Preparation method of anticoagulant blood contact material

By forming active groups in situ on the surface of the blood-contacting material and fixing anticoagulant drugs, the problems of protein adhesion and denaturation are solved, and efficient anticoagulation and anti-inflammatory effects are achieved, and the service time of the material is extended.

CN120478743APending Publication Date: 2025-08-15WEST CHINA HOSPITAL SICHUAN UNIV
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Patent Information

Application Number
CN202510623799.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-15
Publication Date
2025-08-15

AI Technical Summary

Technical Problem

During use, existing blood-contacting materials have acute thrombosis and inflammation problems caused by protein adhesion and denaturation. The drug load of traditional coatings is insufficient and has a short timeliness, making it difficult to maintain anticoagulation and anti-inflammatory effects for a long time.

Method used

Silane reagent is used to form active groups in situ on the surface of the material, and anticoagulant drugs are fixed on the surface of the material through gentle click chemical reactions and amidation reactions to form a superhydrophilic coating to improve drug loading and stability.

Benefits of technology

It achieves efficient anticoagulation and anti-inflammatory properties on the surface of the material, extends service time, is simple to operate, is green and economical, and has wide applicability.

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Abstract

The invention discloses a preparation method of an anticoagulant blood contact material, which comprises the following steps: S1, dissolving a silane reagent containing different functional groups by using ethanol, immersing the blood contact material into the silane solution, and reacting for a period of time in a constant-temperature environment in a dark place for later use; s2, immersing the sample obtained in the step S1 in an ethanol solution containing 1mM of TCEP (tris (2-carboxyethyl) phosphine), reacting, fully cleaning, and carrying out vacuum drying for later use; s3, dissolving an anticoagulant with a PBS (Phosphate Buffer Solution) to obtain an anticoagulant solution for later use; and S4, immersing the sample obtained in the step S2 in the anticoagulant solution prepared in the step S3, fully reacting at a constant temperature, cleaning, and drying with nitrogen to obtain the anticoagulant blood contact material. The method is simple to operate, mild in reaction condition, green, economical, free of large equipment and convenient to popularize and use. The silane reagent is used for treating the blood contact material, so that active groups such as sulfydryl, carboxyl, amido and hydroxyl can be generated on the surface of the material in situ, and meanwhile, the hydrophilicity of the material is improved. Then, the functionalized material is immersed in an anticoagulant solution, an anticoagulant drug is fixed on the surface of the material through a mild click chemical reaction, an amidation reaction and the like, and the blood contact material is endowed with excellent anticoagulant performance.
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