Blood glucose real-time detection and early warning device in hemodialysis

Abstract

This invention discloses a real-time blood glucose monitoring and early warning device for hemodialysis, comprising a connector, a housing base, and a dynamic blood glucose meter. One end of the connector is fixedly connected to the dialysis artery tube. The open end of the housing base is inserted into the connector. A flow guide plate is laterally arranged inside the housing base near the open end. A dynamic blood glucose meter mounting cavity is provided on the side of the housing base away from the open end, and the dynamic blood glucose meter is installed in the mounting cavity. This real-time blood glucose monitoring and early warning device for hemodialysis, through the cooperation of the connector and the housing base, allows the dynamic blood glucose meter to be installed on the housing base, enabling real-time monitoring of blood glucose in the blood flowing through the dialysis artery tube. The monitored data can be connected to the controller and display of the dialysis machine to display blood glucose data in real time, and an early warning can be issued through the dialysis machine's alarm.

Description

Technical Field

[0001] This invention relates to a device for detecting blood glucose during hemodialysis, specifically a real-time blood glucose detection and early warning device for hemodialysis. Background Technology

[0002] With societal development, the number of patients with chronic kidney disease requiring hemodialysis to sustain life is increasing. Currently, most dialysis centers in China use glucose-free dialysate. Symptomatic or asymptomatic hypoglycemia during dialysis is a common acute complication, which can lead to death and other related complications in severe cases. Therefore, medical staff must closely monitor patients' blood glucose levels during dialysis.

[0003] Currently, two common blood collection methods are used to detect patients' blood glucose levels during dialysis:

[0004] The first method is an invasive procedure: fingertip blood sampling. The blood collection site on the patient's ring finger is disinfected with alcohol and allowed to dry. A lancet is used to puncture the finger, the first drop of blood is discarded, and the second drop is placed on a test strip. The data is read and recorded, and a cotton swab is used to press the blood collection site. This invasive method requires puncturing the tip of the patient's ring finger, which increases patient discomfort and psychological stress.

[0005] The second method is non-invasive. After hemodialysis begins, a nurse tests the patient's blood glucose using an online blood sampling method at the arterial end of the extracorporeal circulation tubing: first, ultrafiltration is stopped, then the blood flow rate is slowed to 100 mL / min. After 15–30 seconds, the blood sampling point at the arterial end of the extracorporeal circulation tubing is disinfected with alcohol and allowed to dry. 0.1 mL of blood is drawn using a 1 mL syringe and dropped onto the test strip. The data is then read and recorded. This second non-invasive method is convenient, non-invasive, does not increase patient pain, and reduces the risks of infection and bleeding associated with routine finger-prick blood sampling. Therefore, most patients choose this second non-invasive method.

[0006] The above detection method has the following shortcomings:

[0007] 1. Both of the above detection methods involve collecting blood glucose data at regular intervals. If it is necessary to continuously obtain changes in the patient's blood glucose during dialysis, it is necessary to repeatedly puncture the tip of the patient's ring finger or repeatedly puncture the arterial end of the circulating blood vessels to collect blood online. Repeated punctures of the tip of the patient's ring finger will increase the patient's pain. Repeated punctures of the arterial end of the circulating blood vessels will also generate debris. Once the debris enters the human body, it can cause vascular thrombosis.

[0008] 2. The above two testing methods rely entirely on medical personnel, which is time-consuming and cannot achieve continuous real-time data collection, nor can they monitor blood glucose fluctuations in real time.

[0009] 3. The blood collection needles, syringes, and test strips used in the above process are all disposable. The more times the samples are collected, the more consumables are needed, and the higher the cost will be. Summary of the Invention

[0010] To address the shortcomings of the existing technology, the present invention provides a real-time blood glucose monitoring and early warning device for hemodialysis.

[0011] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0012] A real-time blood glucose monitoring and early warning device for hemodialysis includes a connector mounted on a dialysis artery tube, a housing base connected to the connector, and a dynamic blood glucose meter mounted on the housing base for detecting blood glucose in the dialysis artery tube. One end of the connector is fixedly connected to the dialysis artery tube, and one end of the housing base is open. The open end of the housing base is inserted into the connector from the other end of the connector and is sealed to the inner wall of the connector. A guide plate is laterally arranged in the housing base near the open end. The guide plate is perpendicular to the axis of the dialysis artery tube and gradually thickens from the inner side near the housing base to the outer side of the open end. A dynamic blood glucose meter mounting cavity is provided on the housing base on the side away from the open end. The dynamic blood glucose meter is installed in the dynamic blood glucose meter mounting cavity. The sensor of the dynamic blood glucose meter is located at the bottom of the dynamic blood glucose meter mounting cavity. The soft needle electrode of the dynamic blood glucose meter passes through the housing base at the bottom of the dynamic blood glucose meter mounting cavity and extends into the inner cavity of the housing base. The signal transmitter of the dynamic blood glucose meter is located near the outer side of the dynamic blood glucose meter mounting cavity.

