Multifunctional detector and multifunctional detection method

Abstract

The invention provides a multifunctional detector and a multifunctional detection method. A kit 09 is conveyed to a sample adding module 03 through a mobile platform module 02, then automatic negative pressure suction, TIP head suction, sampling and sample adding are performed through the sample adding module 03, a sample to be detected is added to a sample adding position corresponding to a detection item to be detected, and then detection is performed through an optical detection module 04 or an electrochemical detection module 05 corresponding to the sample adding position. Various items of the two platforms can be automatically detected only through one-time blood sample detection. In addition, the user can measure the blood pressure through the multifunctional detector, and then one-time detection of the blood pressure, electrochemistry (such as blood glucose, blood ketone or uric acid) and blood fat can be achieved.

Description

Technical Field

[0001] Embodiments of the present disclosure relate to the technical field of medical devices, and particularly to a multifunctional detector and a multifunctional detection method. Background Art

[0002] Currently, most detectors are single-functional. For example, a sphygmomanometer can measure blood pressure, a blood glucose meter can detect blood glucose, a lipid meter can detect blood lipids, etc.

[0003] In addition, current devices for detecting blood glucose and blood lipids, etc. all require users to collect blood, then use a pipette to aspirate the blood sample, add the sample to the display area of the reagent card, and finally manually place the reagent card into the instrument for detection and reading. The above operations of aspirating and adding samples are highly difficult and not suitable for ordinary users.

[0004] Moreover, if multiple detection items need to be detected, different detection instruments need to be operated multiple times, and the user's operation steps are numerous and complicated. Summary of the Invention

[0005] Embodiments of the present disclosure provide a multifunctional detector and a multifunctional detection method.

[0006] In a first aspect, embodiments of the present disclosure provide a multifunctional detector, which includes: a support base 01, a moving platform module 02, a sample addition module 03, an optical detection module 04, an electrochemical detection module 05, a blood pressure detection module 06, a control circuit board 07, and a power supply 08, wherein:

[0007] The support base 01 is used to provide a positioning reference and structural support for each functional component, and complete the assembly and installation of each functional component;

[0008] The moving platform module 02 is used to transport a reagent kit 09 carrying a sample to be detected. The reagent kit 09 includes at least one dry chemical sample addition position 095 and at least one electrochemical sample addition position 096. A dry chemical test strip is arranged below the dry chemical sample addition position 095, and an electrochemical test strip is arranged below the electrochemical sample addition position 096;

[0009] The sample addition module 03 is used to automatically suck negative pressure, suck a TIP head, sample, and add sample to the reagent kit 09;

[0010] The optical detection module 04 is used to perform photoelectric signal conversion on the dry chemical sample addition position 095 of the reagent kit 09;

[0011] The electrochemical detection module 05 is used to perform current detection on the electrochemical sample addition position 096 of the reagent kit 09;

[0012] The blood pressure detection module 06 is used to measure human blood pressure;

[0013] The control circuit board 07 is used to control the mobile platform module 02, the sample addition module 03, the optical detection module 04, the electrochemical detection module 05, and the blood pressure detection module 06 to perform multi-functional detection, and calculate the blood lipid detection result according to the electrical signal received from the optical detection module 04, and calculate the electrochemical detection result according to the current data received from the electrochemical detection module 05;

[0014] The power supply 08 is used to supply electrical energy to the mobile platform module 02, the sample addition module 03, the optical detection module 04, the electrochemical detection module 05, the blood pressure detection module 06, and the control circuit board 07.

[0015] In some alternative embodiments, the kit 09 further includes: at least one sampling position 092.

[0016] In some alternative embodiments, the multi-functional detector is further provided with: a reagent bin 12, and the reagent bin 12 is used to fix the kit 09.

[0017] In some alternative embodiments, the mobile platform module 02 includes: a first base 021, a second base 022, a third base 023, a first sliding guide rail 024, a second sliding guide rail 025, a first motor 026, and a second motor 027;

[0018] The second base 022 is installed on the first base 021, the first sliding guide rail 024 connects the first base 021 and the second base 022, and the second base 022 can slide along the extension direction of the first sliding guide rail 024, and the extension direction of the first sliding guide rail 024 is the first direction;

[0019] The third base 023 is installed on the second base 022, the second sliding guide rail 025 connects the second base 022 and the third base 023, and the third base 023 can slide along the extension direction of the second sliding guide rail 025, and the extension direction of the second sliding guide rail 025 is the second direction;

[0020] The second base 022 is driven by the first motor 026, and the third base 023 is driven by the second motor 027.

[0021] In some alternative embodiments, the sample addition module 03 includes:

[0022] A sampling head 031, a plunger pump 032, and a lifting drive mechanism 033, wherein the sampling head 031 is used to suck negative pressure, suck a TIP head, sample, and add a sample under the control of the plunger pump 032, and the lifting drive mechanism 033 is used to control the moving distance of the sampling head 031.

[0023] In some alternative embodiments, the sampling head 031 has a front end 031a and a tail end 031b. From the tail end 031b to the front end 031a, the sampling head 031 includes a connecting section 0311, a boss 0312, and a sampling section 0313.

[0024] In some alternative embodiments, the plunger pump 032 includes a plunger chamber 0321 and a plunger rod 0322. The plunger rod 0322 is sleeved inside the plunger chamber 0321. The plunger rod 0322 has a first end 0322a. The extending directions of the plunger chamber 0321 and the plunger rod 0322 are the second direction. The connecting section 0311 includes a partial first connecting section 03111 extending along the second direction and a second connecting section 03112 extending along a third direction perpendicular to the first direction and the second direction. The second connecting section 03112, the boss 0312, and the sampling section 0313 extend along the third direction.

[0025] In some alternative embodiments, the first connecting section 03111 is fixedly and sealingly connected to the plunger chamber 0321. The sampling head 031 is a hollow pipe structure inside. The plunger rod 0322 can move along the second direction in the plunger chamber 0321 and the first connecting section 03111.

[0026] In some alternative embodiments, the lifting drive mechanism 033 is used to drive the sampling head 031 to move along the third direction.

[0027] In some alternative embodiments, the plunger rod 0322 further has a second end 0322b opposite to the first end 0322a, and the plunger pump 032 further includes a plunger induction sheet 0323 fixedly arranged at the second end 0322b.

[0028] In some alternative embodiments, the sample adding module 03 is further provided with a third in-place sensor 034, and the third in-place sensor 034 is used to identify whether the sampling head 031 and the plunger pump 032 reach the initial position in the third direction.

[0029] In some alternative embodiments, the sample adding module 03 is further provided with a fourth in-place sensor 035, and the fourth in-place sensor 035 is used to identify whether the plunger rod 0322 reaches the initial position in the second direction.

[0030] In some alternative embodiments, the sample adding module 03 is further provided with a star-shaped sealing ring 0391, an O-ring 0392 and a negative pressure sealing ring 0393;

[0031] A first groove is provided on the inner wall of the first connection section 03111 in contact with the plunger rod 0322. The plunger rod 0322 slides along the first groove in the first connection section 03111 in the first direction. The star-shaped sealing ring 0391 is arranged at the first groove for realizing the moving seal between the first connection section 03111 and the plunger rod 0322;

[0032] The O-ring 0392 is arranged at the end face of the plunger cavity 0321 close to the first connection section 03111 for realizing the static seal between the plunger cavity 0321 and the first connection section 03111;

[0033] The negative pressure sealing ring 0393 is arranged on the sample suction section 0313 of the sample suction head 031 for forming a negative pressure seal between the sample suction head 031 and the surface to be sampled when the sample suction section contacts the surface to be sampled.

