A fungicidal composition containing pyridinitrilamide and thiaflavionol

Abstract

The present application provides a fungicidal composition containing pyridinylamide and thiamethoxam, wherein the weight ratio of pyridinylamide to thiamethoxam is 1:200 to 200:1. The fungicidal composition can be prepared into emulsifiable concentrate, suspension concentrate, microemulsion, suspoemulsion, aqueous emulsion, dispersible oil suspension, wettable powder, water dispersible granule, suspension seed coating, etc. by adding agriculturally acceptable adjuvants and / or carriers. The present application also relates to the method and application of the composition for controlling agricultural diseases.

Description

Technical Field

[0001] This invention belongs to the agricultural field, specifically relating to a fungicide composition containing pyridoxin and thiamethoxam and its application. Background Technology

[0002] Florylpicoxamid is a second-generation pyridine amide fungicide with a novel mechanism of action. It acts on the cytochrome bc1 complex of the mitochondrial respiratory system of pathogens, exerting its fungicidal activity by inhibiting mitochondrial respiration at the binding site of Qi ubiquinone (coenzyme Q) in the fungal complex III. Florylpicoxamid has a preventative effect, preventing spore germination on leaf surfaces; it also has a curative effect when used in the early stages of fungal infection in crops. Florylpicoxamid inhibits mycelial growth and spore development in fungi, thus preventing further spread of the fungus within the crop. Florylpicoxamid is used on various plants, including cereals, grapes, fruit trees, nut trees, vegetables, rapeseed, and sugar beets, to control plant diseases such as powdery mildew, anthracnose, scab, coin spot, leaf blight, gray mold, black shank, early blight, and sclerotinia rot.

[0003] The patent application for the technical compound of pyridine amide is WO2016109257, and the Chinese patent is CN107205405B. It is a pyridine amide compound with fungicidal activity, and the application date is December 18, 2015.

[0004] It is known that pyridabenamide can be mixed with tebuconazole and other fungicides to control crop diseases, exhibiting a synergistic effect. For example, CN114668012A discloses a fungicide composition containing pyridabenamide and tebuconazole, in which pyridabenamide and tebuconazole have a synergistic effect, and can be prepared into a pesticide formulation for the control of diseases of vegetables, fruit trees, corn, peanuts, and wheat caused by pathogens.

[0005] Thiamethoxam, also known as 1,2-benzisothiazolin-3-one, belongs to the isothiazole heterocyclic compound class. It is a novel, highly effective, low-toxicity, broad-spectrum fungicide, mainly used to control and treat various diseases such as downy mildew, black spot, scab, anthracnose, black rot, rot, canker, black shank, and leaf spot. Thiamethoxam is a protective fungicide. Its mechanism of action mainly involves binding to anions or sulfhydryl groups on the surface of pathogen cell membranes, disrupting the pathogen's nuclear structure, damaging protein and cell membrane synthesis systems, interfering with pathogen cell metabolism, inhibiting pathogen reproduction, and leading to pathogen death. This compound has good control effects on crops caused by bacteria and fungi, and is very safe for crops.

[0006] No reports have been found of a combination of pyridabenamide and thiamethoxam in the existing technology. Invention Overview

[0007] This invention relates to a fungicidal composition containing pyridabenamide and thiamethoxam, which has a synergistic effect in the prevention and control of agricultural diseases.

[0008] The present invention mainly includes the following technical solutions.

[0009] A bactericidal composition, characterized in that the active ingredients of the bactericidal composition contain pyridoxin and thiamethoxam, wherein the weight ratio of pyridoxin to thiamethoxam is 1:200 to 200:1.

[0010] The bactericidal composition according to the present invention is characterized in that the weight ratio of pyridabenamide to thiamethoxam is preferably 1:100 to 100:1.

[0011] The bactericidal composition according to the present invention is characterized in that the weight ratio of pyridabenamide to thiamethoxam is more preferably 1:75 to 75:1.

[0012] The bactericidal composition according to the present invention is characterized in that the bactericidal composition further comprises agriculturally acceptable adjuvants and / or carriers.

[0013] The bactericidal composition according to the present invention is characterized in that the bactericidal composition is prepared as one or more of the following: emulsifiable concentrate, suspension concentrate, microemulsion, suspension emulsion, water emulsion, dispersible oil suspension, wettable powder, water-dispersible granules, and suspension seed coating agent.