[0013] In a preferred embodiment of the present invention, the dynamic blood glucose meter is fixedly installed in a box with one open end. The box is inserted into the dynamic blood glucose meter mounting cavity, and the open end of the box is located outside the dynamic blood glucose meter mounting cavity. Both the bottom of the box and the housing base at the bottom of the dynamic blood glucose meter mounting cavity are provided with through holes I, through which the soft needle electrode of the dynamic blood glucose meter passes.

[0014] As a preferred embodiment of the present invention, a puncture hole is provided on the side of the housing base away from the open end, and a sealing plug is provided in the puncture hole.

[0015] As a preferred embodiment of the present invention, the guide plate divides the open end of the housing base into an inlet and an outlet, and a filter membrane is provided between the inner wall of the housing base and the guide plate and near the outlet.

[0016] In a preferred embodiment of the present invention, the puncture hole is located on the left side of the continuous glucose meter mounting cavity. After the box is inserted into the continuous glucose meter mounting cavity, the box is fixed in the continuous glucose meter mounting cavity by a snap-fit ​​mechanism, and the bottom of the box is sealed to the bottom of the continuous glucose meter mounting cavity.

[0017] In a preferred embodiment of the present invention, the latching mechanism includes a spring I, a locking tongue, a positioning sleeve I, a push rod, a spring II, and a positioning sleeve II; guide holes I are provided on both the front and rear walls of the housing, and through guide holes II are provided on the housing base at the front and rear positions of the dynamic blood glucose meter mounting cavity; the two guide holes I of the housing and the two guide holes II on the housing base correspond one-to-one in the front-rear direction; each guide hole I is provided with a spring I, a locking tongue, and a positioning sleeve I, the positioning sleeve I is fixedly installed in the guide hole I and close to the opening, the locking tongue passes through the positioning sleeve I and slides with the inner wall of the positioning sleeve I, one end of the locking tongue is located inside the positioning sleeve I, and the other end of the locking tongue is inserted into the corresponding guide hole II, one end of the spring I presses against the inner wall of the guide hole I, and the other end of the spring I presses against the locking tongue; each guide hole II is provided with a push rod, a spring II, and a positioning sleeve II, and the guide hole II is composed of guide hole segment I, guide hole segment II, and guide hole segment III in sequence. Section I is close to the mounting cavity of the continuous glucose meter. Section III is close to the outer wall of the housing base. The inner diameter of section III is larger than that of section II, and the inner diameter of section II is larger than that of section I. The push rod is inserted into the guide hole II. One end of the push rod is located inside the guide hole I, and the other end is located outside the housing base. Guide protrusion I and guide protrusion II are provided on the outer wall of the push rod. Guide protrusion I is located inside the guide hole II and slides in cooperation with the inner wall of the guide hole II. Positioning sleeve II is fixedly set inside the guide hole III and close to the orifice. The push rod passes through the positioning sleeve II and slides in cooperation with the inner wall of the positioning sleeve II. Guide protrusion II is located inside the guide hole III and slides in cooperation with the inner wall of the guide hole III. The guide protrusion II is located inside the positioning sleeve II. Spring II is sleeved on the push rod. One end of spring II presses on the annular protrusion formed between guide hole I and guide hole II, and the other end of spring II presses on guide protrusion II.

[0018] As a preferred embodiment of the present invention, the real-time blood glucose monitoring and early warning device in hemodialysis further includes a clamping sleeve. The puncture hole is composed of puncture hole segment I, puncture hole segment II and puncture hole segment III from bottom to top. The inner diameter of the puncture hole segment III is larger than the inner diameter of the puncture hole segment II, and the inner diameter of the puncture hole segment II is larger than the inner diameter of the puncture hole segment I. The sealing plug is installed in the puncture hole segment II. The clamping sleeve is inserted into the puncture hole segment III and presses on the top of the sealing plug. The bottom of the sealing plug is pressed against the circular protrusion formed between the puncture hole segment I and the puncture hole segment II near the outer circle.

[0019] As a preferred embodiment of the present invention, the inner wall of the puncture hole section III is provided with an L-shaped guide groove consisting of an axial guide groove arranged along its axial direction and a radial guide groove arranged along its radial direction. A first guide block is provided on the outer wall of the clamping sleeve near the bottom. The first guide block on the clamping sleeve is inserted into the L-shaped guide groove and rotated into the radial guide groove.

[0020] In a preferred embodiment of the present invention, the inner wall of the connector is provided with an L-shaped guide groove consisting of an axial groove arranged along its axial direction and a radial groove arranged along its radial direction. A second guide block is provided on the outer wall of the housing base near the open end. The second guide block on the housing base is inserted into the L-shaped guide groove and rotated into the radial groove. A sealing groove is provided on the inner wall of the connector along the circumferential direction at the bottom of the radial groove. A sealing ring is provided in the sealing groove. The housing base is sealed to the connector through the sealing ring.