[0034] In a second aspect, an embodiment of the present disclosure provides a multi-functional detection method, which is applied to the multi-functional detector described in any implementation manner of the first aspect. The method includes:

[0035] In order to solve the problems of the existing single-functional detector with single function, complex operation and multiple blood samplings required for multiple detection items, the multi-functional detector and the multi-functional detection method provided by the embodiments of the present disclosure utilize the mobile platform module 02 to transport the reagent kit 09 to the sample adding module 03, and then the sample adding module 03 automatically sucks negative pressure, sucks the TIP head, samples and adds the sample, adds the sample to be detected to the adding position corresponding to the detection item to be detected, and then detects through the optical detection module 04 or the electrochemical detection module 05 corresponding to the adding position, so that multiple items of two platforms can be automatically detected with only one blood sample. In addition, the user can also measure blood pressure through the multi-functional detector, and further can realize the one-time detection of blood pressure, electrochemistry (such as blood glucose, blood ketone or uric acid), and blood lipid. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] By reading the detailed description of the non-limiting embodiments with reference to the following drawings, other features, objects and advantages of the present disclosure will become more obvious. The drawings are only for the purpose of showing the specific implementation manners and are not considered as a limitation to the present disclosure. In the drawings:

[0037] Figure 1A is a three-dimensional schematic diagram of a perspective of the multi-functional detector according to the present disclosure;

[0038] Figure 1B It is a three-dimensional schematic diagram of the assembly relationship among the support base 01, the mobile platform module 02, and the sample addition module 03;

[0039] Figure 2A It shows a three-dimensional schematic diagram of an embodiment of the mobile platform module 02 from the first perspective;

[0040] Figure 2B It shows a three-dimensional schematic diagram of an embodiment of the mobile platform module 02 from the second perspective;

[0041] Figure 3A It is a three-dimensional schematic diagram of a perspective of the sample addition module 03;

[0042] Figure 3B is Figure 3A The sectional view of the sample addition module 03 shown;

[0043] Figure 4 It is a flowchart schematic diagram of an embodiment of the multi-functional detection method according to the present disclosure.

[0044] Explanation of reference numerals:

[0045] 01 - Support base; 02 - Mobile platform module; 021 - First base; 022 - Second base; 023 - Third base; 024 - First sliding guide rail; 025 - Second sliding guide rail; 026 - First motor; 027 - Second motor; 028 - First in - place sensor; 029 - Second in - place sensor; 03 - Sampling module; 031 - Sampling head; 031a - Front end; 031b - Tail end; 0311 - Connecting section; 03111 - First connecting section; 03112 - Second connecting section; 0312 - Boss; 0313 - Sampling section; 032 - Plunger pump; 0321 - Plunger chamber; 0321a - Third end; 0321b - Fourth end; 0322 - Plunger rod; 0322a - First end; 0322b - Second end; 0323 - Plunger induction sheet; 0324 - Fourth motor; 0325 - Second rack; 0326 - Second gear; 033 - Lifting drive mechanism; 0331 - Third motor; 0332 - First rack; 034 - Third in - place sensor; 035 - Fourth in - place sensor; 036 - Support plate; 037 - Guide rod; 0381 - Sensor fixing plate; 0382 - Connecting plate; 0383 - Flexible cable; 0384 - Plug - in terminal interface; 0391 - Star - shaped sealing ring; 0392 - O - ring; 0393 - Negative pressure sealing ring; 04 - Optical detection module; 05 - Electrochemical detection module; 06 - Blood pressure detection module; 07 - Control circuit board; 08 - Power supply; 09 - Reagent kit; 091 - Sample tube position; 092 - Sampling position; 093 - TIP head grasping position; 094 - TIP head discarding position; 095 - Dry chemistry sampling position; 096 - Electrochemical sampling position; 10 - Sample tube; 11 - TIP head; 12 - Reagent bin; 13 - Sampling module fixing part; 14 - U - shaped sheet metal part; 15 - Adapter plate; 16 - Power supply fixing groove. Detailed implementation manners

[0046] The embodiments of the present disclosure will be described in detail below. The examples of the embodiments are shown in the drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are intended to explain the present disclosure, and should not be construed as a limitation to the present disclosure.

[0047] It should be noted that, without conflict, the embodiments and features in the embodiments of the present disclosure may be combined with each other. The present disclosure will be described in detail below with reference to the drawings and in combination with the embodiments.

[0048] It should be understood that in the description of the present disclosure, the orientation or positional relationship indicated by terms such as "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "clockwise", "counterclockwise", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present disclosure and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation to the present disclosure.

[0049] In addition, the terms "first" and "second" are only used for descriptive purposes and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present disclosure, unless otherwise stated, the meaning of "a plurality of" is two or more, unless otherwise clearly defined.

[0050] In the present disclosure, unless otherwise clearly specified and defined, terms such as "installed", "connected", "joined", "fixed", etc. should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be a mechanical connection or an electrical connection; it may be directly connected or indirectly connected through an intermediate medium, and it may be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present disclosure can be understood according to specific circumstances.

[0051] In the present disclosure, unless otherwise clearly specified and defined, the first feature being "above" or "below" the second feature may include the direct contact between the first and second features, or may include the situation where the first and second features are not in direct contact but in contact through other features therebetween. Moreover, the first feature being "above", "over" and "on top of" the second feature includes that the first feature is directly above and obliquely above the second feature, or merely indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature being "under", "beneath" and "underneath" the second feature includes that the first feature is directly below and obliquely below the second feature, or merely indicates that the horizontal height of the first feature is lower than that of the second feature.

[0052] Refer to the following Figure 1A and Figure 1B , where Figure 1A is a three-dimensional schematic diagram of a perspective of a multi-functional detector according to the present disclosure, Figure 1B and

[0053] such as Figure 1A and Figure 1BAs shown, the multi-functional detector may include a support base 01, a mobile platform module 02, a sample addition module 03, an optical detection module 04, an electrochemical detection module 05, a blood pressure detection module 06, a control circuit board 07, and a power supply 08. Among them:

[0054] The support base 01 provides a positioning reference and structural support for each functional part, and completes the assembly and installation of each functional part. Here, the functional parts may include, for example: the mobile platform module 02, the sample addition module 03, the optical detection module 04, the electrochemical detection module 05, the blood pressure detection module 06, the control circuit board 07, and the power supply 08, etc.

[0055] The mobile platform module 02 is used to transport the reagent kit 09 carrying the sample to be tested. It can be understood that various implementation methods can be adopted here to design the mobile platform module 02 so that the mobile platform module 02 can transport the reagent kit 09.

[0056] The reagent kit 09 is used to hold the sample to be tested (for example, blood sample).

[0057] Here, as Figure 1B shown, the reagent kit 09 may include: a sample tube position 091, a sampling position (or suction negative pressure position) 092, a TIP head grasping position 093, a TIP head discarding position 094, and at least one dry chemical sample addition position 095 and at least one electrochemical sample addition position 096. Among them, the sample tube position 091 is used to support the sample tube 10 and communicate with the sample tube 10. The sample tube 10 may contain the sample to be tested (for example, blood sample).

[0058] The sample tube 10 is provided with a sealed tube cap. The middle part of the tube cap of the sample tube 10 is made of silica gel. The reagent kit 09 is provided with a hollow puncture tip corresponding to the silica gel in the middle of the tube cap of the sample tube 10. When the tube cap of the sample tube 10 is buckled downward onto the sample tube position 091, the hollow puncture tip provided by the reagent kit 09 can pierce the silica gel in the middle of the tube cap of the sample tube 10, and the sample tube position 091 is a sample transfer cavity below the buckling position of the sample tube 10. In this way, the sample tube 10 can be communicated with the above sample transfer cavity, and then the sample to be tested in the sample tube 10 can enter the sample transfer cavity of the reagent kit 09 under the action of negative pressure.

[0059] In addition, a sampling cavity is provided below the sampling position 092. The sampling cavity is communicated with the sample transfer cavity. When the sampling head 031 of the sample addition module 03 contacts the sampling position 092 to suck negative pressure, the sample to be tested in the sample tube 10 can be sucked into the sample transfer cavity of the reagent kit 09 by sucking negative pressure, and then into the sampling cavity below the sampling position 092. Subsequently, the sampling head 031 can use the TIP head 11 to suck the sample to be tested from the sampling cavity corresponding to the sampling position 092 of the reagent kit 09.

[0060] Among them, a TIP head cavity can be provided below the TIP head gripping position 093. At least one TIP head 11 is accommodated in the TIP head cavity. The pipette tip 031 can aspirate the TIP head 11 from the above-mentioned TIP head gripping position 093 and assemble it on the pipetting section 0313 of the pipette tip 031.

