Mouse cervical vertebra dislocation killing machine

Abstract

The invention particularly relates to a mouse cervical vertebra dislocation killing machine which comprises a lower-layer plate, an upper-layer plate is arranged above the lower-layer plate, a shell is arranged between the upper-layer plate and the lower-layer plate, the upper-layer plate and the lower-layer plate are connected through the shell, a clamping mechanism is arranged on the upper-layer plate in a left-right moving mode, and the clamping mechanism is used for clamping the tail of a mouse. A clamping mechanism is arranged on the right side of the upper-layer plate and used for clamping the neck of the mouse; according to the device, neck dislocation killing treatment of a mouse can be achieved, the tail of the mouse can be rapidly fixed by arranging the clamping mechanism capable of conveniently clamping the tail of the mouse, meanwhile, the head of the mouse can be rapidly limited by arranging the clamping mechanism capable of rapidly limiting the neck of the mouse, and in addition, after a lifting rod is reset, the mouse can be rapidly fixed by arranging the clamping mechanism capable of rapidly limiting the neck of the mouse. The upper clamping arc-shaped ring is automatically opened under the acting force of the torsional spring, so that the next mouse can be more conveniently subjected to dislocation treatment; and the clamping mechanism capable of adjusting the clamping degree is arranged, so that different clamping forces on the tail of the mouse can be changed according to needs, and meanwhile, the device is suitable for more mice with tails of different thicknesses to use.

Description

Technical Field

[0001] The invention relates to the technical field of medical experimental equipment, in particular to a mouse cervical dislocation killing machine. Background Art

[0002] In the experiment of animal death model, how to achieve accurate processing of animal death model becomes an important technical problem. Existing animal killing methods are highly, among which cervical dislocation method is widely used because of its rapidity and pain to animals.

[0003] Traditional methods of killing mice usually include anesthesia, injection of lethal drugs, and mechanical killing. However, traditional methods of treating cervical dislocation often have the problems of cumbersome operation and low efficiency. During the execution process, the operator needs to accurately dislocate the mouse's neck and fix the head and tail of the neck at the same time, which requires higher technical skills of the operator. In addition, in traditional devices, the position of the device for fixing the mouse's tail is often not stable enough, which can easily cause the tail to be offset or unstable or the tail fixation is cumbersome and inefficient, thereby affecting the treatment effect. In order to improve operational efficiency and accuracy and improve the deficiencies in existing methods, a new device is urgently needed that can quickly and accurately complete the mouse's cervical dislocation.

[0004] For example, a mouse cervical dislocation killing device with patent number CN116831772A relates to the technical field of medical experimental equipment, including a storage box, an opening and closing door is arranged on the left side of the storage box, and a first handle is fixedly arranged on the opening and closing door. The present invention realizes the perfect simulation of the characteristic that the mouse tail needs to be pulled obliquely upward when the mouse is artificially killed through the arrangement of two connecting rods, a telescopic rod, two limit shafts, two acceleration gears, two meshing racks, two guide shafts, two guide grooves and a third locking hole. Under the action of the rotation of the acceleration gear, the displacement of the mouse tail is twice the displacement of the telescopic rod, thereby achieving the acceleration effect, and when moving to the moving distance, the acceleration gear is disengaged to avoid the situation that the mouse tail is subjected to excessive tension, resulting in body fracture and bleeding. It can accelerate the killing of mice without letting the mice experience pain, and can also avoid nausea and disgust of novice experimenters when seeing blood. Although the above structure can achieve the death of the mouse by dislocating the neck, the method of fixing the mouse's tail in the above device is extremely inconvenient, and it is difficult to control the clamping force of the mouse's tail through the acceleration gear, which can easily cause the tail to break prematurely.

[0005] For this reason, we provide a kind of mouse cervical dislocation killing machine which can realize mouse cervical dislocation killing and can conveniently take, place and fix the mouse. Summary of the invention

[0006] The invention aims to overcome the deficiencies in the prior art and provide a mouse cervical dislocation killing machine.