[0021] As a preferred embodiment of the present invention, the real-time blood glucose monitoring and early warning device in hemodialysis further includes an operating pad disposed on the dialysis artery tube, wherein the operating pad and the connector are located on the same cross section of the dialysis artery tube and on opposite sides of the dialysis artery tube along its axial direction.

[0022] Compared with the prior art, the beneficial effects of the present invention are:

[0023] 1. This real-time blood glucose monitoring and early warning device for hemodialysis uses a connector and a housing base to mount a dynamic blood glucose meter on the housing base, enabling real-time monitoring of blood glucose in the blood flowing through the dialysis artery tube. The monitoring is more accurate, and the data can be connected to the controller and display of the dialysis machine to display blood glucose data in real time, monitor blood glucose fluctuations in real time, and issue early warnings through the dialysis machine's alarm.

[0024] 2. This real-time blood glucose monitoring and early warning device during hemodialysis can detect changes in blood glucose during hemodialysis in real time. Compared with existing blood sampling tests, it avoids the infection risk associated with existing puncture blood sampling tests, reduces manual operation by medical staff, and reduces measurement data deviation.

[0025] 3. This real-time blood glucose monitoring and early warning device for hemodialysis is not only equipped with a continuous glucose meter, but also has a puncture hole on the housing base. The puncture hole is fitted with a sealing rubber stopper. If blood is needed for testing or medication, the syringe needle only needs to puncture the sealing rubber stopper to draw blood or administer medication. To prevent debris from entering the patient's body when the puncture needle punctures the sealing rubber stopper, a filter membrane is installed between the inner wall of the housing base and the guide plate, near the outlet.

[0026] 4. This real-time blood glucose monitoring and early warning device during hemodialysis can closely monitor the patient's blood glucose level during dialysis, detect hypoglycemia early and provide timely intervention measures to prevent other complications caused by severe hypoglycemia, thereby ensuring the patient's dialysis safety. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the structure of a real-time blood glucose monitoring and early warning device in hemodialysis;

[0028] Figure 2 This is a three-dimensional structural diagram of the connector;

[0029] Figure 3 This is a schematic diagram of the connector cut along its guide groove;

[0030] Figure 4 This is a schematic diagram of the structure in which the sealing ring is installed in the sealing groove on the joint;

[0031] Figure 5 This is a three-dimensional structural diagram of the shell base;

[0032] Figure 6 This is a schematic diagram of the cross-sectional structure of the shell base;

[0033] Figure 7 This is a schematic diagram of the three-dimensional structure of the box;

[0034] Figure 8 A schematic diagram of the structure in which the box body and sealing plug are installed in the housing base;

[0035] Figure 9 This is a schematic diagram of the continuous glucose monitoring device and the sealing plug installed in the housing base;

[0036] Figure 10 yes Figure 8 Schematic diagram of the cross-sectional structure along the AA direction;

[0037] Figure 11 yes Figure 10 Enlarged structural diagram at point B;

[0038] Figure 12 yes Figure 10 An enlarged structural diagram of section B, excluding the latching mechanism;

[0039] Figure 13 This is a schematic diagram of the push rod structure;

[0040] Figure 14 This is a schematic diagram of the compression sleeve.

[0041] In the diagram: 1—Dialysis artery cannula; 2—Connector; 21—Guide groove; 22—Sealing groove; 3—Housing base; 31—Dynamic blood glucose meter mounting cavity; 32—Puncture hole; 321—Puncture hole segment I; 322—Puncture hole segment II; 323—Puncture hole segment III; 3231—Guide groove; 33—Guide hole II; 331—Guide hole segment I; 332—Guide hole segment II; 333—Guide hole segment III; 4—Dynamic blood glucose meter; 41—Sensor; 42—Soft needle electrode; 43—Signal transmitter; 5—Flow guide plate; 6—Box body; 61—Through hole I; 62—Guide hole I; 63—Boss I; 7—Sealing plug; 8—Filter membrane; 9—Snapping mechanism; 91—Spring I; 92—Lock tongue; 93—Positioning sleeve I; 94—Push rod; 941—Guide protrusion I; 942—Guide protrusion II; 943—Operating handle; 95—Spring II; 96—Positioning sleeve II; 10—Pressure sleeve; 101—First guide block; 102—Annular boss II; 11—Sealing ring; 12—Operating pad. Detailed Implementation

[0042] The present invention will now be described in detail with reference to the embodiments and accompanying drawings.

