A traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: Psoralea 6-18g, Herba Epimedii 6-20g, prepared Fufangpi 3-15g, Rhizoma Drynariae 6-20g, Radix Cyathulae 9-18g, Radix et Rhizoma Ampelopsis 12-24g, Radix et Rhizoma Clematis 6-12g, Herba Lysimachiae 10-30g, Radix et Rhizoma Smilacis glabrae 10-30g, Radix Paeoniae Rubra 9-15g, natural copper 6-12g, Geotrupes 3-9g, Radix et Rhizoma Ampelopsis 6-12g, Rhizoma Notopterygii 6-15g, Radix Angelicae Pubescentis 6-15g, Radix Angelicae Pubescentis 6-12g, Radix et Rhizoma Baphicacanthis 3-9g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicacanthis 6-15g, Radix et Rhizoma Baphicac

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof. BACKGROUND

[0002] Ankylosing spondylitis is a chronic autoimmune disease, and existing treatment schemes mainly use non-steroidal anti-inflammatory drugs, immunosuppressants and biological agents. Traditional Chinese medicine treatment is based on the principle of 'tonifying kidney and strengthening bones, expelling wind and removing dampness, and activating blood and dredging collaterals'.

[0003] The existing technical problems and defects are that the existing treatment schemes have large side effects (such as gastrointestinal damage, liver and kidney toxicity) and high costs after long-term use; and the existing compound preparations of traditional Chinese medicine generally have problems such as complicated prescription, unstable curative effect and lack of standardized process. SUMMARY

[0004] The purpose of the present application is to provide a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof, which has a scientific prescription, definite curative effect and standardized preparation process, and can precisely improve the inflammatory response, bone destruction and pain symptoms of ankylosing spondylitis through multi-target synergistic effect, and at the same time, the preparation process is standardized to ensure stable drug efficacy.

[0005] To achieve the above-mentioned purpose, the technical scheme adopted by the present application is as follows:

[0006] A traditional Chinese medicine composition for treating ankylosing spondylitis is prepared from the following raw materials: Psoralea 6-18g, Herba Epimedii 6-20g, Radix Aconiti Preparata 3-15g, Rhizoma Drynariae 6-20g, Radix Anemarrhenae 9-18g, Radix Sanguinariae 12-24g, Radix Clematidis 6-12g, Herba Lycopodii 10-30g, Radix Gentianae Phaeo 10-30g, Radix Paeoniae Rubra 9-15g, Natura Cuprum (Vinegar Quenching) 6-12g, Armadillidium 3-9g, Radix Aconiti 6-12g, Rhizoma Notopterygii 6-15g, Radix Angelicae Pubescentis 6-15g, Radix Angelicae Sinensis 6-12g, Radix Paeoniae Alba 9-15g, Radix Rehmanniae Preparata 6-18g, Rhizoma Anemarrhenae 6-15g, Radix Saussureae Involucratae 6-12g, Radix Atractylodis 3-9g, Radix Paeoniae Rubra 6-15g, and Radix Angelicae Pubescentis 6-15g.

[0007] Further, the specific amount is Psoralea 12g, Herba Epimedii 12g, Radix Aconiti Preparata 12g, Radix Paeoniae Rubra 12g, Radix Paeoniae Alba 12g, Radix Saussureae Involucratae 9g, Radix Atractylodis 6g, Radix Anemarrhenae 12g, Natura Cuprum 9g, Radix Rehmanniae Preparata 9g, Radix Aconiti 9g, Rhizoma Drynariae 15g, Rhizoma Anemarrhenae 18g, Radix Angelicae Pubescentis 9g, Radix Angelicae Sinensis 9g, Radix Angelicae Pubescentis 6g, Radix Angelicae Sinensis 20g, Radix Paeoniae Rubra 15g.

[0008] Furthermore, the prepared Radix Aconiti Lateralis Preparata and Ephedra need to be detoxified before use; the Pyritum is used after being processed by quenching with vinegar and removing the dregs.

[0009] Another object of the present invention is to provide a preparation method of a traditional Chinese medicine composition for treating ankylosing spondylitis, comprising the following steps:

[0010] S1. Calcine the Pyritum until it turns red, then immerse it in rice vinegar until it becomes crisp, remove the impurities and grind it into powder for later use; detoxify the prepared Radix Aconiti Lateralis Preparata and Ephedra according to the processing specifications of the Chinese Pharmacopoeia for later use;

[0011] S2. Mix all the raw medicinal materials and decoct them with water to make a decoction; or dry all the raw medicinal materials, mix and pulverize them until the particle size is ≤200 μm, pass through a 50-mesh sieve and fill them into capsules.

[0012] Therapeutic mechanism: This prescription is modified from Guizhi Shaoyao Zhimu Decoction in Synopsis of the Golden Chamber. The monarch drugs (Psoralea corylifolia, Epimedium brevicornu, prepared Radix Aconiti Lateralis Preparata): Their properties are warm, and they belong to the kidney meridian, warming the kidney yang and strengthening the muscles and bones. The ministerial drugs (Achyranthes bidentata, Dipsacus asperoides, Drynaria fortunei): They belong to the liver and kidney meridians, tonifying the liver and kidney, strengthening the waist and knees, and inhibiting bone destruction. The adjuvant and guiding drugs (Paeonia lactiflora, Eupolyphaga sinensis, Pyritum): Paeonia lactiflora, Eupolyphaga sinensis and Pyritum promote blood circulation to remove blood stasis, dredge collaterals and relieve pain; Herba Speranskiae tuberculata and Herba Lycopodii dispel wind and dampness. The harmonizing drugs (Paeonia lactiflora, Rehmannia glutinosa, Anemarrhena asphodeloides): Their properties are relatively cool, nourishing yin and clearing heat, balancing the warm and dry properties, and reducing side effects.

