis of the ophthalmic imaging device is aligned with the pupil. Of course, the subject can also be guided to directly move his head to achieve this purpose.

[0108] Optionally, the pupil illumination light source 51 may be a pupil illumination LED.

[0109] Specifically, the light emitted by the pupil illumination light source 51 illuminates the entire ocular surface, and the pupil camera 52 collects the light reflected back by the pupil to generate a pupil image, and the pupil camera 52 can collect the pupil image of the subject in real time.

[0110] Optionally, the movable component can be a head support component, which is used to place the subject's head and drive the subject's head to move according to the displacement of the pupil to adjust the relative position of the optical axis of the ophthalmic imaging device and the pupil so that the optical axis of the ophthalmic imaging device is aligned with the pupil.

[0111] Alternatively, the moving component may also drive the ophthalmic imaging device to move so as to adjust the relative position of the optical axis of the ophthalmic imaging device and the pupil so as to align the optical axis of the ophthalmic imaging device with the pupil.

[0112] Alternatively, the movable component can also drive both the subject's head and the ophthalmic imaging device to move, so as to adjust the relative position of the optical axis of the ophthalmic imaging device and the pupil, so that the optical axis of the ophthalmic imaging device is aligned with the pupil.

[0113] like Figure 2As shown, the acquisition control module 40 also includes a moving component controller 46. The data acquisition unit 41 in the acquisition control module 40 is also used to acquire the pupil image generated in real time by the pupil camera 52. Then, the calculation unit 42 calculates the pupil offset based on the pupil image, and controls the moving component to move the subject's head and / or the ophthalmic imaging device through the moving component controller 46 based on the pupil offset, so that the optical axis of the ophthalmic imaging device is aligned with the pupil.

[0114] When the moving component is a head support component, the head support component can be a three-axis head support motor, and the moving component controller 46 can be a motor controller. The motor controller controls the three-axis head support motor to drive the subject's head to move, so as to achieve the purpose of aligning the optical axis of the ophthalmic imaging device with the pupil.

[0115] It should be noted that the optical axis of the ophthalmic imaging device can be the optical axis of the scanning beam emitted by the beam scanning module 20, the optical axis of the fundus camera 32 in the image module 30, or the optical axis of the pupil camera 52 in the pupil positioning module 50, depending on the specific circumstances.

[0116] Optional, such as Figure 2 As shown, the acquisition control module 40 also includes a light source controller 47;

[0117] The calculation unit 42 also controls the opening and closing of the infrared collimated light source 11 and the light intensity of the infrared collimated light emitted by the infrared collimated light source 11 through the light source controller 47;

[0118] The calculation unit 42 also controls the opening and closing of the pupil illumination light source 51 and the light intensity of the pupil illumination light emitted by the pupil illumination light source 51 through the light source controller 47;

[0119] The calculation unit 42 also controls the turning on and off of the fundus illumination light source 31 and the light intensity of the fundus illumination light emitted by the fundus illumination light source 31 through the light source controller 47 .

[0120] In summary, if Figure 2As shown, the acquisition control module 40 can receive four input signals, namely, the reflection detection signal / scanning image generated by the reflection detector 12, the wavefront detection signal / wavefront dot pattern generated by the wavefront detector 13, the fundus image generated by the fundus camera 32, and the pupil image generated by the pupil camera 52. In addition, the acquisition control module 40 can control the fixation unit 33 through the fixation unit controller 43 to guide the subject's eye to change its gaze direction, so as to adjust the angle of the scanning light beam entering the subject's eyeball and realize navigation of the scanning light beam on the retina; and can control the deflection state of each galvanometer in the beam scanning module 20 through the scanning element controller 44 to realize fundus navigation, scanning and eye movement tracking; and can also control the wavefront compensation amount of the beam phase modulation device 22 in the beam scanning module 20 through the compensation controller 45 to realize aberration compensation; and can adjust the relative position of the optical axis of the ophthalmic imaging device and the pupil through the moving component controller 46 to align the optical axis of the ophthalmic imaging device with the pupil to improve the imaging quality; and can control the opening and closing of each light source (infrared collimated light source 11, fundus illumination light source 31 and pupil illumination light source 51) and the light intensity of the emitted light through the light source controller 47 to facilitate automation.

