BODIPY compounds, preparation methods and uses thereof as photosensitizers

By introducing a specific structure into the BODIPY molecule and designing a near-infrared pure type I photosensitizer with high reactive oxygen production, the problem of insufficient reactive oxygen production in existing BODIPY dimer photosensitizers was solved, achieving a more efficient photodynamic therapy effect.

CN120209006BActive Publication Date: 2025-09-16ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
2 Cites 0 Cited by

Patent Information

Application Number
CN202510316997.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-03-18
Publication Date
2025-09-16
Estimated Expiration
2045-03-18

AI Technical Summary

Technical Problem

The existing BODIPY dimer photosensitizer molecules have insufficient ability to generate reactive oxygen species and are unable to meet the needs of efficient photodynamic therapy.

Method used

By introducing heavy atoms and 2,4,6-trimethylphenyl groups at specific positions in the BODIPY molecular structure, a near-infrared pure type-I photosensitizer with high reactive oxygen production rate was designed and constructed, and the excited state energy level was regulated to increase the ISC rate and triplet lifetime of the photosensitizer.

Benefits of technology

The active oxygen production rate is significantly improved, which is 50 times that of the common photosensitizer indocyanine green. It has higher photothermal stability and photodynamic therapy effect, and the preparation method is simple and efficient.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The present invention belongs to the field of photodynamic therapy technology, and more particularly to a BODIPY compound, a preparation method and its use as a photosensitizer. The present invention provides a series of novel small molecule compound photosensitizers with BODIPY dimer as basic skeleton and pure type I photodynamic. By the combined action of heavy atoms, 2,4,6-trimethylphenyl groups and limited structure R groups introduced at specific positions, the reactive oxygen species yield is increased, and the regulation of pure type I photosensitizer is carried out by regulating energy levels. Compared with common photosensitizer molecule indocyanine green (ICG), the reactive oxygen species yield is about 50 times that of ICG, has higher photothermal stability, can significantly increase the applicability of photodynamic agents, and the preparation method is simple, the reaction efficiency is high, the yield is high, and there is good industrial application prospect.
Need to check novelty before this filing date? Find Prior Art