[0013] Compatibility effect of monarch drugs

[0014] The monarch drugs mainly play a major therapeutic role in the main disease or main syndrome, and are an indispensable core part of the prescription. In this prescription, Psoralea corylifolia, Epimedium brevicornu, prepared Radix Aconiti Lateralis Preparata and Drynaria fortunei work together to play the role of tonifying the kidney and filling essence, warming yang and dispelling cold, and are the key to treating the pathogenesis of "kidney deficiency and governor vessel cold" in ankylosing spondylitis. Psoralea corylifolia and Epimedium brevicornu: Both have the effects of warming the kidney yang and strengthening the muscles and bones. Psoralea corylifolia focuses on tonifying the kidney and assisting yang, and is the basic medicine for treating the root cause of kidney deficiency; Epimedium brevicornu can not only warm the kidney yang and strengthen the muscles and bones, but also has a positive effect on improving osteoporosis. The combination of the two drugs enhances the power of warming the kidney yang and strengthening the muscles and bones, fundamentally improving the bone problems caused by kidney deficiency in patients and laying a foundation for treating the disease. Prepared Radix Aconiti Lateralis Preparata and other monarch drugs: Prepared Radix Aconiti Lateralis Preparata warms the kidney and dispels cold, and dredges the twelve meridians, and can effectively relieve the typical symptom of "kidney deficiency and governor vessel cold" of spinal cold pain. It synergizes with Psoralea corylifolia and Epimedium brevicornu, while warming the kidney yang, strengthening the power of dispelling cold and dredging collaterals, enabling yang qi to reach all the meridians of the body and improving the cold appearance of the patient's body. Drynaria fortunei tonifies the kidney and strengthens bones, promotes bone repair and inhibits bone destruction. Combined with the other three monarch drugs, it acts comprehensively on the kidney and bones, improving the bone lesions caused by kidney deficiency from multiple angles and jointly targeting the core pathogenesis of ankylosing spondylitis. [[ID=ig]]

[0015] Compatibility effect of ministerial drugs

[0016] Ministerial herbs assist the monarch and ministerial herbs to strengthen the treatment of the main disease or main symptoms, or treat the secondary disease or secondary symptoms. In this prescription, Radix Cyathulae, Radix et Rhizoma Lamiophlomis rotata, Radix et Rhizoma Clematidis, Radix et Rhizoma Smilacis glabrae and Radix et Rhizoma Polygoni multiflori directly relieve symptoms of "wind-dampness blockage" and "stagnant blood obstructing collaterals". Radix Cyathulae and Radix et Rhizoma Lamiophlomis rotata: Radix Cyathulae leads the medicine downward, strengthens the waist and knees, promotes blood circulation and unblocks channels and collaterals, and can guide other medicines to the disease site, enhancing the effect of the medicine on the waist and knees. Radix et Rhizoma Lamiophlomis rotata supplements the liver and kidney and strengthens the tendons and bones, and also expels wind-dampness, which, in combination with Radix Cyathulae, enhances the effects of supplementing the liver and kidney and strengthening the tendons and bones, and expels wind-dampness together, so that the liver and kidney are supplemented, the tendons and bones are strengthened, and wind-dampness is expelled. Radix et Rhizoma Clematidis, Radix et Rhizoma Smilacis glabrae and Radix et Rhizoma Polygoni multiflori: Radix et Rhizoma Clematidis expels wind-dampness and unblocks channels and collaterals, and is good at relieving joint stiffness; Radix et Rhizoma Smilacis glabrae is good at attacking bone joint wind-dampness and softening ligament adhesion; and Radix et Rhizoma Polygoni multiflori focuses on relaxing the tendons and collaterals and improving joint mobility. These three herbs, in combination, treat various symptoms caused by wind-dampness blockage in the joints and channels and collaterals from different aspects, and comprehensively improve joint stiffness, mobility and other conditions, and, in combination with Radix Cyathulae and Radix et Rhizoma Lamiophlomis rotata, assist the monarch and ministerial herbs to strengthen the treatment of secondary symptoms.

[0017] Compatibility of auxiliary herbs

[0018] Auxiliary herbs have three meanings: one is to assist the monarch and ministerial herbs to strengthen the treatment, or directly treat the secondary symptoms; the second is to eliminate or reduce the toxicity or intensity of the monarch and ministerial herbs; and the third is to use herbs with opposite properties to the monarch herb to achieve a complementary effect. In this prescription, there are many auxiliary herbs, each of which plays a different role.

[0019] Auxiliary herbs for promoting blood circulation and removing blood stasis and regulating properties

[0020] Radix Paeoniae Rubra: clears heat and cools blood, removes blood stasis and relieves pain. It can assist the monarch and ministerial herbs to promote blood circulation and unblock channels and collaterals, and prevent the warm yang herbs from generating heat. When combined with Radix Paeoniae Alba, it regulates and harmonizes qi and blood, making the circulation of qi and blood more smooth and peaceful.

[0021] Natural copper (vinegar quenching): removes blood stasis and relieves pain, and promotes fracture healing. It enhances the effect of promoting blood circulation of the prescription, has a certain repairing effect on bone damage caused by the disease, further strengthens the treatment of the pathogenesis of blood stasis and obstruction of collaterals, and assists the monarch and ministerial herbs to achieve better efficacy.

[0022] Geophilus carinatus: breaks blood and removes blood stasis, unblocks channels and collaterals and relieves pain. As an insect herb, it is good at penetrating into channels and collaterals and has a good effect on stubborn pain. In the prescription, it is used to treat stubborn blood stasis and pain, and assists the monarch and ministerial herbs to strengthen the treatment.

[0023] Radix et Rhizoma Aconiti: purges heat and unblocks bowels, promotes blood circulation and removes blood stasis. For patients with constipation, retaining this herb can expel accumulated heat in the body through purgation, and its effect of promoting blood circulation and removing blood stasis also helps to improve the state of blood stasis, assisting other herbs to achieve better therapeutic effect.

[0024] Wind-dispelling and Cold-Dispelling Adjuvant Herbs

[0025] Notopterygium and Angelica Pubescent: Notopterygium is good at dispelling upper body wind-damp, while Angelica Pubescent is good at dispelling lower body wind-damp. The two herbs can be used together to dispel wind-damp throughout the body. Depending on the patient's specific condition, one or both can be used to enhance the dispelling of wind-damp and assist the monarch and ministerial herbs in treating symptoms of wind-damp obstruction in the meridians.

[0026] Szechwan Lovage Root: Wind-dispelling and surface-relieving, dampness-stopping and pain-relieving, it has certain anti-inflammatory effects. In the prescription, it can enhance the overall wind-damp dispelling power of the prescription, and its anti-inflammatory effects can help relieve pain caused by inflammation, assisting the monarch and ministerial herbs in better exerting their effects.

[0027] Ephedra: Sweating and dispelling cold, it promotes the flow of yang qi. When cold symptoms are obvious, this herb can be retained to enhance the dispelling of cold in the prescription, allowing yang qi to flow freely and improving the patient's cold symptoms along with other herbs, assisting the monarch herb in warming and dispelling cold.

[0028] Compatibility of Adjuvant Herbs

[0029] Adjuvant herbs mainly harmonize the other herbs, allowing them to better exert their synergistic effects. White Peony Root, Prepared Rehmannia, and Anemarrhena Cooperate to nourish yin and blood, balancing the warm and dry nature of other herbs such as Cinnamon Twig and Prepared Aconite.

