Rapamycin-induced extracellular vesicles and application thereof in preparation of drugs for promoting wound repair

Through rapamycin-induced extracellular vesicles inhibit macrophage function, promote endothelial cell migration and duct formation, activate the PI3K/Akt signaling pathway, solve the problem of poor healing in diabetic wounds and achieve rapid wound repair.

CN120361052APending Publication Date: 2025-07-25ANHUI PROVINCIAL HOSPITAL
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Patent Information

Application Number
CN202510520364.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-24
Publication Date
2025-07-25

AI Technical Summary

Technical Problem

Poor healing and pathological healing of diabetic wounds are clinical problems, and the prior art is difficult to effectively promote angiogenesis and alleviate macrophage-mediated inflammatory responses.

Method used

Using rapamycin-induced extracellular vesicles, by inhibiting the proliferation and migration of macrophages, promote endothelial cell migration and tube formation, activate the PI3K/Akt signaling pathway, accelerate angiogenesis, and prepare drugs to promote wound repair.

Benefits of technology

Extracellular vesicles induced by rapamycin can effectively inhibit the expression of pro-inflammatory mediators in macrophages, promote endothelial cell migration and tube formation, increase VEGF levels, reduce inflammatory responses, and promote rapid healing of diabetic wounds.

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Abstract

The invention relates to the technical field of biological medicines, in particular to rapamycin-induced extracellular vesicles and application thereof in preparation of a medicine for promoting wound repair. The rapamycin-induced extracellular vesicles can enhance the migration and tube forming ability of endothelial cells, so that angiogenesis is promoted; meanwhile, the proliferation and migration capabilities of macrophages can be inhibited, and the proportion of M1 type macrophages in a wound is reduced, so that the inflammatory response mediated by the macrophages is relieved; and the composition shows extraordinary effects in the aspect of accelerating wound repair. The biological activity of the extracellular vesicles induced by the rapamycin depends on the activation of a PI3K / Akt signal channel.
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