[0043] like Figure 1 As shown, the real-time blood glucose monitoring and early warning device for hemodialysis includes a connector 2 mounted on the dialysis artery tube 1, a housing base 3 connected to the connector 2, a dynamic blood glucose meter 4 mounted on the housing base 3 for detecting blood glucose in the dialysis artery tube 1, a flow guide plate 5, a housing 6, a sealing rubber stopper 7, a filter membrane 8, and a clamping sleeve 10. The dynamic blood glucose meter 4 is existing technology, mainly comprising a sensor 41 and a signal transmitter 43. The sensor 41 has a soft needle electrode 42. The signal transmitter 43 can be connected to the controller of the hemodialysis machine or to a medical staff's mobile phone. After receiving a signal from the sensor 41, the signal transmitter 43 transmits it to the hemodialysis machine, which displays the patient's blood glucose level in real time. If the patient's blood glucose exceeds a preset maximum value or falls below a preset minimum value, a real-time warning is issued.

[0044] The bottom end of connector 2 is fixedly connected to dialysis artery tube 1, and the structure of connector 2 is as follows: Figure 2 As shown, the inner wall of the connector 2 is provided with an L-shaped guide groove 21 consisting of an axial groove arranged along its axial direction and a radial groove arranged along its radial direction. In this embodiment, two L-shaped guide grooves 21 are provided on the inner wall of the connector 2, and the radial grooves of the two guide grooves 21 are arranged in the same clockwise or counterclockwise direction along the circumference. A sealing groove 22 is provided on the inner wall of the connector 2 at the bottom of the radial groove along the circumferential direction, such as... Figure 3 As shown, a sealing ring 11 is provided inside the sealing groove 22, such as Figure 4As shown, the housing base 3 is sealed to the connector 2 via a sealing ring 11. In this embodiment, the inner wall of the connector 2, located at the bottom of the sealing groove 22, has an annular support platform with an inner diameter smaller than that of the upper inner hole. After the sealing ring 11 is inserted into the sealing groove 22, the annular support platform can better support the sealing ring 11.

[0045] The structure of the shell base 3 is as follows Figure 5 and Figure 6 As shown, one end of the housing base 3 is open, forming a cavity with an open bottom inside the housing base 3. A second guide block 34 is provided on the outer wall of the housing base 3 near the open end. In this embodiment, two second guide blocks 34 are provided on the outer wall of the housing base 3 near the open end, corresponding one-to-one with the two guide grooves 21 on the inner wall of the connector 2. The open end of the housing base 3 is inserted into the connector 2 from the top of the connector. The second guide blocks 34 on the housing base 3 move downward along the axial groove of the guide groove 21 and rotate into the radial groove, thereby connecting the housing base 3 to the connector 2. The open end of the housing base 3 presses against the sealing ring 11 and is sealed to the inner wall of the connector 2 through the sealing ring 11. A flow guide plate 5 is laterally arranged inside the housing base 3 near the open end. The flow guide plate 5 is perpendicular to the axis of the dialysis artery tube 1. The flow guide plate 5 gradually thickens from the inner side near the housing base 3 to the outer side of the open end, that is, the thickness of the flow guide plate 5 gradually increases from the side away from the axis of the dialysis artery tube 1 to the side closer to the axis of the dialysis artery tube 1. Figure 1 As shown, all edges of the guide plate 5 are rounded. The guide plate 5 divides the open end of the housing base 3 into an inlet and an outlet. When the blood flowing through the dialysis artery tube 1 passes through the connector 2, under the guidance and diversion effect of the guide plate 5, the blood near the inner wall of the dialysis artery tube 1 enters the cavity of the housing base 3 through the inlet, flows along the flow channel formed between the guide plate 5 and the inner wall of the cavity of the housing base 3, and finally flows out from the outlet and returns to the dialysis artery tube 1.

[0046] A dynamic blood glucose meter mounting cavity 31 and a puncture hole 32 are provided on the side of the housing base 3 away from the open end. The puncture hole 32 is located on the left side of the dynamic blood glucose meter mounting cavity 31. Figure 6 As shown.