[0030] White Peony Root: It has the effects of nourishing blood and yin, soothing the liver and relieving pain. In the prescription, it can assist Prepared Rehmannia and Anemarrhena in nourishing yin and blood, and can also restrain the warm and dry nature of other herbs such as Cinnamon Twig and Prepared Aconite, making the overall prescription more gentle and avoiding excessive damage to yin by warm and dry herbs.

[0031] Prepared Rehmannia: It nourishes yin and blood, and fills essence and marrow. It can nourish liver and kidney yin and supplement the body's yin fluid, cooperating with White Peony Root and Anemarrhena to enhance yin-nourishing power, while balancing the dryness of warm yang herbs in the prescription, allowing yin and yang to coordinate with each other and achieving better therapeutic effects.

[0032] Anemarrhena: It clears heat and drains fire, and nourishes yin and dryness. It cooperates with White Peony Root and Prepared Rehmannia to clear heat and prevent warm yang herbs from generating heat and damaging yin, and to nourish yin and dryness, further restraining the side effects of warm and dry herbs such as Cinnamon Twig and Prepared Aconite, allowing the prescription to warm yang and dispel cold, dispel wind and damp, and promote blood circulation and remove blood stasis while maintaining yin and yang balance and reducing adverse reactions of drugs.

[0033] Compatibility of Secondary Herbs

[0034] These herbs can be appropriately added or subtracted according to the patient's specific symptoms, and they can play an auxiliary therapeutic role in specific situations.

[0035] Radix Saussureae Volubilis: It promotes qi and relieves pain. When the patient's qi stagnation and pain are obvious, adding this herb can dredge the qi and relieve pain caused by qi stagnation, enhancing the prescription's therapeutic effects on pain symptoms.

[0036] Atractylodes: dry dampness and invigorate the spleen. For patients with spleen deficiency and excessive dampness, retaining atractylodes can enhance the function of spleen and stomach transportation, eliminate internal dampness, improve related symptoms caused by spleen deficiency and excessive dampness, and assist the overall effect of the prescription.

[0037] Dry cassia twig: warm and unblock meridians. When the symptoms of cold and blood stasis are prominent, adding dry cassia twig can enhance the effect of warming and unblocking blood vessels, promote blood circulation, and improve pain and numbness caused by cold and blood stasis. It works synergistically with other drugs to treat diseases.

[0038] Boneset: dispel wind and dampness, and relieve pain. Since its function has been covered by the boneset and the Stretches Grass, it can be used according to the actual symptoms. When the boneset and the Stretches Grass can fully play a role, the boneset can be reduced to simplify the prescription.

[0039] The above types of drugs are compatible with each other and work synergistically to treat the complex pathogenesis and diverse symptoms of ankylosing spondylitis, achieving the best overall therapeutic effect.

[0040] Properties, meridians, effects and medical records of each drug:

[0041] Psoralea: pungent, bitter, warm; kidney and spleen meridians.

[0042] Effect: warm kidney and assist yang, consolidate essence and shrink urine, warm spleen and stop diarrhea, and absorb qi and relieve asthma; for kidney yang deficiency, cold and cough, and cold pain in waist and knees.

[0043] Medical records: "Compendium of Materia Medica" says it "benefits kidney qi and strengthens original yang", and is often used for kidney deficiency and five-day diarrhea.

[0044] Epimedium: pungent, sweet, warm; liver and kidney meridians.

[0045] Effect: tonifying kidney yang, strengthening bones and muscles, and dispelling wind and dampness; for kidney yang deficiency and rheumatic pain.

[0046] Medical records: "Shennong's Herbal Classic" lists it as a middle-grade herb, saying it "mainly treats impotence and pain in the stem".

[0047] Prepared aconite: pungent, sweet, and extremely hot; heart, kidney, and spleen meridians.

[0048] Effect: restore yang and rescue from collapse, supplement fire and assist yang, dispel cold and relieve pain; for yang collapse, cold and dampness, and rheumatic pain.

[0049] Medical records: Aconite is the main drug in the four adverse soup and aconite soup in "Treatise on Febrile Diseases".

[0050] Rubus parvifolius: bitter, warm; liver and kidney meridians.

[0051] Effect: tonifying kidney and strengthening bones, and relieving pain; for kidney deficiency and waist pain, and injury.

[0052] Medical records state: "Yaoxing Lun" records that it "treats poisonous qi in bones and pain caused by wind and blood".

[0053] Achyranthes bidentata: Nature, flavor, and meridian tropism: Bitter, sweet, sour, neutral; attributing to the liver and kidney meridians.

[0054] Functions: Promote blood circulation to remove stasis, tonify the liver and kidneys, strengthen tendons and bones; used for soreness and weakness in the waist and knees, amenorrhea, and mass in the abdomen.

[0055] Medical records state: "Compendium of Materia Medica" states that it "treats chronic malaria with fever and chills, and stranguria with hematuria".

[0056] Dipsacus asperoides: Nature, flavor, and meridian tropism: Bitter, pungent, slightly warm; attributing to the liver and kidney meridians.

[0057] Functions: Tonify the liver and kidneys, strengthen tendons and bones, and continue fractured injuries; used for soreness and weakness in the waist and knees, and falls and injuries.

[0058] Medical records state: "Huayan of Materia Medica" states that "the severed blood vessels cannot be continued without this, and the injured tendons and bones cannot be nourished without this".

[0059] Clematis chinensis: Nature, flavor, and meridian tropism: Pungent, salty, warm; attributing to the bladder meridian.

[0060] Functions: Dispel wind-dampness, dredge meridians, and relieve bone obstruction; mainly treating wind-dampness arthralgia and limb numbness.

[0061] Medical records state: "Kaibao Materia Medica" records that it "treats various winds, promotes the circulation of qi in the five zang-organs, and removes cold stagnation in the abdomen".

[0062] Phryma leptostachya L. var. asiatica Hara: Nature, flavor, and meridian tropism: Pungent, warm; attributing to the liver and kidney meridians.

[0063] Functions: Dispel wind-dampness, relax tendons and activate collaterals, promote blood circulation to relieve pain; used for wind-dampness arthralgia and traumatic swelling and pain.

[0064] Medical records state: Commonly used in external washing prescriptions, such as treating wind-dampness bone pain in "Orthodox Manual of Surgery".

[0065] Lycopodium clavatum L.: Nature, flavor, and meridian tropism: Slightly bitter, pungent, warm; attributing to the liver, spleen, and kidney meridians.

