A biosafety type small and medium-sized animal transmission infection device

Abstract

The application relates to a biosafety type small and medium-sized animal transmission infection device, and relates to the technical field of transmission infection experiment devices. The device comprises an infected animal cabin, a droplet infection cabin which is arranged beside the infected animal cabin and is communicated with the infected animal cabin, and the communication part is isolated through two layers of screens; an aerosol infection cabin which is communicated with the droplet infection cabin through a pipeline; a drying and cooling device which is communicated with the infected animal cabin; a first fan, a communication pipeline of which is provided with a first filter, and the first filter is communicated with the aerosol infection cabin; a transmission window which is arranged on a cabin body in communication and is used for inputting or outputting articles into the cabin; a second fan which is arranged in communication and is provided with a second filter, and the second filter is communicated with the transmission window. An animal limiting module is arranged in the cabin body and is used for limiting the activity range of animals. The application is suitable for the cabin body of the small and medium-sized animal transmission infection experiment, and meets the needs of the small and medium-sized animal transmission infection experiment.

Description

Technical Field

[0001] This application relates to the field of experimental devices for the transmission of infection, and in particular to a biosafety-compliant device for the transmission of infection in small and medium-sized animals. Background Technology

[0002] Currently, in order to make rapid and accurate diagnoses of infectious diseases, comprehensive testing and analysis of pathogenic microorganisms are often required. Inhalation toxicology is a science that studies the various conditions, laws and mechanisms under which the toxicological effects of inhalable substances occur, develop and are eliminated in the body, as well as the risk assessment of inhalable substances.

[0003] With the increasing activity in international inhalation toxicology research, many domestic experts have also fully recognized the importance of inhalation toxicology. For example, some existing inhalation toxicology studies involve conducting experiments with healthy animals and animals carrying pathogens together. The pathogen-carrying animals infect the healthy animals through exhaled droplets and aerosols, and then conduct experiments on the transmission of infection between animals through droplets and aerosols.

[0004] Some animals, such as mice, are small in size and do not require much space, so multiple mice can be placed in one experimental device at the same time. However, for some larger animals, such as monkeys, they require a lot of space, and it is difficult for a single experimental three-level cabinet or similar device to accommodate two or more monkeys or monkey cages at the same time. Therefore, there is a need to provide a transmission and infection device for conducting transmission and infection experiments on small and medium-sized animals. Summary of the Invention

[0005] In view of the above problems, this application is made in order to provide a biosafety device for the transmission of infection in small and medium-sized animals that overcomes or at least partially solves the above problems.

[0006] The biosafety-based small and medium-sized animal transmission and infection device provided in this application adopts the following technical solution:

[0007] A biosafety-compliant device for transmitting infection in small and medium-sized animals, comprising an infected animal compartment for housing infected animals;

[0008] A droplet infection chamber, used to house healthy animals, is located next to and connected to the infected animal chamber, with the connection point isolated by two layers of screens;

[0009] An aerosol infection chamber is used to house healthy animals and is connected to the droplet infection chamber via a pipe.

[0010] A drying and cooling device is connected to the infected animal compartment and is used to deliver air with a certain temperature and humidity into the infected animal compartment;

[0011] The first fan has a first filter installed in the connecting pipe, and the first filter is connected to the aerosol infection chamber.

[0012] A pass-through window is connected to the infected animal cabin, the droplet infection cabin, and the aerosol infection cabin, and is used to input or output items into or out of the cabin;

[0013] The second fan is connected to a second filter, and the second filter is connected to the transfer window.

[0014] An animal containment module is provided, which is installed in the infected animal chamber, the droplet infection chamber, and the aerosol infection chamber to limit the range of animal activity.

[0015] Optionally, the animal restraint module includes,

[0016] The isolation frame is horizontally installed inside the cabin and can move vertically up and down along the height of the cabin.

[0017] The lifting assembly includes a lifting screw with a lifting nut and a lifting drive mechanism. The lifting screw is vertically installed in the isolation chamber below the cabin body and rotatably connected to it. A lifting plate is installed on the lifting nut. The lifting plate is connected to the isolation frame through a support rod that runs vertically through the bottom of the cabin body. The lifting drive mechanism is used to drive the lifting screw to rotate.

[0018] The extrusion frame is vertically installed inside the chamber and can slide horizontally along the length of the chamber.