[0121] like Figure 1 As shown, the ophthalmic imaging device may further include a reflector D1 and a beam splitter D2, which are arranged in front of the subject's eyes. Not only can the light emitted by the beam scanning module 20 enter the subject's eyeball E through the reflector D1 and the beam splitter D2, but the light emitted by the fundus illumination light source 31 and the pupil illumination light source 51 can also enter the subject's eyeball E through the reflector D1 and the beam splitter D2.

[0122] Figure 4 A workflow diagram of the ophthalmic imaging device provided in an embodiment of the present application is further shown, which is divided into two types: automated operation and user operation. The automated operation is actively initiated and controlled by the computing unit (represented by a solid line frame in the figure), and the user operation requires the user to select the timing and parameters of the operation (represented by a dotted line frame in the figure).

[0123] Specifically, first, after the subject places the head on the head support component, the pupil camera 51 of the pupil positioning module 50 automatically generates a pupil image and transmits it to the acquisition control module 40. The acquisition control module 40 determines the displacement of the pupil based on the pupil image, and drives the subject's head to move through the head support component according to the displacement of the pupil, so that the optical axis of the ophthalmic imaging device is aligned with the pupil, that is, through the control loop of the pupil camera 51-acquisition control module 40-head support component, "automatic pupil positioning" is achieved;

[0124] Moreover, the fundus camera 31 in the image module 30 also automatically generates a fundus image and transmits it to the acquisition control module 40. The operator can select a target area in the fundus image for navigation, i.e., "select ROI (region of interest) according to the fundus navigation map". The acquisition control module 40 automatically calculates the corresponding fixation coordinates, which are displayed by the fixation unit 33. The fixation unit 33 guides the subject's eyeball to change the gaze direction to adjust the angle of the scanning light beam entering the subject's eyeball so that the scanning light beam is aligned with the target area of ​​the subject's eyeball, i.e., "fixation sight mark position movement".

[0125] In addition, the optical path system composed of the light source detection module 10, the light beam scanning module 20 and the subject's eyeball E collects the reflection detection signal of the subject's eyeball E, and obtains a blurred scanned image after being processed by the acquisition control module 40; then the wavefront detector 13 automatically adjusts the exposure, that is, "adjust the wavefront detector exposure", the operator clicks "adaptive optical correction", the acquisition control module 40 controls the light beam phase modulation device 22 (that is, the compensation mirror) to first perform low-order aberration pre-compensation, and then turns on the "adaptive optical closed-loop control loop", and keeps it until the end of shooting. After the adaptive optical correction is successfully turned on The acquisition control module 40 automatically controls the beam phase modulation device 22 to perform aberration compensation in real time, and the blurred scanned image becomes clear. The system automatically enters the focus search, finds the photoreceptor cell layer and automatically adjusts the exposure of the scanned image. The operator can observe the real-time scanned image becoming clearer and the exposure adjustment process, which corresponds to the two steps of "focusing and searching the photoreceptor cell layer" and "adjusting the image exposure". Of course, since the search accuracy is not absolutely perfect, the operator can manually focus and fine-tune the image to the best state. After that, different modes can be selected according to the microstructure (cells or blood vessels) of interest to the operator.

[0126] If the operator selects the "visual cell" mode and clicks "shooting", the real-time tracking function of the scanned image is immediately turned on, that is, the control loops of the acquisition control module 40 and the galvanometers in the beam scanning module 20 are used to realize eye tracking. The acquisition control module 40 records the scanned image as a short-term video (it can also be saved in the form of multiple pictures), and performs image registration and superposition on the recorded video to generate a cell image with a high signal-to-noise ratio. The calculation unit 42 in the acquisition control module 40 automatically segments the cell image and outputs a series of quantitative parameters such as cell density and regularity into the cell analysis results;

[0127] If the operator selects the "vascular blood flow" mode and clicks to shoot, a single fundus image is taken. The operator clicks on the position of the blood vessel to be measured on the fundus image, and the acquisition control module 40 controls the beam scanning module 20 to enter the line scanning mode, and saves the line scanning image in the form of a short video (it can also be saved in the form of multiple pictures). The calculation unit 42 in the acquisition control module 40 analyzes the line scanning data to calculate the blood flow velocity and outputs it to the vascular blood flow analysis result.