[0066] Functions: Dispel wind-dampness, relax tendons and activate collaterals; mainly treating difficult flexion and extension of joints and muscle spasms.

[0067] Medical records state: "Compendium of Materia Medica": "Lycopodium clavatum L. dispels wind-dampness, relaxes tendons and activates collaterals, and treats wind-dampness arthralgia."

[0068] Paeonia lactiflora Pall.: Nature, flavor, and meridian tropism: Bitter, slightly cold; attributing to the liver meridian.

[0069] Functions: Clear heat and cool blood, disperse stasis and relieve pain; used for epidemic febrile disease with maculae, and hematemesis and epistaxis due to blood heat.

[0070] Medical records state: Listed as a medium-grade herb in "Shennong's Classic of Materia Medica", mainly treating "abdominal pain due to pathogenic factors and removing blood stasis obstruction".

[0071] Natural copper (vinegar quenching): nature and taste meridian: Xing, flat; Liver meridian.

[0072] Effect: dispelling blood stasis and pain, setting broken bones and treating injuries; for contusions and fractures, swelling and pain.

[0073] Medical records: often combined with frankincense, myrrh, see "Medical Classic" setting broken bones purple gold pills.

[0074] Ground beetle (earthworm): nature and taste meridian: salty, cold; Liver meridian.

[0075] Effect: breaking blood and stasis, tendon and bone; for contusions and injuries, tendon and bone fractures.

[0076] Medical records: "Treatise on the Classics" said it "has a miraculous effect on treating contusions and injuries, tendon and bone."

[0077] Fried Chuanjun (Rhubarb): nature and taste meridian: bitter, cold; spleen, stomach, large intestine, liver, pericardium.

[0078] Effect: purgation and accumulation, clearing heat and purging fire, cooling blood and detoxifying; after wine, blood circulation and stasis are enhanced.

[0079] Medical records: "Treatise on Febrile Diseases" uses rhubarb to remove stasis and heat in peach kernel and ginger decoction.

[0080] Notopterygium: nature and taste meridian: Xing, bitter, warm; Bladder, kidney meridian.

[0081] Effect: dispelling and dispelling wind and dampness, relieving pain; for wind, cold and dampness, shoulder and back pain.

[0082] Medical records: "Compendium of Materia Medica" said it was "a drug for treating wind and dampness of the sun channel."

[0083] Angelica: nature and taste meridian: Xing, bitter, slightly warm; kidney, bladder meridian.

[0084] Effect: dispelling wind and dampness, relieving pain; for wind, cold and dampness, waist and knee pain.

[0085] Medical records: "Orthodox Classic of Materia Medica" said it "promotes the flow of blood and regulates the meridians."

[0086] Wind-preventing: nature and taste meridian: Xing, sweet, slightly warm; Bladder, liver, spleen meridian.

[0087] Effect: dispelling wind and relieving pain, dampness; for external symptoms, wind and dampness.

[0088] Medical records: "Shennong's Classic of Materia Medica" is listed as the top product, mainly "headache and dizziness."

[0089] Ephedra: nature and taste meridian: Xing, slightly bitter, warm; lung, bladder meridian.

[0090] Actions: Inducing perspiration, relieving the exterior, relieving the lung and asthma, promoting diuresis and removing edema; for wind-cold exterior without sweating.

[0091] Medical Records: In Treatise on Cold Damage Disorders, Ma Huang Tang is a representative formula for inducing perspiration to release the exterior.

[0092] White Peony Root: Nature, flavor and meridian entry: bitter, sour, and cold; it pertains to the liver and spleen meridians.

[0093] Actions: Nourishing blood and regulating menstruation, astringing yin and stopping sweating, soothing the liver and relieving pain; for blood deficiency and emaciation, spontaneous sweating and night sweating.

[0094] Medical Records: In Compendium of Materia Medica, it is recorded that it “benefits the spleen, purges the liver, and alleviates the middle.”

[0095] Dried Rehmannia Root: Nature, flavor and meridian entry: sweet and warm; it pertains to the liver and kidney meridians.

[0096] Actions: Tonifying blood and yin, and nourishing essence and marrow; for blood deficiency and emaciation, and liver and kidney yin deficiency.

[0097] Medical Records: In Complete Works of Jing Yue, it is recorded that it “greatly tonifies blood deficiency and nourishes kidney water.”

[0098] Anemarrhena Rhizome: Nature, flavor and meridian entry: bitter and sweet, and cold; it pertains to the lung, stomach, and kidney meridians.

[0099] Actions: Clearing heat and purging fire, and nourishing yin and moistening dryness; for heatiness with thirst, lung heat with cough.

[0100] Medical Records: In Shennong Bencao Jing, it is listed as a middle-grade herb, and it is recorded that it “dissipates heat and treats heat in the middle.”

[0101] Costus Root: Nature, flavor and meridian entry: pungent and bitter, and warm; it pertains to the spleen, stomach, large intestine, and Sanjiao meridians.

[0102] Actions: Regulating qi and relieving pain, and invigorating the spleen and promoting digestion; for abdominal distention and pain, and post- diarrhea heaviness.

[0103] Medical Records: In Compendium of Materia Medica, it is recorded that it “is a drug for the qi aspect of Sanjiao, and can ascend and descend various qi.”

[0104] Chinese Atractylodes Rhizome: Nature, flavor and meridian entry: pungent and bitter, and warm; it pertains to the spleen, stomach, and liver meridians.

[0105] Actions: Drying dampness and invigorating the spleen, and dispelling wind and removing cold; for dampness in the middle, and wind-damp bi-syndrome.

[0106] Medical Records: In Compendium of Materia Medica, it is recorded that it “treats dampness, phlegm, and fluid retention, and the spleen dampness flows downward and turbidly.”

[0107] Dried Guizhi: Nature, flavor and meridian entry: pungent and sweet, and warm; it pertains to the heart, lung, and bladder meridians.

[0108] Actions: Inducing perspiration to release the exterior, warming and unblocking meridians, and assisting yang and transforming qi; for wind-cold exterior and blood stasis due to cold.

[0109] Medical Records: In Treatise on Cold Damage Disorders, Guizhi Tang is a representative formula for regulating the Ying and Wei.

[0110] Radix Acanthopanacis Senticosi: Pungent, bitter, and neutral in flavor; meridian-organ relationship of liver channel.

[0111] Function: Expelling wind-dampness, dredging collaterals and relieving pain; for arthralgia due to wind-dampness, numbness of limbs.