[0047] The continuous glucose monitoring (CGM) meter 4 is installed inside the CGM meter mounting cavity 31. The sensor 41 of the CGM meter 4 is located at the bottom of the CGM meter mounting cavity 31. The soft needle electrode 42 of the CGM meter 4 passes through the housing base 3 at the bottom of the CGM meter mounting cavity 31 and extends into the inner cavity of the housing base 3. The signal transmitter 43 of the CGM meter 4 is located near the outside of the CGM meter mounting cavity 31. In this embodiment, the CGM meter 4 is fixedly installed in a box 6 with an open end. The structure of the box 6 is as follows: Figure 7As shown, the housing 6 is inserted into the continuous glucose meter mounting cavity 31, with the open end of the housing 6 located on the outside of the continuous glucose meter mounting cavity 31, as... Figure 8 As shown, both the bottom of the box 6 and the base 3 at the bottom of the continuous glucose meter mounting cavity 31 are provided with through holes I 61. The soft needle electrode 42 of the continuous glucose meter 4 passes through the through hole I 61, as shown. Figure 9 As shown. To facilitate the installation or removal of the housing 6, a protruding boss I 63 can be provided on the outer side of the housing 6 near the top. After the housing 6 is installed in the continuous glucose meter mounting cavity 31, the boss I 63 is located on the outer side of the continuous glucose meter mounting cavity 31. Applying force through the boss I 63 makes it easier to install or remove the housing 6. The continuous glucose meter 4 is installed in the housing 6, so that the four sides and bottom of the continuous glucose meter 4 (except for the soft needle electrode 42 protruding from the through hole I 61) are sealed with the inner sides and bottom of the housing 6. After removing the housing 6, only the outer surface of the housing 6 and the soft needle electrode 42 need to be disinfected to allow the continuous glucose meter 4 to be reused. If the box 6 is installed in the continuous glucose meter mounting cavity 31, and the bottom of the box 6 is sealed to the bottom of the continuous glucose meter mounting cavity 31 (except for the soft needle electrode 42 protruding from the through hole I 61), then only the outer wall of the housing base 3, the inner wall of the cavity, and the soft needle electrode 42 need to be disinfected, and the housing base 3 and the continuous glucose meter 4 installed inside it can be reused, greatly reducing the cost of use.

[0048] After the housing 6 is inserted into the dynamic blood glucose meter mounting cavity 31, the housing 6 is fixed in the dynamic blood glucose meter mounting cavity 31 by the snap-fit ​​mechanism 9, and the bottom of the housing 6 is sealed to the bottom of the dynamic blood glucose meter mounting cavity 31. The housing base 3 is provided with snap-fit ​​mechanisms 9 at both the front and rear of the dynamic blood glucose meter mounting cavity 31, such as... Figure 10 As shown. The latching mechanism 9 includes spring I 91, locking tongue 92, positioning sleeve I 93, push rod 94, spring II 95, and positioning sleeve II 96, as follows. Figure 11 As shown, guide holes I 62 are provided on both the front and rear walls of the housing 6, and through guide holes II 33 are provided on both the housing base 3 and at the front and rear positions of the dynamic blood glucose meter mounting cavity 31. Figure 12 As shown. The two guide holes I62 on the box body 6 and the two guide holes II33 on the shell base 3 correspond one-to-one in the front-back direction. Each guide hole I62 is equipped with a spring I91, a locking tongue 92 and a positioning sleeve I93, as shown. Figure 11As shown, the positioning sleeve I 93 is fixedly installed inside the guide hole I 62 and close to the opening. The locking tongue 92 passes through the positioning sleeve I 93 and slides against the inner wall of the positioning sleeve I 93. The left end of the locking tongue 92 is located on the left side of the positioning sleeve I 93, and the right end of the locking tongue 92 is inserted into the corresponding guide hole II 33. The bottom of the locking tongue 92 forms a slope near the right end, and all edges are rounded. When the box body 6 is first inserted into the dynamic blood glucose meter mounting cavity 31, it is convenient for the locking tongue 92 to slide into the dynamic blood glucose meter mounting cavity 31 and retract into the guide hole I 62. When the box body 6 is fully inserted into the dynamic blood glucose meter mounting cavity 31, the locking tongue 92 extends and inserts into the guide hole II 33, thereby fixing the box body 6 in the dynamic blood glucose meter mounting cavity 31. One end of the spring I 91 presses against the inner wall of the guide hole I 62, and the other end of the spring I 91 presses against the locking tongue 92. Each guide hole II33 is equipped with a push rod 94, a spring II95, and a positioning sleeve II96, such as Figure 11 As shown, guide hole II 33 is composed of guide hole segment I 331, guide hole segment II 332 and guide hole segment III 333 in sequence, as follows. Figure 12 As shown, guide hole segment I 331 is close to the dynamic blood glucose meter mounting cavity 31, and guide hole segment III 333 is close to the outer wall of the housing base 3. The inner diameter of guide hole segment III 333 is larger than the inner diameter of guide hole segment II 332, and the inner diameter of guide hole segment II 332 is larger than the inner diameter of guide hole segment I 331. Push rod 94 is inserted into guide hole II 33, with one end of push rod 94 located inside guide hole segment I 331 and the other end of push rod 94 located outside the housing base 3. Guide protrusion I 941 and guide protrusion II 942 are provided on the outer wall of push rod 94, and the outer end of push rod 94 protrudes in the circumferential direction to form an operating handle 943, as shown. Figure 13 As shown, guide protrusion I 941 is located inside guide hole section II 332 and slides with the inner wall of guide hole section II 332. Positioning sleeve II 96 is fixedly set inside guide hole section III 333 and close to the orifice. Push rod 94 passes through positioning sleeve II 96 and slides with the inner wall of positioning sleeve II 96. Guide protrusion II 942 is located inside guide hole section III 333 and slides with the inner wall of guide hole section III 333. Guide protrusion II 942 is located inside positioning sleeve II 96. Spring II 95 is sleeved on push rod 94. One end of spring II 95 presses on the annular protrusion formed between guide hole section I 331 and guide hole section II 332, and the other end of spring II 95 presses on guide protrusion II 942.

