A method for monitoring respiratory viral infectious diseases

Abstract

The present invention relates to the technical field of virus monitoring, and in particular to a method for monitoring respiratory viral infectious diseases, comprising establishing a virus gene library, wherein the virus gene library stores gene sequences of multiple different respiratory viruses; collecting sound information in public places and calculating an environmental risk coefficient, extracting cough events through the sound information, calculating the virus transmission index of the public place, and allocating sampling equipment to the public places in the order of the virus transmission index for sampling; after the sampling is completed, testing the samples, comparing the test results with the gene sequences in the virus gene library to obtain the load of respiratory viruses, and calculating the risk value of the virus; the present invention extracts cough events through sound information, and the cough events can quantify the intensity of virus release behavior in the place, providing a basis for subsequent risk assessment; calculating the environmental risk coefficient and ranking them, allocating and utilizing limited medical resources, and actively sampling in places with a higher probability of transmission.

Description

Technical Field

[0001] The present invention relates to the technical field of virus monitoring, and in particular to a method for monitoring respiratory viral infectious diseases. Background Art

[0002] The transmission routes of respiratory infectious diseases are difficult to monitor and control, and current early warning methods rely on case surveillance. Confirming a respiratory infectious disease case typically requires laboratory testing, and by the time test results are available, the disease has likely already spread.

[0003] However, existing technologies usually have high requirements for data sources, usually including at least biochemical results of laboratory tests, to identify risks and monitor and warn from the perspective of confirmed cases. These data mainly come from sentinel hospitals or large hospitals in big cities, and there is a lag, that is, monitoring and early warning is a passive process, which in turn causes a lag in warning; therefore, a respiratory viral infectious disease monitoring method that can actively monitor and provide early warning is needed. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a method for monitoring respiratory viral infectious diseases that can actively monitor and provide early warning.

[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0006] A method for monitoring respiratory viral infectious diseases, comprising:

[0007] Establish a viral gene bank that stores the gene sequences of a variety of different respiratory viruses;

[0008] Collect sound information of public places, personnel density D, ventilation volume V, relative humidity H, Concentration; extract n types of cough events through sound information and calculate the cough event weighted index CFWI, CFWI= × ;

[0009] Calculate the environmental risk coefficient ERC, ERC=( )×(1- )×( )

[0010] in, is the count of cough events of type i, The total monitoring duration per unit time, with the unit being less than or equal to hours; Weight for cough type; Environmental baseline concentration, is the threshold;

[0011] Get the area S of the public place and calculate the virus transmission index VPI of the public place, VPI= The larger the VPI is, the higher the risk of the public place is, and the higher the priority of sampling is; different public places are ranked by VPI as follows: 、 、……、 ,in, to Sequential numbers are generated for different public places due to VPI sorting; and sampling equipment is allocated to public places for sampling in the order of front and back;

[0012] After the sampling is completed, the sample is tested by PCR, and the test results are compared with the gene sequence of the virus gene library to obtain the load of the respiratory virus to be monitored in different public places 、 、……、 ,in, to It is the sequence number generated by VPI sorting in different public places; and the risk value RISK of the virus is calculated, RISK= + 、……、 .

[0013] Preferably, a heat map of each virus is created using the risk value RISK of each virus. When creating the heat map, the locations corresponding to public places are marked on the map, and the risk value of each virus corresponding to each public place is calculated separately:

[0014] = ; 、…、 ;

[0015] and will 、 、……、 Fill in the corresponding public places respectively; among them, to It is the sequence number generated by VPI sorting in different public places.

[0016] Preferably, 、 、……、 Fill in the corresponding public places in the form of a bar chart.

[0017] Preferably, the plurality of different respiratory viruses include a transmission coefficient β, β={ 、 、……、 }, the risk value RISK of each virus, RISK={ 、 、……、 }; where m is the serial number of the virus, is the propagation coefficient corresponding to viruses with different serial numbers, is the risk value corresponding to viruses with different serial numbers;

[0018] The risk value is corrected by the propagation coefficient, and the corrected risk value ,

[0019] = , = ,…… = ;

[0020] to is the corrected risk value of viruses corresponding to different serial numbers after correction.

[0021] Preferably, the adjusted risk value is Rank the risk of the virus.

[0022] Preferably, a prompt is given when the cough event weighted index CFWI rises rapidly.

[0023] Preferably, when the cough event weighted index CFWI is 1.5 times the average cough event weighted index CFWI of the public place yesterday, a prompt is given and sampling equipment is urgently allocated to the public place for sampling.

[0024] Preferably, there are two types of cough events, including short coughs and continuous coughs. =0.5; when coughing continuously =1.2.