[0061] The TIP head discard position 094 is used to release the unnecessary TIP head 11 to the TIP head discard position 094 after the pipette tip 031 completes the tasks of aspirating and dispensing samples using the TIP head 11.

[0062] A dry chemical test strip can be provided below the dry chemical dispensing position 095 of the reagent kit 09. In this way, when the sample to be tested is added to the dry chemical dispensing position 095, during the uniform and rapid infiltration process, blood cells are filtered out. The sample to be tested reacts with the enzymes and chemical substances in the reaction layer, resulting in a color change. The intensity of this color is proportional to the concentration of the analyte. Subsequently, the reagent kit 09 can be transported to the optical detection module 04 by the moving platform module 02. The optical detection module 04 measures the reflection intensity of the dry chemical dispensing position 095, performs photoelectric conversion to obtain the photoelectric conversion result, and then the optical detection module 04 sends the photoelectric conversion result to the control circuit board 07 for calculation to obtain the blood lipid detection result. For example, the concentrations of total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) are calculated, and the concentration of low-density lipoprotein cholesterol (LDL) is calculated through the following formula, and the value of TC / HDL can also be calculated:

[0063] LDL = TC - HDL - TG / 5 (mg / dL)

[0064] Or LDL = TC - HDL - TG / 2.2 (mmol / L).

[0065] An electrochemical test strip can be provided below the electrochemical dispensing position 096 of the reagent kit 09. Enzyme and other active substances are fixed in the reaction area of the electrochemical test strip. Blood reacts with the enzyme and other active substances in the electrochemical test strip through siphon action, generating a microcurrent. Different concentrations of analytes produce different microcurrents. Subsequently, the reagent kit 09 can be transported to the electrochemical detection module 05 by the moving platform module 02. The electrochemical detection module 05 performs microcurrent detection on the electrochemical dispensing position 096, and then sends the microcurrent data to the control circuit board 07. The control circuit board 07 converts the microcurrent data into specific electrochemical concentration values (for example, blood glucose value, blood ketone value, or uric acid value). Among them, the blood glucose detection enzyme can be glucose dehydrogenase (coenzyme: flavin adenine dinucleotide glucose dehydrogenase (FAD-GDH)). The electrons generated by the reaction of glucose pass through the current counting facility, the number of electrons is read, and then converted into a glucose concentration reading.

[0066] Optionally, as Figure 1A shown, a reagent bin 12 may also be provided in the multi-functional detector, and the reagent bin 12 is a cabin for fixing the reagent kit 09. A U-shaped groove is provided inside the reagent bin 12 for limiting both sides of the reagent kit 09.

[0067] Exemplarily, reference may be made to Figure 2A and Figure 2B . Figure 2A FIG. shows a perspective schematic diagram of an embodiment of the mobile platform module 02 from a first perspective, Figure 2B FIG. shows a perspective schematic diagram of an embodiment of the mobile platform module 02 from a second perspective.

[0068] As Figure 2A and Figure 2B shown, the mobile platform module 02 includes a first base 021, a second base 022, a third base 023, and related sliding parts and driving parts. Among them, the second base 022 is installed on the first base 021, and the two are connected by a first sliding guide rail 024. The second base 022 can slide along the extension direction of the first sliding guide rail 024, and the extension direction of the first sliding guide rail 024 can be the first direction.

[0069] The third base 023 is installed on the second base 022, and the two are connected by a second sliding guide rail 025. The third base 023 can slide along the extension direction of the second sliding guide rail 025, and the extension direction of the second sliding guide rail 025 can be the second direction.

[0070] The driving force for the sliding of the first base 021, the second base 022, and the third base 023 is provided by a motor, and the driving method adopts the meshing method of a gear and a rack. Specifically, the second base 022 is provided with driving force by a first motor 026, and the third base 023 is provided with driving force by a second motor 027.

[0071] The reagent kit 09 can be installed on the third base 023. Furthermore, the reagent kit 09 can be driven by the second motor 027 to move along the extension direction of the second sliding guide rail 025 (i.e., the second direction). In addition, since the third base 023 is provided on the second base 022, the reagent kit 09 can also be driven by the first motor 026 to move along the extension direction of the first sliding guide rail 024 (i.e., the first direction). Finally, the reagent kit 09 can be driven by the mobile platform module 02 to move along the first direction and / or the second direction. It can be understood that the process of the reagent kit 09 entering the detector from the outside of the detector is a movement along the second direction.

[0072] Optionally, the mobile platform module 02 may further include a first in-place sensor 028 and a second in-place sensor 029. The first in-place sensor 028 is used to identify whether the second base 022 reaches the initial position in the first direction, and the second in-place sensor 029 is used to identify whether the third base 023 reaches the initial position in the second direction.

[0073] Specifically, the initial position of the second base 022 in the first direction can be determined by the first in-place sensor 028, and the initial position of the third base 023 in the second direction can be determined by the second in-place sensor 029. To achieve the positioning of the initial position of the second base 022 in the first direction and the initial position of the third base 023 in the second direction. After each detection is completed, the second base 022 in the mobile platform module 02 needs to return to the initial position in the first direction, and the third base 023 needs to return to the initial position in the second direction. And before each detection, it is also necessary to detect whether the second base 022 and the third base 023 are respectively in their initial positions in the first direction and the second direction. And when it is confirmed that both are in the initial positions, precise control of the movement distance and direction of the second base 022 and the third base 023 is achieved by controlling the first motor 026 and the second motor 027, and then precise control of the movement distance and direction of the reagent kit 09 is achieved.

[0074] The sample addition module 03 is used to automatically suck negative pressure, aspirate the TIP head, sample, and add samples to the reagent kit 09.

[0075] Exemplarily, reference can be made to Figure 3A and Figure 3B . Figure 3A is a perspective three-dimensional schematic diagram of one perspective of the sample addition module 03, Figure 3B is Figure 3A the sectional view of the sample addition module 03 shown.

[0076] As Figure 3A shown, the sample addition module 03 may include: a sampling head 031, a plunger pump 032, and a lifting drive mechanism 033. Among them:

[0077] The sampling head 031 provides the functions of sucking negative pressure, aspirating the TIP head, sampling, and adding samples (or spitting samples). The sampling head 031 includes a front end 031a and a tail end 031b. The head (or sampling section) of the sampling head 031 near the front end 031a can be adaptively designed according to the shape and size of the TIP head 11 to be aspirated, so as to fix the TIP head 11 on the head of the sampling head 031.

[0078] Exemplarily, the head of the sampling head 031 can be conical, cooperating with and sealing the TIP head 11. As Figure 3AAs shown, for good stability, the inner wall of the tail of the TIP head 11 to be aspirated has a first taper, and the outer wall of the head (or aspirating section) of the pipette tip 031 has a taper adapted to the first taper of the inner wall of the tail of the TIP head 11. After the up and down movement of the TIP head 11 and the pipette tip 031, the outer wall of the head of the pipette tip 031 can be stuck to the inner wall of the tail of the TIP head 11.

[0079] To achieve the function of aspirating negative pressure of the pipette tip 031, from the tail end 031b to the front end 031a, the pipette tip 031 may include a connecting section 0311, a boss 0312, and an aspirating section 0313 (i.e., the aspirating part of the pipette tip 031 close to the front end 031a). Among them, the connecting section 0311 and the boss 0312 are connected through a groove, and the sealing between the connecting section 0311 and the boss 0312 is achieved by fixing a sealing ring through the above groove. The material of the pipette tip 031 can be selected as SUS 304 according to wear resistance and service life. The boss 0312 and the aspirating section 0313 can also be connected through a groove, and the sealing between the boss 0312 and the aspirating section 0313 is achieved by fixing a sealing ring through the above groove.

[0080] The plunger pump 032 may include a plunger chamber 0321 and a plunger rod 0322. The plunger rod 0322 is sleeved inside the plunger chamber 0321, and the plunger rod 0322 has a first end 0322a. The extending direction of the plunger chamber 0321 and the plunger rod 0322 (as Figure 3A shown, the left - right direction) is the second direction.

