Anti-corrosion magnetic bead as well as preparation method and application thereof
By modifying the surface of the magnetic core and wrapping it with a double layer of polymer, the corrosion problem of immunomagnetic beads in acid and metal chelators was solved, high stability and corrosion resistance were achieved, and the quality of the diagnostic kit was improved.
CN120594825APending Publication Date: 2025-09-05ZHENGZHOU IMMUNO BIOTECH
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Patent Information
- Application Number
- CN202510814398.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-18
- Publication Date
- 2025-09-05
AI Technical Summary
Technical Problem
Existing immunomagnetic beads are easily corroded in acidic substances and metal chelators, resulting in poor stability and affecting the quality of diagnostic kits.
Method used
A surface-modified magnetic core is used, with divinylbenzene and styrene forming the first polymer wrapping layer, and ethylene glycol dimethacrylate and methyl methacrylate forming the second polymer wrapping layer, forming a dense double-layer structure to improve corrosion resistance.
Benefits of technology
It significantly improves the stability of magnetic beads, enhances their corrosion resistance in acidic and metal chelating agents, and improves the stability of immunodiagnostic kits and clinical user experience.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of biological detection, in particular to a corrosion-resistant magnetic bead and a preparation method and application thereof. The invention provides a corrosion-resistant magnetic bead and a preparation method and application thereof. After the magnetic core is modified, the polymer of divinylbenzene and styrene is used as the first wrapping layer, and the polymer of ethylene glycol dimethacrylate and methyl methacrylate is used as the second wrapping layer to wrap the modified magnetic core, so that the corrosion-resistant magnetic bead is obtained, the preparation steps of the magnetic bead are simple, the cost is low, the appearance is relatively smooth, and the magnetic bead has a good application prospect. The immunologic diagnostic reagent has extremely high metal chelating agent and acid solution corrosion resistance, the stability of the related immunologic diagnostic reagent is improved to a great extent, and the immunologic diagnostic reagent has relatively good popularization and application prospects.
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