[0019] The equipment includes left and right extrusion components, including an extrusion screw with an extrusion nut and an extrusion drive mechanism. The extrusion screw is horizontally disposed in the chamber and rotatably connected thereto. The extrusion nut is connected to the extrusion frame. The extrusion drive mechanism is used to drive the extrusion screw to rotate.

[0020] Optionally, the extrusion frame includes,

[0021] The frame is connected to the compression nut;

[0022] A pair of grid frames are provided, which are arranged vertically side by side within the frame, and the sides of the grid frames that are close to each other are rotatably connected to the frame through a pivot; each of the two pivots is provided with a gear, and the two gears mesh to drive each other.

[0023] A locking mechanism is provided between the frame and the grid frame, and is used to adjust and control the unfolding and folding of a pair of grid frames.

[0024] Optionally, the locking mechanism includes,

[0025] A locking base is sleeved on the outside of each of the rotating shafts, and a pair of locking bases are connected to each other or both are connected to the frame;

[0026] A locking ratchet is provided on each of the rotating shafts and located inside the locking base;

[0027] And a locking spring pin is provided on each of the locking bases, with a locking ratchet tooth at the end that meshes with the locking ratchet, and the two pairs of corresponding locking ratchet and locking ratchet teeth have the same meshing direction.

[0028] Optionally, the locking base is movably configured, and each locking base is connected to a retractable drive rod, and the frame is provided with limiting fasteners for limiting the drive rod.

[0029] Optionally, the limiting fastener includes a pair of baffles, which are respectively disposed on both sides of the frame.

[0030] Optionally, the limiting fastener includes a pair of retaining rings, which are respectively disposed on both sides of the frame.

[0031] Optionally, the isolation frame includes a first isolation frame and a second isolation frame, and both the first isolation frame and the second isolation frame are respectively provided with vertical lifting components.

[0032] Optionally, multiple extrusion screws are provided, and the multiple extrusion screws are evenly arranged along the circumferential direction of the cabin.

[0033] Optionally, each of the cabins is provided with multiple glove openings, and each glove opening is provided with an opening / closing plate for closing its opening, the opening / closing plate comprising,

[0034] The plate body corresponds to the shape of the glove opening, and one side of the plate body is hinged to the glove opening; the plate body is provided with a groove along its radial direction;

[0035] A sliding buckle is provided in the sliding groove and can slide along its length; a locking groove is provided on the inner side wall of the glove opening, and when the plate is in the state of blocking the glove opening, the sliding buckle can be inserted into the locking groove;

[0036] A knob is provided on the plate and is used to drive the sliding buckle to move inward toward the inside of the groove;

[0037] A reset spring is provided in the slide groove and is used to drive the sliding buckle to move and reset along the outer side of the slide groove.

[0038] Optionally, multiple sliding buckles (N≥2) can be provided. The plate body is uniformly provided with sliding grooves corresponding to the number of sliding buckles along its circumferential direction. The inner sidewall of the glove opening is uniformly provided with locking grooves corresponding to the number of sliding buckles along its circumferential direction. The inner end of each sliding buckle is rotatably connected to a connecting rod.

[0039] The knob is concentrically arranged with the plate and rotatably connected to the plate; the ends of the multiple connecting rods away from the sliding buckle are rotatably connected to the edge of the knob and are evenly arranged along the circumferential direction of the knob.

[0040] Optionally, each of the transfer window and the cabin is provided with an opening and closing door, and the transfer window is also provided with an opening and closing assembly for controlling the opening and closing of the opening and closing door, the opening and closing assembly including,

[0041] A shaft is arranged parallel to the side wall of the transfer window and rotatably connected to it;

[0042] A roller groove is located on the opening and closing door and is arranged along the length direction of the opening and closing door;

[0043] The opening and closing rod has one end fixedly connected to the shaft, and the other end passes through the groove and is rotatably connected to a roller, and the roller can roll and slide along the length of the groove.

[0044] And an opening and closing drive mechanism for driving the shaft to rotate.

[0045] Optionally, multiple pairs (N≥2) of the roller groove and the opening / closing rod can be provided, that is, multiple roller grooves and multiple opening / closing rods are provided in a one-to-one correspondence.