[0014] The bactericidal composition according to the present invention is characterized in that the agriculturally acceptable adjuvants and / or carriers include: solvents, dispersants, wetting agents, emulsifiers, stabilizers, thickeners, antifreeze agents, binders, disintegrants, defoamers, warning colors, film-forming agents, and fillers.

[0015] The bactericidal composition according to the present invention is characterized in that the total weight percentage of active ingredients in the bactericidal composition is 1-80%.

[0016] The method for using the bactericidal composition of the present invention to control agricultural diseases is characterized in that the bactericidal composition is brought into contact with the agricultural plant or its propagation material before or after the occurrence of the agricultural disease.

[0017] The use of the bactericidal composition according to the present invention for the prevention and control of agricultural diseases.

[0018] According to the uses described in this invention, the agricultural diseases include powdery mildew, leaf spot, smut, rust, curvularia leaf spot, large leaf spot, small leaf spot, black shank, sclerotinia rot, early blight, black spot, downy mildew, gray mold, anthracnose, Phytophthora blight, flower rot, leaf spot, black spot, and brown rot that occur on field crops, vegetables, and fruit trees. Invention Details

[0020] This invention relates to a fungicidal composition containing pyridabenamide and thiamethoxam. Studies have found that pyridabenamide and thiamethoxam have a synergistic effect in the control of agricultural diseases. Moreover, the application of the synergistic composition can reduce the development of pathogen resistance, reduce the total amount of pesticides applied, and improve the control effect, which is beneficial to the control of agricultural diseases.

[0021] The present invention provides a bactericidal composition containing pyridabenamide and thiamethoxam, wherein the weight ratio of pyridabenamide to thiamethoxam in the composition is 1:200 to 200:1, preferably 1:100 to 100:1, more preferably 1:75 to 75:1, and even more preferably, for example, 1:50 to 50:1, 1:45 to 45:1, 1:40 to 40:1, 1:35 to 35:1, 1:30 to 30:1, 1:25 to 25:1, 1:20 to 20:1, 1:15 to 15:1, 1:10 to 10:1, 1:5 to 5:1, etc.

[0022] The bactericidal composition of the present invention can be prepared into an agriculturally usable formulation by adding agriculturally acceptable adjuvants and / or carriers, including but not limited to: emulsifiable concentrates, suspensions, microemulsions, suspension emulsions, water emulsions, dispersible oil suspensions, wettable powders, water-dispersible granules, suspension seed coating agents, etc.

[0023] In the formulation preparation process described in this invention, the agriculturally acceptable adjuvants and / or carriers used include, but are not limited to: solvents, dispersants, wetting agents, emulsifiers, stabilizers, thickeners, antifreeze agents, binders, disintegrants, defoamers, warning colors, film-forming agents, and fillers.

[0024] The solvents include, but are not limited to, one or more of the following: dimethylformamide, dimethyl sulfoxide, ethanol, acetone, xylene, dichloromethane, ethyl acetate, cyclohexane, cyclohexanone, N-methylpyrrolidone, coconut oil fatty acid methyl ester, cyclohexanol, methyl glycol ether, and acetonitrile.

[0025] The dispersant includes, but is not limited to, one or more of the following: lignin sulfonate, nonylphenol polyoxyethylene ether, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, alkyl naphthalene sulfonate, sodium salt of naphthalene sulfonic acid formaldehyde condensate, sodium p-hydroxyphenyl lignin sulfonate, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, alkyl dimethyl benzyl ammonium salt, p-methoxy fatty amide benzene sulfonic acid, p-methoxy fatty amide benzene sulfonate, and polyoxyethylene sorbitan fatty acid ester.

[0026] The wetting agents include, but are not limited to, one or more of the following: sodium dodecyl sulfate, calcium dodecylbenzene sulfonate, sodium lauroyl sarcosinate, fatty alcohol polyoxyethylene ether, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, trisiloxane polyoxyethylene ether, sodium isooctyl succinate sulfonate, sodium oleoyl methyl taurate, triphenylethylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, polyoxyethylene fatty acid ester, and sorbitan fatty acid ester.