[0081] The pipette tip 031 is a 90 - degree corner pipette tip. Among them, the connecting section 0311 includes a partial first connecting section 03111 extending along the second direction and a partial second connecting section 03112 extending along the third direction (as Figure 3A shown, the up - down direction) perpendicular to both the first direction and the second direction. The second connecting section 03112, the boss 0312, and the aspirating section 0313 extend along the third direction.

[0082] The first connecting section 03111 of the pipette tip 031 is fixedly and sealingly connected to the plunger chamber 0321.

[0083] The pipette tip 031 is an internally hollow pipe structure, and the plunger rod 0322 can move along the second direction within the plunger chamber 0321 and the first connecting section 03111. That is, it can be understood that there is gas communication between the pipette tip 031 and the plunger chamber 0321. Furthermore, the air pressure inside the plunger chamber 0321 and the pipette tip 031 can be controlled by the movement of the plunger rod 0322, and then the pipette tip 031 can be controlled to aspirate negative pressure, aspirate the TIP head, aspirate samples or add samples, as well as the specific volume of aspirating samples or adding samples.

[0084] The lifting drive mechanism 033 is used to drive the sampling head 031 and the plunger pump 032 to move along the third direction (such as Figure 3A shown, the up and down direction), that is, the sampling head 031 can move along the third direction driven by the lifting drive mechanism 033.

[0085] Exemplarily, as Figure 3A shown, the lifting drive mechanism 033 may include a third motor 0331, a first rack 0332 and a first gear ( Figure 3A not shown in the figure). The first rack 0332 extends along the third direction (such as Figure 3A shown, the up and down direction). When the third motor 0331 is powered on and rotates, its output shaft can drive the first gear to rotate. The teeth of the first gear mesh with the teeth of the first rack 0332. The rotational motion of the first gear is transmitted to the first rack 0332 through the meshing of the tooth profiles. Then, the first rack 0332 moves linearly along its length direction (such as Figure 3A shown, the up and down direction). The first rack 0332 is meshed and connected with the plunger chamber 0321. Since the sampling head 031 is fixedly connected to the plunger chamber 0321, the linear motion of the first rack 0332 drives the plunger chamber 0321 and the sampling head 031 to move along the third direction (such as Figure 3A shown, the up and down direction).

[0086] Optionally, as Figure 3A shown, the plunger rod 0322 further has a second end (or tail) 0322b opposite to the first end 0322a, and the plunger pump 032 may further include a plunger induction sheet 0323 fixedly arranged at the second end 0322b. The plunger chamber 0321 correspondingly has a third end 0321a and a fourth end 0321b respectively corresponding to the first end 0322a and the second end 0322b of the plunger rod 0322.

[0087] Optionally, the sample addition module 03 may further be provided with a third in-place sensor 034. Among them:

[0088] The third in-place sensor 034 is used to identify whether the sampling head 031 and the plunger pump 032 reach the initial position in the third direction. Optionally, the initial positions of the sampling head 031 and the plunger pump 032 in the third direction are the initial positions where the sampling head 031 and the plunger pump 032 are farthest from the front end 031a in the third direction (such as Figure 3AAs shown, it can be understood as the uppermost position, or the topmost position). The third in-place sensor 034 can be fixedly arranged relative to the lifting drive mechanism 033 and is arranged at the position farthest from the front end 031a in the third direction. The third in-place sensor 034 can be used to detect the parts of the sampling head 031 and the plunger pump 032 in the direction farthest from the front end 031a, indicating that the sampling head 031 and the plunger pump 032 reach the initial position in the third direction, that is, reach the uppermost position. Subsequently, precise control of the movement distance and direction of the sampling head 031 and the plunger pump 032 in the third direction can be achieved by controlling the third motor 0331.

[0089] Optionally, the sample addition module 03 can also be provided with a fourth in-place sensor 035. The fourth in-place sensor 035 is used to identify whether the plunger rod 0322 reaches the initial position in the second direction.

[0090] Optionally, the initial position of the plunger rod 0322 in the second direction is the initial position where the plunger rod 0322 is closest to the first end 0322a in the second direction (as Figure 3A shown, it can be understood as the rightmost position).

[0091] The fourth in-place sensor 035 can be arranged at the position of the fourth end 0321b of the plunger cavity 0321 closest to the second end 0322b of the plunger rod 0322. In this way, if the plunger rod 0322 moves towards the first end 0322a and finally the plunger induction piece 0323 arranged at the second end 0322b of the plunger rod 0322 reaches the position of the fourth in-place sensor 035 (i.e., the fourth end 0321b), the fourth in-place sensor 035 detects the target, indicating that the plunger rod 0322 reaches the initial position in the second direction, the plunger rod 0322 discharges the gas in the plunger cavity 0321, and then a negative pressure is formed in the sampling head 031. Subsequently, precise control of the movement distance and direction of the plunger rod 0322 in the second direction can be achieved by controlling the plunger pump 032, and further control the negative pressure suction, TIP head suction, sample suction or sample ejection of the sampling head 031, and precisely quantify the sample suction or sample ejection to achieve adjustable sample suction volume and adjustable sample addition (or sample ejection) volume.

[0092] Specifically, as Figure 3A shown, the plunger pump 032 can also include a fourth motor 0324, a second rack 0325 and a second gear 0326. Among them, the second rack 0325 extends in the second direction. When the fourth motor 0324 is energized and rotates, its output shaft can drive the second gear 0326 to rotate. The teeth of the second gear 0326 mesh with the teeth of the second rack 0325. The rotational movement of the second gear 0326 is transmitted to the second rack 0325 through the tooth shape engagement, and then the second rack 0325 moves along its length direction (as Figure 3AAs shown, it makes a linear motion in the left - right direction. There is an engaged connection between the plunger rod 0322 and the second rack 0325. The linear motion of the second rack 0325 drives the plunger rod 0322 to move along the second direction (such as Figure 3A As shown, the left - right direction). Furthermore, by controlling the fourth motor 0324, the movement distance and direction of the plunger rod 0322 in the second direction can be precisely controlled. Thus, the negative pressure of the sampling head 031 can be controlled, the TIP head can be aspirated, sampling or sample ejection can be performed, and precise quantitative control of sampling or sample ejection can be achieved, realizing the adjustability of the sampling volume and the adjustability of the sample addition (or sample ejection) volume.

[0093] Optionally, the sample addition module 03 may further include a support plate 036 and a guide rod 037. The support plate 036 cooperates with the plunger cavity 0321 to provide a positioning reference and structural support for each functional part, and complete the assembly and installation of each functional part. Among them, the functional part, the guide rod 037 and the first rack 0332 of the lifting drive mechanism 033 are arranged on the support plate 036, and the functional part, the plunger rod 0322 is arranged in the plunger cavity 0321.

[0094] Here, the guide rod 037 is used to provide support and guidance for the sampling head 031 and the first rack 0332.

[0095] Optionally, the sample addition module 03 may further include: a sensor fixing plate 0381 and a connecting plate 0382. Here, the sensor fixing plate 0381 is used to fix and support the fourth in - place sensor 035, and the connecting plate 0382 is used to fix and support the third motor 0331.

[0096] Optionally, as Figure 3A shown, the sample addition module 03 may further include a flexible cable 0383. The flexible cable 0383 is a flexible cable used for internal connection in the sample addition module 03. One end of the flexible cable 0383 is connected to the control circuit board 07, and the other end is connected to each electronic component inside the sample addition module 03, such as the plunger pump 032, the lifting drive mechanism 033, the third in - place sensor 034, the fourth in - place sensor 035, etc. That is, the control circuit board 07 can send control instructions to each electronic component inside the sample addition module 03 through the flexible cable 0383, and conversely, the electronic components inside the sample addition module 03 can also send feedback messages to the control circuit board 07.

[0097] Optionally, the sample addition module 03 may further include a plug - in terminal interface 0384. The plug - in terminal interface 0384 is the corresponding terminal interface of the flexible cable 0383. The power supply lines, data lines, etc. of each electronic component in the sample addition module 03 can be connected to the plug - in terminal interface 0384.

[0098] Optionally, please refer to Figure 3B , Figure 3B is Figure 3AA cross-sectional view of the sample addition module 03 shown. As Figure 3B shown, the sample addition module 03 may further include a star-shaped sealing ring 0391, an O-ring 0392, and a negative pressure sealing ring 0393.