[0025] Preferably, different public places are sorted by VPI: 、 、……、 , and arrange the sampling frequencies in the order of high first and low later.

[0026] Preferably, the The value is 400ppm, The value is 1000ppm.

[0027] The beneficial effects of the present invention are as follows: coughing events are extracted through sound information. Since coughing is the main characteristic of respiratory viral infectious diseases, coughing events are virus release behaviors, and viruses do not die immediately after reaching the air, but have a certain survival time. Coughing events can quantify the intensity of virus release behavior in the venue. Moreover, coughing is the main early symptom of respiratory viral infectious diseases, and thus observation is more direct. It is also easy to screen and identify from sound signals, providing a basis for subsequent risk assessment. By combining the calculation of the VPI with the environmental risk coefficient and sorting them, limited medical resources can be allocated and utilized, and occasions with a higher probability of transmission can be found for active sampling and detection of transmission. The test results are multiplied by the virus transmission index to obtain the risk value of a certain virus, thereby achieving the effect of virus monitoring and early warning. It is the total monitoring time per unit time, measured in hours or less. Once the frequency of coughing events surges, the VPI ranking will change rapidly. The changed objects can be selected for emergency sampling, which can greatly improve the response speed. DETAILED DESCRIPTION

[0028] To explain the technical content, achieved objectives and effects of the present invention in detail, the following describes them in conjunction with the implementation methods.

[0029] A method for monitoring respiratory viral infectious diseases, comprising:

[0030] Establish a viral gene bank that stores the gene sequences of a variety of different respiratory viruses;

[0031] Collect sound information of public places, personnel density D, ventilation volume V, relative humidity H, Concentration; extract n types of cough events through sound information and calculate the cough event weighted index CFWI, CFWI= × ;

[0032] Calculate the environmental risk coefficient ERC, ERC=( )×(1- )×( )

[0033] in, is the count of cough events of type i, The total monitoring duration per unit time, with the unit being less than or equal to hours; Weight for cough type; Environmental baseline concentration, is the threshold;

[0034] Get the area S of the public place and calculate the virus transmission index VPI of the public place, VPI= The larger the VPI is, the higher the risk of the public place is, and the higher the priority of sampling is; different public places are ranked by VPI as follows: 、 、……、 ,in, to Sequential numbers are generated for different public places due to VPI sorting; and sampling equipment is allocated to public places for sampling in the order of front and back;

[0035] After the sampling is completed, the sample is tested by PCR, and the test results are compared with the gene sequence of the virus gene library to obtain the load of the respiratory virus to be monitored in different public places 、 、……、 ,in, to It is the sequence number generated by VPI sorting in different public places; and the risk value RISK of the virus is calculated, RISK= + 、……、 .

[0036] From the above description, we can see that coughing events can be extracted through sound information. Since coughing is the main characteristic of respiratory viral infectious diseases, coughing events are the release of viruses. Viruses do not die immediately after entering the air, but have a certain survival time. Coughing events can quantify the intensity of virus release behavior in the venue. Moreover, coughing is the main early symptom of respiratory viral infectious diseases, so observation is more direct and it is easy to screen and identify from sound signals, providing a basis for subsequent risk assessment. By combining the calculation of the VPI with the environmental risk coefficient and sorting it, limited medical resources can be allocated and utilized, and occasions with a higher probability of transmission can be found for active sampling and detection. The test results are multiplied by the virus transmission index to obtain the risk value of a certain virus, thereby achieving the effect of virus monitoring and early warning. It is the total monitoring time per unit time, measured in hours or less. Once the frequency of coughing events surges, the VPI ranking will change rapidly. The changed objects can be selected for emergency sampling, which can greatly improve the response speed.

[0037] Furthermore, a heat map of each virus is created using the risk value RISK of each virus. When creating the heat map, the corresponding locations of public places are marked on the map, and the risk value of each virus corresponding to each public place is calculated separately:

[0038] = ; 、…、 ;

[0039] and will 、 、……、 Fill in the corresponding public places respectively; among them, to It is the sequence number generated by VPI sorting in different public places.

[0040] From the above description, we can see that by calculating the risk value for each virus and each location separately, we can find the spread trend and source of the virus. For example, the risk value of virus B in public place A is the highest. With this as the center, the risk value gradually decreases. It can be considered that virus B is mainly spreading from public place A, which facilitates timely response.

[0041] Further, 、 、……、 Fill in the corresponding public places in the form of a bar chart.

[0042] From the above description, it can be seen that the bar chart can be more prominent and clear.