[0112] Medical records: “New Record of Decoction Pieces” records that it “dispels wind and dampness, dredges collaterals, and treats arthralgia due to wind-dampness.”

[0113] The monarch drug in the prescription tonifies kidney and strengthens bones, warms yang and dredges the du channel; specifically, Fructus Psoraleae tonifies kidney and strengthens yang, and is used to treat the root of kidney deficiency; Herba Epimedii tonifies kidney yang and strengthens bones and muscles, and is used to treat osteoporosis; Prepared Fuzi (first decoction) warms kidney and dispels cold, dredges twelve meridians, and relieves cold pain of the spine. Radix Drynariae tonifies kidney and strengthens bones, promotes bone repair, and inhibits bone destruction; the four drugs together tonify kidney, fill essence, warm yang, and dispel cold, which is the core of treating ankylosing spondylitis with the pathogenesis of “kidney deficiency and du channel cold”; the ministerial drugs expel wind and dampness, promote blood circulation and dredge collaterals; specifically, Radix Anemarrhenae descends drugs, strengthens waist and knees, and promotes blood circulation and dredges channels; Radix et Rhizoma Notoginseng tonifies liver and kidney, strengthens bones and muscles, and expels wind and dampness; Radix Clematidis expels wind and dampness, dredges channels and collaterals, and relieves joint stiffness; Herba Phrymarithi specifically attacks bone and joint wind-dampness, and softens adhesions of ligaments; Herba Lycopodii relaxes tendons and collaterals, and improves joint mobility; it directly relieves symptoms by targeting the pathogenesis of “wind-dampness blockage” and “stagnant blood obstructing collaterals.” DETAILED DESCRIPTION

[0114] Example 1

[0115] A traditional Chinese medicine composition for treating ankylosing spondylitis is composed of 24 kinds of traditional Chinese medicines, including Fructus Psoraleae 12g, Herba Epimedii 12g, Prepared Fuzi (first decoction) 12g, Radix Drynariae 15g, Radix Anemarrhenae 12g, Radix et Rhizoma Notoginseng 18g, Radix Clematidis 9g, Herba Phrymarithi 20g, Herba Lycopodii 20g, Radix Paeoniae Rubra 12g, Natura Cuprum 9g (vinegar quenching residue removed), Periplaneta 9g, Radix et Rhizoma Bistortae 9g, Rhizoma et Radix Notopterygii 9g, Radix Angelicae Pubescentis 9g, Ephedra 6g, Radix Paeoniae Alba 12g, Radix Rehmanniae Recens 9g, Rhizoma Anemarrhenaeh 9g, Radix Saussureae 9g, Radix et Rhizoma Atractylodis 6g, Radix et Rhizoma Eucommiae 12g, Radix Acanthopanacis Senticosi 15g, etc.

[0116] A preparation method of a traditional Chinese medicine composition for treating ankylosing spondylitis, comprising the following steps:

[0117] Step one: pretreatment. Natura Cuprum is treated by vinegar quenching (after calcining red, immerse in rice vinegar to quench, remove impurities, and grind into powder for use). Radix et Rhizoma Aconiti and Ephedra are treated according to the reduction processing specification in Chinese Pharmacopoeia.

[0118] Step two: mixing and crushing. Dry all raw materials, mix, crush to a particle size of ≤200 μm, pass through a 50 mesh sieve, and obtain uniform fine powder.

[0119] Step three: preparation of the preparation. According to clinical needs, it can be prepared into a decoction or a capsule (note: the decoction does not need to be crushed).

[0120] Decoction preparation: according to the proportion, each medicinal material is weighed and added with 7 times of water for soaking for 30-60 minutes. Each medicinal material is decocted once in the morning and once in the evening (1.5 hours for the first time and 1 hour for the second time). The decoction is concentrated to 1g of crude drug per ml.

[0121] Capsule preparation is to fill the powder into the capsule shell, each containing 0.5g of crude drug, 4 capsules each time, 3 times a day.

[0122] Application example

[0123] Clinical cases

[0124] Statistical data: a total of 220 cases were treated, 174 males and 46 females, 71% of whom were under 40 years old and 29% of whom were over 60 years old. 161 cases were cured, 23 cases were markedly effective, and 21 cases were effective.

[0125] Evaluation criteria:

[0126] Cure: the symptoms of lumbosacral and peripheral joint pain, stiffness, etc. disappeared completely, the range of motion of the spine returned to normal, Schober test, "4" test, and pelvic compression test were negative. ESR, CRP returned to normal, sacroiliac joint CT showed joint surface bone repair and joint space improvement.

[0127] Marked effect: the symptoms of lumbosacral and peripheral joint pain, stiffness, etc. were significantly reduced, the range of motion of the spine was significantly improved, Schober test, "4" test, and pelvic compression test were significantly improved compared with before treatment. ESR, CRP decreased significantly, sacroiliac joint CT showed that the progression of joint surface bone destruction was controlled.

[0128] Effective: the symptoms of lumbosacral and peripheral joint pain, stiffness, etc. were relieved, the range of motion of the spine was improved, Schober test, "4" test, and pelvic compression test were improved. ESR, CRP decreased, sacroiliac joint CT showed that the joint surface bone destruction had no obvious progression.

[0129] Ineffective: those who do not meet the above criteria.

[0130] After 3 courses of treatment, among the 220 patients, 161 cases were cured (73.18%), 23 cases were markedly effective (10.45%), 21 cases were effective (9.55%), 15 cases were ineffective (6.82%), and the total effective rate was 93.18%. In terms of age distribution, the effective rate of patients under 40 years old was 97.44% (152 / 156), and the effective rate of patients over 60 years old was 82.81% (53 / 64). The effective rate of patients under 40 years old was significantly higher than that of patients over 60 years old (P<0.05). In terms of gender, the effective rate of male patients was 94.25% (164 / 174), and the effective rate of female patients was 89.13% (41 / 46). The effective rate of male patients was slightly higher than that of female patients, but the difference was not statistically significant (P>0.05).

[0131] Specific cases

[0132] Case 1: Ankylosing spondylitis of liver and kidney deficiency combined with cold dampness block

[0133] Patient information: Lin, male, 30 years old, programmer. Permanent address: Shangqiu City, Henan Province, unmarried.

[0134] Initial diagnosis date: March 5, 2023

[0135] Initial symptoms: The patient has been feeling pain in the lumbosacral region for nearly 8 months, which worsens in the morning and after rest, and slightly alleviates after activity. He also experiences soreness in the waist and knees, fatigue, and pain exacerbation in cold and rainy weather. He also has numbness in both lower extremities and poor sleep quality at night. His tongue is pale and swollen with teeth marks, and his pulse is weak and slow.