[0128] from Figure 4 It can be seen that the ophthalmic imaging device provided in the embodiment of the present application can use the acquisition control module 40 to realize the automated control process, and use the hardware control loop to transfer most of the operation steps ( Figure 4 The steps in the solid line frame are changed to automated adjustment, making the ophthalmic imaging device convenient and easy to use, and solving the problem of complex and low efficiency operation of existing retinal imaging devices.

[0129] It can be seen that in the ophthalmic imaging device provided in the embodiment of the present application, in the first aspect, the light source detection module 10 generates a scanning light beam which is incident on the light beam scanning module 20, and the light beam scanning module 20 modulates the incident angle of the scanning light beam, and the modulated scanning light beam enters the eyeball of the subject, and the feedback light beam reflected by the retina passes through the light beam scanning module 20 and is incident on the light source detection module 10; the light source detection module 10 generates a scanning image based on the feedback light beam; the image module 30 generates a fundus illumination light to illuminate the fundus, and collects a fundus image; since the imaging area displayed by the fundus image is significantly larger than and includes the imaging area displayed by the scanning image, the fundus image and the scanning image can be compared to determine the position of the imaging area of ​​the scanning image on the retina, so that the user can determine whether the current scanning image is the target area, and can also determine where the scanning image should move to reach the target area, that is, under the navigation of the fundus image, the user can directly and quickly find the target area on the retina, and the operation steps are simple and the clinical efficiency is high, that is, the ophthalmic imaging device provided in the embodiment of the present application can quickly locate the area of ​​interest on the retina and is convenient and easy to use.

[0130] Secondly, the acquisition control module 40 also controls the optical path state of the beam scanning module 20 according to the scanned image and / or fundus image to achieve eye movement tracking and solve the problem of image tearing and blurring and low image availability caused by large eye jitter.

[0131] Thirdly, the beam scanning module 20 may further include a beam phase modulator 22 for aberration compensation; the light source detection module 10 may further include a wavefront detector 13, which is used to generate a wavefront detection signal based on the feedback beam; the acquisition control module 40 also controls the beam phase modulator 22 in the beam scanning module 20 to perform aberration compensation based on the wavefront detection signal generated by the wavefront detector 13, thereby improving the resolution of the ophthalmic imaging device and achieving ultra-high-definition cell-level retinal imaging resolution, so as to generate cell images, vascular blood flow analysis results and other results for the operator to observe the conditions of the retinal visual cells and microvessels of the subject's eyeball.

[0132] Fourthly, the ophthalmic imaging device also includes a pupil positioning module 50, which is used to collect pupil images, determine the offset of the pupil, and adjust the relative position of the optical axis of the ophthalmic imaging device and the pupil according to the offset of the pupil, so that the optical axis of the ophthalmic imaging device is aligned with the pupil, thereby improving clinical efficiency.

[0133] Fifthly, the acquisition control module 40 can be used to realize an automated control process, and the hardware control loop can be used to change most of the operation steps into automated adjustments, making the ophthalmic imaging device convenient and easy to use, thus solving the problem of complex and inefficient operation of existing ophthalmic imaging devices.