[0027] The emulsifiers include, but are not limited to, one or more of the following: lignin sulfonate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, naphthalene sulfonate formaldehyde condensate, styrene-phenyl polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, nonylphenol polyoxyethylene ether phosphate, styrene polyoxyethylene ether ammonium sulfate, sorbitan monostearate, and dehydrated sorbitan monostearate polyoxyethylene ether.

[0028] The stabilizers include, but are not limited to, one or more of the following: triphenyl phosphite, epoxidized soybean oil, epoxidized linseed oil, dialkyl succinate sulfonate, butyl glycidyl ether, etc.

[0029] The thickeners include, but are not limited to, one or more of the following: carboxymethyl cellulose, sodium carboxymethyl cellulose, gum arabic, xanthan gum, gelatin, magnesium aluminum silicate, and sodium alginate.

[0030] The antifreeze agent includes, but is not limited to, one or more of ethylene glycol, propylene glycol, glycerol, and polyethylene glycol.

[0031] The adhesive includes, but is not limited to, one or more of the following: gum arabic, xanthan gum, starch, carboxymethyl cellulose, carboxyethyl cellulose, and gelatin.

[0032] The disintegrants include, but are not limited to, one or more of the following: sodium bicarbonate, ammonium sulfate, sodium carboxymethyl starch, sodium sulfate, calcium sulfate, and urea.

[0033] The defoaming agent includes, but is not limited to, one or more of the following: butyl phosphate, isobutyl phosphate, n-octanol, and silicone.

[0034] The warning colors include, but are not limited to, one or more of the following: Basic Rose Essence, Acid Fire Red, Acid Red B, and Acid Orange.

[0035] The film-forming agent includes, but is not limited to, one or more of the following: polyvinyl alcohol, gum arabic, carboxymethyl cellulose, and polyethylene glycol.

[0036] The filler / carrier includes solid filler / carrier and liquid filler / carrier, and specific varieties include but are not limited to: kaolin, bentonite, diatomaceous earth, attapulgite, montmorillonite, calcium carbonate, clay; water, soybean oil, corn oil, castor oil, rapeseed oil, and mineral oil, one or more of these.

[0037] In the bactericidal composition of the present invention, the total weight percentage of the active ingredient is 1-80%, preferably 2-70%, and more preferably 5-60%. For example, the minimum total weight percentage of the active ingredient in the bactericidal composition is 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc. The maximum total weight percentage of the active ingredient in the bactericidal composition is 60%, 59%, 58%, 57%, 56%, 55%, 54%, 53%, 52%, 51%, 50%, 49%, 48%, 47%, 46%, 45%.

[0038] Specifically:

[0039] In one embodiment of the present invention, the bactericidal composition of the present invention is prepared into an emulsifiable concentrate, the formulation of which is: 5-60% active ingredient, 2-20% emulsifier, 2-10% dispersant, and solvent to make up to 100%. The preparation method is as follows: dissolve each component in a solvent and mix evenly to obtain the emulsifiable concentrate.

[0040] In one embodiment of the present invention, the bactericidal composition of the present invention is prepared into a suspension, the formulation of which is as follows: 5-60% active ingredient, 2-10% dispersant, 2-10% wetting agent, 0.5-5% thickener, 0.5-5% antifreeze agent, 0.5-5% defoamer, and water to 100%. The preparation method is as follows: the active ingredient and various additives are mixed with water, dispersed by high-speed shearing, and then milled in a sand mill to obtain the suspension.

[0041] In one embodiment of the present invention, the bactericidal composition of the present invention is prepared into a microemulsion, the formulation of which is as follows: 5-60% active ingredient, 5-30% solvent, 2-20% emulsifier, 2-20% dispersant, 0.5-5% thickener, 0.5-5% defoamer, 0.5-5% antifreeze, and water to 100%. The preparation method is as follows: the active ingredient is dissolved in a solvent to prepare an oil phase; the other components are added to water and stirred evenly to prepare an aqueous phase; then, the oil phase is added to the aqueous phase while stirring, and the mixture is stirred evenly to obtain the microemulsion.