[0136] Physical examination: The physiological curvature of the spine is straightened, and the range of motion is limited. The distance from the fingertips to the ground is 20 cm (normal is less than 10 cm) when bending forward, the angle of extension is 10° (normal is greater than 30°), the left bending angle is 15° (normal is greater than 20°), and the right bending angle is 15° (normal is greater than 20°). Schober test is positive (<4 cm), "4" test is positive, and pelvic compression test is positive. During the bilateral "4" test, the right hip and groin are significantly painful, and the left side is slightly less painful. During the pelvic compression test, the patient's lumbosacral pain worsens. Auxiliary examination: ESR (erythrocyte sedimentation rate) is 50 mm / h (normal male 0-15 mm / h), CRP (C-reactive protein) is 30 mg / L (normal <8 mg / L). Sacroiliac joint MRI shows bilateral sacroiliac joint surface roughness, long T2 signal shadow in the joint space, suggesting arthritis; small cystic long T1 and long T2 signal lesions are visible in the subarticular bone, suggesting bone erosion. Lumbar spine X-ray shows that the lumbar vertebral body edge is blurred, and part of the intervertebral joint space is narrowed.

[0137] Diagnosis: TCM diagnosis: Bi syndrome (liver and kidney deficiency combined with cold dampness and blockage); Western medicine diagnosis: ankylosing spondylitis.

[0138] Initial diagnosis and medication: Gubujiaqiangji Decoction.

[0139] Prescription: Fructus Psoraleae 12g, Herba Epimedii 12g, Prepared Fuzi 12g (first decoction), Radix Paeoniae Rubra 12g, Radix Paeoniae Alba 12g, Radix Saussureae Volubilis 9g, Radix Atractylodis 6g, Radix Nelumbinis 12g, Natrium 9g (vinaigrette residue), Radix Rehmanniae Preparata 9g, Radix Sophorae Tonkinensis 9g, Radix Psuedobuxuriae 15g, Rhizoma Corydalis 20g, Radix Ampelopsis 18g, Radix Saposhnikoviae 9g, Ramulus Lonicerae 12g, Radix Notopterygii 9g, Radix Angelicae Pubescentis 9g, Herba Ephedrae 6g, Herba Sedi 20g, Radix Ilicis Rotundae 15g. 7 doses, 1 dose per day, decocted in water and taken twice a day.

[0140] Efficacy and follow-up: First follow-up (March 13, 2023): The patient complained of slight relief of lumbosacral pain, but still felt weak, soreness in the waist and knees. Remove the prepared Radix Sophorae Tonkinensis from the original prescription and add 15g of Ramulus Loranthus to enhance the liver and kidney tonifying and bone strengthening effect. Continue taking 14 doses. Second follow-up (March 28, 2023): The patient's lumbosacral pain was significantly relieved, the numbness in the lower extremities was reduced, and the sleep quality was improved, but the symptoms were still aggravated when exposed to cold. Add 3g of Herba Asari to the original prescription to enhance the effect of dispelling cold and relieving pain. Continue taking 14 doses. Third follow-up (April 15, 2023): The patient's symptoms improved significantly, only slightly uncomfortable after exertion. Take 14 doses of the original prescription to consolidate the effect. After the condition stabilizes, take the capsule regularly, 4 capsules each time, 3 times a day, with warm water. Efficacy evaluation: After treatment, the patient's symptoms were significantly reduced and the quality of life was significantly improved. Follow-up for 3 months, the condition is stable and there is no obvious recurrence.

[0141] Case 2: Ankylosing spondylitis with kidney yang deficiency and blood stasis

[0142] Patient information: Ms. Gu, 38 years old, accountant. Permanent address: Shangqiu City, Henan Province, married.

[0143] Initial diagnosis date: May 10, 2023

[0144] Initial symptoms: The patient has had lumbosacral pain for more than half a year, the pain is stabbing, fixed and immovable, the waist movement is limited, accompanied by cold limbs and frequent night urination. Tongue is dark with ecchymosis, thin white fur, pulse is sunken and sticky.

[0145] Physical examination: Spinal mobility was significantly limited, the distance between the chest and the thigh was 15 cm during lumbar flexion (normal should be close), pain was aggravated and the angle was only 5° (normal was more than 30°) during extension, and both sides were less than 10° (normal was more than 20°) during lateral flexion. Schober test was positive (<4 cm), "4" test was positive, and pelvic compression test was positive. During the "4" test, the patient's bilateral hip joints were severely painful and could not complete the standard action. During the pelvic compression test, the patient's expression was painful and the lumbosacral pain was unbearable. Auxiliary examination: erythrocyte sedimentation rate (ESR) was 48 mm / h, and C-reactive protein (CRP) was 25 mg / L. CT scan of the sacroiliac joint showed that the bilateral sacroiliac joint surface was not smooth, the joint space was uneven, and bone hyperplasia and worm-eaten bone destruction were seen in some areas. Pelvic X-ray showed increased bone density on both sides of the sacroiliac joint, and the joint space was blurred.

[0146] Diagnosis: TCM diagnosis: Bi syndrome (deficiency of kidney yang combined with blood stasis blocking collaterals); Western medicine diagnosis: ankylosing spondylitis.

[0147] Initial diagnosis and medication: Buguqiangji Decoction.

[0148] Prescription: Buguzhi 12g, Yinyanghuo 12g, Zhifu Pian (first decoction) 12g, Chishao 12g, Baishao 12g, Guangmuxiang 9g, Cangshu 6g, Niuxi 12g, Zhenzhugui 9g, Zhikuan 9g, Gushubu 15g, Zhimu 9g, Dibiechong 9g, Weilingxian 9g, Tougucao 20g, Chuanjuan 18g, Fangfeng 9g, Ganguqian 12g, Qianghuo 9g, Duhuo 9g, Mahuang 6g, Shenzhicao 20g, Xungufeng 15g. 14 doses, 1 dose per day, decocted with water and taken twice a day.

[0149] Efficacy and follow-up: First follow-up (May 26, 2023): The patient's lumbosacral pain was relieved, but still had a tingling sensation, and the frequency of nocturia was reduced. Remove Cangshu from the original prescription and add Taoeren 9g to enhance the effect of promoting blood circulation and removing blood stasis. Continue taking 14 doses. Second follow-up (June 19, 2023): The patient's pain was further relieved, the range of motion of the waist increased, and the symptoms of cold intolerance decreased. Remove Mahuang from the original prescription and add Bajitian 12g to enhance the effect of tonifying kidney yang. Continue taking 28 doses. Third follow-up (July 28, 2023): The patient's symptoms improved significantly, and only had slight discomfort after prolonged sitting. Take the original prescription and make it into a capsule, 4 capsules each time, 3 times a day, and take it with warm water.