[0134] It should be emphasized that the optical system for retinal scanning composed of the light source detection module 10 and the light beam scanning module 20 is used in combination with the image module 30, the pupil positioning module 50 and the acquisition control module 40. First, the image module 30 can be used to capture fundus images, and the reflected detection signal captured by the optical system can be used to generate a scanning image. The acquisition control module 40 can quickly determine the position of the imaging area displayed by the scanning image on the retina by comparing the fundus image and the scanning image, and locate the target area, determine the relative position information of the scanning image and the target area, and adjust the angle of the scanning light beam entering the subject's eyeball according to the relative position information of the scanning image and the target area, so that the scanning light beam is aligned with the target area of ​​the subject's eyeball, thereby realizing the navigation of the scanning light beam on the retina, and greatly improving the scanning efficiency of the above optical system; secondly, the acquisition control module 40 can quickly determine the position of the imaging area displayed by the scanning image on the retina by comparing the fundus image and the scanning image, and locate the target area, determine the relative position information of the scanning image and the target area, and adjust the angle of the scanning light beam entering the subject's eyeball according to the relative position information of the scanning image and the target area, so as to align the scanning light beam with the target area of ​​the subject's eyeball, thereby realizing the navigation of the scanning light beam on the retina, and greatly improving the scanning efficiency of the above optical system; secondly, the acquisition control module 40 can quickly determine the position of the imaging area displayed by the scanning image on the retina, and locate the target area, determine the relative position information of the scanning image and the target area, and adjust the relative position information of the scanning light beam entering the subject's eyeball according to the relative position information of the scanning light beam and the target area, so as to align the scanning light beam with the target area of ​​the subject's eyeball, thereby realizing the navigation of the scanning light beam on the retina, and greatly improving the scanning efficiency of the above optical system; secondly, the acquisition control module 4 The collection control module 40 determines the pupil offset based on the pupil image generated by the pupil positioning module 50, adjusts the relative position of the optical axis of the ophthalmic imaging device and the pupil, aligns the optical axis of the ophthalmic imaging device with the pupil, and ensures that the above-mentioned optical system scans the subject's eyeball efficiently and accurately; furthermore, during the scanning of the retina by the above-mentioned optical system, the pupil positioning module 50 can adjust the optical axis of the ophthalmic imaging device to align with the pupil in real time, and the image module 30 or the light beam scanning module 20 can adjust the angle of the scanning light beam entering the subject's eyeball in real time, which has high clinical efficiency, and the acquisition control module 40 also automates most of the steps.

[0135] In summary, the ophthalmic imaging device provided in the embodiments of the present application can quickly locate the region of interest on the retina and can track eye movements, and the scanned image has high resolution and is convenient and easy to use.

[0136] The present application also provides an ophthalmic imaging method, which is applied to the ophthalmic imaging device provided in any of the above embodiments. Figure 4 The workflow of the “Photocell” mode in the ophthalmology imaging method includes:

[0137] S10: using a scanning device to obtain an eyeball retina scanning image, using an imaging device to obtain a fundus image, and selecting a target area in the fundus image;

[0138] Specifically, the light source detection module 10 and the light beam scanning module 20 in the ophthalmic imaging device constitute a scanning device. The light source detection module 10 generates a scanning light beam incident on the light beam scanning module 20. The light beam scanning module 20 modulates the incident angle of the scanning light beam. The modulated scanning light beam enters the subject's eyeball. The feedback light beam reflected by the retina passes through the light beam scanning module 20 and is incident on the light source detection module 10. The light source detection module 10 also obtains a reflection detection signal based on the feedback light beam, and the reflection detection signal can generate a scanning image of the retina of the eyeball. At the same time, the image module 30 in the ophthalmic imaging device collects fundus images, so that the target area (i.e., the area of ​​interest) can be selected in the fundus image. It should be noted that the scanning device and the image device involved in the method are not limited to the structure disclosed in this embodiment. Those skilled in the art will know that other alternatives that can obtain scanning images and fundus images are adopted.

[0139] S11: According to the relative position information of the scanned image and the target area, the angle of the scanning light beam of the scanning device entering the subject's eyeball is adjusted so that the scanning light beam is aligned with the target area of ​​the eyeball, thereby achieving navigation of the scanning light beam on the retina.

[0140] Specifically, the acquisition control module 40 in the ophthalmic imaging device can determine the relative position information of the scanned image and the target area based on the target area on the fundus image, and adjust the angle of the scanning light beam of the scanning device entering the subject's eyeball according to the relative position information of the scanned image and the target area, so that the scanning light beam is aligned with the target area of ​​the eyeball, thereby realizing the navigation of the scanning light beam on the retina.

[0141] S12: Acquire the eyeball retina scanning image in real time and perform aberration compensation on the scanning optical path.

[0142] Specifically, while the scanning device composed of the light source detection module 10 and the light beam scanning module 20 acquires the retinal scanning image of the eye in real time, the wavefront detector 13 in the light source detection module 10 generates a wavefront detection signal based on the feedback light beam, and then the acquisition control module 40 controls the light beam phase modulation device 22 in the light beam scanning module 20 to perform aberration compensation based on the wavefront detection signal.

[0143] S13: focusing the scanning device on the photoreceptor layer, obtaining a photoreceptor image, and performing real-time eye tracking.