[0043] Furthermore, the transmission coefficient of various respiratory viruses includes β, β={ 、 、……、 }, the risk value RISK of each virus, RISK={ 、 、……、 }; where m is the serial number of the virus, is the propagation coefficient corresponding to viruses with different serial numbers, is the risk value corresponding to viruses with different serial numbers;

[0044] The risk value is corrected by the propagation coefficient, and the corrected risk value ,

[0045] = , = ,…… = ;

[0046] to is the corrected risk value of viruses corresponding to different serial numbers after correction.

[0047] From the above description, we can see that by adding additional transmission coefficients, the transmission effect of each virus is different, which can make the risk value more accurate.

[0048] Furthermore, according to the adjusted risk value Rank the risk of the virus.

[0049] Furthermore, when the cough event weighted index CFWI rises rapidly, a prompt is given.

[0050] From the above description, we can see that a rapid increase in the cough event weighted index CFWI means that an acute infectious event may occur, and a timely response can be made. Even if it is not an infectious disease, a quick response can be made just in case.

[0051] Furthermore, when the weighted index CFWI of cough events is 1.5 times the average weighted index CFWI of cough events in the public place yesterday, a prompt will be issued and sampling equipment will be urgently allocated to the public place for sampling.

[0052] From the above description, it can be seen that by conducting emergency sampling and testing in places where coughing incidents increase sharply, the cause of the outbreak can be quickly determined to determine whether it is a sudden outbreak of acute respiratory viral infectious diseases. If so, an emergency response will be given to achieve a monitoring effect.

[0053] Furthermore, there are two types of cough events, including short coughs and continuous coughs. =0.5; when coughing continuously =1.2.

[0054] From the above description, we can see that continuous coughing may release more viruses, so it has a greater weight.

[0055] Furthermore, different public places are ranked by VPI. 、 、……、 , and arrange the sampling frequencies in the order of high first and low later.

[0056] From the above description, we can see that since the risk is greater where the VPI is high, a higher sampling frequency is used to ensure the monitoring effect.

[0057] Furthermore, the The value is 400ppm, The value is 1000ppm.

[0058] Example 1

[0059] A method for monitoring respiratory viral infectious diseases, comprising:

[0060] Establish a viral gene bank that stores the gene sequences of a variety of different respiratory viruses;

[0061] Collect sound information in public places (microphones are set up in fixed places for collection), the density of people in the place D (the camera calculates the number of people divided by the area of ​​the place S), the ventilation volume V (the ventilation volume is specified when public places are designed and built, which can be found by querying the design specifications), the relative humidity H (humidity sensor), Concentration (carbon dioxide sensor); extract one cough event through sound information, which is a short cough. =0.5 (small amount of virus released); calculate the cough event weighted index CFWI, CFWI= × When the cough event weighted index CFWI is 1.5 times the average cough event weighted index CFWI of the public place yesterday, an alarm will be triggered and sampling equipment will be urgently dispatched to the public place for sampling;

[0062] Calculate the environmental risk coefficient ERC, ERC=( )×(1- )×( )

[0063] in, is the count of cough events of type i, The total monitoring duration per unit time, with the unit being less than or equal to hours; Weight for cough type; Environmental baseline Concentration, the value is 400ppm; is the threshold value, which is 1000ppm;

[0064] Get the area S of the public place and calculate the virus transmission index VPI of the public place, VPI= The larger the VPI is, the higher the risk of the public place is, and the higher the priority of sampling is; different public places are ranked by VPI as follows: 、 、……、 ,in, to Sequential numbers are generated for different public places due to VPI sorting; sampling equipment is allocated to go to public places for sampling in a front-to-back order; and the sampling frequency is arranged in the order of high to low, that is, the frequency is high in places with a high virus transmission index, and the frequency is low in places with a low virus transmission index.

[0065] After the sampling is completed, the sample is tested by PCR, and the test results are compared with the gene sequence of the virus gene library to obtain the load of the respiratory virus to be monitored in different public places 、 、……、 ,in, to It is the sequence number generated by VPI sorting in different public places; and the risk value RISK of the virus is calculated, RISK= + 、……、 The transmission coefficient of various respiratory viruses is β, β={ 、 、……、 }, the risk value RISK of each virus, RISK={ 、 、……、 }; where m is the serial number of the virus, is the propagation coefficient corresponding to viruses with different serial numbers, is the risk value corresponding to viruses with different serial numbers;

[0066] The risk value is corrected by the propagation coefficient, and the corrected risk value ,

[0067] = , = ,…… = ;

[0068] to is the corrected risk value of viruses corresponding to different serial numbers after correction.

[0069] According to the adjusted risk value Rank the risk of the virus.