[0046] In summary, this application includes the following beneficial technical effects:

[0047] 1. This application meets the needs of small and medium-sized animal transmission and infection experiments by setting up a cabin that is also suitable for small and medium-sized animal transmission and infection experiments;

[0048] 2. This application achieves the clamping and limiting of experimental animals by setting a limiting module that can limit the experimental animals in three directions inside the chamber, which facilitates the operation of experimental personnel such as sampling or blood collection, and ensures the safety of experimental personnel. Attached Figure Description

[0049] Figure 1 This is a schematic diagram of the overall structure of an embodiment of this application;

[0050] Figure 2 This is a schematic diagram of the animal restraint module in an embodiment of this application;

[0051] Figure 3This is a schematic diagram of the transfer window structure in an embodiment of this application;

[0052] Figure 4 This is a schematic diagram of the opening and closing component in an embodiment of this application;

[0053] Figure 5 This is a schematic diagram of the structure of the first embodiment of the extrusion frame in this application;

[0054] Figure 6 This is a schematic diagram of the structure of the first embodiment of the locking mechanism in this application;

[0055] Figure 7 This is a schematic diagram of the structure of the second embodiment of the extrusion frame in this application. Figure 1 ;

[0056] Figure 8 This is a schematic diagram of the second embodiment of the locking mechanism in this application. Figure 1 ;

[0057] Figure 9 This is a schematic diagram of the structure of the second embodiment of the extrusion frame in this application. Figure 2 ;

[0058] Figure 10 This is a schematic diagram of the second embodiment of the locking mechanism in this application. Figure 2 ;

[0059] Figure 11 This is a schematic diagram showing the connection relationship between the glove opening and the opening / closing plate in an embodiment of this application;

[0060] Figure 12 This is a schematic diagram of the opening and closing plate in an embodiment of this application;

[0061] Explanation of reference numerals in the attached diagrams: 1. Animal infection chamber; 2. Droplet infection chamber; 3. Aerosol infection chamber; 4. Pass-through window; 41. Opening / closing door; 42. Opening / closing assembly; 421. Shaft; 422. Roller groove; 423. Opening / closing lever; 5. Animal restraint module; 51. Isolation frame; 52. Upward and downward lifting assembly; 521. Lifting screw; 522. Lifting plate; 53. Compression frame; 531. Frame; 5311. Baffle; 5312. Clamping ring; 53 2. Grille frame; 5321. Rotating shaft; 5322. Gear; 533. Locking mechanism; 5331. Locking base; 53311. Drive rod; 5332. Locking ratchet; 5333. Locking spring pin; 54. Left and right pressing components; 541. Pressing screw; 6. Glove opening; 61. Opening and closing plate; 611. Plate body; 6111. Slide groove; 612. Sliding buckle; 613. Knob; 614. Return spring; 615. Connecting rod. Detailed Implementation

[0062] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of this invention. Obviously, the described embodiments are one embodiment of this invention, and not all embodiments. Based on the described embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0063] Unless otherwise defined, the technical or scientific terms used in this invention shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.

[0064] This embodiment provides a biosafety-based device for the transmission of infection in small and medium-sized animals.

[0065] Reference Figure 1 A biosafety-compliant small and medium-sized animal transmission infection device includes an infected animal chamber 1, a droplet infection chamber 2, an aerosol infection chamber 3, a drying and cooling device, a first fan, a transfer window 4, and a second fan. The infected animal chamber 1 is used to house infected animals, i.e., animals carrying pathogenic microorganisms; the droplet infection chamber 2 and the aerosol infection chamber 3 are used to house healthy animals. The droplet infection chamber 2 is located next to and connected to the infected animal chamber 1, with the connection point separated by two layers of screens, preferably 10 cm apart. The aerosol infection chamber 1 is connected to the droplet infection chamber 2 via a pipe, preferably 1.5 m in length.

[0066] A drying and cooling device is connected to the infected animal chamber 1 to introduce air of a certain temperature and humidity into the infected animal chamber 1, providing environmental conditions for simulating the transmission and infection conditions of pathogenic microorganisms under different temperature and humidity environments in the infected animal chamber 1, droplet infection chamber 2, and aerosol infection chamber 3. A first fan is connected to the aerosol infection chamber 3, and a first filter is also connected between the first fan and the aerosol infection chamber 3 to prevent aerosol leakage from the chamber to the outside. Three transfer windows 4 are provided, which are respectively connected to the chamber bodies of the infected animal chamber 1, droplet infection chamber 2, and aerosol infection chamber 3 (in this application, the chamber body refers to the infected animal chamber 1, droplet infection chamber 2, and aerosol infection chamber 3), and the connection state between the transfer windows 4 and the chamber body can be controlled so as to input or output items into or out of the chamber during the experiment. A second fan is connected to all the transfer windows 4 set on the chamber body, and a second filter is also connected between the second fan and the transfer windows 4 to prevent aerosol leakage from the transfer windows 4 to the outside.