[0042] In one embodiment of the present invention, the bactericidal composition of the present invention is prepared into an aqueous emulsion, the formulation of which is as follows: 5-60% active ingredient, 5-20% solvent, 2-10% emulsifier, 2-10% dispersant, 0.5-5% thickener, 0.5-5% defoamer, 0.5-5% antifreeze, and water to 100%. The preparation method is as follows: the active ingredient is dissolved in a solvent to prepare an oil phase; the other components are added to water and stirred evenly to prepare an aqueous phase; then, while stirring, the oil phase is added to the aqueous phase and stirred evenly to obtain the aqueous emulsion.

[0043] In one embodiment of the present invention, the bactericidal composition of the present invention is prepared into a dispersible oil suspension, the formulation of which is: 5-60% active ingredient, 2-10% dispersant, 2-10% wetting agent, 0.5-5% thickener, and liquid carrier to make up to 100%. The preparation method is as follows: the active ingredient and various additives are mixed with the liquid carrier, dispersed by high-speed shearing, and then milled in a sand mill to obtain the oil suspension.

[0044] In one embodiment of the present invention, the bactericidal composition of the present invention is prepared into a wettable powder, the formulation of which is: 5-60% active ingredient, 2-10% dispersant, 2-10% wetting agent, and solid carrier to make up to 100%. The preparation method is as follows: the components are mixed, ground and pulverized to obtain the wettable powder.

[0045] In one embodiment of the present invention, the bactericidal composition of the present invention is prepared into a water-dispersible granule, the formulation of which is as follows: 5-60% active ingredient, 2-10% dispersant, 2-10% wetting agent, 0.5-5% disintegrant, 0.5-5% binder, and solid carrier to make up to 100%. The preparation method is as follows: the components are mixed evenly, pulverized, and granulated to obtain the water-dispersible granule.

[0046] Another aspect of the present invention relates to the use of the bactericidal composition for the prevention and control of agricultural diseases. Wherein:

[0047] Applicable agricultural plants include, but are not limited to:

[0048] Field crops: rice, wheat, corn, soybeans, peanuts, rapeseed, etc.

[0049] Vegetables: cucumber, eggplant, tomato, potato, cabbage, strawberry, etc.

[0050] Fruit trees: apple, peach, grape, pear, etc.

[0051] Agricultural diseases that can be controlled include: powdery mildew, leaf spot, smut, rust, curvularia leaf spot, large leaf spot, small leaf spot, rice blast, black shank, sclerotinia rot, early blight, black spot, downy mildew, gray mold, anthracnose, Phytophthora blight, flower rot, leaf spot, black spot, brown rot, etc.

[0052] Specifically, agricultural diseases include:

[0053] Rice: Rice blast, sheath blight;

[0054] Wheat: Powdery mildew, leaf spot;

[0055] Corn: Head smut, rust, Curvularia leaf spot, large leaf spot, small leaf spot;

[0056] Peanuts: Leaf spot disease;

[0057] Rapeseed: Blackleg disease, Sclerotinia stem rot;

[0058] Cucumber: Early blight, black spot, downy mildew;

[0059] Tomatoes: Gray mold, anthracnose, leaf spot, early blight;

[0060] Chili peppers: Anthracnose, Phytophthora blight;

[0061] Potatoes: Blackleg disease;

[0062] Strawberries: Gray mold;

[0063] Fruit trees: apple blossom blight, apple leaf spot, pear scab, grape gray mold, peach brown rot.

[0064] Another aspect of the present invention relates to a method for using the bactericidal composition to control agricultural diseases, wherein the bactericidal composition is contacted with the agricultural plant or its propagation material before or after the occurrence of the agricultural disease.

[0065] Specifically, the fungicidal composition of this invention can be applied to the leaves, rhizomes, and seeds of the plant to be treated, particularly to parts susceptible to or affected by pathogens harmful to crop growth, through spraying, root irrigation, seed coating, or seed dressing. The dosage and timing of application are determined by those skilled in the art, for example, by comprehensively considering the recommended dosage of the agent, the specific disease occurrence, and the pathogen's resistance factors. Detailed Implementation

[0066] The present invention will be further described below with reference to embodiments, but the present invention is not limited thereto.

[0067] All reagents used in the following embodiments of the present invention can be obtained commercially available or in-house. The plant pathogenic fungi used were cultured in the laboratory. Furthermore, unless otherwise specified, all percentages mentioned in the following embodiments are weight percentages.