[0150] Efficacy evaluation: After treatment, the patient's symptoms were effectively controlled and the activity was restored. Follow-up for 3 months, the disease is stable.

[0151] Case three: Ankylosing spondylitis of deficiency of both qi and blood combined with wind-dampness blockage

[0152] Patient information: Xu, male, 35 years old, express delivery man. Permanent address: Shangqiu City, Henan Province, married.

[0153] Initial diagnosis date: July 15, 2023

[0154] Initial symptoms: The patient has had pain in the lumbosacral region and bilateral hip joints for 1 year. The pain is migratory, accompanied by limb numbness, weakness, pale complexion, shortness of breath, and reluctance to speak. The tongue is pale, the fur is thin and white, and the pulse is weak.

[0155] Physical examination: The spinal mobility is poor, and the patient needs external force when bending forward, with fingertips 30 cm from the ground. The extension is almost impossible, and the left and right lateral flexion angles are less than 5°. Schober test is positive (<4 cm), "4" test is positive, and pelvic compression test is positive. During the "4" test, bilateral hip joints alternately appear pain, with the right side being more severe. During the pelvic compression test, the patient feels pain in the lumbosacral region and bilateral hip joints. Auxiliary examination: ESR 42 mm / h, CRP 22 mg / L. Sacroiliac joint angiography shows irregular stenosis of bilateral sacroiliac joint space, rough and uneven joint surface, and uneven distribution of contrast agent. Blood routine examination shows hemoglobin 100 g / L (normal male 120-160 g / L), suggesting anemia.

[0156] Diagnosis: TCM diagnosis: Bi syndrome (qi and blood deficiency combined with wind-dampness blockage); Western medicine diagnosis: ankylosing spondylitis.

[0157] Initial diagnosis: Buguqiangji Decoction.

[0158] Prescription: Buguzhi 12g, Yinyanghuo 12g, Zhifu Pian (first decoction) 12g, Chishao 12g, Baishao 12g, Guangmuxiang 9g, Cangshu 6g, Niuxi 12g, Zhenzhugong 9g, Shudiuhuang 9g, Zhichuanjun 9g, Gushubu 15g, Zhimu 9g, Dibiechong 9g, Weilingxian 9g, Tougucao 20g, Chuanjuan 18g, Fangfeng 9g, Ganguqizi 12g, Qianghuo 9g, Duhuo 9g, Mahuang 6g, Shentengcao 20g, Xungufeng 15g, Huangqi 30g, Danggui 12g. 7 doses, 1 dose per day, decocted with water and taken twice a day.

[0159] Efficacy and re-examination: First re-examination (July 23, 2023): The patient's pain is reduced, but still feels weak. Remove Zhichuanjun from the original prescription, add Taizishen 15g to strengthen the qi. Continue taking 14 doses. Second re-examination (August 9, 2023): The patient's limb numbness is reduced, and the complexion is gradually red, but still has mild joint pain. Remove Mahuang and Cangshu from the original prescription, add Qinjia 9g to enhance the wind-dampness eliminating ability. Continue taking 14 doses. Third re-examination (August 26, 2023): The patient's symptoms have improved significantly, and the physical strength has recovered. Continue taking the original prescription for 1 month to consolidate the efficacy, and then change to capsule for long-term use, 4 capsules each time, 3 times a day, taken with warm water.

[0160] Efficacy evaluation: After treatment, the patient's symptoms were relieved, and the patient's life and work were basically not affected. Follow-up for 6 months, the disease is stable.

[0161] Case four: ankylosing spondylitis of cold-damp stagnation and liver and kidney deficiency

[0162] Patient information: Deng, female, 26 years old, kindergarten teacher. Permanent address: Shangqiu City, Henan Province, unmarried.

[0163] Initial diagnosis date: September 20, 2023

[0164] Initial symptoms: The patient has had lumbar and sacral pain and stiffness for 3 months, and the stiffness is particularly pronounced in the morning. It takes more than half an hour to relieve the pain, and the pain worsens with cold and improves with warmth. It is accompanied by dizziness, tinnitus, and soreness of the waist and knees. The tongue is pale, the fur is white, and the pulse is slow.

[0165] Physical examination: Spinal stiffness, severe limitation of activity, body and thigh angle is 45° (normal close to 0°) when bending forward, the angle is about 8° (normal is greater than 30°) when stretching back, and the left and right activity ranges are less than 12° (normal is greater than 20°) when bending sideways. Schober test is positive (<4cm), "4" test is positive, and pelvic compression test is positive. During the "4" test, the patient's right hip and inner thigh were in severe pain. During the pelvic compression test, the patient's lumbar and sacral pain worsened, and the expression was painful. Auxiliary examination: erythrocyte sedimentation rate (ESR) 55mm / h, C-reactive protein (CRP) 32mg / L. Sacroiliac joint ultrasound showed bilateral sacroiliac joint synovial thickening, joint cavity fluid, uneven joint surface echo, and partial area echo enhancement or weakening. Dual-energy X-ray bone density detection suggests that the lumbar spine and pelvis have reduced bone mass.

[0166] Diagnosis: TCM diagnosis: Bi syndrome (cold-damp stagnation and liver and kidney deficiency type); Western medicine diagnosis: ankylosing spondylitis.

[0167] Initial medication: Buguqiangji Decoction.

[0168] Prescription: Buguizi 12g, Yinyanghuo 12g, Zhi Fupian (first decoction) 12g, Chishao 12g, Baishao 12g, Guangmuxiang 9g, Cangshu 6g, Niuxi 12g, Zhenzhugong 9g, Zhuyangrong 9g, Zhuyanggun 9g, Gushudu 15g, Zhimutou 9g, Weilingxian 9g, Tougucao 20g, Chuanjuan 18g, Fangfeng 9g, Ganguqian 12g, Qianghuo 9g, Duhuo 9g, Mahuang 6g, Shenzhengcao 20g, Xungufeng 15g. 14 doses, 1 dose per day, decocted with water and taken twice a day.

[0169] Efficacy and follow-up: First follow-up (October 4, 2023): The patient's lumbosacral pain has decreased, but the stiffness has not improved significantly. The original recipe is removed from the Chuanjun and added with Wusong Tongluo 9g to improve the stiffness symptoms. Continue taking 21 doses.