[0067] Reference Figures 1-4Each transfer window 4 is equipped with an opening and closing door 41 at the connection point between itself and the cabin. The opening and closing door 41 is hinged to the transfer window 4, and the opening and closing of the opening and closing door 41 is controlled by an opening and closing assembly 42, which is also provided on the transfer window 4. The opening and closing assembly 42 includes a shaft 421, a roller groove 422, an opening and closing rod 423, and an opening and closing drive assembly.

[0068] The shaft 421 is arranged parallel to the side wall of the transfer window 4 and is rotatably connected to the transfer window 4. The opening and closing drive mechanism is used to drive the rotating shaft 5321 to rotate, preferably a handwheel, motor, etc. The roller groove 422 is located in the middle of the inner side of the opening and closing door 41 and is arranged along its length. One end of the opening and closing rod 423 is fixedly connected to the shaft 421, and the other end passes through the roller groove 422 and is rotatably connected to a roller. The roller can roll and slide along the length of the roller groove 422. Therefore, during the process of the shaft 421 driving the opening and closing rod 423 to rotate, the roller rolls along the roller groove 422, driving the opening and closing door 41 to rotate along the hinge point, thereby realizing the opening and closing control of the opening and closing door 41.

[0069] In the specific implementation process, in order to ensure the support stability of the opening and closing door 41 in the opening and closing state, multiple pairs of roller grooves 422 and opening and closing rods 423 can be correspondingly provided. Multiple roller grooves 422 are evenly distributed along the inner width direction of the opening and closing door 41, and multiple opening and closing rods 423 are evenly distributed along the axis 421, and multiple roller grooves 422 and multiple opening and closing rods 423 are provided in a one-to-one correspondence. In this application, the preferred embodiment is: each pair of opening and closing rods 423 and roller grooves 422 is provided, with a pair of opening and closing rods 423 distributed on both sides of the axis 421, and a pair of roller grooves 422 correspondingly distributed on both sides of the inner side of the opening and closing door 41.

[0070] To further ensure the tight connection between the opening and closing door 41 and the transfer window 4 when the door is closed, an electromagnetic adsorption component can be installed between the opening and closing door 41 and the transfer window 4 to prevent gas inside the cabin from entering the transfer window 4 when the transfer window 4 is not in operation and causing contamination to the transfer window 4.

[0071] Reference Figure 1 , Figure 2 In order to facilitate blood collection and other operations on animals inside the chamber, each chamber is equipped with an animal restraint module 5 for restricting the animal's limbs, and each chamber is also equipped with a glove opening 6 to facilitate the insertion of the experimenter's hands into the chamber.

[0072] The animal restraint module 5 includes an isolation frame 51, an up-and-down lifting assembly 52, a squeezing frame 53, and a left-and-right squeezing assembly 54.

[0073] The isolation frame 51 is horizontally installed inside the cabin. The lifting assembly 52 is used to drive the isolation frame 51 to slide along the height direction of the cabin to restrict the height of the animal's movement space. It includes a lifting screw 521 with a lifting nut and a lifting drive mechanism. An isolation chamber is provided below the cabin. The lifting screw 521 is vertically installed in the isolation chamber and rotatably connected to it. The lifting drive mechanism is used to drive the lifting screw 521 to rotate.

[0074] The lifting assembly 52 also includes a lifting plate 522, which is horizontally positioned within the isolation chamber and connected to a lifting nut. The lifting plate 522 is connected to the isolation frame 51 via a vertical support rod extending through the bottom of the chamber. As the lifting nut moves along the lifting screw, it drives the lifting plate 522 to move vertically, which in turn drives the isolation frame 51 to move vertically, thus achieving height-limiting control of the animal. In practice, multiple support rods can be provided, evenly distributed circumferentially along the edge of the lifting plate 522 to ensure the connection stability between the lifting plate 522 and the isolation frame 51. Furthermore, to ensure the connection stability between the lifting nut and the lifting plate 522, a smooth rod can be provided at the top of the isolation chamber, with the lifting plate 522 vertically slidingly connected to the smooth rod.

[0075] In practical application, in order to facilitate the input or output of items into or out of the cabin through the transfer window 4, the isolation frame 51 may include a first isolation frame and a second isolation frame arranged side by side, and each of the first isolation frame and the second isolation frame is equipped with a corresponding up-and-down lifting component 52.