[0068] I. Combined toxicity test

[0069] 1. Determination of the combined toxicity of pyridaben and thiamethoxam against Pyricularia oryzae.

[0070] The tested pathogenic fungus was *Pyricularia oryzae*, the blast fungus of rice.

[0071] Test reagents: Pyridamole technical grade, Thiamethoxam technical grade;

[0072] Experimental method: The toxicity of the agent to the pathogenic fungus was determined by the growth rate method, referring to the agricultural industry standard of the People's Republic of China NY / T1156.2006.

[0073] Prepare a 1000 mg / L stock solution of the agent. Then, take an appropriate amount and mix it according to the predetermined ratio in Table 1. Prepare five concentration gradients using an aqueous solution containing 1% Tween-80. Add the solutions to PDA medium at 45-50℃, with a volume ratio of agent to medium of 1:9. Mix thoroughly and pour into sterile petri dishes. After cooling, form a virus-containing medium. Each concentration is repeated three times. Use an aqueous solution containing 1% Tween-80 as a control. Then, under aseptic conditions, inoculate the pathogenic bacterial pellets into the center of the virus-containing medium. Incubate the petri dishes in an incubator at 25℃ and 90% humidity. When the colony radius on the control plate reaches about 2 / 3 of the plate radius, measure the colony diameter of each treatment using the cross-cross method. Calculate the growth inhibition rate of each agent treatment on the pathogen using the following formula, and determine the EC50 of each treatment on the pathogen. 50 .

[0074]

[0075] Then, following Sun Yunpei's method, the EC values ​​of each treatment were measured. 50 Convert to Actual Toxicity Index (ATI); calculate the Theoretical Toxicity Index (TTI) based on the formulation ratio of the mixture, and calculate the Co-toxicity Coefficient (CTC) of the mixture according to the following formula. The results are shown in Table 1 below.

[0076]

[0077] Theoretical (mixed) toxicity index (TTI) = Toxicity index of A × Content of A in the mixture (%)

[0078] +B toxicity index × B content in the mixture (%)

[0079]

[0080] If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if the co-toxicity coefficient is less than 80, it indicates an antagonistic effect; if the co-toxicity coefficient is between 100 and 120, it indicates an additive effect.

[0081] Table 1 Results of Indoor Toxicity Measurement

[0082] medicine <![CDATA[EC 50 (mg / L)]]> ATI TTI Cotoxicity coefficient (CTC) (A) Pyridamylamide 0.80 100.00 - - (B) Thiamethoxam 15.21 5.26 - - A:B = 200:1 0.89 89.89 99.53 90.31 A:B = 100:1 0.71 112.68 99.06 113.74 A:B = 75:1 0.64 125.00 98.75 126.58 A:B = 50:1 0.66 121.21 98.14 123.51 A:B = 25:1 0.63 126.98 96.36 131.79 A:B = 5:1 0.67 119.40 84.21 141.79 A:B = 1:1 1.17 68.38 52.63 129.92 A:B = 1:5 2.89 27.68 21.05 131.51 A:B = 1:25 6.05 13.22 8.90 148.52 A:B = 1:50 8.33 9.60 7.12 134.94 A:B = 1:75 10.16 7.87 6.51 121.02 A:B = 1:100 10.84 7.38 6.20 119.08 A:B = 1:200 13.12 6.10 5.73 106.40

[0083] Table 1 shows that pyridabenamide and thiamethoxam have additive or synergistic effects in inhibiting rice blast fungus. For example, they have additive / synergistic effects in the ratio range of 200:1 to 1:200, and especially in the ratio range of 75:1 to 1:75, they all show synergistic effects.

[0084] 2. Combined virulence determination of pyridaben and thiamethoxam against Botrytis cinerea Pers., the causal agent of gray mold in strawberries.

[0085] The combined virulence of the composition of the present invention against *Botrytis cinerea* was determined using a similar method. The results are shown in Table 2 below.