[0049] When installing the housing 6, under the action of spring II 95, the push rod 94 is on the side away from the dynamic blood glucose meter mounting cavity 31. When the housing 6 is just inserted into the dynamic blood glucose meter mounting cavity 31, the bottom of the housing 6 contacts the top of the inner wall of the dynamic blood glucose meter mounting cavity 31. Under the action of the squeezing force, the locking tongue 92 retracts into the guide hole I 62, and the housing 6 slides downward in the dynamic blood glucose meter mounting cavity 31. When the housing 6 is fully inserted into the dynamic blood glucose meter mounting cavity 31, the locking tongue 92 corresponds to the guide hole II 33. Under the action of spring I 91, the locking tongue 92 is driven to insert into the guide hole II 33 and fix the housing 6 in the dynamic blood glucose meter mounting cavity 31. When it is necessary to remove the box 6, press the operating handles 943 on both the front and back sides with your fingers to drive the push rod 94 to move inward. The push rod 94 pushes the locking tongue 92, causing the locking tongue 92 to exit the guide hole II 33 and retract into the guide hole I 62. The springs I 91 and II 95 are compressed. At the same time, use your hand or other tools to drive the boss I 63 to move upward, thereby driving the box 6 to move upward until the box 6 leaves the dynamic blood glucose meter mounting cavity 31, and then the dynamic blood glucose meter 4 can be removed.

[0050] The puncture hole 32 consists of puncture hole segment I 321, puncture hole segment II 322, and puncture hole segment III 323 from bottom to top, as follows: Figure 6 As shown, the inner diameter of puncture hole section III 323 is larger than that of puncture hole section II 322, and the inner diameter of puncture hole section II 322 is larger than that of puncture hole section I 321. The sealing plug 7 is installed in puncture hole section II 322. An L-shaped guide groove 3231, consisting of an axial guide groove along its axial direction and a radial guide groove along its radial direction, is provided on the inner wall of puncture hole section III 323. The structure of the clamping sleeve is as follows... Figure 14As shown, a first guide block 101 is provided on the outer wall of the clamping sleeve 10 near the bottom, and an outwardly protruding annular boss II 102 is provided on the outer wall of the clamping sleeve 10 near the top. After the clamping sleeve 10 is installed in the puncture hole section III 323, the annular boss II 102 is located outside the puncture hole section III 323. Applying force through the boss I 103 makes it easier to install or remove the clamping sleeve 10. In this embodiment, two L-shaped guide grooves 3231 are provided on the inner wall of the puncture hole section III 323. The radial guide grooves of the two guide grooves 3231 are arranged in the same clockwise or counterclockwise direction along the circumference. Two first guide blocks 101 corresponding to the two guide grooves 3231 are provided near the bottom of the outer wall of the clamping sleeve 10. The clamping sleeve 10 is inserted into the puncture hole section III 323 from the top. The first guide blocks 101 on the clamping sleeve 10 move downward along the axial guide groove of the L-shaped guide groove 3231 and rotate into the radial guide groove. The bottom of the clamping sleeve 10 presses on the top of the sealing plug 7. The bottom of the sealing plug 7 and near the outer circle presses on the circular boss formed between the puncture hole section I 321 and the puncture hole section II 322. When installing the sealing plug 7, simply place the sealing plug 7 in the puncture hole section II 322, hold the clamping sleeve 10 with the annular boss II 102, align the first guide block 101 on the clamping sleeve 10 with the guide groove 3231, press down, and then rotate it a certain angle to press the sealing plug 7 tightly into the puncture hole 32. After the real-time blood glucose test is completed, hold the annular boss II 102 again, rotate the clamping sleeve 10 a certain angle, and then pull the clamping sleeve 10 upwards to replace the sealing plug 7. After disinfecting the clamping sleeve 10 and the housing base 3, the housing base 3 and the clamping sleeve 10 can be reused, greatly reducing costs.

[0051] If blood tests or medication administration are required, the syringe needle simply punctures the sealing stopper 7 to draw blood flowing through the cavity of the housing base 3, i.e., blood flowing through the dialysis artery tube 1. Medication can also be administered into the cavity of the housing base 3; the medication mixes with the blood in the cavity and flows forward into the dialysis artery tube 1, eventually reaching the patient. To prevent debris from entering the patient's body when the needle punctures the sealing stopper 7, a filter membrane 8 is installed between the inner wall of the housing base 3 and the guide plate 5, near the outlet. The filter membrane 8 effectively filters out debris.