[0076] Reference Figure 1 , Figure 2 as well as Figures 5-10 The compression frame 53 is vertically installed inside the chamber and above the isolation frame 51. The left and right compression components 54 are used to drive the compression frame 53 to slide along the length of the chamber, thereby limiting the animal's movement space in the left and right directions. The left and right compression components 54 include a compression screw 541 with a compression nut and a compression drive mechanism. The compression screw 541 is horizontally installed inside the chamber and rotatably connected to it. The compression nut is connected to the compression frame 53. The compression drive mechanism is used to drive the compression screw 541 to rotate, so that as the compression nut moves along the compression screw 541, it drives the compression frame 53 to slide along the length of the chamber, thereby achieving the left and right direction limitation control of the animal.

[0077] In the specific implementation process, multiple extrusion screws 541 can be provided, and the multiple extrusion screws 541 are evenly distributed along the circumferential direction of the extrusion frame 53 to ensure the stability of the sliding movement of the extrusion frame 53. In this application, the optimal implementation is: four extrusion screws 541 are provided, and the four extrusion screws 541 are distributed at the four corners of the cabin, which can ensure the stability of the sliding of the extrusion frame 53 while ensuring the rational utilization of the internal space of the cabin.

[0078] To further limit the animal's movement space, the compression frame 53 is designed to be foldable, thereby limiting the animal's movement space in three directions, minimizing the animal's movement space, and facilitating operations such as blood collection or sampling by personnel.

[0079] The extrusion frame 53 includes a frame 531 and a grid frame 532. A pair of grid frames 532 are arranged side by side in the frame 531, and the sides of the pair of grid frames 532 that are close to each other are rotatably connected to the frame 531 through a rotating shaft 5321. A gear 5322 is provided on each of the pair of rotating shafts 5321, and the pair of gears 5322 mesh and drive each other.

[0080] To facilitate control of the mutual folding angle of the pair of grid frames 532, the compression frame 53 also includes a locking mechanism 533, which includes a pair of locking bases 5331, a pair of locking ratchet wheels 5332 and a pair of locking spring pins 5333.

[0081] In the first embodiment, a pair of locking bases 5331 are respectively sleeved on the outside of a pair of rotating shafts 5321 and connected to each other or both are fixedly connected to the frame 531. A pair of locking ratchet wheels 5332 are respectively sleeved on a pair of rotating shafts 5321 and located inside the locking bases 5331. A pair of locking spring pins 5333 are respectively disposed on a pair of locking bases 5331, and the ends of the locking spring pins 5333 are each provided with locking ratchet teeth that mesh with the corresponding locking ratchet wheels 5332. The locking directions of the two pairs of corresponding locking ratchet wheels 5332 and locking ratchet teeth are the same.

[0082] In the above embodiment, when both locking ratchet teeth are engaged with the corresponding locking ratchet wheels 5332, the pair of grid frames 532 are locked together and cannot rotate. When the locking ratchet teeth disengage from the corresponding locking ratchet wheels 5332 under the driving action of the locking spring pins 5333, the grid frames 532 can be unfolded or folded.

[0083] To facilitate understanding of the locking state of the locking mechanism 533 described above, this application uses... Figure 5 , Figure 6 As a specific embodiment, the locking ratchet 5332 and the locking ratchet tooth mesh in a counterclockwise direction. That is, when the corresponding locking ratchet 5332 and the locking ratchet tooth are in the meshing state, the locking ratchet 5332 can rotate counterclockwise.

[0084] when Figure 6 When the locking ratchet teeth on both sides are engaged with the corresponding locking ratchet 5332, the locking ratchet 5332 can only rotate counterclockwise. Since the rotation direction of a pair of grid frames 532 is opposite when the grid frame 532 is folded or unfolded, they are locked together. At this time, neither of the grid frames 532 can move.

[0085] when Figure 6 When the locking ratchet on the right is disengaged from the corresponding locking ratchet 5332 under the drive of the locking spring pin 5333, the locking ratchet 5332 on the left can rotate counterclockwise, which can drive a pair of grid frames 532 to move to the side away from each other, so as to realize the unfolding of the grid frames 532.

[0086] when Figure 6 When the locking ratchet on the left is disengaged from the corresponding locking ratchet 5332 under the drive of the locking spring pin 5333, the locking ratchet on the right can rotate counterclockwise. This drives a pair of grid frames 532 to move toward each other, thus folding the grid frames 532.