[0086] Table 2 Results of Indoor Toxicity Measurement

[0087] medicine <![CDATA[EC 50 (mg / L)]]> ATI TTI Cotoxicity coefficient (CTC) (A) Pyridamylamide 1.51 100.00 - - (B) Thiamethoxam 10.20 14.80 - - A:B = 200:1 1.22 123.77 99.58 124.30 A:B = 100:1 1.26 119.84 99.16 120.86 A:B = 75:1 1.18 127.97 98.88 129.42 A:B = 50:1 1.13 133.63 98.33 135.90 A:B = 25:1 1.15 131.30 96.72 135.75 A:B = 5:1 1.23 122.76 85.80 143.08 A:B = 1:1 1.76 85.80 57.40 149.46 A:B = 1:5 3.59 42.06 29.00 145.02 A:B = 1:25 6.85 22.04 18.08 121.92 A:B = 1:50 6.72 22.47 16.47 136.39 A:B = 1:75 8.36 18.06 15.92 113.42 A:B = 1:100 8.95 16.87 15.65 107.82 A:B = 1:200 9.44 16.00 15.23 105.04

[0088] Table 2 shows that pyridabenamide and thiamethoxam have additive or synergistic effects in inhibiting strawberry gray mold, for example, in the ratio range of 200:1 to 1:200, they have additive / synergistic effects, especially in the ratio range of 200:1 to 1:50, they all show synergistic effects.

[0089] 3. Combined toxicity test of pyridaben and thiamethoxam against tomato early blight (Alternaria solani).

[0090] The combined virulence of the composition of the present invention against *Early Blight of Tomato* was determined using a similar method. The results are shown in Table 3 below.

[0091] Table 3 Results of Indoor Toxicity Measurement

[0092]

[0093]

[0094] Table 3 shows that pyridaben and thiamethoxam have additive or synergistic effects in inhibiting early blight pathogens of tomato. For example, they have additive / synergistic effects in the ratio range of 200:1 to 1:200, especially in the ratio range of 75:1 to 1:5 and even 25:1 to 1:5.

[0095] 4. Combined virulence assay of pyridaben and thiamethoxam against Sclerotinia scleroriorum, the causal agent of cucumber disease.

[0096] The combined virulence of the composition of the present invention against *Sclerotinia sclerotiorum* of cucumber was determined using a similar method. The results are shown in Table 4 below.

[0097] Table 4 Results of Indoor Toxicity Measurement

[0098] medicine <![CDATA[EC 50 (mg / L)]]> ATI TTI Cotoxicity coefficient (CTC) (A) Pyridamylamide 1.47 100.00 - - (B) Thiamethoxam 29.84 4.93 - - A:B = 200:1 1.42 103.52 99.53 104.01 A:B = 100:1 1.56 94.23 99.06 95.13 A:B = 75:1 1.35 108.89 98.75 110.27 A:B = 50:1 1.08 136.11 98.14 138.70 A:B = 25:1 1.60 91.88 96.34 95.36 A:B = 5:1 1.37 107.30 84.15 127.50 A:B = 1:1 2.01 73.13 52.46 139.40 A:B = 1:5 6.48 22.69 20.77 109.21 A:B = 1:25 12.62 11.65 8.58 135.71 A:B = 1:50 20.72 7.09 6.79 104.48 A:B = 1:75 17.65 8.33 6.18 134.83 A:B = 1:100 24.39 6.03 5.87 102.72 A:B = 1:200 27.45 5.36 5.40 99.18

[0099] Table 4 shows that pyridabenamide and thiamethoxam have additive or synergistic effects in inhibiting Sclerotinia sclerotiorum var. cucumberis, for example, in the ratio range of 200:1 to 1:200, with the ratio of synergistic effect being discretely distributed, specifically 50:1, 5:1, 1:1, 1:25 and 1:75.

[0100] II. Formulation Examples

[0101] Example 1: Suspension

[0102] Pyridamole 20%, Thiamethoxam 1%, Fatty alcohol polyoxyethylene ether 6%, Sodium dodecyl sulfate 5%, Carboxymethyl cellulose 4%, Propylene glycol 4%, Butyl phosphate 0.5%, Water balance.

[0103] The preparation method is as follows: add each component to water, mix and stir, disperse by high-speed shearing and grinding to obtain a suspension.

[0104] Example 2: Suspension

[0105] Pyridamole 2%, Thiamethoxam 10%, Sodium lignosulfonate 3%, Trisiloxane polyoxyethylene ether 5%, Magnesium aluminum silicate 2%, Propylene glycol 4%, Butyl phosphate 0.5%, Water balance.

