Application of gold cluster fluorescent probe in animal hematopoietic stem cell transplantation evaluation

Through the combination of infrared 2-zone gold cluster fluorescence probe and near-infrared 2-zone fluorescence imaging technology, the problem that traditional imaging methods are difficult to monitor deep tissue cells is solved, high-resolution dynamic imaging of transplanted hematopoietic stem cells is achieved, accurate evaluation methods are provided, and the development of hematopoietic stem cell transplant treatment plans and regenerative medicine research is supported.

CN119791596AInactive Publication Date: 2025-04-11ACADEMY OF MILITARY MEDICAL SCIENCES
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Patent Information

Application Number
CN202411908310.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-23
Publication Date
2025-04-11
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Traditional imaging methods are difficult to achieve high sensitivity and real-time tracking of transplanted cells in deep tissues, and it is impossible to accurately monitor the survival, distribution and migration of transplanted hematopoietic stem cells.

Method used

The infrared second-zone gold cluster fluorescent probe is used to target recognition of specific cells through surface modification, and combined with near-infrared second-zone fluorescent imaging technology, targeted imaging and dynamic monitoring of transplanted hematopoietic stem cells are achieved.

Benefits of technology

High-resolution, deep-level dynamic imaging of transplanted hematopoietic stem cells is achieved, accurate evaluation methods are provided, helping to develop hematopoietic stem cell transplant treatment plans, and providing reliable tools for regenerative medicine research.

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Abstract

The invention discloses application of a gold cluster fluorescent probe to evaluation of in-vivo conditions of animals with transplanted mouse hematopoietic stem cells. Based on the research basis of a high-sensitivity and high-specificity infrared two-region targeting gold cluster probe, a mouse model with hematopoietic stem cell injury caused by radiation injury is constructed, hematopoietic system injury of people suffering from ionizing radiation is simulated, and the reconstruction of a hematopoietic system and an immune function is successfully realized by transplanting hematopoietic stem cells. The quantity of hematopoietic stem cells in a transplanted mouse body is evaluated by utilizing the fluorescence intensity of a targeting gold cluster probe in an infrared second region, so that in-vivo imaging and evaluation of the transplanted mouse hematopoietic stem cells are realized; the method is of great significance to fundamental research and clinical treatment method evaluation of hematopoietic stem cell transplantation treatment of hematopoietic system injury related diseases.
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