A gold film-space engineering array integrated microfluidic chip and a preparation method and application thereof

By integrating microfluidic chips with a gold film-space engineering array, the problems of SERS signal stability and multi-target detection in microfluidic chips have been solved, enabling efficient and sensitive simultaneous detection of multiple molecules and improving the efficiency and sensitivity of analysis and detection.

CN119951600BActive Publication Date: 2026-07-24HANGZHOU NORMAL UNIVERSITY
4 Cites 0 Cited by

Patent Information

Application Number
CN202510126029.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-01-27
Publication Date
2026-07-24
Estimated Expiration
2045-01-27

AI Technical Summary

Technical Problem

Existing microfluidic chips suffer from problems such as poor SERS signal stability, limitations in laser angle, and inability to detect multiple targets simultaneously.

Method used

The microfluidic chip is integrated with a gold film-space engineering array, combining a fine channel design with a gold film-space engineering array SERS substrate. It includes a polystyrene compound eye array structure layer, a nano gold film layer and a nano gold ball layer arranged from bottom to top, integrating multiple parallel detection chips and modifying them with different probe molecules to achieve simultaneous detection of multiple molecules.

Benefits of technology

It significantly improves the sensitivity and efficiency of detection, enables rapid sample detection, reduces reagent consumption, has high anti-reflection capability and omnidirectional light capture characteristics, and has high signal intensity and good stability.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The application discloses a gold film-space engineering array integrated microfluidic chip and a preparation method and application thereof, and belongs to the technical field of microfluidic detection, and comprises a microfluidic channel, wherein the microfluidic channel comprises a sample inlet area, a detection area and a sample outlet area, the detection area is provided with a plurality of parallel detection chips; the detection chip is a gold film-space engineering arrayed SERS substrate which is modified with probe molecules; the gold film-space engineering arrayed SERS substrate comprises a polystyrene compound eye array structure layer, a nano-gold film layer and a nano-gold ball layer which are arranged from bottom to top; the polystyrene compound eye array structure layer is a monolayer film which is composed of polystyrene microspheres, and a plurality of non-overlapping pits are distributed on each polystyrene microsphere. The gold film-space engineering array integrated microfluidic chip can significantly improve the efficiency and sensitivity of analysis and detection.
Need to check novelty before this filing date? Find Prior Art