[0106] The preparation method is the same as in Example 1.

[0107] Example 3 Water-based emulsion

[0108] Pyridamole 5%, Thiamethoxam 5%, Dimethylformamide 20%, Calcium dodecylbenzenesulfonate 6%, Sodium naphthalenesulfonic acid formaldehyde condensate 5%, Magnesium aluminum silicate 0.6%, n-Octanol 0.5%, Ethylene glycol 5%, Water to 100%.

[0109] The preparation method is as follows: the active ingredient is dissolved in a solvent to prepare an oil phase, and the other components are added to water and stirred evenly to prepare an aqueous phase. Then, while stirring, the oil phase is added to the aqueous phase and stirred evenly to obtain an emulsion.

[0110] Example 4 Water-based emulsion

[0111] Pyridamole 8%, Thiamethoxam 0.2%, Dimethylformamide 16%, Nonylphenol polyoxyethylene ether phosphate 4%, Sodium lignosulfonate 4%, Sodium alginate 0.5%, n-Octanol 0.5%, Propylene glycol 4%, Water to 100%.

[0112] The preparation method is the same as in Example 3.

[0113] Example 5 Water-dispersible granules

[0114] Pyridamole 1%, Thiamethoxam 20%, Calcium lignin sulfonate 6%, Fatty alcohol polyoxyethylene ether 7%, Ammonium sulfate 5%, Carboxymethyl cellulose 5%, Attapulgite balance.

[0115] The preparation method involves mixing all components except the binder evenly and pulverizing them, then adding the binder aqueous solution to granulate, and drying to obtain water-dispersible granules.

[0116] Example 6 Water-dispersible granules

[0117] Pyridine amide 10%, thiamethoxam 2%, calcium lignosulfonate 4%, trisiloxane polyoxyethylene ether 4%, ammonium sulfate 5%, gelatin 3%, attapulgite balance.

[0118] The preparation method is the same as in Example 5.

[0119] Example 7 Wettable Powder

[0120] Pyridamole 0.5%, Thiamethoxam 20%, Nonylphenol polyoxyethylene ether 6%, Sodium isooctanol succinate sulfonate 8%, Diatomaceous earth to make up to 100%.

[0121] The preparation method is as follows: the components are mixed, ground and pulverized to obtain a wettable powder.

[0122] Example 8 Wettable Powder

[0123] Pyridamole 15%, Thiamethoxam 15%, Sodium lignosulfonate 7%, Triphenylethylphenol polyoxyethylene ether 6%, Bentonite to make up to 100%.

[0124] The preparation method is the same as in Example 7.

[0125] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A bactericidal composition, characterized in that, The active ingredients of the bactericidal composition contain pyridoxin and thiamethoxam, wherein the weight ratio of pyridoxin to thiamethoxam is 1:75 to 75:

1.

2. The bactericidal composition according to claim 1, characterized in that, The bactericidal composition further includes agriculturally acceptable adjuvants and / or carriers.

3. The bactericidal composition according to claim 2, characterized in that, The bactericidal composition is prepared as one or more of the following: emulsifiable concentrate, suspension concentrate, microemulsion, suspension emulsion, water emulsion, dispersible oil suspension, wettable powder, water-dispersible granules, and suspension seed coating agent.

4. The bactericidal composition according to claim 2, characterized in that, The agriculturally acceptable adjuvants and / or carriers include one or more of the following: solvents, dispersants, wetting agents, emulsifiers, stabilizers, thickeners, antifreeze agents, binders, disintegrants, defoamers, warning colors, film-forming agents, and fillers.

5. The bactericidal composition according to claim 2, characterized in that, The total weight percentage of active ingredients in the bactericidal composition is 1-80%.

6. A method for using the bactericidal composition according to any one of claims 1-5 to control agricultural diseases, characterized in that, The fungicide composition is applied to the agricultural plant or its propagation material before or after the occurrence of an agricultural disease; the agricultural disease is rice blast, strawberry gray mold, tomato early blight, or cucumber sclerotinia stem rot.

7. The use of the bactericidal composition according to any one of claims 1-5 in the prevention and control of agricultural diseases, characterized in that, The agricultural diseases mentioned are rice blast, strawberry gray mold, tomato early blight, and cucumber sclerotinia stem rot.

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