[0052] The real-time blood glucose monitoring and early warning device for hemodialysis also includes an operating pad 12 installed on the dialysis artery tube 1. The operating pad 12 and the connector 2 are located on the same cross section of the dialysis artery tube 1 and on opposite sides of the dialysis artery tube 1 along its axis. When blood is needed for testing or medication administration, one hand can hold the operating pad 12 to fix the position of the housing base 3, while the other hand can operate the syringe needle to pierce the sealing rubber stopper 7 to perform blood drawing or medication administration.

[0053] When blood flows through connector 2 in the dialysis artery tube 1, the blood near connector 2 is guided and diverted by the flow guide plate 5. The blood near the inner wall of connector 2 enters the cavity of housing base 3 through the inlet and flows along the flow channel formed between the flow guide plate 5 and the inner wall of the cavity of housing base 3. When the blood entering the cavity of housing base 3 flows through soft needle electrode 42, soft needle electrode 42 reacts with blood glucose in the blood to form an oxidation reaction and a current proportional to the blood glucose concentration. The level of the electrical signal directly reflects the level of blood glucose in the patient's body and transmits the signal to the outside through the signal transmitter 43 of dynamic blood meter 4. The guide plate 5 alters the flow direction of blood entering the cavity of the housing base 3, reducing its velocity. The volume of the cavity is larger than the cross-section intercepted by the guide plate 5 at the connector 2, further reducing the blood velocity. The filter membrane 8 further slows the blood flow, prolonging the brief contact time between the blood and the soft needle electrode 42. This facilitates a more stable and accurate blood glucose reading. The filter membrane 8 not only slows the blood flow but also filters out debris generated during needle puncture of the sealing plug 7. After being filtered by the membrane 8, the blood flows out through the outlet and returns to the dialysis artery tube 1.

[0054] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A real-time blood glucose monitoring and early warning device for hemodialysis, characterized in that: It includes a connector (2) installed on the dialysis artery tube (1), a housing base (3) connected to the connector (2), and a dynamic blood glucose meter (4) installed on the housing base (3) for detecting blood glucose in the dialysis artery tube (1). One end of the connector (2) is fixedly connected to the dialysis artery tube (1). One end of the housing base (3) is open. The open end of the housing base (3) is inserted into the connector (2) from the other end of the connector (2) and is sealed to the inner wall of the connector (2). A guide plate (5) is arranged horizontally in the housing base (3) near the open end. The guide plate (5) is perpendicular to the axis of the dialysis artery tube (1). The guide plate (5) gradually thickens from the inner side near the housing base (3) to the outer side of the open end. A dynamic blood glucose meter mounting cavity (31) is provided on the side of the housing base (3) away from the open end. The dynamic blood glucose meter (4) is installed in the dynamic blood glucose meter mounting cavity (31). The sensor (41) of the dynamic blood glucose meter (4) is located at the bottom of the dynamic blood glucose meter mounting cavity (31). The soft needle electrode (42) of the dynamic blood glucose meter (4) passes through the housing base (3) at the bottom of the dynamic blood glucose meter mounting cavity (31) and extends into the inner cavity of the housing base (3). The signal transmitter (43) of the dynamic blood glucose meter (4) is close to the outside of the dynamic blood glucose meter mounting cavity (31). The dynamic blood glucose meter (4) is fixedly installed in a box (6) with one end open. The box (6) is inserted into the dynamic blood glucose meter mounting cavity (31). The open end of the box (6) is located outside the dynamic blood glucose meter mounting cavity (31). The bottom of the box (6) and the housing base (3) at the bottom of the dynamic blood glucose meter mounting cavity (31) are both provided with through holes I (61). The soft needle electrode (42) of the dynamic blood glucose meter (4) passes through the through hole I (61). After the box (6) is inserted into the dynamic blood glucose meter mounting cavity (31), the box (6) is fixed in the dynamic blood glucose meter mounting cavity (31) by the buckling mechanism (9), and the bottom of the box (6) is sealed to the bottom of the dynamic blood glucose meter mounting cavity (31). The buckling mechanism (9) includes spring I (91), locking tongue (92), positioning sleeve I (93), push rod (94), spring II (95) and positioning sleeve II (96); guide holes I (62) are provided on the front and rear walls of the box body (6), and through guide holes II (33) are provided on the housing base (3) at the front and rear positions of the dynamic blood glucose meter mounting cavity (31); the two guide holes I (62) of the box body (6) and the two guide holes II (33) on the housing base (3) correspond one-to-one in the front and rear direction; Each of the guide holes I (62) is provided with a spring I (91), a locking tongue (92) and a positioning sleeve I (93). The positioning sleeve I (93) is fixedly installed in the guide hole I (62) and close to the opening. The locking tongue (92) passes through the positioning sleeve I (93) and slides with the inner wall of the positioning sleeve I (93). One end of the locking tongue (92) is located inside the positioning sleeve I (93), and the other end of the locking tongue (92) is inserted into the corresponding guide hole II (33). One end of the spring I (91) is pressed on the inner wall of the guide hole I (62), and the other end of the spring I (91) is pressed on the locking tongue (92). Each of the guide holes II (33) is provided with a push rod (94), a spring II (95), and a positioning sleeve II (96). The guide hole II (33) is composed of guide hole section I (331), guide hole section II (332), and guide hole section III (333) in sequence. The guide hole section I (331) is close to the dynamic blood glucose meter mounting cavity (31), and the guide hole section III (333) is close to the outer wall of the housing base (3). The inner diameter of the guide hole section III (333) is larger than the inner diameter of the guide hole section II (332), and the inner diameter of the guide hole section II (332) is larger than the inner diameter of the guide hole section I (331). The push rod (94) is inserted into the guide hole II (33). One end of the push rod (94) is located inside the guide hole section I (331), and the other end of the push rod (94) is located outside the housing base (3). A guide is provided on the outer wall of the push rod (94). The guide protrusion I (941) and guide protrusion II (942) are located inside guide hole section II (332) and slide in cooperation with the inner wall of guide hole section II (332). The positioning sleeve II (96) is fixedly set inside guide hole section III (333) and close to the opening. The push rod (94) passes through positioning sleeve II (96) and slides in cooperation with the inner wall of positioning sleeve II (96). The guide protrusion II (942) is located inside guide hole section III (333) and slides in cooperation with the inner wall of guide hole section III (333). The guide protrusion II (942) is located inside positioning sleeve II (96). The spring II (95) is sleeved on the push rod (94). One end of the spring II (95) presses on the annular protrusion formed between guide hole section I (331) and guide hole section II (332). The other end of the spring II (95) presses on guide protrusion II (942).