[0087] In the second embodiment, the difference from the first embodiment is that the locking base 5331 is movably configured, that is, the locking base 5331 is neither connected to each other nor to the frame 531, but each locking base 5331 is connected to a retractable drive rod 53311, and the frame 531 is provided with limiting fasteners for limiting the drive rod 53311. The limiting fasteners are preferably a pair of baffles 5311 or a pair of retaining rings 5312.

[0088] When the limiting fastener is a pair of baffles 5311 respectively disposed on both sides of the frame 531. To facilitate understanding of the locking state of the locking mechanism 533 described above, this application uses... Figure 7 , Figure 8 As a specific embodiment, the locking ratchet 5332 and the locking ratchet tooth mesh in a counterclockwise direction. That is, when the corresponding locking ratchet 5332 and the locking ratchet tooth are in the meshing state, the locking ratchet 5332 can rotate counterclockwise.

[0089] In the initial state, a pair of drive rods 53311 abut against the outer side of a pair of baffles 5311 respectively. At this time, the baffles 5311 restrict the outward folding of the grille frame 532, and the drive rods 53311 restrict the inward folding of the grille frame 532. At this time, the grille frame 532 is in a fully unfolded state.

[0090] When folding the grid frame 532, firstly, the right drive rod 53311 is retracted and driven to rotate clockwise by a certain angle. Then, the left locking spring pin 5333 is pulled out, and then the right drive rod 53311 is controlled to rotate counterclockwise. This, in turn, drives the right grid frame 532 to rotate counterclockwise through the cooperation of the locking ratchet and locking ratchet wheel 5332. At the same time, the right grid frame 532 drives the left grid frame 532 to move clockwise through the gear 5322, thus realizing the folding of the grid frame 532. When the grid frame 532 is folded to a suitable angle, the right drive rod 53311 is then pressed against the inside of the baffle 5311 and the left locking spring pin 5333 is inserted. Finally, the left drive rod 53311 is pressed against the inside of the baffle 5311. At this time, the pair of grid frames 532 are mutually limited and the grid frame 532 is fixed.

[0091] When the grid frame 532 is unfolded, the left drive rod 53311 is retracted and driven to rotate clockwise. Then, the right locking spring pin 5333 is pulled out, and the left drive rod 53311 is controlled to rotate counterclockwise. This, in turn, drives the left grid frame 532 to rotate counterclockwise through the cooperation of the locking ratchet and locking ratchet 5332, thus unfolding the grid frame 532. When it is unfolded to the appropriate state, the right locking spring pin 5333 is then inserted and the left drive rod 53311 is brought into contact with the inner (or outer) side of the baffle 5311. This brings the right drive rod 53311 into contact with the inner (or outer) side of the baffle 5311, thus unfolding (or fully unfolding) the grid frame 532.

[0092] When the limiting fastener is a pair of retaining rings 5312 respectively located on both sides of the frame 531, the drive rod 53311 is located on the outside of the grid frame 532 and can be controlled by telescopic movement to pass through the retaining rings 5312. Figure 9 , Figure 10 In the case shown, when folding the grille frame 532, simply pull out the locking spring pin 5333 on the left side, and then drive the right grille frame 532 to rotate counterclockwise via the drive rod 53311 on the right side. This, in turn, drives the left grille frame 532 to rotate clockwise via the gear 5322, thus achieving the folding of the grille frame 532. When unfolding the grille frame 532, simply pull out the locking spring pin 5333 on the right side, and then drive the left grille frame 532 to rotate counterclockwise via the drive rod 53311 on the left side. This, in turn, drives the right grille frame 532 to rotate clockwise via the gear 5322, thus achieving the unfolding of the grille frame 532.

[0093] Reference Figure 1 , Figure 11 as well as Figure 12To prevent experimental animals in the chamber from scratching the gloves at the glove opening 6 during the experiment, each glove opening 6 is equipped with an opening / closing plate 61 for sealing the opening. The opening / closing plate 61 includes a plate body 611, a sliding buckle 612, a knob 613, and a return spring 614.

[0094] A plate 611 is disposed inside the glove opening 6, corresponding to the shape of the glove opening 6 and used to seal the opening, and one side of the plate 611 is hinged to the glove opening 6. A groove 6111 is provided on the plate 611 along its radial direction, and a sliding buckle 612 is located in the groove 6111 and can slide along its length. A knob 613 is disposed on the plate 611 and is used to drive the sliding buckle 612 to slide inward to the inside of the groove 6111. A return spring 614 is disposed in the groove 6111 and is used to drive the sliding buckle 612 to slide and return to its original position along the outside of the groove 6111. When the plate 611 is in the state of sealing the glove opening 6, the sliding buckle 612 can be inserted into the locking groove provided on the inner wall of the glove opening 6.