[0007] The objective of the present invention is achieved as follows: a mouse cervical dislocation killing machine comprises a lower plate, an upper plate is arranged above the lower plate, a shell is arranged between the upper plate and the lower plate, the upper plate and the lower plate are connected by the shell, a clamping mechanism is arranged on the upper plate which can move left and right, the clamping structure is used to clamp the mouse's tail, a clamping mechanism is arranged on the right side of the upper plate, the clamping mechanism is used to clamp the mouse's neck.

[0008] Furthermore, the clamping mechanism includes a clamping box, a clamping groove is provided in the middle of the clamping box, a plurality of clamping block mechanisms are arranged transversely in the clamping groove, the clamping block mechanism includes two symmetrically distributed clamping blocks, an arc-shaped groove is provided in the middle of the inner side surface of the clamping block; the clamping block can move forward and backward relative to the clamping box, a connecting rod is fixedly provided on the outer side surface of the clamping block, a transmission rod is rotatably provided on the outer end of the connecting rod, and the transmission rod is located in the clamping box which can move forward and backward; a limit plate is fixedly provided on the transmission rod, a partition is provided in the clamping box below the limit plate, the partition is located on the inner side of the limit plate, and the left and right ends of the limit plate are respectively Spring 2 is symmetrically arranged, and the two ends of spring 2 are connected to the limit plate and the clamping block respectively; Spring 3 is set on the outer side of the transmission rod, and an adjustment plate is arranged in the clamping box at the outer end of spring 3, which can move forward and backward; Sleeve 1 is arranged on the outside of the transmission rod, which can rotate and move forward and backward, and the outer end of sleeve 1 can rotate and move forward and backward through the clamping box, and sleeve 1 is threadedly connected to the adjustment plate, and the two ends of spring 3 are respectively connected to the inner end surface of sleeve 1 and the limit plate; Sleeve 2 is rotatably arranged in the middle of the adjustment plate, and the outer end of sleeve 2 passes through the outer side of the clamping box, and sleeve 2 is threadedly connected to the clamping box. A push plate is fixedly arranged at the bottom of the clamping box, and the push plate passes through the upper plate. The push plate can move left and right along the upper plate. A driving mechanism 2 is arranged on the lower surface of the upper plate, and the driving mechanism 2 drives the push plate to move left and right. A telescopic rod is arranged between the clamping mechanism and the placement mechanism, and the telescopic rod can be telescoped. The two ends of the telescopic rod are respectively connected to the clamping box and the placement plate, and the telescopic rod can be fixed and telescoped.

[0009] When the present invention is used, the head of the mouse is placed on the clamping mechanism, and the mouse's neck is clamped and limited by the clamping mechanism to prevent it from escaping from the device, that is, the mouse's neck is placed in the clamping groove, and the lifting rod is driven downward by controlling the driving mechanism. When the lifting rod moves downward, the clamping arc ring is driven to move downward. At this time, the clamping arc ring is rotated backward by the force of the torsion spring, and the clamping arc ring is driven downward by the lifting rod. The outer side surface of the clamping arc ring is driven to rotate forward by the inclined surface of the upper end of the guide rod. When it continues to move downward, the clamping arc ring is driven by the side force of the guide rod to rotate until the front end of the clamping arc ring is horizontal with the rear end. At this time, the clamping arc ring cannot rotate backward, and the front end of the clamping arc ring is located in the moving groove. Under the continuous driving of the lifting rod, the clamping arc ring continues to move downward to clamp the mouse's neck to prevent it from escaping from the device, until the clamping arc ring cooperates with the clamping groove to clamp the mouse's neck, and the driving mechanism stops driving the lifting rod to fall.

[0010] At this time, the mouse's body is located in the arc-shaped groove on the placement board, and the left end of the placement board protrudes upward to provide a certain degree of support for the contact position between the mouse's neck and body, and when the mouse moves backward, its protruding position can drive the mouse's body to move backward (when the placement boards move relative to each other).