[0070] Example 2

[0071] A method for monitoring respiratory viral infectious diseases, which is the same as that of embodiment 1 and will not be repeated here, wherein the coughing event is a continuous cough. =1.2 (high virus release).

[0072] Example 3

[0073] A method for monitoring respiratory viral infectious diseases, which is the same as that of embodiment 1 and will not be repeated here, wherein:

[0074] Two types of cough events are extracted through sound information, including short cough and continuous cough. =0.5 (small amount of virus released); when coughing continuously =1.2 (high virus release).

[0075] Example 4

[0076] A method for monitoring respiratory viral infectious diseases, which is similar to that of Examples 1 to 3 and is not described in detail, further comprising:

[0077] Create a heat map for each virus using the risk value RISK of each virus. When creating a heat map, mark the corresponding locations of public places on the map, and calculate the risk value for each virus in each public place separately:

[0078] = ; 、…、 ;

[0079] Will 、 、……、 Fill in the corresponding public places in the form of a bar chart; among them, to It is the sequence number generated by VPI sorting in different public places.

[0080] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent transformations made using the contents of the present invention specification, or directly or indirectly applied in related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A method for monitoring respiratory viral infectious diseases, characterized in that: include: Establish a viral gene bank that stores the gene sequences of a variety of different respiratory viruses; Collect sound information of public places, personnel density D, ventilation volume V, relative humidity H, Concentration; extract n types of cough events through sound information and calculate the cough event weighted index CFWI, CFWI= × ; Calculate the environmental risk coefficient ERC, ERC=( )×(1- )×( ) in, is the count of cough events of type i, The total monitoring duration per unit time, with the unit being less than or equal to hours; Weight for cough type; Environmental baseline concentration, is the threshold; Get the area S of the public place and calculate the virus transmission index VPI of the public place, VPI= The larger the VPI is, the higher the risk of the public place is, and the higher the priority of sampling is; different public places are ranked by VPI as follows: 、 、……、 ,in, to Sequential numbers are generated for different public places due to VPI sorting; and sampling equipment is allocated to public places for sampling in the order of front and back; After the sampling is completed, the sample is tested by PCR, and the test results are compared with the gene sequence of the virus gene library to obtain the load of the respiratory virus to be monitored in different public places 、 、……、 ,in, to It is the sequence number generated by VPI sorting in different public places; and the risk value RISK of the virus is calculated, RISK= + 、……、 .

2. The respiratory viral infectious disease monitoring method according to claim 1, characterized in that: Create a heat map for each virus using the risk value RISK of each virus. When creating a heat map, mark the corresponding locations of public places on the map, and calculate the risk value for each virus in each public place separately: = ； 、…、 ； and will 、 、……、 Fill in the corresponding public places respectively; among them, to It is the sequence number generated by VPI sorting in different public places.

3. The method for monitoring respiratory viral infectious diseases according to claim 2, characterized in that: Will 、 、……、 Fill in the corresponding public places in the form of a bar chart.

4. The method for monitoring respiratory viral infectious diseases according to claim 1, wherein: The transmission coefficient of various respiratory viruses is β, β={ 、 、……、 }, the risk value RISK of each virus, RISK={ 、 、……、 }; where m is the serial number of the virus, is the propagation coefficient corresponding to viruses with different serial numbers, is the risk value corresponding to viruses with different serial numbers; The risk value is corrected by the propagation coefficient, and the corrected risk value , = ， = ，…… = ； to is the corrected risk value of viruses corresponding to different serial numbers after correction.

5. The method for monitoring respiratory viral infectious diseases according to claim 4, characterized in that: According to the adjusted risk value Rank the risk of the virus.

6. The respiratory viral infectious disease monitoring method according to claim 1, characterized in that: When the cough event weighted index CFWI rises rapidly, a prompt will be given.

7. The method for monitoring respiratory viral infectious diseases according to claim 6, characterized in that: When the weighted index CFWI of cough events is 1.5 times the average weighted index CFWI of cough events in the public place yesterday, a prompt will be issued and sampling equipment will be urgently allocated to the public place for sampling.

8. The method for monitoring respiratory viral infectious diseases according to claim 1, wherein: There are two types of coughing events, including short coughs and continuous coughs. =0.5; when coughing continuously =1.

2.

9. The method for monitoring respiratory viral infectious diseases according to claim 1, characterized in that: Use VPI to sort different public places. 、 、……、 , and arrange the sampling frequencies in the order of high first and low later.

10. The method for monitoring respiratory viral infectious diseases according to claim 1, wherein: described The value is 400ppm, The value is 1000ppm.

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