Chiral nitrogen-nitrogen-phosphine compound as well as preparation method and application thereof

By using the complex of chiral nitrogen nitrogen sulfsulfonic compound and the iridium catalyst to carry out the asymmetric hydrogenation reaction of o-aminodiaryl ketone, the problems of low catalyst activity and insufficient enantioselectivity in the prior art are solved, and high-efficiency preparation of high-purity o-aminodiaryl methanol is achieved.

CN120484023APending Publication Date: 2025-08-15GOLDENKEYS HIGH TECH MATERIALS CO LTD +1
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Patent Information

Application Number
CN202510667734.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-22
Publication Date
2025-08-15

AI Technical Summary

Technical Problem

The prior art has problems of low catalyst activity and insufficient enantioselectivity in the asymmetric hydrogenation reaction of o-aminodiaryl ketones, making it difficult to directly prepare high-purity o-aminodiaryl methanol.

Method used

A chiral nitrogen phosphine compound was developed as a ligand, and a stable complex with the transition metal iridium was used for the asymmetric hydrogenation reaction of antho-aminodiaryl ketone, and in situ catalyzed in an organic solvent with a specific structure, using nitrogen phosphine compound with an iridium catalyst.

Benefits of technology

The high conversion rate of antho-aminodiaryl ketone and enantiomer selectivity of more than 96%, significantly improving the activity and selectivity of the catalyst and reducing the reaction time and cost.

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Abstract

The invention belongs to the technical field of asymmetric catalysis, and particularly relates to a chiral nitrogen-nitrogen-phosphine compound as well as a preparation method and application thereof. The chiral nitrogen-nitrogen-phosphine-phosphine compound contains two achiral phosphine atoms and two chiral nitrogen atoms, and when the chiral nitrogen-nitrogen-phosphine-phosphine compound is adopted as a ligand to catalyze an asymmetric hydrogenation reaction of o-amino diaryl ketone, the conversion rate is high, the capability of stabilizing a catalytic active center is achieved, and the enantiomer selectivity reaches 96% or above.
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