[0099] A groove is provided on the inner wall of the plunger rod 0322 in contact with the portion of the sample pipette tip 031 extending in the second direction. The plunger rod 0322 can slide in the second direction inside the sample pipette tip 031 along the groove, and the star-shaped sealing ring 0391 is provided at the groove for achieving a moving seal between the sample pipette tip 031 and the plunger rod 0322. Since the contact area of the star-shaped sealing ring is relatively large, the sealing performance between the plunger rod 0322 and the sample pipette tip 031 is relatively good when the plunger rod 0322 is in a moving state.

[0100] The O-ring 0392 is provided at the end face of the plunger cavity 0321 close to the sample pipette tip 031 for achieving a static seal between the plunger cavity 0321 and the sample pipette tip 031.

[0101] The negative pressure sealing ring 0393 is provided at the sample suction section 0313 of the sample pipette tip 031, for example, at one end of the sample suction section 0313 away from the front end 031a. When the sample pipette tip 031 contacts the sampling position 092 of the reagent kit 09, a negative pressure seal is formed between the sample pipette tip 031 and the sampling position 092 to ensure the negative pressure during the sample suction process. Then, the sample to be tested can be sucked from the sample tube 10 to the sample transfer cavity of the reagent kit 09. Subsequently, the sample pipette tip 031 can use the TIP head 11 to suck the sample to be tested from the sampling cavity corresponding to the sampling position 092 of the reagent kit 09.

[0102] Optionally, various performance parameters of the fourth motor 0324 can be determined according to the moving speed of the plunger rod 0322 in the second direction.

[0103] Optionally, as Figure 3B shown, the length of the plunger rod 0322 consists of three parts: an effective functional length L1, a driving requirement length L2, and a structural requirement length L3.

[0104] Among them, the effective functional length L1 is determined according to the maximum sample suction volume requirement.

[0105] The structural requirement length L3 is determined according to the structural support requirements of the plunger pump 032.

[0106] Since the plunger pump 032 itself also has the function of structural support, it needs to support the sensor fixing plate 0381, the plunger induction piece 0323, and the plug-in terminal interface 0384. Therefore, the structural requirement length L3 can be designed according to the structural support requirements of the sensor fixing plate 0381, the plunger induction piece 0323, and the plug-in terminal interface 0384.

[0107] The sample addition process using the sample addition module 03 may include: sucking negative pressure, sucking a TIP head, sucking a sample, and adding the sample (or discharging the sample).

[0108] This sample addition process includes a lifting motion (i.e., the sampling head 031 and the plunger pump 032 move along the third direction driven by the third motor 0331) and a left - right motion (i.e., the plunger pump 032 moves along the second direction driven by the fourth motor 0324).

[0109] Here, the required driving length L2, that is, the length of the second rack 0325, is determined according to the motion stroke of the left - right motion in the above - mentioned sample addition process.

[0110] Various performance parameters of the third motor 0331 can be comprehensively determined according to the motion stroke of the lifting motion and the downward pressure required to pick up the TIP head 11 in the above - mentioned sample addition process. For example, the torque, holding torque, rotational speed, etc. of the third motor 0331.

[0111] The optical detection module 04 is used to measure the reflection intensity at the dry - chemical sample addition position 095 of the reagent kit 09, perform photoelectric conversion to obtain a photoelectric conversion result, and then the optical detection module 04 sends the photoelectric conversion result to the control circuit board 07 for calculation to obtain a blood lipid detection result.

[0112] The optical detection module 04 can be electrically connected to the power supply 08 to obtain electrical energy, and can also be communicatively connected to the control circuit board 07 to transmit the detected electrical signal to the control circuit board 07.

[0113] The electrochemical detection module 05 is used to perform micro - current detection on the electrochemical sample addition position 096 of the reagent kit 09, and then send the micro - current data to the control circuit board 07, and the control circuit board 07 converts the micro - current data into a specific electrochemical concentration value (for example, blood glucose value, blood ketone value, or uric acid value).

[0114] The electrochemical detection module 05 can be electrically connected to the power supply 08 to obtain electrical energy, and can also be communicatively connected to the control circuit board 07 to transmit the detected current data to the control circuit board 07.

[0115] The blood pressure detection module 06 is used to measure the human blood pressure and send the measured blood pressure data to the control circuit board 07. Specifically, it can measure the diastolic blood pressure, systolic blood pressure and pulse of the human arm, and send the measured diastolic blood pressure value, systolic blood pressure value and pulse value to the control circuit board 07. Specifically, the blood pressure detection module 06 uses the oscillometric method to measure the human blood pressure, and its measurement method is the step-down measurement method: use an air pump to inflate and pressurize the cuff, use the inflated cuff to compress the artery, and make the artery in a completely blocked state. Then open the deflation valve to slowly reduce the pressure in the cuff. As the pressure in the cuff decreases, the artery changes from complete occlusion - gradual opening - full opening. During the step-down process, the amplitude of the arterial pressure changes, and the pressure sensor collects the changing pressure in the cuff, converts it into a digital signal and sends it to the CPU in the blood pressure detection module 06. Through the embedded software, the corresponding pressure points during the arterial blood flow obstruction process are identified, and the diastolic blood pressure, systolic blood pressure and pulse of the human body are obtained according to the software algorithm accumulated by experience.

[0116] The control circuit board 07 is communicatively connected to the mobile platform module 02, the sample addition module 03, the optical detection module 04, the electrochemical detection module 05, and the blood pressure detection module 06, and is used to control the above-mentioned modules and receive the data fed back by the above-mentioned modules.

[0117] The power supply 08 is electrically connected to the mobile platform module 02, the sample addition module 03, the optical detection module 04, the electrochemical detection module 05, the blood pressure detection module 06, and the control circuit board 07, and is used to supply power to the above-mentioned modules. Here, the power supply 08 can be various types of power supply devices. For example, the power supply 08 can be used to receive an external input power supply (such as mains AC or DC) and convert it into the voltage or current required by each component in the detector. The power supply 08 can also be used to convert the built-in battery into the voltage or current required by each component in the detector.

[0118] Optionally, as Figure 1A shown, a sample addition module fixing member 13 and a U-shaped sheet metal part 14 can also be provided in the multifunctional detector. The sample addition module fixing member 13 is used to support the sample addition module 03, and the U-shaped sheet metal part 14 is used to support the whole of the sample addition module 03 and the sample addition module fixing member 13.

[0119] Optionally, as Figure 1A shown, a transfer board 15 can also be provided in the multifunctional detector. The transfer board 15 is used to realize the signal transmission between the control circuit board 07, the optical detection module 04, the electrochemical detection module 05, and the blood pressure detection module 06. The transfer board 15 is not a functional module, and the electrical signals of the optical detection module 04, the electrochemical detection module 05, and the blood pressure detection module 06 are forwarded to the control circuit board 07 through the transfer board 15. That is, the transfer board 15 is used to realize the line transfer.

[0120] Optionally, as Figure 1A shown, a power supply fixing groove 16 may also be provided in the multi-functional detector. The power supply fixing groove 16 and the support base 01 are integrally designed for fixing the power supply 08. Here, the power supply 08 may be a battery.

[0121] Optionally, the multi-functional detector may further include an information input module ( Figure 1A not shown in the figure). The information input module is used to receive the input instruction of the user and transmit the input instruction of the user to the control circuit board 07. For example, the information input module may be an input button and / or a touch screen. The input instruction of the user may include a detection category. For example, the detection category may be blood pressure detection, blood lipid detection, or electrochemical detection. In this way, the control circuit board 07 may determine to activate a specific function module according to the above detection category to complete the operation corresponding to the input instruction of the user.

[0122] For another example, the input instruction of the user may further include the specific blood lipid detection type corresponding to each dry chemical sampling position 095 in the reagent kit 09, or may further include the specific electrochemical detection type corresponding to each electrochemical sampling position 096 in the reagent kit 09. In this way, the control circuit board 07 may control the sampling module 03 to sample and then add the volume of the sample according to the needs of the detection type corresponding to each sampling position, and may control the working parameters of the optical detection module 04 to perform optical detection on the dry chemical sampling position 095, and / or control the working parameters of the electrochemical detection module 05 to perform electrochemical detection on the electrochemical sampling position 096.