[0095] In the specific implementation process, in order to ensure the stability of the connection between the plate 611 and the glove opening 6, multiple sliding buckles 612 can be provided (N≥2), and multiple sliding grooves 6111, locking grooves and return springs 614 are provided accordingly.

[0096] Multiple sliding grooves 6111 are evenly arranged along the circumference of the plate 611, and multiple locking grooves are evenly arranged along the circumference of the inner sidewall of the glove opening 6 and correspond one-to-one with the multiple sliding grooves 6111. A knob 613 is concentrically arranged with the plate 611 and rotatably connected to it. Each sliding buckle 612 has a connecting rod 615 rotatably connected to its inner end, and the ends of multiple connecting rods 615 facing away from the sliding buckles 612 are rotatably connected to the edge of the knob 613 and evenly arranged along the circumference of the knob 613. In this case, the knob 613 can synchronously drive multiple sliding buckles 612 to slide synchronously along the sliding grooves 6111 via the multiple connecting rods 615. In this application, a preferred embodiment is that a pair of sliding buckles 612 are provided, and the pair of sliding buckles 612 are symmetrically distributed.

[0097] In medium-sized animal transmission and infection experiments, one medium-sized animal is placed in each of the infected animal chamber 1, droplet infection chamber 2, and aerosol infection chamber 3. In small animal laboratories, the special cages for small animal transmission experiments can be placed directly into the chambers. In this case, the chambers can be regarded as three-level cabinets, which can further ensure the safety of transmission and infection experiments.

[0098] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A biosafety-compliant device for transmitting infection in small and medium-sized animals, characterized in that: include, Infected animal compartment (1), used to house infected animals; Droplet infection chamber (2), used to place healthy animals, is set up next to and connected to the infected animal chamber (1), and the connection is isolated by two layers of screens; The aerosol infection chamber (3) is used to place healthy animals and is connected to the droplet infection chamber (2) via a pipe. A drying and cooling device is connected to the infected animal chamber (1) and is used to deliver air with a certain temperature and humidity into the infected animal chamber (1); The first fan has a first filter installed in the connecting pipe, and the first filter is connected to the aerosol infection chamber (3). A pass-through window (4) is connected to the infected animal chamber (1), the droplet infection chamber (2) and the aerosol infection chamber (3) for inputting or outputting items into or out of the chamber; The second fan is connected to the second filter, and the second filter is connected to the transfer window (4); And an animal confinement module (5) is installed in the infected animal chamber (1), the droplet infection chamber (2) and the aerosol infection chamber (3) to limit the range of animal activity; The animal restraint module (5) includes, The extrusion frame (53) is vertically installed in the chamber and can slide horizontally along the length of the chamber. The extrusion frame (53) includes, The frame (531) is connected to the compression nut; A pair of grid frames (532) are provided, and the pair of grid frames (532) are arranged vertically side by side in the frame (531), and the sides that are close to each other are rotatably connected to the frame (531) through a rotating shaft (5321); a gear (5322) is provided on each of the pair of rotating shafts (5321), and the pair of gears (5322) mesh and drive each other; And a locking mechanism (533) is disposed between the frame (531) and the grid frame (532) and is used to adjust and control the unfolding and folding of a pair of grid frames (532).

2. The biosafety-based small and medium-sized animal transmission and infection device according to claim 1, characterized in that: The animal restraint module (5) also includes, The isolation frame (51) is horizontally installed inside the cabin and can move vertically up and down along the height of the cabin. The lifting assembly (52) includes a lifting screw (521) with a lifting nut and a lifting drive mechanism. The lifting screw (521) is vertically installed in the isolation chamber below the cabin body and rotatably connected to it. A lifting plate (522) is provided on the lifting nut. The lifting plate (522) is connected to the isolation frame (51) through a support rod that runs vertically through the bottom of the cabin body. The lifting drive mechanism is used to drive the lifting screw (521) to rotate. And left and right extrusion assemblies (54), including an extrusion screw (541) with an extrusion nut and an extrusion drive mechanism. The extrusion screw (541) is horizontally arranged in the chamber and rotatably connected thereto. The extrusion nut is connected to the extrusion frame (53). The extrusion drive mechanism is used to drive the extrusion screw (541) to rotate.