[0170] Second follow-up (October 28, 2023): The patient's stiffness has decreased, and the dizziness and tinnitus symptoms have slightly improved, but still feels soreness in the waist and knees. Add Du Zhong 15g to the original recipe to enhance the effects of tonifying liver and kidney and strengthening the waist and knees. Continue taking 28 doses. Third follow-up (December 2, 2023): The patient's symptoms have significantly improved, and he can move freely. Take 28 doses of the original recipe to consolidate the efficacy. After the condition stabilizes, replace it with capsule, 4 capsules each time, 3 times a day, and take it with warm water.

[0171] Efficacy evaluation: After treatment, the patient's symptoms have significantly improved, and daily activities are not limited. Follow-up for 6 months, the condition is stable.

[0172] Case Five: Ankylosing Spondylitis with Phlegm and Blood Stasis Obstruction and Kidney Yang Deficiency

[0173] Patient Information: Huang, male, 52 years old, driver. Permanent address: Shangqiu City, Henan Province, married.

[0174] Initial diagnosis date: November 10, 2023

[0175] Initial symptoms: The patient has had lumbosacral pain with limited mobility for 2 years, the pain is like a needle, the pain does not move, the joints are swollen and deformed, the skin is distorted, accompanied by cold limbs, fatigue and weakness. Tongue is purple and dark with ecchymosis, white and greasy fur, and wiry and astringent pulse.

[0176] Physical examination: The spine is slightly kyphotic, with severe mobility limitation, the distance between the chest and the thigh is 25cm when bending forward, and the posterior extension and lateral flexion cannot be completed. Schober test is positive (<4cm), "4" test is positive, and pelvic compression test is positive. During the "4" test, both hip joints are severely painful and joint mobility is significantly limited. During the pelvic compression test, the patient's lumbosacral region is severely painful and difficult to tolerate. Auxiliary examination: ESR (erythrocyte sedimentation rate) 58mm / h, CRP (C-reactive protein) 35mg / L. Sacroiliac joint MRI enhanced scan shows severe destruction of bilateral sacroiliac joint surface, obvious joint space narrowing, thickening of soft tissue around the joint, and obvious enhancement, indicating active inflammation. Serum immunoglobulin examination shows mild elevation of IgA and IgG.

[0177] Diagnosis: TCM diagnosis: Bi syndrome (phlegm and blood stasis obstruction with kidney yang deficiency type); Western medicine diagnosis: Ankylosing spondylitis.

[0178] Initial diagnosis: Bugu Qiangji Decoction.

[0179] Prescription: Psoralea corylifolia 12g, Epimedium brevicornu 12g, Prepared Aconitum carmichaelii (decocted first) 12g, Paeonia lactiflora 12g, Paeonia veitchii 12g, Aucklandia lappa 9g, Atractylodes lancea 6g, Achyranthes bidentata 12g, Natural copper (quenched in vinegar to remove residue) 9g, Rehmannia glutinosa 9g, Prepared rhubarb 9g, Drynaria fortunei 15g, Anemarrhena asphodeloides 9g, Eupolyphaga sinensis 9g, Clematis chinensis 9g, Clematis armandii 20g, Dipsacus asper 18g, Saposhnikovia divaricata 9g, Cinnamomum cassia 12g, Notopterygium incisum 9g, Angelica pubescens 9g, Ephedra sinica 6g, Lycopodium clavatum 20g, Clematis armandii 15g. 28 doses, one dose daily, decocted in water and taken warm in two divided doses.

[0180] Treatment efficacy and follow-up visits: First follow-up visit (December 8, 2023): The patient's pain was slightly relieved, but the joint swelling was still significant. The original prescription was modified by removing Atractylodes lancea and adding 6g of pangolin scales (a substitute) to enhance the effects of resolving phlegm, removing blood stasis, and clearing the meridians. 28 doses were continued. Second follow-up visit (January 10, 2024): The patient's joint pain lessened, the swelling was somewhat relieved, and the symptoms of aversion to cold lessened. The original prescription was modified by removing Ephedra and adding 15g of Cuscuta chinensis to enhance the kidney-yang tonifying effect. 28 doses were continued. Third follow-up visit (February 18, 2024): The patient's symptoms improved significantly, and the range of motion of the joints increased. The same prescription was continued for another 14 doses to consolidate the therapeutic effect, after which capsules were taken regularly, 4 capsules each time, 3 times a day, with warm water.

[0181] Treatment efficacy assessment: After systematic treatment, the patient's symptoms improved and joint function gradually recovered. During a 6-month follow-up, the condition remained stable.

Claims

1. A traditional Chinese medicine composition for treating ankylosing spondylitis, characterized in that: Is made of the following raw materials: Fructus Psoraleae 12g, Herba Epimedii 12g, prepared Aconiti Lateralis Radix 12g, Radix Paeoniae Rubra 12g, Radix Paeoniae Alba 12g, Radenophora Glucyphylla 9g, Radix Atractylodis 6g, Radix Hedysari 12g, Radix Rehmanniae Preparata 9g, Radix et Rhizoma Bistortae 9g, Radix et Rhizoma Anemarrhenae 9g, Scolopendra Subsp 9g, Radix et Rhizoma Clematidis 9g, Radix et Rhizoma Asarum 20g, Radix et Rhizoma Corydalis 18g, Radix Saposhnikoviae 9g, Radix et Rhizoma Baphlami 12g, Radix Angelicae Pubescentis 9g, Radix Angelicae Pubescentis 9g, Herba Ephedrae 6g, Radix et Rhizoma Smilacis Glabrae 20g, Radix et Rhizoma Asarum 15g. ​ 2. The traditional Chinese medicine composition for treating ankylosing spondylitis according to claim 1, characterized in that: The prepared Aconiti Lateralis Radix and Herba Ephedrae need to be attenuated before use; the Radenophora Glucyphylla is used after being treated by vinegar quenching and removing residues.

3. The method of claim 2, wherein the Chinese medicine composition for treating ankylosing spondylitis is prepared by mixing the following ingredients: It comprises the following steps: ​ S1. Calcine the Radenophora Glucyphylla to red, then immerse it in rice vinegar to quench, remove impurities, and grind to powder for use; the prepared Aconiti Lateralis Radix and Herba Ephedrae are attenuated according to the processing specification of Chinese Pharmacopoeia for use; S2. Mix all the raw materials, decoct them with water to make a decoction, or dry and mix all the raw materials, grind them to a particle size of ≤200 μm, fill them into capsules after passing through a 50 mesh sieve.