[0011] Then straighten the mouse's tail and place it in the clamping groove from top to bottom. When the tail moves downward, it squeezes the front and rear clamps (the upper part of the inner side of the clamp is an inclined structure), so that the front and rear clamps move away from each other, and the connecting rod drives the transmission rod to move outward, the limit plate is separated from the partition, and the spring 2 and spring 3 are compressed until the tail is located in the arc groove of the two clamps (the inner side of the arc groove is a structure or material with strong friction, etc., which is used to increase the friction between the tail and the clamp); at this time, the clamp is driven by the elastic force of spring 2 and spring 3 to move inward to clamp the tail. Since the tail is a structure with a thick front end and a thin rear end, in order to increase the fitting area of ​​the arc groove of the clamp and the tail, that is, to increase the friction between the two; the spring 2 and the rotatable structure between the transmission rod and the connecting rod can change the inclination angle of the clamp, adapt to the inclination degree of the tail, and increase the contact surface between the tail and the clamp.

[0012] When the clamping force of the tail needs to be adjusted, the squeezing force on the spring three can be adjusted by rotating the drum one (the rear end of the drum one moves backward when the drum one rotates). When the pressure on all the springs three on one side of the whole needs to be increased, the adjustment plate is driven inward by rotating the drum two to achieve squeezing of the spring three.

[0013] Then, the push plate is driven to move by controlling the driving mechanism 2, thereby driving the clamp to move to the left, thereby pulling the mouse's tail, and dislocating the mouse's neck after driving it to a moving distance (most clinical treatments for mice are to dislocate the neck by holding the tail and the head, so this application is mainly set for the above-mentioned operation. For very few cases or methods that cannot pull the tail and the neck to kill the mouse, they are not reflected in the application of this application or are not killed by this application), and the mouse is dislocated. Since the mouse's tail has a certain strength, and there is also a certain friction between the body parts and the application, in order to avoid excessive friction between the body parts and the application, causing some mice to use the body's muscle strength to cause the situation that they cannot be dislocated, the application adopts a placement plate that can move left and right to place the mouse. In the process of pulling the mouse's tail, the placement plate can move left and right with the body, thereby reducing the friction between the body parts and the application, and increasing the probability of successful dislocation.

[0014] A telescopic rod is provided to limit its length as needed. After the length is limited, the placing plate moves with the clamping box. While pulling the mouse's tail, the placing plate moves backward, and the protruding structure on the placing plate drives the mouse's body to the left to achieve the dislocation of the mouse's neck.

[0015] The device of the present invention also has a design of adjustable gradient strength, and the strength of the tail clamping can be adjusted as needed. This function not only enables the device to adapt to mice of different sizes, but also ensures that mice with tails of different thicknesses can be effectively processed. The automatic opening mechanism after the lifting rod is reset enables the device to quickly process the next mouse, thereby improving the efficiency of the experiment and reducing the labor intensity of the operator.

[0016] Beneficial effects: the device can achieve the killing of mice by dislocating their necks, and is provided with a clamping mechanism that can conveniently clamp the mouse's tail, so as to quickly fix the mouse's tail. At the same time, a clamping mechanism that can quickly limit the mouse's neck can quickly limit the mouse's head. In addition, after the lifting rod is reset, the upper clamping arc ring is automatically opened by the force of the torsion spring, which is more convenient for dislocating the next mouse; and a clamping mechanism with adjustable clamping degree can change the clamping strength of the mouse's tail as needed, and at the same time adapt to the use of this device by mice with tails of different thicknesses. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the structure of the invention.

[0018] Figure 2 This is a cross-sectional view of the local structure of the upper plate of the invention.

[0019] Figure 3 It is a schematic diagram of the local structure of the invention.

[0020] Figure 4 Schematic diagram of the clamping mechanism structure of the invention

[0021] Figure 5 It is a schematic diagram of the partial structure of the clamping mechanism of the invention.

[0022] Figure 6 It is a schematic diagram of the structure of the push plate and the driving mechanism of the invention.

[0023] Figure 7 The invention is a schematic diagram of the spring, slide plate and slide rod structure.

