Methyl thiophene modified ruthenium polypyridine complex as well as preparation method and application thereof

The methylthiophene-modified ruthenium pyridine complex addresses the challenge of treating antibiotic-resistant bacteria by enhancing membrane penetration and disrupting bacterial integrity to inhibit hemolysin secretion and biofilms, achieving effective antibacterial activity against MRSA.

CN120309662APending Publication Date: 2025-07-15CHONGQING KUIKANG PHARMACEUTICAL TECHNOLOGY CO LTD
0 Cites 0 Cited by

Patent Information

Application Number
CN202510487614.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-18
Publication Date
2025-07-15

AI Technical Summary

Technical Problem

Existing antibiotics are difficult to effectively eradicate the biofilms of Staphylococcus aureus and inhibit the hemolytic toxins it produces. Especially methicillin-resistant strains are severely resistant to traditional antibiotics, making it difficult to treat infections.

Method used

By synthesizing methylthiophene, the ruthenium polypyridine complex is modified, and its positively charged organic molecular chains bind to anions on the surface of the bacterial cell membrane, destroy the cell membrane structure, enhance the transmembrane effect, penetrate into the bacteria, destroy its integrity, inhibit toxin secretion and biofilm formation.

Benefits of technology

It has achieved efficient bactericidal and biofilm eradication of Staphylococcus aureus, inhibited the production of hemolytic toxins, and showed excellent antibacterial activity, especially at a concentration of 0.78125 µg/mL to effectively inhibit bacterial growth and toxin secretion.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention discloses a methyl thiophene modified ruthenium polypyridine complex as well as a preparation method and application thereof, and relates to the technical field of antibacterial medicines. The complex has a structure shown as follows: # imgabs0 #. The invention also provides application of the complex in preparation of drugs for inhibiting staphylococcus aureus, drugs for inhibiting bacterial secretion of toxins and drugs for eradicating staphylococcus aureus biofilms. Molecules of the compound carry positive charges, compared with traditional small organic molecules, the capability of penetrating through bacterial cell membranes and the retention effect of the compound are enhanced, the transmembrane effect on bacteria is enhanced, the compound can effectively permeate into the bacterial cell membranes, the integrity of bacterial structures is destroyed, and therefore bacterial death is caused. Tests prove that the complex disclosed by the invention has the effects of effectively eradicating biofilms and inhibiting hemolytic toxins.
Need to check novelty before this filing date? Find Prior Art