2. The device for real-time blood glucose detection and early warning in hemodialysis according to claim 1, characterized in that: A puncture hole (32) is provided on the side of the housing base (3) away from the open end, and a sealing plug (7) is provided in the puncture hole (32).

3. The device for real-time blood glucose detection and early warning in hemodialysis according to claim 2, characterized in that: The guide plate (5) divides the open end of the housing base (3) into an inlet and an outlet. A filter membrane (8) is provided between the inner wall of the housing base (3) and the guide plate (5) and near the outlet.

4. The blood glucose real-time detection and early warning device in hemodialysis according to claim 3, characterized in that: The puncture hole (32) is located on the left side of the dynamic blood glucose meter mounting cavity (31).

5. The blood glucose real-time detection and early warning device in hemodialysis according to claim 4, characterized in that: It also includes a clamping sleeve (10). The puncture hole (32) is composed of puncture hole section I (321), puncture hole section II (322) and puncture hole section III (323) from bottom to top. The inner diameter of the puncture hole section III (323) is larger than the inner diameter of the puncture hole section II (322). The inner diameter of the puncture hole section II (322) is larger than the inner diameter of the puncture hole section I (321). The sealing plug (7) is installed in the puncture hole section II (322). The clamping sleeve (10) is inserted into the puncture hole section III (323) and pressed on the top of the sealing plug (7). The bottom of the sealing plug (7) and close to the outer circle are pressed on the circular protrusion formed between the puncture hole section I (321) and the puncture hole section II (322).

6. The real-time blood glucose monitoring and early warning device for hemodialysis according to claim 5, characterized in that: The inner wall of the puncture hole section III (323) is provided with an L-shaped guide groove (3231) consisting of an axial guide groove arranged along its axial direction and a radial guide groove arranged along its radial direction. The outer wall of the clamping sleeve (10) and near the bottom is provided with a first guide block (101). The first guide block (101) on the clamping sleeve (10) is inserted into the L-shaped guide groove (3231) and rotated into the radial guide groove.

7. The device for real-time blood glucose detection and early warning in hemodialysis according to claim 6, characterized in that: The inner wall of the connector (2) is provided with an L-shaped guide groove (21) consisting of an axial groove along its axial direction and a radial groove along its radial direction. A second guide block (34) is provided on the outer wall of the housing base (3) near the open end. The second guide block (34) on the housing base (3) is inserted into the L-shaped guide groove (21) and rotated into the radial groove. A sealing groove (22) is provided on the inner wall of the connector (2) at the bottom of the radial groove along the circumferential direction. A sealing ring (11) is provided in the sealing groove (22). The housing base (3) is sealed to the connector (2) through the sealing ring (11).

8. The blood glucose real-time detection and early warning device in hemodialysis according to claim 7, characterized in that: It also includes an operating pad (12) disposed on the dialysis artery tube (1), wherein the operating pad (12) and the connector (2) are located on the same cross section of the dialysis artery tube (1) and on opposite sides of the dialysis artery tube (1) along the axial direction.

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