[0024] Description of reference numerals:

[0025] 1. Support legs, 2. Lower plate, 3. Shell, 4. Upper plate, 5. Clamping box, 6. Telescopic rod, 7. Placement plate, 8. Vertical plate, 9. Clamping arc ring, 10. Guide rod, 11. Lifting rod, 12. Driving mechanism 1, 13. Sleeve 1, 14. Spring 3, 15. Sleeve 2, 16. Transmission rod, 17. Adjustment plate, 18. Partition plate, 19. Limit plate, 20. Spring 2, 21. Connecting rod, 22. Clamping block, 23. Push plate, 24. Driving mechanism 2, 25. Spring 1, 26. Slide plate, 27. Slide rod. DETAILED DESCRIPTION

[0026] Embodiment 1, as Figure 1-7 As shown, the purpose of the present invention is achieved as follows: a mouse cervical dislocation killing machine includes a lower plate 2, a plurality of supporting legs 1 are evenly arranged on the lower surface of the lower plate 2, an upper plate 4 is arranged above the lower plate 2, a shell 3 is arranged between the upper plate 4 and the lower plate 2, the upper plate 4 and the lower plate 2 are connected by the shell 3, a clamping mechanism is arranged on the upper plate 4 which can be moved left and right, the clamping structure is used to clamp the mouse's tail, a clamping mechanism is arranged on the right side of the upper plate 4, the clamping mechanism is used to clamp the mouse's neck.

[0027] The clamping mechanism includes a vertical plate 8, a clamping groove is provided on the vertical plate 8, and a moving groove is provided on the vertical plate 8 at both sides of the clamping groove, and a clamping arc ring 9 is provided in the moving groove so as to be movable up and down. A lifting groove is provided at the lower part of the moving groove on the rear side of the vertical plate 8, and a lifting rod 11 is provided in the lifting groove so as to be movable up and down, and the upper end of the lifting rod 11 is rotatably connected to the clamping arc ring 9.

[0028] A torsion spring is arranged between the upper end of the lifting rod 11 and the clamping arc ring 9. When the clamping arc ring 9 is not affected by external force, the force of the torsion spring rotates backward to open the support groove. A guide rod 10 is arranged on the rear side of the lifting groove. The side of the guide rod 10 is in contact with the side of the lifting rod 11. The front side of the upper end of the guide rod 10 is an inclined structure, which is used to guide the support arc ring to rotate forward step by step. The bottom of the clamping groove is an arc structure, which is convenient for clamping the mouse neck.

[0029] A driving mechanism 12 is disposed on the lower surface of the upper plate 4, and the driving mechanism 12 drives the lifting rod 11 to move up and down.

[0030] A placing mechanism is provided on the upper plate 4 on the left side of the clamping mechanism, and the placing mechanism is used to place mice. The placing mechanism includes a placing plate 7, and the placing plate 7 is located on the upper plate 4 and can move left and right. An arc groove is provided in the middle of the upper surface of the placing plate 7, and the left end of the placing plate 7 protrudes upward. A slide groove is provided on the upper plate 4 below the placing plate 7, and a slide plate 26 is provided in the slide groove and can move left and right. The slide plate 26 is fixedly connected to the placing plate 7, and a spring 25 is provided on the left side of the slide plate 26. The two ends of the spring 25 are respectively connected to the slide plate 26 and the left end of the slide groove. A slide rod 27 is provided in the slide groove, and the guide rod can slide through the slide plate 26, and the spring 25 is sleeved on the slide rod 27.

