Compound capable of inhibiting activity of acetylcholin esterase and preparation method thereof
The new acetylcholinesterase inhibitor prepared through microbial fermentation and purification technology of Anoru Neptune has solved the problem of limited efficacy of existing drugs and achieved efficient acetylcholinesterase inhibition effect. It is suitable for Alzheimer's disease treatment and anti-aging drugs, and has broad market application prospects.
Patent Information
- Application Number
- CN202510653239.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-21
- Publication Date
- 2025-08-19
AI Technical Summary
The existing acetylcholinesterase inhibitors have limited efficacy, slow onset, short acting time and adverse reactions in the treatment of Alzheimer's disease. The existing drug raw materials are limited or the synthesis cost is high, which cannot meet the needs of large-scale applications.
Using microbial fermentation technology of angelica numbus, compounds with inhibitory acetylcholinesterase activity were prepared by fermentation, product extraction and separation and purification, and solid or liquid fermentation was performed using angelica numbus as bacterial species, and purification was carried out in combination with reverse phase silica gel column chromatography, gel column chromatography and normal phase silica gel column chromatography.
The prepared new acetylcholinesterase inhibitor has strong inhibitory activity and is suitable for the treatment of Alzheimer's disease and Alzheimer's disease. It has broad market prospects and is simple and easy to produce in industrial use.