3. The biosafety-based small and medium-sized animal transmission and infection device according to claim 1, characterized in that: The locking mechanism (533) includes, A locking base (5331) is sleeved on the outside of each of the pivots (5321), and a pair of locking bases (5331) are connected to each other or both are connected to the frame (531); A locking ratchet (5332) is provided on each of the said pivots (5321) and located inside the locking base (5331); And a locking spring pin (5333) is provided on each of the locking bases (5331), with a locking ratchet tooth at the end that meshes with the locking ratchet (5332), and the two pairs of corresponding locking ratchets (5332) and the locking ratchet teeth have the same meshing direction.

4. The biosafety-based small and medium-sized animal transmission and infection device according to claim 3, characterized in that: The locking base (5331) is movably configured, and each locking base (5331) is connected to a retractable drive rod (53311), and the frame (531) is provided with a limiting fastener for limiting the drive rod (53311).

5. A biosafety-based small and medium-sized animal transmission and infection device according to claim 4, characterized in that: The limiting fastener includes a pair of baffles (5311), which are respectively disposed on both sides of the frame (531).

6. The biosafety-based small and medium-sized animal transmission and infection device according to claim 4, characterized in that: The limiting fastener includes a pair of retaining rings (5312), which are respectively disposed on both sides of the frame (531).

7. A biosafety-based small and medium-sized animal transmission and infection device according to claim 2, characterized in that: The isolation frame (51) includes a first isolation frame and a second isolation frame, and both the first isolation frame and the second isolation frame are respectively provided with a vertical lifting component (52).

8. A biosafety-based small and medium-sized animal transmission and infection device according to claim 2, characterized in that: Multiple extrusion screws (541) are provided, and the multiple extrusion screws (541) are evenly arranged along the circumferential direction of the cabin.

9. A biosafety-based small and medium-sized animal transmission and infection device according to claim 1, characterized in that: Each of the cabins is provided with multiple glove openings (6), and each glove opening (6) is provided with an opening / closing plate (61) for closing its opening. The opening / closing plate (61) includes, The plate (611) corresponds to the shape of the glove opening (6), and one side of the plate (611) is hinged to the glove opening (6); the plate (611) is provided with a groove (6111) in its radial direction; A sliding buckle (612) is provided in the sliding groove (6111) and can slide along its length; a locking groove is provided on the inner side wall of the glove opening (6), and when the plate (611) is in the state of blocking the opening of the glove opening (6), the sliding buckle (612) can be inserted into the locking groove; A knob (613) is provided on the plate (611) and is used to drive the sliding buckle (612) to move inward toward the groove (6111); A reset spring (614) is provided in the groove (6111) and is used to drive the sliding buckle (612) to move and reset along the outer side of the groove (6111).

10. A biosafety-based small and medium-sized animal transmission and infection device according to claim 9, characterized in that: Multiple sliding buckles (612) can be provided (N≥2). The plate (611) is uniformly provided with grooves (6111) corresponding to the number of sliding buckles (612) along its circumferential direction. The inner wall of the glove opening (6) is uniformly provided with locking grooves corresponding to the number of sliding buckles (612) along its circumferential direction. The inner end of each sliding buckle (612) is rotatably connected to a connecting rod (615). The knob (613) is concentrically arranged with the plate (611) and rotatably connected to the plate (611); the ends of the multiple connecting rods (615) away from the sliding buckle (612) are rotatably connected to the edge of the knob (613) and are evenly arranged along the circumferential direction of the knob (613).

11. A biosafety-based small and medium-sized animal transmission and infection device according to claim 1, characterized in that: The transfer window (4) and the cabin are both provided with opening and closing doors (41), and the transfer window (4) is also provided with an opening and closing assembly (42) for controlling the opening and closing of the opening and closing doors (41). The opening and closing assembly (42) includes, A shaft (421) is arranged parallel to the side wall of the transfer window (4) and rotatably connected to it; A groove (422) is located on the opening and closing door (41) and is provided along the length direction of the opening and closing door (41); The opening and closing rod (423) is fixedly connected to the shaft (421) at one end and passes through the groove (422) at the other end and is rotatably connected to a roller. The roller can roll and slide along the length of the groove (422). And an opening and closing drive mechanism for driving the shaft (421) to rotate.

12. A biosafety-based small and medium-sized animal transmission and infection device according to claim 11, characterized in that: The roller groove (422) and the opening and closing rod (423) can be provided in multiple pairs (N≥2), that is, multiple roller grooves (422) and multiple opening and closing rods (423) are provided in one-to-one correspondence.

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