[0031] The clamping mechanism includes a clamping box 5, a clamping groove is provided in the middle of the clamping box 5, and a plurality of clamping blocks 22 are transversely arranged in the clamping groove. The clamping block 22 mechanism includes two symmetrically distributed clamping blocks 22, and an arc-shaped groove is provided in the middle of the inner side surface of the clamping block 22; the clamping block 22 can move forward and backward relative to the clamping box 5, and a connecting rod 21 is fixedly provided on the outer side surface of the clamping block 22, and a transmission rod 16 is rotatably provided on the outer end of the connecting rod 21, and the transmission rod 16 is located in the clamping box 5 and can move forward and backward; a limit plate 19 is fixedly provided on the transmission rod 16, and a partition plate 18 is provided in the clamping box 5 below the limit plate 19, and the partition plate 18 is located on the inner side of the limit plate 19, and the left and right ends of the limit plate 19 are symmetrically provided with elastic Spring 20, the two ends of spring 20 are respectively connected with the limit plate 19 and the clamping block 22; the outer side surface of the transmission rod 16 is sleeved with spring 3 14, and the outer end of the spring 3 14 is provided with an adjustment plate 17 that can move forward and backward in the clamping box 5; the outside of the transmission rod 16 is rotatably and movable forward and backward. A sleeve 13 is provided, and the outer end of the sleeve 13 can rotate and move forward and backward through the clamping box 5, and the sleeve 13 and the adjustment plate 17 are threadedly connected. The two ends of the spring 3 14 are respectively connected with the inner end surface of the sleeve 13 and the limit plate 19; the middle part of the adjustment plate 17 is rotatably provided with a sleeve 2 15, and the outer end of the sleeve 2 15 passes through the outer side surface of the clamping box 5, and the sleeve 2 15 and the clamping box 5 are threadedly connected. A push plate 23 is fixedly arranged at the bottom of the clamping box 5, and the push plate 23 penetrates the upper plate 4. The push plate 23 can move left and right along the upper plate 4. A driving mechanism 24 is arranged on the lower surface of the upper plate 4, and the driving mechanism 24 drives the push plate 23 to move left and right. A telescopic rod 6 is arranged between the clamping mechanism and the placement mechanism, and the telescopic rod 6 can be telescoped. The two ends of the telescopic rod 6 are respectively connected to the clamping box 5 and the placement plate 7, and the telescopic rod 6 can be fixed to a telescopic length.

[0032] When the present invention is used, the head of the mouse is placed on the clamping mechanism, and the neck of the mouse is clamped and limited by the clamping mechanism to prevent it from escaping from the device. That is, the neck of the mouse is placed in the clamping groove, and the lifting rod 11 is driven downward by the control driving mechanism 12. When the lifting rod 11 moves downward, the clamping arc ring 9 is driven to move downward. At this time, the clamping arc ring 9 is rotated backward by the force of the torsion spring. When the lifting rod 11 is driven downward, the outer side surface of the clamping arc ring 9 is driven forward by the upper end inclined surface of the guide rod 10. The arc ring 9 rotates sideways, and when it continues to move downward, the clamping arc ring 9 is driven by the side force of the guide rod 10 to rotate until the front end of the arc ring 9 is level with the rear end. At this time, the arc ring 9 cannot rotate backward, and the front end of the arc ring 9 is located in the moving groove. Driven by the lifting rod 11, the arc ring 9 continues to move downward to clamp the mouse's neck and prevent it from leaving the device, until the arc ring 9 cooperates with the clamping groove to clamp the mouse's neck, and the driving mechanism 12 stops driving the lifting rod 11 to fall.

[0033] At this time, the mouse's body is located in the arc-shaped groove on the placement board 7, and the left end of the placement board 7 protrudes upward to support the contact position between the mouse's neck and body to a certain extent, and when the mouse moves backward, its protruding position can drive the mouse's body to move backward (when the placement boards 7 move relative to each other).

[0034] Then straighten the mouse's tail and place it in the clamping groove from top to bottom. When the tail moves downward, it squeezes the front and rear clamping blocks 22 (the upper part of the inner side surface of the clamping block 22 is a slope structure), so that the front and rear clamping blocks 22 move away from each other, and the connecting rod 21 drives the transmission rod 16 to move outward, the limit plate 19 is separated from the partition plate 18, and the spring 20 and the spring 3 are compressed until the tail is located in the arc grooves of the two clamping blocks 22 (the inner side surface of the arc groove is a structure or material with strong friction, etc., which is used to increase the friction between the tail and the clamping block 22); at this time, the clamping block 22 is driven by the elastic force of the spring 20 and the spring 3 14 to move inward to clamp the tail. Since the tail has a structure with a thick front end and a thin rear end, in order to increase the fitting area between the arc-shaped groove of the clamping block 22 and the tail, that is, to increase the friction between the two; a spring 20 and a rotatable structure between the transmission rod 16 and the connecting rod 21 are provided to change the inclination angle of the clamping block 22, adapt to the inclination degree of the tail, and increase the contact surface between the tail and the clamping block 22.

