Method for extracting bisphenol A and / or related compounds thereof in powder food and application of bisphenol A and / or related compounds thereof

Through liquid-liquid extraction and ultra-high performance liquid chromatography tandem mass spectrometry technology, the problem of detecting a variety of bisphenol A analogs in infant food was solved, and efficient, low-cost and accurate quantitative detection effects were achieved.

CN120522306APending Publication Date: 2025-08-22SOUTH CHINA AGRICULTURAL UNIVERSITY
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Patent Information

Application Number
CN202510660702.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-21
Publication Date
2025-08-22

AI Technical Summary

Technical Problem

The prior art lacks fast, accurate and simple methods to detect the exposure levels of various bisphenol A analogs and their new derivatives in infant milk powder and rice powder. The existing methods such as liquid chromatography-mass spectrometry are costly and complex in operation, and the sensitivity of spectrophotometry is insufficient. The stability and selectivity of biosensing technology need to be improved.

Method used

The pre-treatment of liquid-liquid extraction samples combined with ultra-high performance liquid chromatography tandem mass spectrometry technology was used to extract by mixing acetonitrile and dichloromethane solvents, and then centrifuged after ultrasonic mixing. Combined with isotope internal standard, C18 chromatography column and gradient elution program were used, and finally detected by ultra-high performance liquid chromatography triple quadratic rod tandem mass spectrometry.

Benefits of technology

Simultaneous extraction and quantitative detection of 20 kinds of bisphenol A and its analogs has been achieved. It is simple to operate, low cost, high sensitivity and strong specificity, complies with recognized standards and meets actual testing needs.

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Abstract

The invention discloses a method for extracting bisphenol A and / or related compounds thereof in powder food and application, and the method comprises the following steps: fully and uniformly mixing the powder food, a salting-out reagent and an extraction solvent, carrying out solid-liquid separation, and collecting a solution to obtain the bisphenol A and / or related compounds thereof. According to the method disclosed by the invention, liquid-liquid extraction which is simple and efficient to operate, low in cost and good in repeatability is adopted as a sample pretreatment method, and is combined with an isotope label method and an ultra-high performance liquid chromatography-tandem mass spectrometry technology, so that qualitative and quantitative detection and separation of 20 bisphenol A related compounds in different powder foods are realized; meanwhile, the method has the advantages of high sensitivity, small quantity of isotope internal standards and small solvent loss, meets actual detection requirements, and has higher simplicity and wider detection limit.
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