[0144] Specifically, in the process of using the acquisition control module 40 to control the beam phase modulation device 22 in the beam scanning module 20 to perform aberration compensation, the scanned image becomes clear, that is, the scanning device focuses on the visual cell layer. Since the search accuracy is not absolutely perfect, the operator can manually focus and fine-tune the image to the best state to obtain the visual cell image. In addition, the acquisition control module 40 is also used to calculate the eye movement displacement value based on the scanned image and / or the fundus image, and the eye movement displacement value is used to control the optical path state of the beam scanning module 20 to perform eye movement tracking.

[0145] S14: Process the visual cell image to obtain cell analysis results.

[0146] Specifically, the acquisition control module 40 may be used to process the visual cell image to obtain the cell analysis result.

[0147] It should be noted that the distinction between step S11 to step S14 is intended to achieve different functions and is not intended to limit the order of precedence.

[0148] The present application also provides another ophthalmic imaging method, which is applied to the ophthalmic imaging device provided in any of the above embodiments. Figure 4 The workflow of the “Vascular Blood Flow” mode in the ophthalmology imaging method includes:

[0149] S20: using a scanning device to obtain an eyeball retina scanning image, using an imaging device to obtain a fundus image, and selecting a target area in the fundus image;

[0150] S21: According to the relative position information of the scanned image and the target area, the angle of the scanning light beam of the scanning device entering the subject's eyeball is adjusted so that the scanning light beam is aligned with the target area of ​​the eyeball, thereby achieving navigation of the scanning light beam on the retina.

[0151] S22: Acquire the eyeball retina scanning image in real time and perform aberration compensation on the scanning optical path.

[0152] The specific implementation of step S20 to step S22 can refer to step S10 to step S12, which will not be described in detail here. S23: Focus the scanning device on the photoreceptor layer, and obtain the blood vessel image of the photoreceptor by line scanning.

[0153] Specifically, in the process of using the acquisition control module 40 to control the beam phase modulation device 22 in the beam scanning module 20 to perform aberration compensation, the scanned image becomes clear, that is, the scanning device is focused on the photoreceptor layer. Since the search accuracy is not absolutely perfect, the operator can manually focus and fine-tune the image to the best state. After using the acquisition control module 40 and the image module 30 to navigate the scanning beam to the target blood vessel area on the retina, the beam scanning module 20 is used to perform a line scan of the target blood vessel on the retina to obtain a vascular image of the photoreceptor.

[0154] S24: Process the blood vessel image of the visual cell to obtain a blood flow analysis result.

[0155] Specifically, the acquisition control module 40 may be used to process the blood vessel image of the visual cell to obtain the blood flow analysis result.

[0156] It should be noted that the distinction between step S21 to step S24 is intended to achieve different functions and is not intended to limit the order of precedence.

[0157] The various parts in this manual are described in a combination of parallel and progressive ways. Each part focuses on the differences from other parts, and the same or similar parts between the various parts can be referenced to each other.

[0158] With respect to the above description of the disclosed embodiments, the features described in the embodiments in this specification may be replaced or combined with each other, so that professionals in the field can implement or use the present application. Various modifications to these embodiments will be apparent to professionals in the field, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An ophthalmic imaging device, characterized in that: It includes a light source detection module, a light beam scanning module and an image module; The light source detection module is used to generate a scanning light beam incident on the light beam scanning module; The beam scanning module is used to modulate the incident angle of the scanning beam, and the modulated scanning beam enters the eyeball of the subject, and the feedback beam reflected by the retina passes through the beam scanning module and is incident on the light source detection module; The light source detection module is also used to obtain a reflection detection signal according to the feedback light beam, and the reflection detection signal is used to generate a scan image; The image module is used to generate fundus illumination light to illuminate the fundus and to collect fundus images; the fundus images are used to compare with the scanned images to determine the position of the imaging area displayed by the scanned images on the retina.

2. The ophthalmic imaging device according to claim 1, characterized in that: The ophthalmic imaging device also includes an acquisition control module, which is used to determine the relative position information of the scanned image and the target area based on the target area on the fundus image, and adjust the angle of the scanning light beam entering the subject's eyeball according to the relative position information.