[0123] Optionally, the multi-functional detector may further include an information collection module ( Figure 1A not shown in the figure). The information collection module is used to collect the information stored in the RFID tag provided on the outer side of the cabin of the reagent kit 09 to identify the detection item information. Specifically, it may include what the detection item is, which sampling position is required for sampling, and the sampling volume required for sampling, etc. For example, the information collection module may be an RFID reader.

[0124] It should be noted that each in-place sensor in the present disclosure may be various sensors used to detect whether an object or a device reaches a predetermined position, and the present disclosure does not make specific limitations thereon. For example, it may include, but is not limited to, the following types of in-place sensors: photoelectric type, magnetic induction type, Hall type, proximity type, etc.

[0125] The multi-functional detector provided in this embodiment transports the reagent kit 09 to the sample addition module 03 by using the mobile platform module 02, and then the sample addition module 03 automatically sucks negative pressure, aspirates the TIP head, samples and adds the sample, adding the sample to be tested to the sample addition position corresponding to the test item to be detected. Then, the optical detection module 04 or the electrochemical detection module 05 corresponding to the sample addition position is used for detection, and it can realize automatic detection of multiple items on two platforms with only one blood sample. In addition, the user can also measure blood pressure through the multi-functional detector, and thus can realize one-time detection of blood pressure, electrochemistry (such as blood glucose, blood ketone or uric acid), and blood lipid.

[0126] Please refer to the following Figure 4 , Figure 4 which shows the process of the multi-functional detection method using the multi-functional detector described in Figure 1A and the above various alternative embodiments. The multi-functional detection method includes the following steps:

[0127] Step 401, the control circuit board 07 determines to start the blood pressure detection module 06 or start the blood sample detection according to the detection type input by the user.

[0128] As an example, the multi-functional detector can be designed in various ways for the user to input the detection type. For example, the multi-functional detector can be provided with a touch screen, and the touch screen can display a user interaction interface. The above user interaction interface can include start detection display objects for indicating different detection types (for example, written with "detect blood pressure", "detect blood lipid", "detect blood glucose"). The user interacts with the above start detection display object to send a start detection instruction to the control circuit board 07, and then the control circuit board 07 can determine which function module to start according to the detection type input by the user. Here, if the detection type input by the user is blood pressure detection, go to step 402 to start the blood pressure detection module 06.

[0129] If the detection type input by the user is blood sample detection, such as blood lipid detection and / or electrochemical detection, it can go to step 403 to start the blood sample detection.

[0130] Step 402, the control circuit board 07 starts the blood pressure detection module 06.

[0131] Specifically, the control circuit board 07 can control the power supply 08 to supply power to the blood pressure detection module 06, and the blood pressure detection module 06 presents user operation prompt information and waits for the user to place the arm in the cuff and press the start button of the blood pressure detection module 06 (for example, a physical button or a display object on the touch screen) before starting the subsequent operations related to blood pressure measurement. After obtaining the blood pressure data, the blood pressure data is transmitted to the control circuit board 07 for the control circuit board 07 to output the blood pressure data through the display module or upload it to the cloud.

[0132] Step 403: In response to detecting the blood sample detection start instruction, the control circuit board 07 controls the mobile platform module 02 to transport the reagent kit 09 to the preset negative pressure position.

[0133] If the detection type input by the user in step 401 is blood sample detection (blood lipid detection and / or electrochemical detection), that is, it is necessary to detect the sample to be tested (for example, a blood sample), the control circuit board 07 can remind the user to prepare the reagent kit through the display module in the detector. Furthermore, the user needs to prepare the sample tube 10 and the reagent kit 09, and place the sample tube 10 upside down on the sample tube position 091 of the reagent kit 09. The top of the reagent kit 09 needs to be provided with a test strip corresponding to the item to be detected. For example, a dry chemical test strip for blood lipid detection or an electrochemical test strip. If blood lipid needs to be detected, a dry chemical test strip for specific blood lipid detection items needs to be provided below the dry chemical sample addition position 095 in the reagent kit 09. If blood glucose, blood ketone or uric acid needs to be detected, an electrochemical test strip corresponding to specific electrochemical detection items needs to be provided below the electrochemical sample addition position 096 in the reagent kit 09.

[0134] Then, the user can continue to input an instruction through various information input channels provided by the multifunctional detector, indicating that the reagent kit 09 is ready and the blood sample detection can start. The above instruction will be transmitted to the control circuit board 07. Next, the user can place the reagent kit 09 inside the multifunctional detector, or the multifunctional detector can also be provided with a device for the automatic entry of the reagent kit 09 to move the reagent kit 09 into the multifunctional detector and place it on the third base 023 of the mobile platform module 02.

[0135] Then, the control circuit board 07 can first control the first motor 026 and / or the second motor 027 to work, and detect whether the third base 023 reaches the initial position in the second direction through the second in-place sensor 029 and the first in-place sensor 028, and detect whether the second base 022 reaches the initial position in the first direction through the first in-place sensor 028. If both reach, the control circuit board 07 then controls the working parameters of the first motor 026 and / or the second motor 027, and then drives the movement of the reagent kit 09, so that the reagent kit 09 reaches the preset negative pressure suction position, specifically, the sampling position (i.e., the negative pressure suction position) 092 of the reagent kit 09 is located below the sampling section 0313 of the sampling head 031.

[0136] Then, go to step 404 for execution.

[0137] Step 404, the sampling module 03 applies negative pressure to the reagent kit 09.

[0138] Specifically, first, the lifting drive mechanism 033 in the sampling module 03 can be controlled to drive the sampling head 031 and the plunger pump 032 to move in the third direction (as Figure 3A shown, the up and down direction), so that the sampling section 0313 is in sealed contact with the sampling position 092 (i.e., the negative pressure suction position) of the reagent kit 09. Since the sampling position 092 (i.e., the negative pressure suction position) of the reagent kit 09 is connected to the sampling cavity, the sampling cavity is connected to the sample transfer cavity, and then the sampling position 092 (i.e., the negative pressure suction position) of the reagent kit 09 is also connected to the sample transfer cavity of the reagent kit 09, and the sample transfer cavity of the reagent kit 09 is connected to the sample tube 10.

[0139] Then, by controlling the movement of the plunger rod 0322 in the sampling module 03 to control the formation of negative pressure inside the plunger cavity 0321 and the sampling head 031, under the action of the above negative pressure, the test sample in the sample tube 10 will flow through the sample transfer cavity of the reagent kit 09 and enter the sampling cavity below the sampling position 092.

[0140] Step 405, the sampling head 031 aspirates the sample from the reagent kit 09.

[0141] Specifically, it can include the following steps:

[0142] The first step: Assemble the TIP head

[0143] Specifically, first,

[0144] The mobile platform module 02 transports the reagent kit 09 so that the TIP head grasping position of the reagent kit 09 is located directly below the sampling head 031.

[0145] Then, the sampling head 110 is assembled with the TIP head 11 on the outermost surface under the TIP head gripping position 093 to form a sealed structure. Specifically, by controlling the operating parameters of the third motor 0331 in the lifting drive mechanism 033, the sampling head 031 can be lowered into the TIP head cavity under the TIP head gripping position 093 to suck the TIP head 11. Eventually, the TIP head 11 is assembled with the sampling head 031 to form a sealed structure. For example, the sampling section 0313 can be assembled with the tail of the TIP head. Step 2: Sampling

[0146] First, the moving platform module 02 transports the reagent kit 09 so that the sampling position 092 of the reagent kit 09 is directly below the TIP head assembled on the sampling section 0313.

[0147] After that, by controlling the operating parameters of the third motor 0331 in the lifting drive mechanism 033, the sampling head 031 can be lowered so that the TIP head assembled below the sampling section 0313 enters the sampling position 092 of the reagent kit 09.