[0035] When it is necessary to adjust the clamping force of the tail, the squeezing force on the spring three 14 can be adjusted by rotating the drum one (the rear end of the drum one moves backward when the drum one rotates). When it is necessary to increase the pressure on all the springs three 14 on one side of the whole, the adjustment plate 17 is driven to move inward by rotating the drum two to achieve squeezing of the spring three 14.

[0036] Then, the push plate 23 is driven to move by controlling the driving mechanism 24, thereby driving the clamping to move to the left, thereby pulling the mouse's tail, and dislocating the mouse's neck after driving it to the moving distance (most clinical treatments for mice are to dislocate the neck by holding the tail and the head, so this application is mainly set for the above-mentioned placement. For very few cases or methods that cannot pull the tail and the neck to kill the mouse, they are not reflected in the application of this application or are not killed by this application). To achieve dislocation of the mouse, the mouse's tail has a certain strength, and there is also a certain friction between the body parts and the application. In order to avoid excessive friction between the body parts and the application, which causes some mice to use the body's muscle strength to cause the situation that they cannot be dislocated, the application adopts a placement plate 7 that can move left and right to place the mouse. In the process of pulling the mouse's tail, the placement plate 7 can move left and right with the body, thereby reducing the friction between the body parts and the application, and increasing the probability of successful dislocation.

[0037] A telescopic rod 6 is provided to limit its length as needed. After the length is limited, the placement plate 7 moves along with the clamping box 5. While pulling the mouse's tail, the placement plate 7 moves backward, and the protrusion structure on the placement plate 7 drives the mouse's body to the left to dislocate the mouse's neck.

[0038] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0039] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various changes and variations. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A rat cervical dislocation killing machine, comprising a lower plate, an upper plate is arranged above the lower plate, and is characterized in that: A shell is arranged between the upper plate and the lower plate, and the upper plate and the lower plate are connected by the shell. A clamping mechanism is arranged on the upper plate and can be moved left and right. The clamping structure is used to clamp the mouse's tail. A clamping mechanism is arranged on the right side of the upper plate. The clamping mechanism is used to clamp the mouse's neck.

2. A rat cervical dislocation killing machine according to claim 1, characterized in that: The clamping mechanism comprises a vertical plate, a clamping groove is formed on the vertical plate, movable grooves are formed on the vertical plates at both sides of the clamping groove, and a clamping arc ring is arranged in the movable groove so as to be movable up and down.

3. A rat cervical dislocation killing machine according to claim 2, characterized in that: A lifting groove is provided at the lower part of the movable groove at the rear side of the vertical plate, and a lifting rod is provided in the lifting groove so as to be movable up and down, and the upper end of the lifting rod is rotatably connected to the clamping arc ring.

4. A rat cervical dislocation killing machine according to claim 3, characterized in that: A torsion spring is arranged between the upper end of the lifting rod and the clamping arc ring.

5. A rat cervical dislocation killing machine according to claim 4, characterized in that: A guide rod is arranged at the rear side of the lifting slot, and the front side of the upper end of the guide rod is an inclined surface structure.

6. A rat cervical dislocation killing machine according to claim 2, characterized in that: The bottom of the clamping groove is an arc-shaped structure.

7. A rat cervical dislocation killing machine according to claim 5, characterized in that: A driving mechanism 1 is arranged on the lower surface of the upper plate, and the driving mechanism 1 drives the lifting rod to move up and down.

8. The rat cervical dislocation killing machine according to claim 1, characterized in that: A placing mechanism is arranged on the upper plate on the left side of the clamping mechanism, and the placing mechanism is used for placing mice.

9. A rat cervical dislocation killing machine according to claim 8, characterized in that: The placing mechanism comprises a placing plate, and the placing plate is movable leftward and rightward and is located on the upper plate.

10. A rat cervical dislocation killing machine according to claim 9, characterized in that: An arc-shaped groove is provided in the middle of the upper surface of the placement plate, and the left end of the placement plate protrudes upward.

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