3. The ophthalmic imaging device according to claim 2, characterized in that: The image module includes a fixation unit, and the acquisition control module adjusts the angle at which the scanning light beam enters the subject's eyeball according to the relative position information, including: The acquisition control module determines an adjustment signal of the fixation unit according to the relative position information, and the fixation unit guides the subject's eyeball to change its gaze direction according to the adjustment signal to adjust the angle at which the scanning light beam enters the subject's eyeball.

4. The ophthalmic imaging device according to claim 2, characterized in that: The acquisition control module adjusts the angle at which the scanning light beam enters the subject's eyeball according to the relative position information, including: The acquisition control module controls the optical path state of the light beam scanning module according to the relative position information to adjust the angle at which the scanning light beam enters the eyeball of the subject.

5. The ophthalmic imaging device according to claim 2, characterized in that: The acquisition control module is also used to calculate the eye movement displacement value based on the scanned image and / or the fundus image, and use the eye movement displacement value to control the optical path state of the light beam scanning module to achieve eye movement tracking.

6. The ophthalmic imaging device according to claim 5, characterized in that: The beam scanning module includes first to third galvanometer mirrors; The first galvanometer is used to realize the lateral scanning of the scanning light beam; The second galvanometer is used to realize the lateral tracking of the scanning light beam; The third galvanometer is used to realize longitudinal scanning and longitudinal tracking of the scanning light beam.

7. The ophthalmic imaging device according to claim 1, characterized in that: The beam scanning module includes a plurality of scanning elements; the ophthalmic imaging device also includes an acquisition control module, the acquisition control module includes a data acquisition unit, a calculation unit and a scanning element controller; The data acquisition unit is used to receive the fundus image and the scanned image, or to receive the fundus image and the reflected detection signal, and the calculation unit generates the scanned image according to the reflected detection signal; The calculation unit is used to determine the position of the imaging area displayed by the scanned image on the retina based on the fundus image and the scanned image; The calculation unit is also used to send a scanning signal and / or a tracking signal to each scanning element in the light beam scanning module through the scanning element controller according to the scanning image, so as to control the deflection state of each scanning element in the light beam scanning module.

8. The ophthalmic imaging device according to claim 1, characterized in that: The beam scanning module includes a beam phase modulation device for performing aberration compensation; The light source detection module includes a wavefront detector, and the wavefront detector is used to generate a wavefront detection signal according to the feedback light beam; The ophthalmic imaging device further comprises an acquisition control module, and the acquisition control module is used to control the beam phase modulation device in the beam scanning module to perform aberration compensation according to the wavefront detection signal.

9. The ophthalmic imaging device according to claim 1, characterized in that: The ophthalmic imaging device further comprises a pupil positioning module, wherein the pupil positioning module comprises a pupil illumination light source and a pupil camera; The pupil illumination light source is used to generate pupil illumination light, and the pupil camera collects pupil images for determining the displacement of the pupil.

10. An ophthalmic imaging method, characterized in that: include: Acquire an eyeball retina scanning image using a scanning device, acquire an eye fundus image using an imaging device, and select a target area in the eye fundus image; According to the relative position information of the scanned image and the target area, adjusting the angle at which the scanning light beam of the scanning device enters the eyeball of the subject so that the scanning light beam is aligned with the target area of ​​the eyeball, thereby achieving navigation of the scanning light beam on the retina; Acquire the retina scanning image of the eye in real time and perform aberration compensation on the scanning device; Focusing the scanning device on the photoreceptor layer, obtaining a photoreceptor image, and performing real-time eye tracking; The visual cell images are processed to obtain cell analysis results.

11. An ophthalmic imaging method, characterized in that: include: Acquire a retina scanning image of an eyeball using a scanning device, acquire a fundus image using an imaging device, and select a target area in the fundus image; According to the relative position information of the scanned image and the target area, adjusting the angle at which the scanning light beam of the scanning device enters the eyeball of the subject so that the scanning light beam is aligned with the target area of ​​the eyeball, thereby achieving navigation of the scanning light beam on the retina; Acquire the retina scanning image of the eye in real time and perform aberration compensation on the scanning device; Focusing the scanning device on the photoreceptor layer, and obtaining the blood vessel image of the photoreceptor by line scanning; The blood vessel images of the visual cells are processed to obtain blood flow analysis results.

Images