[0148] Finally, the operating parameters of the fourth motor 0324 in the plunger pump 032 can be controlled so that the plunger rod 0322 moves in the second direction. Furthermore, the movement of the plunger rod 0322 is controlled to evacuate the gas in the plunger cavity 121, so as to create a negative pressure in the sampling head 031 and the TIP head. Then, the movement of the plunger rod 0322 is controlled to suck the sample to be tested from the sampling position 092 of the reagent kit 09 through the TIP head 11, that is, to suck the sample to be tested from the sample transfer cavity of the reagent kit 09 from the sample tube 10. The sample to be tested is held within the TIP head 11 under the action of the negative pressure, so as to keep the sample to be tested within the TIP head 11 before the sampling head 031 is transferred to the dry chemical sample addition position 095 or the electrochemical sample addition position 096. It can be understood that the specific volume value of the sample to be tested can also be controlled by controlling the operating parameters of the fourth motor 0324 here, so as to achieve precise quantitative sampling.

[0149] Step 406, the sampling head 031 adds sample to the reagent kit 09.

[0150] Specifically, first, the control circuit board 07 needs to determine the specific sample addition information, that is, it needs to determine the target sample addition position for adding sample to the reagent kit 09, that is, to which specific dry chemical sample addition position 095 or electrochemical sample addition position 096 to add sample, and how much sample to be tested to add specifically, etc. Here, various implementation methods can be used to obtain the sample addition information.

[0151] For example, the user can input information through the information input path of the detector. For example, input through the user interface provided by the touch screen. Or, an RFID electronic tag can be set on the test kit 09, and the test item information can be stored in the RFID electronic tag. For example, it includes several test items, the sampling information corresponding to each test item. The sampling information can include the target sampling position and the sampling volume. The sampling information is used to indicate which specific sampling position each test item corresponds to, and the sampling volume required for this test item, etc. Correspondingly, an information acquisition module needs to be set in the detector. For example, it can be an RFID electronic tag reader to read the RFID electronic tag set on the test kit 09 to obtain the sampling information in the test item information, and then give the read sampling information to the control circuit board 07.

[0152] Then, the control circuit board 07 can control the mobile platform module 02 to transport the test kit 09 according to the sampling information, so that the pipette tip 031 is directly above the target sampling position. Here, the target sampling position can be a certain dry chemical sampling position 095 or an electrochemical sampling position 096.

[0153] Specifically, the working parameters of the third motor 0331 in the lifting drive mechanism 033 can be controlled here to make the pipette tip 031 move upward, so that the TIP head leaves the sampling position 092 of the test kit 09, and then control the mobile platform module 02 to transport the test kit 09, so that the TIP head assembled under the pipette tip 031 is directly above the target sampling position.

[0154] Next, the movement of the plunger rod 0322 in the plunger pump 032 can be controlled to achieve the addition of the liquid in the TIP head to the target sampling position.

[0155] Specifically, the working parameters of the fourth motor 0324 in the plunger pump 032 can be controlled here to make the plunger rod 0322 move to achieve the addition of the sample to be tested in the TIP head 11 to the target sampling position. Optionally, the working parameters of the fourth motor 0324 in the plunger pump 032 can also be controlled here to make the plunger rod 0322 move to achieve the quantitative addition of the sample to be tested in the TIP head 11 to the target sampling position according to the sampling volume in the sampling information.

[0156] Step 3: Discard the TIP head

[0157] Specifically, the mobile platform module 02 can transport the test kit 09 so that the TIP head discard position 094 of the test kit 09 is directly below the pipette tip 031, and then control the working parameters of the third motor 0331 in the lifting drive mechanism 033 to release the TIP head 11 assembled on the pipette tip 031 to the TIP head discard position 094.

[0158] Then go to step 407 for execution.

[0159] Step 407: The control circuit board 07 controls the mobile platform module 02 to transport the test kit 09 to the detection position of the optical detection module 04 or the electrochemical detection module 05 according to the detection type input by the user.

[0160] If the detection type input by the user is blood lipid detection, the mobile platform module 02 can be controlled to transport the test kit 09 to the detection position of the optical detection module 04, and then go to step 408. Specifically, transporting the test kit 09 to the optical detection module 04 means that the dry chemical sampling position 095 of the test kit 09 is located at the detection position of the optical detection module 04.

[0161] If the detection type input by the user is electrochemical detection, the mobile platform module can be controlled to transport the test kit 09 to the detection position of the electrochemical detection module 05, and then go to step 410. Specifically, transporting the test kit 09 to the detection position of the electrochemical detection module 05 means that the electrochemical sampling position 096 of the test kit 09 is located at the detection position of the electrochemical detection module 05.

[0162] Step 408: The optical detection module 04 performs optical detection on the dry chemical sampling position 095.

[0163] Here, when the dry chemical sampling position 095 of the test kit 09 is located at the detection position of the optical detection module 04, that is, the color development area (or detection area) of the corresponding dry chemical test strip is located at the detection position of the optical detection module 04, the optical detection module 04 can perform excitation light irradiation and perform photoelectric conversion through a photoelectric sensor to obtain a photoelectric signal conversion result, and then transmit the detected electrical signal to the control circuit board 07, and then go to step 409.

[0164] Step 409: The control circuit board 07 converts the electrical signal detected by the optical detection module 04 into a specific blood lipid concentration value.

[0165] Here, the control circuit board 07 can adopt various calculation methods known now or developed in the future for calculating blood lipid concentration based on the electrical signal of the reflection intensity to convert the electrical signal detected by the optical detection module 04 into a specific blood lipid concentration value. For example, it can adopt, including but not limited to: based on the principle of spectrophotometry and the standard curve method. For example, the concentrations of total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) can be calculated, and the concentration of low-density lipoprotein cholesterol (LDL) can be calculated through the following formula, and the value of TC / HDL can also be calculated:

[0166] LDL = TC - HDL - TG / 5 (mg / dL)

[0167] Or LDL = TC - HDL - TG / 2.2 (mmol / L).

[0168] Step 410, the electrochemical detection module 05 performs electrochemical detection on the electrochemical sample loading position 096.

[0169] Here, when the electrochemical sample loading position 096 of the test kit 09 is at the detection position of the electrochemical detection module 05, that is, the color development area (or detection area) of the corresponding electrochemical test strip is at the detection position of the electrochemical detection module 05, the electrochemical detection module 05 can perform micro - current detection on the electrochemical sample loading position 096 of the test kit 09, and then send the micro - current data to the control circuit board 07, and then proceed to step 412.

[0170] Step 411, the control circuit board 07 converts the micro - current data detected by the electrochemical detection module 05 into a specific electrochemical concentration value.

[0171] Here, the electrochemical concentration value can be, for example, a blood glucose value, a blood ketone value, or a uric acid value.

[0172] The control circuit board 07 can adopt various calculation methods known now or developed in the future for calculating the electrochemical concentration value based on the micro - current data to convert the micro - current data detected by the electrochemical detection module 05 into a specific electrochemical concentration value. For example, it can adopt, including but not limited to: the standard curve method (calibration curve method), the Cottrell equation (chronoamperometry), the enzyme kinetics method (enzyme electrode), and so on.

[0173] By using the multi - function detection method shown in the above steps 401 to 411, it can be realized that only one multi - function detector is needed to achieve multiple detection functions. And when it comes to multiple types of detections of blood samples, such as lipid detection and blood glucose detection, or two different lipid detection items, not only is it not necessary to draw blood multiple times, only one tube of blood sample is needed, nor is it necessary to perform multiple detections. With one - key operation, all detection results can be obtained, which is convenient and simplifies the operation of users.

[0174] It should be noted that the implementation details and technical effects of each step in the multi - function detection method provided by the embodiments of the present disclosure can refer to the descriptions of other embodiments in the present disclosure, and will not be elaborated here.

[0175] The flowcharts and block diagrams in the accompanying drawings illustrate the possible architectures, functions, and operations of systems, methods, and computer program products according to various embodiments of the present disclosure. In this regard, each block in the flowchart or block diagram may represent a module, a segment of a program, or a part of code that contains one or more executable instructions for implementing a specified logical function. It should also be noted that in some alternative implementations, the functions marked in the blocks may occur in a different order than that marked in the accompanying drawings. For example, two consecutive blocks shown may actually be executed substantially in parallel, and they may sometimes be executed in the reverse order, depending on the functions involved. It should also be noted that each block in the block diagram and / or flowchart, as well as combinations of blocks in the block diagram and / or flowchart, can be implemented by a dedicated hardware-based system that performs the specified functions or operations, or can be implemented by a combination of dedicated hardware and computer instructions.

[0176] The units or modules involved in the embodiments described in the present disclosure can be implemented in software or in hardware. Among them, the name of the unit or module does not, in some cases, constitute a limitation on the unit or module itself.

[0177] The above description is only a preferred embodiment of the present disclosure and an explanation of the technical principles applied. Those skilled in the art should understand that the scope of the disclosure involved in the present disclosure is not limited to the technical solutions formed by the specific combination of the above technical features, and should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the above disclosure concept. For example, the technical solutions formed by mutually replacing the above features with the technical features (but not limited to) having similar functions disclosed in the present disclosure.

Claims

1. A multifunctional detector, comprising: A supporting base (01), a mobile platform module (02), a sample adding module (03), an optical detection module (04), an electrochemical detection module (05), a blood pressure detection module (06), a control circuit board (07) and a power supply (08), wherein: The support base (01) is used to provide positioning reference and structural support for each functional part, and complete the assembly and installation of each functional part; The mobile platform module (02) is used to transport a test kit (09) carrying a sample to be tested, wherein the test kit (09) comprises at least one dry chemical sample loading position (095) and at least one electrochemical sample loading position (096), a dry chemical test strip is arranged below the dry chemical sample loading position (095), and an electrochemical test strip is arranged below the electrochemical sample loading position (096); The sample adding module (03) is used to automatically suck negative pressure, suck the TIP head, take samples and add samples to the reagent kit (09); The optical detection module (04) is used to convert photoelectric signals from the dry chemical sample loading position (095) of the reagent kit (09); The electrochemical detection module (05) is used to perform current detection on the electrochemical sample loading position (096) of the reagent kit (09); The blood pressure detection module (06) is used to measure human blood pressure; The control circuit board (07) is used to control the mobile platform module (02), the sample adding module (03), the optical detection module (04), the electrochemical detection module (05) and the blood pressure detection module (06) to perform multifunctional detection, and to calculate blood lipid detection results based on the electrical signal received from the optical detection module (04), and to calculate electrochemical detection results based on the current data received from the electrochemical detection module (05); The power supply (08) is used to provide electrical energy to the mobile platform module (02), the sample adding module (03), the optical detection module (04), the electrochemical detection module (05), the blood pressure detection module (06) and the control circuit board (07).

2. The multifunctional detector according to claim 1, wherein: The reagent kit (09) further comprises: at least one sampling position (092).

3. The multifunctional detector according to claim 1, wherein: The multifunctional detector is also provided with: a reagent compartment (12), and the reagent compartment (12) is used to fix the reagent kit (09).

4. The multifunctional detector according to claim 1, wherein: The mobile platform module (02) comprises: a first base (021), a second base (022), a third base (023), a first sliding guide rail (024), a second sliding guide rail (025), a first motor (026) and a second motor (027); The second base (022) is installed on the first base (021), the first sliding guide rail (024) connects the first base (021) and the second base (022), the second base (022) can slide along the extension direction of the first sliding guide rail (024), and the extension direction of the first sliding guide rail (024) is a first direction; The third base (023) is installed on the second base (022), the second sliding guide rail (025) connects the second base (022) and the third base (023), and the third base (023) can slide along the extension direction of the second sliding guide rail (025), and the extension direction of the second sliding guide rail (025) is the second direction; The second base (022) is driven by the first motor (026), and the third base (023) is driven by the second motor (027).

5. The multifunctional detector according to claim 1, wherein: The sample adding module (03) comprises: A sample suction head (031), a plunger pump (032) and a lifting drive mechanism (033), wherein the sample suction head (031) is used to suck negative pressure, suck TIP head, suck sample and add sample under the control of the plunger pump (032), and the lifting drive mechanism (033) is used to control the moving distance of the sample suction head (031).

6. The multifunctional detector according to claim 5, wherein: The sample suction head (031) has a front end (031a) and a rear end (031b). From the rear end (031b) to the front end (031a), the sample suction head (031) includes a connecting section (0311), a boss (0312) and a sample suction section (0313).

7. The multifunctional detector according to claim 6, wherein: The plunger pump (032) comprises a plunger cavity (0321) and a plunger rod (0322), wherein the plunger rod (0322) is sleeved inside the plunger cavity (0321), and the plunger rod (0322) has a first end (0322a). The extension direction of the plunger cavity (0321) and the plunger rod (0322) is the second direction. The connecting section (0311) comprises a first connecting section (03111) extending in a part along the second direction and a second connecting section (03112) extending in a third direction perpendicular to the first direction and the second direction. The second connecting section (03112), the boss (0312) and the sample suction section (0313) extend in the third direction.

8. The multifunctional detector according to claim 7, wherein: The first connecting section (03111) is fixedly and sealedly connected to the plunger cavity (0321); the sample suction head (031) is an internal hollow pipe structure; the plunger rod (0322) can move along the second direction within the plunger cavity (0321) and the first connecting section (03111).

9. The multifunctional detector according to claim 7, wherein: The lifting drive mechanism (033) is used to drive the sample suction head (031) to move along the third direction.

10. The multifunctional detector according to claim 9, wherein: The plunger rod (0322) also has a second end (0322b) opposite to the first end (0322a), and the plunger pump (032) also includes a plunger sensor plate (0323) fixedly arranged on the second end (0322b).

11. The multifunctional detector according to claim 10, wherein: The sample loading module (03) is further provided with a third in-position sensor (034), and the third in-position sensor (034) is used to identify whether the sample suction head (031) and the plunger pump (032) have reached an initial position in the third direction.

12. The multifunctional detector according to claim 7, wherein: The sample loading module (03) is further provided with a fourth in-position sensor (035), and the fourth in-position sensor (035) is used to identify whether the plunger rod (0322) has reached an initial position in the second direction.

13. The multifunctional detector according to claim 7, wherein: The sample adding module (03) is also provided with a star-shaped sealing ring (0391), an O-shaped sealing ring (0392) and a negative pressure sealing ring (0393); The inner wall of the first connecting section (03111) in contact with the plunger rod (0322) is provided with a first groove, and the plunger rod (0322) slides along the first direction in the first connecting section (03111) along the first groove, and a star-shaped sealing ring (0391) is provided at the first groove to achieve a motion seal between the first connecting section (03111) and the plunger rod (0322); The O-ring (0392) is arranged on the end surface of the plunger cavity (0321) close to the first connecting section (03111) to achieve static sealing between the plunger cavity (0321) and the first connecting section (03111); The negative pressure sealing ring (0393) is arranged on the sample suction section (0313) of the sample suction head (031) and is used to form a negative pressure seal between the sample suction head (031) and the surface to be sucked when the sample suction section contacts the surface to be sucked.

14. A multifunctional detection method, applied to the multifunctional detector according to any one of claims 1 to 13, the method comprising: The control circuit board (07) determines to start the blood pressure detection module 06 or start the blood sample detection according to the detection type input by the user; The control circuit board (07) starts the blood pressure detection module (06) in response to the detection type input by the user being blood pressure detection; The control circuit board (07) controls the mobile platform module (02) to transport the test kit (09) to a preset negative pressure suction position in response to detecting a blood sample test start instruction; The sample loading module (03) applies negative pressure to the reagent box (09); The sample loading module (03) sucks samples from the reagent kit (09); The sample adding module (03) adds samples to the reagent kit (09); The control circuit board (07) controls the mobile platform module (02) to transport the reagent kit (09) to the detection position of the optical detection module (04) or the electrochemical detection module (05) according to the detection type input by the user; The optical detection module (04) performs optical detection on the dry chemical sample loading position (095), and sends the electrical signal of the optical detection to the control circuit board (07), so that the control circuit board (07) converts the electrical signal detected by the optical detection module (04) into a specific blood lipid concentration value; The electrochemical detection module (05) performs electrochemical detection on the electrochemical sample adding position (096), and sends the current data of the electrochemical detection to the control circuit board (07), so that the control circuit board (07) can convert the current data detected by the electrochemical detection module (05) into a specific electrochemical concentration value.

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